{"id":849463,"date":"2025-05-09T07:03:26","date_gmt":"2025-05-09T11:03:26","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\/"},"modified":"2025-05-09T07:03:26","modified_gmt":"2025-05-09T11:03:26","slug":"real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\/","title":{"rendered":"Real-World Study Confirms Long-Term Performance of DecisionDx\u00ae-UM for Metastatic Risk Stratification in Uveal Melanoma and Utility of PRAME Biomarker for Refining Risk When Considered with the DecisionDx-UM Class Result"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"left\">FRIENDSWOOD, Texas, May  09, 2025  (GLOBE NEWSWIRE) &#8212; Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced new data from the first independent validation of the recently published Collaborative Ocular Oncology Group Study No. 2 (COOG2.1) by Harbour et al.<sup>1<\/sup> The data, from a real-world cohort of 1,297 patients with uveal melanoma (UM), was presented at the Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting in Salt Lake City. The findings provide further support for adding Preferentially Expressed Antigen in Melanoma (<em>PRAME<\/em>) gene expression information to the DecisionDx-UM test result to further refine metastatic risk prediction for patients with UM, which is a rare but aggressive eye cancer.<\/p>\n<p>&#8220;This real-world validation of the landmark COOG2.1 study both confirms the long-term performance of the DecisionDx-UM test and affirms the clinical value of <em>PRAME<\/em> as an adjunct biomarker that may further refine a patient\u2019s metastatic risk when combined with the DecisionDx-UM class result,\u201d said Rebecca Critchley-Thorne, Ph.D., vice-president, research and development, of Castle Biosciences. \u201cThis enhanced approach to risk stratification is designed to equip clinicians with more precise information to help guide surveillance strategies and enable more personalized treatment planning with the goal of helping to improve outcomes for patients with UM.\u201d<\/p>\n<p>Details regarding Castle\u2019s presentation at ARVO are included below. The abstract may be viewed using the ARVO 2025 <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=vy3C5IBOFmmkl-CMACTuOrsyowvjWoYwhPAaf8xQ8idKbhYjxlPcwTk8f71VBriQY60xSnzPk1eYwKQbs8SJY_beC8NrdGBBXwvAYA8nHAhx9-R_X1txyA25IkwNf-QpY6Eyz5wCjsskvwvJdmG3Dv_AiM1Pur9xums347DJDoo=\" rel=\"nofollow\" target=\"_blank\">mobile meeting planner<\/a>.<\/p>\n<ul type=\"disc\">\n<li>Presentation Number 981: <strong><em>PRAME<\/em><\/strong><strong> status as a risk modifier of 15-gene expression profile class: Evidence from a real-world cohort of 1297 uveal melanoma patients<\/strong><\/li>\n<li>Presentation Type: Poster Session<\/li>\n<li>Session Number: 154<\/li>\n<li>Session Title: Uveal Melanoma<\/li>\n<li>\n          <strong>Summary<\/strong>: An ongoing collaboration with the National Cancer Institute\u2019s Surveillance, Epidemiology and End Results (NCI SEER) Program enabled linkage of UM patient records with such patients\u2019 DecisionDx-UM and <em>PRAME<\/em> test results. In a large, real-world, population-based cohort of patients with UM, this study aimed to validate the findings from the prospective COOG2.1 study, which found that adding the reported expression of the <em>PRAME<\/em> gene to the DecisionDx-UM class result can further refine risk by subdividing Class 1 and Class 2 tumors based on PRAME positive (+) versus negative (-) status. Consistent with the COOG2.1 study, the findings shared at ARVO demonstrate that co-reporting of DecisionDx-UM class and <em>PRAME<\/em> status provides additional insights into a patient\u2019s likelihood of metastasis to better inform treatment pathway decisions.