{"id":860676,"date":"2025-06-16T07:04:27","date_gmt":"2025-06-16T11:04:27","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/ibio-initiates-non-human-primate-study-of-first-in-class-activin-e-antibody-following-positive-preclinical-data-demonstrating-prevention-in-weight-regain-after-glp-1-treatment\/"},"modified":"2025-06-16T07:04:27","modified_gmt":"2025-06-16T11:04:27","slug":"ibio-initiates-non-human-primate-study-of-first-in-class-activin-e-antibody-following-positive-preclinical-data-demonstrating-prevention-in-weight-regain-after-glp-1-treatment","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/ibio-initiates-non-human-primate-study-of-first-in-class-activin-e-antibody-following-positive-preclinical-data-demonstrating-prevention-in-weight-regain-after-glp-1-treatment\/","title":{"rendered":"iBio Initiates Non-Human Primate Study of First-in-Class Activin E Antibody Following Positive Preclinical Data Demonstrating Prevention in Weight Regain After GLP-1 Treatment"},"content":{"rendered":"
\n

\n iBio nominates IBIO-610 as development candidate for its first-in-class Activin E antibody<\/em>\n <\/p>\n

\n New study aims to evaluate the half-life of IBIO-610 in obese, elderly non-human primates (NHP) and assess early signs of efficacy on fat reduction and body composition<\/em>\n <\/p>\n

\n Mouse study shows IBIO-610 alone drives an overall body weight loss of 8.9%*, and prevents weight regain following GLP-1 treatment in obese mice, results of which will be presented at ADA on Monday June 23<\/em>
\n
\n rd<\/em>
\n <\/sup>\n <\/p>\n

SAN DIEGO, June 16, 2025 (GLOBE NEWSWIRE) — iBio, Inc.<\/a>\u00a0(Nasdaq: IBIO), an AI-driven innovator of precision antibody therapies, today announced the initiation of a NHP study for its Activin E engineered antibody candidate, now named IBIO-610. This preclinical study will evaluate the pharmacokinetics and early signs of efficacy of IBIO-610 in obese and elderly NHPs, including its impact on fat and body composition.<\/p>\n

The study initiation follows a successful scale-up in production and encouraging preclinical results demonstrating a 26% reduction in fat, and synergistic effects with GLP-1 therapy in diet-induced obese (DIO) mice, where the fat-selective weight loss increased to 77%. Initial data from the NHP study are expected by early Q4.<\/p>\n

The NHP study launch follows additional positive preclinical data to be presented at the\u00a0American Diabetes Association’s\u00a0(ADA) 85<\/a>th<\/sup><\/a>\u00a0Scientific Sessions<\/a>, taking place\u00a0June 20-23\u00a0in\u00a0Chicago. This poster presentation expands on recent in vivo<\/em> findings<\/a>, which also demonstrated a significant 31% reduction in subcutaneous fat and increased to 74% reduction in subcutaneous fat when IBIO-610 was combined with a GLP-1 receptor agonist. The new data show IBIO-610 can not only enhance GLP-1-driven overall weight loss but also prevent weight-regain in DIO mice after GLP-1 therapy discontinuation. This is especially important, as the post-treatment period is typically marked by rapid weight rebound in humans1<\/sup>.<\/p>\n

\u201cThe promising preclinical data we’ve generated for this novel approach in the field of obesity are highly encouraging, especially regarding its ability to drive fat-selective weight loss and support long-term weight maintenance,\u201d said Martin Brenner, DVM, Ph.D., Chief Executive Officer and Chief Scientific Officer of iBio. \u201cWith this non-human primate study underway and a key scientific presentation at ADA ahead, we are accelerating the path toward clinical development. IBIO-610 exemplifies our commitment to advancing novel, AI-guided antibody therapeutics for serious cardiometabolic conditions like obesity.\u201d<\/p>\n

*non-responder outliers removed<\/p>\n

\n Details of the Poster Presentation at the\u00a0ADA 85<\/strong>
\n
\n th<\/strong>
\n <\/sup>
\n \u00a0Scientific Sessions:<\/strong>\n <\/p>\n

\n Poster Number: <\/strong>1701-P<\/p>\n

\n Abstract Title<\/strong>: Activin E-Blocking Antibody for Treatment of Metabolic Diseases<\/p>\n

\n Date & Time: <\/strong>Monday, June 23, from 12:30 p.m. to 1:30 p.m. CST<\/p>\n

\n Location: <\/strong>Poster Hall (Hall F1)<\/p>\n

\n References<\/strong>\n <\/p>\n

1. Wilding, J. P. H. et al.<\/em> Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes, Obesity and Metabolism<\/em>24<\/strong>, 1553\u20131564 (2022).<\/p>\n

\n About iBio, Inc.<\/strong>\n <\/p>\n

iBio\u202f(Nasdaq:\u202fIBIO<\/strong>) is a cutting-edge biotech company leveraging AI and advanced computational biology to develop next-generation biopharmaceuticals for cardiometabolic diseases, obesity, cancer and other hard-to-treat diseases. By combining proprietary 3D modeling with innovative drug discovery platforms, iBio is creating a pipeline of breakthrough antibody treatments to address significant unmet medical needs. Our mission is to transform drug discovery, accelerate development timelines, and unlock new possibilities in precision medicine.\u202f For more information, visit\u202fwww.ibioinc.com<\/a>\u202for follow us on\u202fLinkedIn<\/a>.<\/p>\n

