{"id":842130,"date":"2025-04-25T08:06:58","date_gmt":"2025-04-25T12:06:58","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/vyne-therapeutics-provides-update-on-vyn202-program\/"},"modified":"2025-04-25T08:06:58","modified_gmt":"2025-04-25T12:06:58","slug":"vyne-therapeutics-provides-update-on-vyn202-program","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/vyne-therapeutics-provides-update-on-vyn202-program\/","title":{"rendered":"VYNE Therapeutics Provides Update on VYN202 Program"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"justify\">BRIDGEWATER, N.J., April  25, 2025  (GLOBE NEWSWIRE) &#8212; VYNE Therapeutics Inc. (Nasdaq: VYNE) (\u201cVYNE\u201d or the \u201cCompany\u201d) today announced that the U.S. Food and Drug Administration (FDA) verbally informed the Company that it placed a clinical hold on the Company\u2019s Phase 1b study evaluating VYN202 for the treatment of moderate-to-severe plaque psoriasis. The clinical hold determination was made following a recent observation of testicular toxicity in dogs from a non-clinical toxicology study with VYN202.<\/p>\n<p align=\"justify\">VYNE has suspended all screening, enrollment and patient dosing in the Phase 1b trial of VYN202 and intends to work diligently with the FDA to resolve the clinical hold as soon as possible. To date, there have been no serious adverse events observed in subjects that have been enrolled in the Phase 1b study.<\/p>\n<p align=\"justify\">The clinical hold does not apply to VYNE\u2019s ongoing Phase 2b trial of repibresib gel in nonsegmental vitiligo. Repibresib is a distinct and unique compound from VYN202. Top-line results from the 24-week double-blind, vehicle-controlled portion of the Phase 2b trial are expected mid-year.<\/p>\n<p align=\"justify\">\u201cWhile we are disappointed by this unexpected development, the safety and well-being of patients in our studies is our top priority,\u201d said David Domzalski, President and Chief Executive Officer of VYNE. \u201cWe intend to work closely with the FDA to address the clinical hold as expeditiously as possible and we plan to provide additional updates pending continued engagement with FDA.\u201d<\/p>\n<p>\n        <strong>About VYNE Therapeutics Inc. <\/strong><br \/>\n        <br \/>VYNE is a clinical-stage biopharmaceutical company focused on developing differentiated therapies to treat chronic inflammatory and immune-mediated conditions with high unmet need. VYNE\u2019s unique and proprietary BET inhibitors, which comprise its InhiBET\u2122 platform, are designed to overcome limitations of early generation BET inhibitors by leveraging alternative routes of administration and enhanced selectivity.<\/p>\n<p>For more information about VYNE Therapeutics Inc. or its product candidates, visit\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=gIR4iJoTR-XBnryyiAdaFyWp2dZA7JysYhDx8eo2yhJrVxUrzx2IPifGqtbOfHG35NCWzFznoBB4lU0KsmfpjOUrOku9e56cUABuBWc8UNclKnQqbpF6ZWuWkYy2gd5ON87ag34c6_enFRGMOAgV336gpkdPoMDjqBd84J3vC1oBaZSusyIJgV6bszv10bEseTWhPwQEg3RxER1APR6i_or4KJFVTSlaA8INQ5cw0faOpZZSVO1vS1kQJqQEIwiDmIQgj20VmSzk7a6Imu6DDg==\" rel=\"nofollow\" target=\"_blank\">www.vynetherapeutics.com<\/a>. VYNE may use its website to comply with its disclosure obligations under Regulation FD. Therefore, investors should monitor VYNE\u2019s website in addition to following its press releases, filings with the U.S. Securities and Exchange Commission, public conference calls, and webcasts.<\/p>\n<p>\n        <strong>Investor Relations:<\/strong><br \/>\n        <br \/>John Fraunces<br \/>LifeSci Advisors, LLC<br \/>917-355-2395<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=oZXmL-gP7vPaiwrva0gxWRK9aCGamArKWXy8csO6D0k-FdYgigaLgtHNbcsKdtz1Uv4L46mvay-kumEOyedtjd9pBH9cRSdtINs4eJY4fT2PB5rWMdvnSsm3rviszlsmpi8lbwUxgOgPMMNkj9VPgef4hPWSsusyQa34e6GNTGiXvdecMP0_M7NkbG5jJ3duuZMRqAFx_VegMdqC7nOYhiEBrs_RttENxFvovnge15s-UbmL9MhUwAhC0mC-r5yPuP97sjeliwgg4qQoNzjb2gMTh7WLTm1RGM8avKqmn3nJboaAFpd0gZfJGgdu7dfT\" rel=\"nofollow\" target=\"_blank\">jfraunces@lifesciadvisors.com<\/a><\/p>\n<p>Tyler Zeronda<br \/>VYNE Therapeutics Inc.