<\/li>\n<\/ul>\n<p>\n        <strong>About DecisionDx-UM<\/strong><br \/>\n        <br \/>DecisionDx-UM is Castle Biosciences\u2019 15-gene expression profile (GEP) test that uses an individual patient\u2019s tumor biology to predict individual risk of metastasis in patients with uveal melanoma (UM). DecisionDx-UM is the standard of care in the management of newly diagnosed UM in the majority of ocular oncology practices in\u00a0the United States. Since 2009, the\u00a0American Joint Committee on Cancer\u00a0(AJCC; v7 and v8) Staging Manual for UM has specifically identified the GEP test as a prognostic factor that is recommended for collection as a part of clinical care. Further, the National Comprehensive Cancer Network (NCCN) guidelines for UM include the DecisionDx-UM test result as a prognostic method for determining risk of metastasis and recommended differential surveillance regimens based on a Class 1A, 1B and 2 result. DecisionDx-UM is currently the only prognostic test for UM that has been validated in prospective, multi-center studies, and it has been shown to be a superior predictor of metastasis compared to other prognostic factors, such as chromosome 3 status, mutational status, AJCC stage and cell type. It is estimated that nearly 8 in 10 patients diagnosed with UM in the\u00a0United States\u00a0receive the DecisionDx-UM test as part of their diagnostic workup. Learn more at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=VMa-L4_sY9_B9Njjgykzumis1c9BBR79b7vQU-9ImYby8edF7KFuK83xAHeo4NF5E9RWZMjGAXaVe0Z9PLHyZFh-MejSPidbXqFMzJYtz8MTD_aX4oPHJIvQhIkeryfbp6jdmJPLJpIq-Ul0y-0xBaWYZeG-s4BjPDYjVr47uPw=\" rel=\"nofollow\" target=\"_blank\">www.CastleBiosciences.com<\/a>.<\/p>\n<p>\n        <strong>About Castle Biosciences<\/strong><br \/>\n        <br \/>Castle Biosciences (Nasdaq: CSTL) is a leading diagnostics company improving health through innovative tests that guide patient care. The Company aims to transform disease management by keeping people first: patients, clinicians, employees and investors.<\/p>\n<p>Castle\u2019s current portfolio consists of tests for skin cancers, Barrett\u2019s esophagus and uveal melanoma. Additionally, the Company has active research and development programs for tests in other diseases with high clinical need, including its test in development to help guide systemic therapy selection for patients with moderate-to-severe atopic dermatitis seeking biologic treatment. To learn more, please visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=VMa-L4_sY9_B9Njjgykzumis1c9BBR79b7vQU-9ImYZTurrudFOmbHLD9xx5yKqvqRH2e4be_E8V_tnHpBLe-gNrNT0m6F2V2o15ai-MyMpa6mseYe1Lkw0iq-rF5lBJ\" rel=\"nofollow\" target=\"_blank\"><u>www.CastleBiosciences.com<\/u><\/a> and connect with us on <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=06kyoxSoVgJruX2MEybn2NGq4O3lECTjbiyTDCTN1q0kVnl-bXqLx33iQmVssfPYo19KbIb3dswM3PkikU_YUZNiTEHycTEZTtPOBimUAcKKxRPbyqgW0R9HNd7g8Bb9\" rel=\"nofollow\" target=\"_blank\"><u>LinkedIn<\/u><\/a>, <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=UGLGNu0frlhBVaD_Lp83eBrmXIGVcuc1xZCSaQuHr7wlezP-zKgAkYqr9ELKBSz4PiQz9Ksta6KmEl34G_IO2yYolQjJSA4fCMVFSxaxigw=\" rel=\"nofollow\" target=\"_blank\"><u>Facebook<\/u><\/a>, <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=QBH0R4kJW_ONZxd-TvD-0ouIcmlGDiPGkvPK4Pi4PpIWjUHfJQeHIGKGqlgLYRAR7Uy_cJzYIJ8_XQIRs5g9khdPuET-vuX7MtjjQunpcDw=\" rel=\"nofollow\" target=\"_blank\"><u>X<\/u><\/a> and <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=9zWlHS8OjvawwwXiqLQrkpryMtS5od1QYUxZ2JJB-mOYES27NaxnR2fQ7Ash6EdOw5V-Iru2oX3sRQOO0F_aoeZ-CGibd4TfD0uPNroMNGk=\" rel=\"nofollow\" target=\"_blank\"><u>Instagram<\/u><\/a>.\u202f<\/p>\n<p>DecisionDx-Melanoma, DecisionDx-CM<em>Seq<\/em>, i31-SLNB, i31-ROR, DecisionDx-SCC, MyPath Melanoma, TissueCypher, DecisionDx-UM, DecisionDx-PRAME and DecisionDx-UM<em>Seq<\/em> are trademarks of Castle Biosciences, Inc.