\n Forward-Looking Statements<\/strong>\n <\/p>\n

Any statements contained in this press release about future expectations, plans, and prospects, as well as any other statements regarding matters that are not historical facts, may constitute \u201cforward-looking statements.\u201d These statements include statements regarding the preclinical study evaluating the pharmacokinetics and early signs of efficacy of IBIO-610 in obese and elderly NHPs, including its impact on fat and body composition, receiving initial data from the NHP study by early Q4, presenting additional positive preclinical data at the American Diabetes Association’s 85th Scientific Sessions on June 20-23 in Chicago, the ability of IBIO-610 to drive fat-selective weight loss and support long-term weight maintenance, accelerating the path toward clinical development and advancing novel, AI-guided antibody therapeutics for serious cardiometabolic conditions like obesity. The words \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccontinue,\u201d \u201ccould,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201cshould,\u201d \u201ctarget,\u201d \u201cwill,\u201d \u201cwould\u201d and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including the ability of IBIO-610 to drive fat-selective weight loss and support long-term weight maintenance; iBio\u2019s ability to complete the preclinical study of IBIO-610 on time and achieve desired results and benefits as expected; iBio\u2019s ability to obtain regulatory approvals for commercialization of its product candidates, or to comply with ongoing regulatory requirements; regulatory limitations relating to iBio\u2019s ability to promote or commercialize its product candidates for specific indications; acceptance of iBio\u2019s product candidates in the marketplace and the successful development, marketing or sale of products; and whether iBio will incur unforeseen expenses or liabilities or other market factors; and the other factors discussed in iBio\u2019s filings with the SEC including its Annual Report on Form 10-K for the year ended June 30, 2024 and its subsequent filings with the SEC on Forms 10-Q and 8-K. The information in this release is provided only as of the date of this release, and iBio undertakes no obligation to update any forward-looking statements contained in this release on account of new information, future events, or otherwise, except as required by law.<\/p>\n

\n Corporate Contact:<\/strong>\u00a0
iBio, Inc.\u00a0
Investor Relations\u00a0
ir@ibioinc.com<\/a><\/p>\n

\n Media Contacts:<\/strong>\u00a0
Ignacio Guerrero-Ros, Ph.D., or David Schull\u00a0
Russo Partners, LLC\u00a0
Ignacio.guerrero-ros@russopartnersllc.com<\/a>\u00a0
David.schull@russopartnersllc.com<\/a>\u00a0
(858) 717-2310 or (646) 942-5604<\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

iBio nominates IBIO-610 as development candidate for its first-in-class Activin E antibody New study aims to evaluate the half-life of IBIO-610 in obese, elderly non-human primates (NHP) and assess early signs of efficacy on fat reduction and body composition Mouse study shows IBIO-610 alone drives an overall body weight loss of 8.9%*, and prevents weight regain following GLP-1 treatment in obese mice, results of which will be presented at ADA on Monday June 23 rd SAN DIEGO, June 16, 2025 (GLOBE NEWSWIRE) — iBio, Inc.\u00a0(Nasdaq: IBIO), an AI-driven innovator of precision antibody therapies, today announced the initiation of a NHP study for its Activin E engineered antibody candidate, now named IBIO-610. This preclinical study will evaluate the pharmacokinetics and early … <\/p>\n

Continue reading “iBio Initiates Non-Human Primate Study of First-in-Class Activin E Antibody Following Positive Preclinical Data Demonstrating Prevention in Weight Regain After GLP-1 Treatment”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-860676","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\niBio Initiates Non-Human Primate Study of First-in-Class Activin E Antibody Following Positive Preclinical Data Demonstrating Prevention in Weight Regain After GLP-1 Treatment - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/ibio-initiates-non-human-primate-study-of-first-in-class-activin-e-antibody-following-positive-preclinical-data-demonstrating-prevention-in-weight-regain-after-glp-1-treatment\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"iBio Initiates Non-Human Primate Study of First-in-Class Activin E Antibody Following Positive Preclinical Data Demonstrating Prevention in Weight Regain After GLP-1 Treatment - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"iBio nominates IBIO-610 as development candidate for its first-in-class Activin E antibody New study aims to evaluate the half-life of IBIO-610 in obese, elderly non-human primates (NHP) and assess early signs of efficacy on fat reduction and body composition Mouse study shows IBIO-610 alone drives an overall body weight loss of 8.9%*, and prevents weight regain following GLP-1 treatment in obese mice, results of which will be presented at ADA on Monday June 23 rd SAN DIEGO, June 16, 2025 (GLOBE NEWSWIRE) — iBio, Inc.\u00a0(Nasdaq: IBIO), an AI-driven innovator of precision antibody therapies, today announced the initiation of a NHP study for its Activin E engineered antibody candidate, now named IBIO-610. 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