{"id":842156,"date":"2025-04-25T08:17:01","date_gmt":"2025-04-25T12:17:01","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-presents-four-posters-at-the-american-association-for-cancer-research-annual-meeting-2025-and-announces-two-new-leaders\/"},"modified":"2025-04-25T08:17:01","modified_gmt":"2025-04-25T12:17:01","slug":"cogent-biosciences-presents-four-posters-at-the-american-association-for-cancer-research-annual-meeting-2025-and-announces-two-new-leaders","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-presents-four-posters-at-the-american-association-for-cancer-research-annual-meeting-2025-and-announces-two-new-leaders\/","title":{"rendered":"Cogent Biosciences Presents Four Posters at the American Association for Cancer Research Annual Meeting 2025 and Announces Two New Leaders"},"content":{"rendered":"
\n

WALTHAM, Mass. and BOULDER, Colo., April 25, 2025 (GLOBE NEWSWIRE) — Cogent Biosciences, Inc.\u00a0(Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically defined diseases, today announced preclinical data from four pipeline programs during poster sessions at the American Association for Cancer Research (AACR) 2025 Annual Meeting taking place in Chicago.<\/p>\n

\u201cWe welcome the opportunity to present updated results from these programs that represent our exciting pipeline of potential best-in-class targeted therapies,\u201d said Andrew Robbins, Cogent\u2019s President and Chief Executive Officer. \u201cThese data demonstrate Cogent\u2019s ability to discover and advance novel therapies for rare disease populations with high unmet medical need, and we look forward to continuing to advance these candidates.\u201d<\/p>\n

\n
\n Poster Details<\/u>
\n <\/strong>\n <\/p>\n

\n Title:<\/strong>\u00a0Identification of a potent KRAS (ON) inhibitor with selectivity for mutant KRAS over HRAS and NRAS
Session Category: <\/strong>Chemistry
Session Title: <\/strong>Lead Identification and Optimization
Session Date and Time: <\/strong>April 30, 2025 – 9:00 AM \u2013 12:00 PM CT (10:00 AM \u2013 1:00 PM ET)
Location: <\/strong>Poster Section 25
Poster Board Number: <\/strong>3
Published Abstract Number: <\/strong>6974<\/p>\n

Mutations in\u00a0KRAS\u00a0are among the most prevalent mutations found in cancer, occurring most often in colorectal cancer, non-small cell lung cancer and pancreatic cancer. The poster presented today describes Cogent\u2019s internally-developed pan KRAS(ON) inhibitor program with selectivity over HRAS and NRAS and picomolar (pM) activity across KRAS mutations. In response to our 30mg\/kg oral dose we observed robust PD including 90% tumor growth inhibition in a mouse TGI model. Lead optimization of this series is ongoing.<\/p>\n

\n Title:<\/strong>\u00a0Preclinical characterization of CGT6297, a novel PI3K\u03b1 H1047R mutant-selective inhibitor
Session Category: <\/strong>Experimental and Molecular Therapeutics
Session Title: <\/strong>Kinase and Phosphatase Inhibitors 2
Session Date and Time: <\/strong>April 28, 2025 – 2:00 PM \u2013 5:00 PM CT (3:00 PM \u2013 6:00 PM ET)
Location: <\/strong>Poster Section 20
Poster Board Number: <\/strong>5
Published Abstract Number: <\/strong>3004<\/p>\n

Cogent is developing a potential best-in-class, wild-type-sparing, PI3K\u03b1 inhibitor that provides coverage for the both the H1047R mutation as well as E542K and E545K helical mutants. The phosphoinositide 3-kinase (PI3K) pathway is a key cell cycle regulating pathway that has an established role in tumor growth and development. The approved agents for these patients often lead to dose limitations, resulting from activity against wild-type PI3K\u03b1.<\/p>\n

In the poster being presented today, Cogent\u2019s preclinical candidate CGT6297 demonstrates broad cellular panel profiling across multiple resistant and mutated cell lines, including, for the first time, efficacy against PI3K helical mutations. The poster also showcases the activity of CGT6297 in both ST1056 (H1047R mutant) and MCF-7 (E545K mutant) breast cancer TGI models.<\/p>\n

\n Title:<\/strong>\u00a0The Reversible and Selective FGFR2\/3 inhibitor CGT4859 has superior target coverage of resistance mutations missed by leading FGFR inhibitors
Session Category: <\/strong>Clinical Research
Session Title: <\/strong>Targeted Therapies and Combinations 2
Session Date and Time: <\/strong>April 29, 2025 – 9:00 AM \u2013 12:00 PM CT (10:00 AM \u2013 1:00 PM ET)
Location: <\/strong>Poster Section 34
Poster Board Number: <\/strong>27
Published Abstract Number: <\/strong>4729<\/p>\n