<\/p>\n<p><strong>Forward-Looking Statements <\/strong><br \/><em>This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the \u201csafe harbor\u201d created by those sections. These forward-looking statements include, but are not limited to, statements concerning: the ability of the DecisionDx-UM test to guide more informed, risk-aligned management decisions through the precise risk-stratification of patients with UM; the potential increased risk stratification from including PRAME gene expression information to a patient\u2019s DecisionDx-UM test result; and DecisionDx-UM\u2019s value in identifying UM patients who may benefit from enhanced surveillance and management strategies to improve outcomes. The words \u201cbelieve,\u201d \u201ccan\u201d and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements that we make. These forward-looking statements involve risks and uncertainties that could cause our actual results to differ materially from those in the forward-looking statements, including, without limitation: subsequent study or trial results and findings may contradict earlier study or trial results and findings or may not support the results obtained in these studies, including with respect to the discussion of our tests in this press release; actual application of our tests may not provide the aforementioned benefits to patients; and the risks set forth under the heading \u201cRisk Factors\u201d in our Annual Report on Form 10-K for the year ended December 31, 2024 and our Quarterly Report on Form 10-Q for the quarter ended March 31, 2025, each filed with the SEC, and in our other filings with the SEC. The forward-looking statements are applicable only as of the date on which they are made, and we do not assume any obligation to update any forward-looking statements, except as may be required by law.<\/em><\/p>\n<ol style=\"list-style-type:decimal\">\n<li>Harbour JW, Correa ZM, Schefler AC, et al. 15-Gene Expression Profile and\u00a0<em>PRAME<\/em>\u00a0as Integrated Prognostic Test for Uveal Melanoma: First Report of Collaborative Ocular Oncology Group Study No. 2 (COOG2.1).\u00a0<em>J Clin Oncol<\/em>. 2024;42(28):3319-3329. doi:10.1200\/JCO.24.00447<\/li>\n<\/ol>\n<p>\n        <strong>Investor Contact:<\/strong><br \/>\n        <br \/>Camilla Zuckero<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=tBPu7m_oXN2Vc3QBpRS9ylsrumNENHPoKvo6lYsmA9twxr5EuFYvj3SdDlcRg4iLkD9cXEEUDsEtDd6GWNYlGm5N8VIooypib_qwvpYJZB03zmcHwczp3hWiu21wH6fC\" rel=\"nofollow\" target=\"_blank\">czuckero@castlebiosciences.com<\/a><\/p>\n<p>\n        <strong>Media Contact:<\/strong><br \/>\n        <br \/>Allison Marshall<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=XwHxCUfUvd_XMdnnwYcTqT1S1W7MeF7Jlp5f4uHbjXAiC4nchsJwaOyo6tXRujnVcAmg0H3Ik83Uv8jH1Z0oq4Y2eN7JYqLfGNY2vhLryHIWosjJ55fJThfvRkMwLnOk\" rel=\"nofollow\" target=\"_blank\">amarshall@castlebiosciences.com<\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQ0Nzk3OCM2OTMwNzgyIzIwOTYwNzQ=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/NmVlOGNjNWItZTBiYS00OWUyLTk5MTctOGUyNWRjZTNlYjFiLTExMDc2NDUtMjAyNS0wNS0wOS1lbg==\/tiny\/Castle-Biosciences-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>FRIENDSWOOD, Texas, May 09, 2025 (GLOBE NEWSWIRE) &#8212; Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced new data from the first independent validation of the recently published Collaborative Ocular Oncology Group Study No. 2 (COOG2.1) by Harbour et al.1 The data, from a real-world cohort of 1,297 patients with uveal melanoma (UM), was presented at the Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting in Salt Lake City. The findings provide further support for adding Preferentially Expressed Antigen in Melanoma (PRAME) gene expression information to the DecisionDx-UM test result to further refine metastatic risk prediction for patients with UM, which is a rare but aggressive eye cancer. &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Real-World