{"id":842490,"date":"2025-04-28T08:32:19","date_gmt":"2025-04-28T12:32:19","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-presents-benchmark-beating-survival-and-clinical-benefit-at-aacr-2025-advancements-in-next-generation-bria-ots-development\/"},"modified":"2025-04-28T08:32:19","modified_gmt":"2025-04-28T12:32:19","slug":"briacell-presents-benchmark-beating-survival-and-clinical-benefit-at-aacr-2025-advancements-in-next-generation-bria-ots-development","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-presents-benchmark-beating-survival-and-clinical-benefit-at-aacr-2025-advancements-in-next-generation-bria-ots-development\/","title":{"rendered":"BriaCell Presents Benchmark Beating Survival and Clinical Benefit at AACR 2025; Advancements in Next Generation Bria-OTS+\u2122 Development"},"content":{"rendered":"<div class=\"mw_release\">\n<ul>\n<li style=\"text-align:justify\">\n          <strong><br \/>\n            <em>Overall survival and clinical benefit in Phase 2 continue to outperform historical benchmarks, including very heavily pretreated patients<\/em><br \/>\n          <\/strong>\n        <\/li>\n<li style=\"text-align:justify\">\n          <strong><br \/>\n            <em>Clinical benefit observed in 83% of evaluable patient sub-group treated with the phase 3 formulation<\/em><br \/>\n          <\/strong>\n        <\/li>\n<li style=\"text-align:justify\">\n          <strong><br \/>\n            <em>Improved new Bria-OTS+ platform provides powerful innate and adaptive immune system activation<\/em><br \/>\n          <\/strong>\n        <\/li>\n<li style=\"text-align:justify\">\n          <strong><br \/>\n            <em>Phase 3 biomarker data to be presented on Wed April 30 from 9:00 AM &#8211; 12:00 PM CST; Abstract # LB408<\/em><br \/>\n          <\/strong>\n        <\/li>\n<\/ul>\n<p align=\"justify\">PHILADELPHIA and VANCOUVER, British Columbia, April  28, 2025  (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care, is presenting positive data from its Phase 2 study of lead product candidate, Bria-IMT\u2122, in metastatic breast cancer, and from its preclinical Bria-OTS+ platform at the 2025 American Association for Cancer Research (AACR) Annual Meeting taking place from April 25th \u2013 30th at McCormick Place Convention Center, Chicago, IL. In addition, Phase 3 early biomarker data will be presented as a late breaking abstract.<\/p>\n<p align=\"justify\">The posters are summarized below and linked here: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=oal8JahEQUIHhBQ1M5TzJbUS4tfxADkNzkZwxuevPTZs2CO3rB1xuYKHN6g_b4yOjEIVWN2sXVxkFgNTtfRdXddfjk_rUf1oWdkaMLIs8HdGDoLbI2H3MASO2InMWPrBUI2R5PkPZFEdbFsJqxmzqo-lqfInBWK5pcnbapADua0=\" rel=\"nofollow\" target=\"_blank\"><u>https:\/\/briacell.com\/scientific-publications\/<\/u><\/a>.<\/p>\n<p align=\"justify\">\n        <strong>Title:\u00a0Survival outcomes in a randomized phase 2 of\u00a0<\/strong><br \/>\n        <strong><br \/>\n          <em>Bria-IMT<\/em><br \/>\n        <\/strong><br \/>\n        <strong>: An allogeneic whole cell cancer vaccine<\/strong><br \/>\n        <br \/>\n        <strong>Session Title:\u00a0<\/strong>Phase II and Phase III Clinical Trials<br \/><strong>Session Start:\u00a0<\/strong>4\/28\/2025 2:00 PM \u2013 5:00 PM CST<br \/><strong>Location:\u00a0<\/strong>Poster Section 50<br \/><strong>Poster Board Number:\u00a0<\/strong>18<br \/><strong>Abstract Presentation Number:\u00a0<\/strong>CT100<\/p>\n<p align=\"justify\">\u201cWe are thrilled to share impressive survival and clinical efficacy data at AACR on the advantages of using Bria-IMT plus checkpoint inhibitor in heavily treated patients who have failed multiple prior treatments, including ADCs and CPIs,\u201d stated lead author, Saranya Chumsri, MD, Principal Investigator and Professor of Oncology, Mayo Clinic. \u201cTreatment options have been limited for patients who progress after ADC therapy, making this a particularly challenging clinical setting. Our clinical findings support the use of Bria-IMT as a well-tolerated, alternative treatment option for these very difficult-to-treat patients with unmet medical needs.\u201d<\/p>\n<p align=\"justify\">\u201cThe excellent survival responses reported in patients with different tumor types in the Phase 2 study is very exciting, and we look forward to seeing these promising data replicate in the pivotal Phase 3 study,\u201d stated Dr. William V. Williams, BriaCell\u2019s President &amp; CEO.