{"id":842259,"date":"2025-04-25T13:13:11","date_gmt":"2025-04-25T17:13:11","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/alx-oncology-announces-encouraging-final-results-from-phase-1-trial-evaluating-evorpacept-in-combination-with-standard-of-care-treatment-in-patients-with-b-cell-non-hodgkin-lymphoma\/"},"modified":"2025-04-25T13:13:11","modified_gmt":"2025-04-25T17:13:11","slug":"alx-oncology-announces-encouraging-final-results-from-phase-1-trial-evaluating-evorpacept-in-combination-with-standard-of-care-treatment-in-patients-with-b-cell-non-hodgkin-lymphoma","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/alx-oncology-announces-encouraging-final-results-from-phase-1-trial-evaluating-evorpacept-in-combination-with-standard-of-care-treatment-in-patients-with-b-cell-non-hodgkin-lymphoma\/","title":{"rendered":"ALX Oncology Announces Encouraging Final Results from Phase 1 Trial Evaluating Evorpacept in Combination with Standard-of-Care Treatment in Patients with\u00a0B-cell Non-Hodgkin Lymphoma"},"content":{"rendered":"
\n

\n – Data to be presented at AACR 2025 Annual Meeting suggest the combination of ALX Oncology\u2019s investigational CD47-blocker, evorpacept, plus rituximab and lenalidomide (R<\/strong>
\n
\n 2<\/strong>
\n <\/sup>
\n ) was well-tolerated and demonstrated promising anti-tumor activity<\/strong>\n <\/p>\n

\n – Combination generated complete responses (CR) in 83% of patients with indolent relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL) comparing favorably to 34% historical CR rate with R<\/strong>
\n
\n 2<\/strong>
\n <\/sup>
\n alone <\/strong>\n <\/p>\n

\n – Phase 2 portion of trial in patients with previously untreated indolent NHL (iNHL) is ongoing and has completed enrollment<\/strong>\n <\/p>\n

SOUTH SAN FRANCISCO, Calif., April 25, 2025 (GLOBE NEWSWIRE) — ALX Oncology Holdings Inc., (\u201cALX Oncology\u201d or the \u201cCompany\u201d) (Nasdaq: ALXO), a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend patients\u2019 lives, today announced encouraging data from an ongoing Phase 1\/2 investigator-sponsored trial (IST) of the company\u2019s lead clinical candidate, evorpacept, in combination with standard-of-care rituximab and lenalidomide (R2<\/sup>) in patients with indolent and aggressive relapsed or refractory B-cell non-Hodgkin lymphoma (R\/R B-NHL). Final results from the Phase 1 portion of the trial will be presented Tuesday, April 29, during a poster presentation at the American Association for Cancer Research\u202f(AACR) Annual Meeting 2025 in Chicago, Illinois.\u00a0<\/p>\n

\u201cIn patients with indolent B-NHL, increases in certain pro-tumoral macrophages can promote resistance to important frontline standard-of-care treatments, including R2<\/sup>,\u201d said Paolo Strati, M.D., the trial\u2019s lead investigator and Associate Professor of Lymphoma-Myeloma at The University of Texas MD Anderson Cancer Center. \u201cEvorpacept is uniquely designed to activate the innate immune system and engage macrophages to enhance the therapeutic benefits of and deepen responses to anti-cancer antibodies such as rituximab. This trial suggests evorpacept has a synergistic effect with R2<\/sup> that may help improve outcomes and overcome resistance to R2 <\/sup>in this patient population.\u201d<\/p>\n

The clinical trial conducted by Dr. Strati and colleagues at MD Anderson enrolled a total of 20 patients with indolent (n=18) and aggressive (n=2) R\/R B-NHL; all 20 had previously received an anti-CD20 monoclonal antibody (rituximab), 72% had received prior chemoimmunotherapy and 80% had progressed within 24 months from frontline therapy. Patients with indolent NHL had received at least one prior line of systemic therapy. Investigators administered the CD47-blocker evorpacept at two dose levels: 30 mg\/kg Q2W (n=3) or 60 mg\/kg Q4W (n=17) in combination with standard R2<\/sup> treatment. The regimen was well- tolerated, and there were no dose-limiting toxicities.<\/p>\n

After a median follow-up of 28 months (95% CI, 18-28 months) the two-year progression-free survival (PFS) rate was 69% and two-year overall survival (OS) rate was 84%. Sixteen patients (80%) achieved complete responses and the best overall response rate (ORR) was 90%. As previously reported at the AACR 2024 Annual Meeting, the CR rate among the 18 patients with iNHL was 83%. This complete response rate achieved by evorpacept + R2<\/sup> in this trial compares favorably to the 34% historical CR rate for R2 <\/sup>alone. During treatment, a significant increase in T cells and anti-tumoral macrophages was observed.<\/p>\n

\u201cThe final results from this Phase 1 study reinforce evorpacept\u2019s potential to meaningfully deepen and enhance responses to many of the most important cancer therapies available today, including anti-cancer antibodies such as rituximab, and to thereby help address significant, unmet needs in cancer treatment,\u201d said Jason Lettmann, Chief Executive Officer of ALX Oncology. \u201cWe look forward to the continued evaluation of evorpacept in patients with previously untreated and high tumor-burden indolent NHL in the Phase 2 portion of this study.\u201d<\/p>\n