FGFR inhibitors are well-established oncogenic drivers in multiple diseases, but approved medicines fail to capture the full landscape of FGFR altered tumor types, with FGFR1-mediated hyperphosphatemia serving as the most common dose-limiting toxicity for pan-FGFR inhibitors. The poster presented today describes Cogent\u2019s internally-developed FGFR2\/3 inhibitor which maintains potency on FGFR2 mutations and is selective against the entire kinome and a broad panel of channels and receptors. Exploratory pharmacokinetics (PK) studies conducted across species showed CGT4859 to be a low-clearance compound with high oral bioavailability. Further, in an AN3 CA model, CGT4859 demonstrated dose-responsive tumor growth inhibition with complete regressions at >2.5 mg\/kg QD or BID and was well-tolerated.<\/p>\n

Cogent is currently enrolling patients in an ongoing Phase 1 trial with CGT4859 in patients with confirmed FGFR2 or FGFR3 mutations, including patients with advanced cholangiocarcinoma. The trial is designed to explore the safety, tolerability and clinical activity of escalating doses with the goal of selecting an active and well tolerated dose for further clinical investigation.<\/p>\n

\n Title:<\/strong>\u00a0Identification of CGT4255 an EGFR-sparing, pan-mutant HER2 clinical development candidate with potential best-in-class brain penetration
Session Category: <\/strong>Experimental and Molecular Therapeutics
Session Title: <\/strong>Novel Antitumor Agents 3
Session Date and Time: <\/strong>April 29, 2025 – 2:00 PM \u2013 5:00 PM CT (3:00 PM \u2013 6:00 PM ET)
Location: <\/strong>Poster Section 21
Poster Board Number: <\/strong>1
Published Abstract Number: <\/strong>5623<\/p>\n

Cogent\u2019s potential best-in-class EGFR-sparing, brain-penetrant ErbB2 inhibitor includes potent coverage of key mutations (YVMA, S310F, V842I, L755S) inadequately addressed by currently approved therapies. Activating mutations in the ErbB2 gene have been identified in multiple cancers and demonstrate a tumorigenic role similar to that of ErbB2 amplification. New data presented on this compound describes CGT4255\u2019s exceptional stability in human whole blood and liver cytosol fractions and high oral bioavailability and low clearance across preclinical species. In addition, CGT4255 is expected to have equivalent brain to plasma exposure suggesting potential best-in class properties.<\/p>\n

All posters will be available on the \u2018Posters and Publications\u2019\u00a0page of Cogent\u2019s website.<\/p>\n

\n
\n New Leadership Appointments<\/u>
\n <\/strong>
\n
Cogent also announced today that Ray Frost has joined Cogent as Senior Vice President, Market Access and Adam Boyd, Ph.D. has joined Cogent as Senior Vice President, Corporate Strategy.<\/p>\n

Mr. Frost joins Cogent with over 20 years of industry experience. Previously he served as\u00a0Vice President\u00a0Market Access\u00a0at Ono Pharma USA and Zealand Pharma (Zealand). While at Zealand he\u00a0played an integral\u00a0part in building the commercial infrastructure to support the launch of their first product. Prior to Zealand he held roles of increasing responsibility in Market Access and Health Policy at Melinta Therapeutics, The Medicines Company, Bayer Healthcare, Eisai and MGI PHARMA.\u00a0Mr. Frost is a graduate of Hofstra University.<\/p>\n

Dr. Boyd joins Cogent with nearly 25 years of industry experience\u00a0building and leading global teams across Development functions including Biostatistics, Clinical Pharmacology, Clinical Operations, and Data Management. In these roles, he\u00a0was instrumental in bringing several products to market, including\u00a0Mektovi\u00ae<\/sup>\u00a0(binimetinib),\u00a0Braftovi\u00ae<\/sup>\u00a0(encorafenib), Jakafi\u00ae<\/sup> (ruxolitinib), and\u00a0Folotyn\u00ae<\/sup>\u00a0(pralatrexate). Prior to joining Cogent, Dr. Boyd was Vice President, Biometrics at Intellia Therapeutics, and prior to that,\u00a0held various roles of increasing responsibility at Pfizer, Array BioPharma, Novartis, and\u00a0Allos\u00a0Therapeutics. Dr. Boyd earned his Ph.D. in Biostatistics from the University of Colorado, where he is\u00a0currently a\u00a0member of the Colorado School of Public Health\u2019s Dean\u2019s\u00a0Advisory\u00a0Board.<\/p>\n