<br \/>908-458-9106<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=pOvmmCW2VN_CoM6E6TSl5PhL1ltHI1UqT5UYpLc4cMOwA7aaDJ7FU1b5HyK8vRHJIIr-GPniD8EBawXaR36GrW7p8fliqsQUa8EwNhE8BILonutBLIQ5YK0T_EISTlMpFrHqwZmFRIDkuETfLMbn5PwtXmoP4Nep0EHOQWslip3PaqrM9E1hA4YKkHywMEmThN8u-SOMtrP6Dnr2p-gXcNZmcsXHiVa5RbP0tlhwhibEGgW3q1_sxBacrv1-4JN30ay2wzbOUYX27hrcjZT1DQ==\" rel=\"nofollow\" target=\"_blank\">Tyler.Zeronda@VYNEtx.com<\/a><\/p>\n<p>\n        <strong>Media Relations:<\/strong><br \/>\n        <br \/>Mike Beyer<br \/>Sam Brown Inc.<br \/>312-961-2502<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=7RuBlV2ru5n9E975Rd5xlJIXWzRmPW0-vDCl-umDIwclxmLYbpqERMMMYxuL5L4KgZmOFg3bd7Vzs3LfTWneDdt3bwk1wblsumdo77iSu1eTRm1SOMdIy1ffQ1y16SLGmlBkGhb0t_W7iGtEosGZsax5yX1PfTaFHbMN1jtJwJcZ_Ho3otI5pvjrnJD_lTHn9H3Ic65uIT6p4Ghn15W6Th6SQyeTCXpICruTxk8HcGJX0LDzx0MnM4UUt1P5aaZ799-rYVdubPVC_YRdKFOm0w==\" rel=\"nofollow\" target=\"_blank\">mikebeyer@sambrown.com<\/a><\/p>\n<p>\n        <strong>Cautionary Statement Regarding Forward-Looking Statements <\/strong><br \/>\n        <br \/>This release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding the clinical development of, and timing for reporting top-line results from trials of, repibresib and VYN202, the resolution of the clinical hold, and other statements regarding the future expectations, plans and prospects of VYNE. All statements in this press release which are not historical facts are forward-looking statements. Any forward-looking statements are based on VYNE\u2019s current knowledge and its present beliefs and expectations regarding possible future events and are subject to risks, uncertainties and assumptions that could cause actual results to differ materially and adversely from those set forth or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to: VYNE\u2019s ability to successfully develop its product candidates; the timing of commencement of future preclinical studies and clinical trials; VYNE\u2019s ability to complete and receive favorable results from clinical trials of its product candidates; VYNE\u2019s ability to obtain additional funding, either through equity or debt financing transactions or collaboration arrangements; and VYNE\u2019s ability to comply with various regulations applicable to its business. For a discussion of other risks and uncertainties, and other important factors, any of which could cause VYNE\u2019s actual results to differ from those contained in the forward-looking statements, see the section titled \u201cRisk Factors\u201d in VYNE\u2019s Annual Report on Form 10-K for the year ended December\u00a031, 2024, and VYNE\u2019s other filings from time to time with the U.S. Securities and Exchange Commission. Although VYNE believes these forward-looking statements are reasonable, they speak only as of the date of this announcement and VYNE undertakes no obligation to update publicly such forward-looking statements to reflect subsequent events or circumstances, except as otherwise required by law. Given these risks and uncertainties, you should not rely upon forward-looking statements as predictions of future events.<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQzODg3NSM2OTA0OTQzIzIwOTM4MDM=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/MmZhZmJlNWEtNmI2OS00ZTAyLWE1YmYtOTNhODUyM2MwZGI1LTExMDUzNzQtMjAyNS0wNC0yNS1lbg==\/tiny\/VYNE-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>BRIDGEWATER, N.J., April 25, 2025 (GLOBE NEWSWIRE) &#8212; VYNE Therapeutics Inc. (Nasdaq: VYNE) (\u201cVYNE\u201d or the \u201cCompany\u201d) today announced that the U.S. Food and Drug Administration (FDA) verbally informed the Company that it placed a clinical hold on the Company\u2019s Phase 1b study evaluating VYN202 for the treatment of