<\/p>\n<p align=\"justify\">Of 54 metastatic breast cancer patients in the Phase 2 study, 37 patients received Bria-IMT formulation that is currently being used in BriaCell\u2019s ongoing pivotal Phase 3 study (ClinicalTrials.gov as\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=QAWau39IqOZTPpBno0KFx46u9GoS1Zpt3Gq1YFJ7SvI57Bf2ApVgJj0JITs_SVGC-P5hkd1XV8Ii8Ikgvr6Jz8gJ7YpTau2g0J-xBvBV-dw0221KXARTHTYLCDdQIooN\" rel=\"nofollow\" target=\"_blank\"><strong><u>NCT06072612<\/u><\/strong><\/a>). Patients have been heavily pre-treated a median of 6 prior treatments &#8212; including Antibody-Drug Conjugates (ADCs) and check point inhibitors (CPIs).<\/p>\n<ul type=\"disc\">\n<li style=\"text-align:left\">Clinical benefit rates [CR, PR, SD] ranged from 45% to 100% based on subtype<\/li>\n<li style=\"text-align:left\">Decrease in size or no change in all tumors noted in 83% of patients receiving Phase 3 formulation<\/li>\n<li style=\"text-align:left\">Overall survival (OS) with the Phase 3 formulation was 17.3 months for HR+ patients and 11.44 months for patients with triple negative breast cancer (TNBC)<\/li>\n<li style=\"text-align:left\">Overall response rate (ORR) for patients with intracranial metastases was 50% with a 75% clinical benefit rate<\/li>\n<li style=\"text-align:left\">Safety profile: No unexpected adverse events, no treatment related discontinuation of therapy<\/li>\n<\/ul>\n<p align=\"justify\">\n        <strong>Title:\u00a0Bria-OTS+: A versatile therapeutic platform for inducing anti-cancer immunity<\/strong><br \/>\n        <br \/>\n        <strong>Session Category:\u00a0<\/strong>Immunology<br \/><strong>Session Title:\u00a0<\/strong>Vaccines, In Situ Vaccines, and Vaccine Combinations<br \/><strong>Session Date and Time:\u00a0<\/strong>4\/28\/2025 2:00 \u2013 5:00 PM CST<br \/><strong>Location:\u00a0<\/strong>Poster Section 39<br \/><strong>Poster Board Number:\u00a0<\/strong>29<br \/><strong>Published Abstract Number:\u00a0<\/strong>3553<\/p>\n<p align=\"justify\">Miguel A. Lopez-Lago, PhD, BriaCell\u2019s Chief Scientific Officer, commented, \u201cWe are very excited with the anti-cancer activity of Bria-OTS+ and expect the platform will enable the delivery of powerful and long-lasting immune activity against cancer.\u201d<\/p>\n<p align=\"justify\">\u201cThis data further validates the mechanism of action of our next-generation Bria-OTS+ platform. Additional immune activating factors are expected to enhance efficacy, and we look forward to replicating these results clinically as we advance our next generation Bria-BRES+ breast cancer and Bria-PROS+ prostate cancer programs,\u201d stated Dr. William V. Williams, BriaCell\u2019s President and CEO.<\/p>\n<p align=\"justify\">Bria-OTS+ is an immunotherapy platform and enhanced version of Bria-OTS\u2122, BriaCell\u2019s personalized pre-manufactured immunotherapy already demonstrating tremendous results <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=TS80SYd5xZMpoPMBr0DWHx8mqQLGFqgjo09HBPWZD9i_AkBgsL-TUdP9JCt86WXm5_jAZJ7y6QMk3p43YFJhsckP75D6ImKwOoBhUdVO0uHsqo6sKtOgdfS9cA7rvCY9Y2amWaxmaY02tjmp9p_f1kRpg7u8py_JOHXzSB31AR7QHw0KHuZkek8WqluFBoVt\" rel=\"nofollow\" target=\"_blank\"><u>as announced on April 24 2025<\/u><\/a>. Bria-OTS+ immunotherapy expresses multiple immune-activating cytokines and co-stimulatory molecules in addition to immune-boosting granulocyte-macrophage colony-stimulating factor (GM-CSF). Bria-BRES+\u2122 for breast cancer and Bria-PROS+\u2122 for prostate cancer are expected to be investigated in BriaCell\u2019s upcoming Phase 1\/2a clinical studies.<\/p>\n<p align=\"justify\">\n        <strong>About BriaCell Therapeutics Corp.<\/strong>\n      <\/p>\n<p align=\"justify\">BriaCell is a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care. More information is available at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=oal8JahEQUIHhBQ1M5TzJbUS4tfxADkNzkZwxuevPTZX2qPddfHNaW-TefTFD-7Kra4oOcD09b0OBU9ifYmGpsR5MpuQza1hmB-2FStkX_U=\" rel=\"nofollow\" target=\"_blank\"><u>https:\/\/briacell.com\/<\/u><\/a>.