The Phase 2 portion of this IST in patients with previously untreated iNHL is ongoing and has completed enrollment.<\/p>\n

\n
\n Details of the poster to be presented at AACR 2025 are as follows:<\/u>
\n <\/strong>\u00a0<\/p>\n

\n Title:<\/strong>\u00a0Final results of a phase I trial of evorpacept (ALX148), lenalidomide, and rituximab for patients with B-cell non-Hodgkin lymphoma<\/a>
<\/a>Presenter:<\/strong>\u00a0Paolo Strati, M.D., Associate Professor of Lymphoma-Myeloma, The University of Texas MD Anderson Cancer Center
Session Title:\u00a0<\/strong>Late-Breaking Research: Clinical Research 3<\/a>
<\/a>Date\/Time:<\/strong>\u00a0Tuesday, April 29, 2025, from\u00a02:00 p.m. – 5:00 p.m. CT\u00a0
Location:<\/strong>\u00a0McCormick Place Convention Center, Poster Section 53
Poster Board Number:\u00a0<\/strong>13
Published Abstract Number:\u00a0<\/strong>LB369<\/p>\n

A copy of the AACR 2025 IST presentation will be available in the \u201cPublications\u201d section of the ALX Oncology website following the presentation.<\/p>\n

\n About ALX Oncology<\/strong>\n <\/p>\n

ALX Oncology (Nasdaq: ALXO) is a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend patients\u2019 lives. ALX Oncology\u2019s lead therapeutic candidate, evorpacept, has demonstrated potential to serve as a cornerstone therapy upon which the future of immuno-oncology can be built. Evorpacept is currently being evaluated across multiple ongoing clinical trials in a wide range of cancer indications. More information is available at www.alxoncology.com<\/a> and on LinkedIn @ALX Oncology<\/a>.<\/p>\n

\n Cautionary note regarding forward-looking statements<\/strong>\n <\/p>\n

This press release contains forward-looking statements that involve substantial risks and uncertainties. Forward-looking statements include statements regarding future results of operations and financial position, business strategy, product candidates, planned preclinical studies and clinical trials, results of clinical trials, research and development costs, regulatory approvals, timing and likelihood of success, plans and objectives of management for future operations, as well as statements regarding industry trends. Such forward-looking statements are based on ALX Oncology\u2019s beliefs and assumptions and on information currently available to it on the date of this press release. Forward-looking statements may involve known and unknown risks, uncertainties and other factors that may cause ALX Oncology\u2019s actual results, performance or achievements to be materially different from those expressed or implied by the forward-looking statements. These and other risks are described more fully in ALX Oncology\u2019s filings with the Securities and Exchange Commission (SEC), including ALX Oncology\u2019s Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and other documents ALX Oncology files with the SEC from time to time. Except to the extent required by law, ALX Oncology undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.<\/p>\n

\n Investor Relations Contact:<\/strong>\n <\/p>\n

Elhan Webb, CFA, IR Consultant
ewebb@alxoncology.com<\/a><\/p>\n

\n Media Contact:<\/strong>\n <\/p>\n

Audra Friis, Sam Brown, Inc.
audrafriis@sambrown.com<\/a>
<\/a>(917) 519-9577<\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

– Data to be presented at AACR 2025 Annual Meeting suggest the combination of ALX Oncology\u2019s investigational CD47-blocker, evorpacept, plus rituximab and lenalidomide (R 2 ) was well-tolerated and demonstrated promising anti-tumor activity – Combination generated complete responses (CR) in 83% of patients with indolent relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL) comparing favorably to 34% historical CR rate with R 2 alone – Phase 2 portion of trial in patients with previously untreated indolent NHL (iNHL) is ongoing and has completed enrollment SOUTH SAN FRANCISCO, Calif., April 25, 2025 (GLOBE NEWSWIRE) — ALX Oncology Holdings Inc., (\u201cALX Oncology\u201d or the \u201cCompany\u201d) (Nasdaq: ALXO), a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend … <\/p>\n

Continue reading “ALX Oncology Announces Encouraging Final Results from Phase 1 Trial Evaluating Evorpacept in Combination with Standard-of-Care Treatment in Patients with\u00a0B-cell Non-Hodgkin Lymphoma”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-842259","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nALX Oncology Announces Encouraging Final Results from Phase 1 Trial Evaluating Evorpacept in Combination with Standard-of-Care Treatment in Patients with\u00a0B-cell Non-Hodgkin Lymphoma - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/alx-oncology-announces-encouraging-final-results-from-phase-1-trial-evaluating-evorpacept-in-combination-with-standard-of-care-treatment-in-patients-with-b-cell-non-hodgkin-lymphoma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ALX Oncology Announces Encouraging Final Results from Phase 1 Trial Evaluating Evorpacept in Combination with Standard-of-Care Treatment in Patients with\u00a0B-cell Non-Hodgkin Lymphoma - 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