\n
\n Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)<\/u>
\n <\/strong>
\n \u00a0<\/strong>
\n
Cogent also announced today that, on April 14, 2025, the Compensation Committee of Cogent\u2019s Board of Directors, made up entirely of independent directors, approved the grants of \u201cinducement\u201d equity awards to five new employees, including Mr. Frost and Dr. Boyd, under the company\u2019s 2020 Inducement Plan with a grant date of April 21, 2025. The awards were approved in accordance with Listing Rule 5635(c)(4) of the corporate governance rules of the Nasdaq Stock Market. The employees received, in the aggregate, nonqualified options to purchase 446,000 shares of Cogent common stock. Each option has a 10-year term, an exercise price equal to the closing price of Cogent\u2019s common stock on the grant date, and a 4-year vesting schedule with 25% vesting on the 1-year anniversary of the grant date and the remainder vesting in equal monthly installments over the subsequent 36 months, provided such employee remains employed through each such vesting date.<\/p>\n

\n About Cogent Biosciences, Inc.<\/strong>
\n
Cogent Biosciences is a biotechnology company focused on developing precision therapies for genetically defined diseases. The most advanced clinical program, bezuclastinib, is a selective tyrosine kinase inhibitor that is designed to potently inhibit the KIT D816V mutation as well as other mutations in KIT exon 17. KIT D816V is responsible for driving systemic mastocytosis, a serious disease caused by unchecked proliferation of mast cells. Exon 17 mutations are also found in patients with advanced gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. The company also has an ongoing Phase 1 study of its novel internally discovered FGFR2 inhibitor. In addition, the Cogent Research Team is developing a portfolio of novel targeted therapies to help patients fighting serious, genetically driven diseases targeting mutations in ErbB2, PI3K\u03b1 and KRAS. Cogent Biosciences is based in Waltham, MA and Boulder, CO. Visit our website for more information at www.cogentbio.com. Follow Cogent Biosciences on social media: X<\/a> (formerly known as Twitter)\u00a0and\u00a0LinkedIn<\/a>. Information that may be important to investors will be routinely posted on our website and X<\/a>.<\/p>\n

\n Forward-Looking Statements<\/strong>
\n
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding the best-in-class therapeutic potential of the company\u2019s pre-clinical pipeline candidates. The use of words such as, but not limited to, “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” or “would” and similar words expressions are intended to identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, our clinical results, the rate of enrollment in our clinical trials and other future conditions. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements. We may not actually achieve the forecasts or milestones disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Such forward-looking statements are subject to a number of material risks and uncertainties including but not limited to those set forth under the caption “Risk Factors” in Cogent’s most recent Annual Report on Form 10-K filed with the\u00a0SEC, as well as discussions of potential risks, uncertainties, and other important factors in our subsequent filings with the\u00a0SEC. Any forward-looking statement speaks only as of the date on which it was made. Neither we, nor our affiliates, advisors or representatives, undertake any obligation to publicly update or revise any forward-looking statement, whether as result of new information, future events or otherwise, except as required by law. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date hereof.<\/p>\n

\n Investor Contact:<\/strong>
\n
Christi Waarich
Senior Director, Investor Relations
christi.waarich@cogentbio.com<\/a>
617-830-1653<\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

WALTHAM, Mass. and BOULDER, Colo., April 25, 2025 (GLOBE NEWSWIRE) — Cogent Biosciences, Inc.\u00a0(Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically defined diseases, today announced preclinical data from four pipeline programs during poster sessions at the American Association for Cancer Research (AACR) 2025 Annual Meeting taking place in Chicago. \u201cWe welcome the opportunity to present updated results from these programs that represent our exciting pipeline of potential best-in-class targeted therapies,\u201d said Andrew Robbins, Cogent\u2019s President and Chief Executive Officer. \u201cThese data demonstrate Cogent\u2019s ability to discover and advance novel therapies for rare disease populations with high unmet medical need, and we look forward to continuing to advance these candidates.\u201d Poster Details Title:\u00a0Identification of a potent KRAS … <\/p>\n

Continue reading “Cogent Biosciences Presents Four Posters at the American Association for Cancer Research Annual Meeting 2025 and Announces Two New Leaders”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-842156","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nCogent Biosciences Presents Four Posters at the American Association for Cancer Research Annual Meeting 2025 and Announces Two New Leaders - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-presents-four-posters-at-the-american-association-for-cancer-research-annual-meeting-2025-and-announces-two-new-leaders\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cogent Biosciences Presents Four Posters at the American Association for Cancer Research Annual Meeting 2025 and Announces Two New Leaders - 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