Study Confirms Long-Term Performance of DecisionDx\u00ae-UM for Metastatic Risk Stratification in Uveal Melanoma and Utility of PRAME Biomarker for Refining Risk When Considered with the DecisionDx-UM Class Result&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-849463","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Real-World Study Confirms Long-Term Performance of DecisionDx\u00ae-UM for Metastatic Risk Stratification in Uveal Melanoma and Utility of PRAME Biomarker for Refining Risk When Considered with the DecisionDx-UM Class Result - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Real-World Study Confirms Long-Term Performance of DecisionDx\u00ae-UM for Metastatic Risk Stratification in Uveal Melanoma and Utility of PRAME Biomarker for Refining Risk When Considered with the DecisionDx-UM Class Result - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"FRIENDSWOOD, Texas, May 09, 2025 (GLOBE NEWSWIRE) &#8212; Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced new data from the first independent validation of the recently published Collaborative Ocular Oncology Group Study No. 2 (COOG2.1) by Harbour et al.1 The data, from a real-world cohort of 1,297 patients with uveal melanoma (UM), was presented at the Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting in Salt Lake City. The findings provide further support for adding Preferentially Expressed Antigen in Melanoma (PRAME) gene expression information to the DecisionDx-UM test result to further refine metastatic risk prediction for patients with UM, which is a rare but aggressive eye cancer. &hellip; Continue reading &quot;Real-World Study Confirms Long-Term Performance of DecisionDx\u00ae-UM for Metastatic Risk Stratification in Uveal Melanoma and Utility of PRAME Biomarker for Refining Risk When Considered with the DecisionDx-UM Class Result&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-05-09T11:03:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQ0Nzk3OCM2OTMwNzgyIzIwOTYwNzQ=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Real-World Study Confirms Long-Term Performance of DecisionDx\u00ae-UM for Metastatic Risk Stratification in Uveal Melanoma and Utility of PRAME Biomarker for Refining Risk When Considered with the DecisionDx-UM Class Result\",\"datePublished\":\"2025-05-09T11:03:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\\\/\"},\"wordCount\":1137,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTQ0Nzk3OCM2OTMwNzgyIzIwOTYwNzQ=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\\\/\",\"name\":\"Real-World Study Confirms Long-Term Performance of DecisionDx\u00ae-UM for Metastatic Risk Stratification in Uveal Melanoma and Utility of PRAME Biomarker for Refining Risk When Considered with the DecisionDx-UM Class Result - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/real-world-study-confirms-long-term-performance-of-decisiondx-um-for-metastatic-risk-stratification-in-uveal-melanoma-and-utility-of-prame-biomarker-for-refining-risk-when-considered-with-the-de\/","og_locale":"en_US","og_type":"article","og_title":"Real-World Study Confirms Long-Term Performance of DecisionDx\u00ae-UM for Metastatic Risk Stratification in Uveal Melanoma and Utility of PRAME Biomarker for Refining Risk When Considered with the DecisionDx-UM Class Result - Market Newsdesk","og_description":"FRIENDSWOOD, Texas, May 09, 2025 (GLOBE NEWSWIRE) &#8212; Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced new data from the first independent validation of the recently published Collaborative Ocular Oncology Group Study No. 2 (COOG2.1) by Harbour et al.1 The data, from a real-world cohort of 1,297 patients with uveal melanoma (UM), was presented at the Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting in Salt Lake City. 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