moderate-to-severe plaque psoriasis. The clinical hold determination was made following a recent observation of testicular toxicity in dogs from a non-clinical toxicology study with VYN202. VYNE has suspended all screening, enrollment and patient dosing in the Phase 1b trial of VYN202 and intends to work diligently with the FDA to resolve the clinical hold as soon as possible. To date, there have been no serious adverse events observed in subjects that &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/vyne-therapeutics-provides-update-on-vyn202-program\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;VYNE Therapeutics Provides Update on VYN202 Program&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-842130","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>VYNE Therapeutics Provides Update on VYN202 Program - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/vyne-therapeutics-provides-update-on-vyn202-program\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"VYNE Therapeutics Provides Update on VYN202 Program - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"BRIDGEWATER, N.J., April 25, 2025 (GLOBE NEWSWIRE) &#8212; VYNE Therapeutics Inc. (Nasdaq: VYNE) (\u201cVYNE\u201d or the \u201cCompany\u201d) today announced that the U.S. Food and Drug Administration (FDA) verbally informed the Company that it placed a clinical hold on the Company\u2019s Phase 1b study evaluating VYN202 for the treatment of moderate-to-severe plaque psoriasis. The clinical hold determination was made following a recent observation of testicular toxicity in dogs from a non-clinical toxicology study with VYN202. VYNE has suspended all screening, enrollment and patient dosing in the Phase 1b trial of VYN202 and intends to work diligently with the FDA to resolve the clinical hold as soon as possible. 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(Nasdaq: VYNE) (\u201cVYNE\u201d or the \u201cCompany\u201d) today announced that the U.S. Food and Drug Administration (FDA) verbally informed the Company that it placed a clinical hold on the Company\u2019s Phase 1b study evaluating VYN202 for the treatment of moderate-to-severe plaque psoriasis. The clinical hold determination was made following a recent observation of testicular toxicity in dogs from a non-clinical toxicology study with VYN202. VYNE has suspended all screening, enrollment and patient dosing in the Phase 1b trial of VYN202 and intends to work diligently with the FDA to resolve the clinical hold as soon as possible. To date, there have been no serious adverse events observed in subjects that &hellip; Continue reading \"VYNE Therapeutics Provides Update on VYN202 Program\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/vyne-therapeutics-provides-update-on-vyn202-program\/","og_site_name":"Market Newsdesk","article_published_time":"2025-04-25T12:06:58+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQzODg3NSM2OTA0OTQzIzIwOTM4MDM=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vyne-therapeutics-provides-update-on-vyn202-program\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vyne-therapeutics-provides-update-on-vyn202-program\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"VYNE Therapeutics Provides Update on VYN202 Program","datePublished":"2025-04-25T12:06:58+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vyne-therapeutics-provides-update-on-vyn202-program\/"},"wordCount":710,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vyne-therapeutics-provides-update-on-vyn202-program\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQzODg3NSM2OTA0OTQzIzIwOTM4MDM=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vyne-therapeutics-provides-update-on-vyn202-program\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/vyne-therapeutics-provides-update-on-vyn202-program\/","name":"VYNE Therapeutics Provides Update on VYN202 Program - 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