<\/p>\n<p align=\"justify\">\n        <strong>Safe Harbor<\/strong>\n      <\/p>\n<p align=\"justify\">This press release contains \u201cforward-looking statements\u201d that are subject to substantial risks and uncertainties. All statements, other than statements of historical fact, contained in this press release are forward-looking statements. Forward-looking statements contained in this press release may be identified by the use of words such as \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccontemplate,\u201d \u201ccould,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cseek,\u201d \u201cmay,\u201d \u201cmight,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201ctarget,\u201d \u201caim,\u201d \u201cshould,\u201d \u201cwill,\u201d \u201cwould,\u201d or the negative of these words or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements, including those about: BriaCell presenting positive data from its Phase 2 study of lead product candidate, Bria-IMT, in metastatic breast cancer, and from its preclinical Bria-OTS+ platform at the AACR as well as Phase 3 early biomarker data being presented at the AACR as a late breaking abstract; whether BriaCell will be able to see prior results replicated in the pivotal Phase 3 study; BriaCell&#8217;s expectations that the Bria-OTS+ platform will enable the delivery of powerful and long-lasting immune activity against cancer; whether additional immune activating factors will enhance efficacy of the Bria-OTS+ platform; whether prior results will be replicated in clinical studies of the next generation Bria-BRES+ breast cancer and Bria-PROS+ prostate cancer programs; and expectations for what will be investigated in BriaCell\u2019s planned Phase 1\/2a clinical studies; are based on BriaCell\u2019s current expectations and are subject to inherent uncertainties, risks, and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. These and other risks and uncertainties are described more fully under the heading \u201cRisks and Uncertainties\u201d in the Company&#8217;s most recent Management\u2019s Discussion and Analysis, under the heading &#8220;Risk Factors&#8221; in the Company&#8217;s most recent Annual Information Form, and under \u201cRisks and Uncertainties\u201d in the Company&#8217;s other filings with the Canadian securities regulatory authorities and the U.S. Securities and Exchange Commission, all of which are available under the Company&#8217;s profiles on SEDAR+ at <strong><u><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=LC_5fBK1qc2869jXfEpgbBHhoANH7UJVYevl8lSNHY77vOen-UeD-LSBTRkZnVPePdh__q_MRdvd8knsOxdIM0-JWrjMkoX6PCLVPoowg40=\" rel=\"nofollow\" target=\"_blank\">www.sedarplus.ca<\/a><\/u><\/strong>\u00a0and on EDGAR at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=LC_5fBK1qc2869jXfEpgbK_lB2Kvhr6HylnSXegrsg8T8AK2DQNx8Z1-or4hHMBYx4lOsghZsOLEJrAClIZWKQ==\" rel=\"nofollow\" target=\"_blank\"><strong><u>www.sec.gov<\/u><\/strong><\/a>. Forward-looking statements contained in this announcement are made as of this date, and BriaCell Therapeutics Corp. undertakes no duty to update such information except as required under applicable law.<\/p>\n<p align=\"justify\">Neither the Toronto Stock Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Toronto Stock Exchange) accepts responsibility for the adequacy or accuracy of this release.<\/p>\n<p align=\"justify\">\n        <strong>Contact Information<\/strong>\n      <\/p>\n<p align=\"justify\">\n        <strong>Company Contact:<\/strong><br \/>\n        <br \/>William V. Williams, MD<br \/>President &amp; CEO<br \/>1-888-485-6340<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=BYQ8xeaXURAAqoxxZUrwOTCQe6d6gPwfRIFWbbUrmxWQwvHOiDeRi82fnmAi4BQJJKN175ew93AARUyf2uaDgbsGSwESNWnjmxeclIRd81A=\" rel=\"nofollow\" target=\"_blank\"><u>info@briacell.com<\/u><\/a><\/p>\n<p align=\"justify\">\n        <strong>Investor Relations Contact:<\/strong><br \/>\n        <br \/>\n        <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=9NGrtxDl82fXpsHdJuAq7Z9SLXhF0XwjKfUu1E58NpmoCgUAxt4XSCKpccPHutB3IK2ukC0iUziisK5aJYOpVB1VYDQEeAjKlBoF8Zu3yCQ=\" rel=\"nofollow\" target=\"_blank\"><br \/>\n          <u>investors@briacell.com<\/u><br \/>\n        <\/a>\n      <\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQzOTc5NSM2OTA3NjU2IzIwOTA2NTg=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/ZTgwNDYxZDEtZjA1Yi00M2I3LWI5NGYtOWI2YjY5Yjg1NTJiLTExMDIyMjktMjAyNS0wNC0yOC1lbg==\/tiny\/BriaCell-Therapeutics-Corp-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Overall survival and clinical benefit in Phase 2 continue to outperform historical benchmarks, including very heavily pretreated patients Clinical benefit observed in 83% of evaluable patient sub-group treated with the phase 3 formulation Improved new Bria-OTS+ platform provides powerful innate and adaptive immune system activation Phase 3 biomarker data to be presented on Wed April 30 from 9:00 AM &#8211; 12:00 PM CST; Abstract # LB408 PHILADELPHIA and VANCOUVER, British Columbia, April 28, 2025 (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care, is presenting positive data from its Phase 2 study of lead product candidate, Bria-IMT\u2122, in metastatic breast cancer, and &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-presents-benchmark-beating-survival-and-clinical-benefit-at-aacr-2025-advancements-in-next-generation-bria-ots-development\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;BriaCell Presents Benchmark Beating Survival and Clinical Benefit at AACR 2025; Advancements in Next Generation Bria-OTS+\u2122 Development&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-842490","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BriaCell Presents Benchmark Beating Survival and Clinical Benefit at AACR 2025; Advancements in Next Generation Bria-OTS+\u2122 Development - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-presents-benchmark-beating-survival-and-clinical-benefit-at-aacr-2025-advancements-in-next-generation-bria-ots-development\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BriaCell Presents Benchmark Beating Survival and Clinical Benefit at AACR 2025; Advancements in Next Generation Bria-OTS+\u2122 Development - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Overall survival and clinical benefit in Phase 2 continue to outperform historical benchmarks, including very heavily pretreated patients Clinical benefit observed in 83% of evaluable patient sub-group treated with the phase 3 formulation Improved new Bria-OTS+ platform provides powerful innate and adaptive immune system activation Phase 3 biomarker data to be presented on Wed April 30 from 9:00 AM &#8211; 12:00 PM CST; Abstract # LB408 PHILADELPHIA and VANCOUVER, British Columbia, April 28, 2025 (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care, is presenting positive data from its Phase 2 study of lead product candidate, Bria-IMT\u2122, in metastatic breast cancer, and &hellip; Continue reading &quot;BriaCell Presents Benchmark Beating Survival and Clinical Benefit at AACR 2025; Advancements in Next Generation Bria-OTS+\u2122 Development&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-presents-benchmark-beating-survival-and-clinical-benefit-at-aacr-2025-advancements-in-next-generation-bria-ots-development\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-04-28T12:32:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQzOTc5NSM2OTA3NjU2IzIwOTA2NTg=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-presents-benchmark-beating-survival-and-clinical-benefit-at-aacr-2025-advancements-in-next-generation-bria-ots-development\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-presents-benchmark-beating-survival-and-clinical-benefit-at-aacr-2025-advancements-in-next-generation-bria-ots-development\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"BriaCell Presents Benchmark Beating Survival and Clinical Benefit at AACR 2025; 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12:00 PM CST; Abstract # LB408 PHILADELPHIA and VANCOUVER, British Columbia, April 28, 2025 (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care, is presenting positive data from its Phase 2 study of lead product candidate, Bria-IMT\u2122, in metastatic breast cancer, and &hellip; Continue reading \"BriaCell Presents Benchmark Beating Survival and Clinical Benefit at AACR 2025; Advancements in Next Generation Bria-OTS+\u2122 Development\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-presents-benchmark-beating-survival-and-clinical-benefit-at-aacr-2025-advancements-in-next-generation-bria-ots-development\/","og_site_name":"Market Newsdesk","article_published_time":"2025-04-28T12:32:19+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQzOTc5NSM2OTA3NjU2IzIwOTA2NTg=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-presents-benchmark-beating-survival-and-clinical-benefit-at-aacr-2025-advancements-in-next-generation-bria-ots-development\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-presents-benchmark-beating-survival-and-clinical-benefit-at-aacr-2025-advancements-in-next-generation-bria-ots-development\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"BriaCell Presents Benchmark Beating Survival and Clinical Benefit at AACR 2025; 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