{"id":841401,"date":"2025-04-24T07:35:53","date_gmt":"2025-04-24T11:35:53","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/"},"modified":"2025-04-24T07:35:53","modified_gmt":"2025-04-24T11:35:53","slug":"briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/","title":{"rendered":"BriaCell Confirms 100% Resolution of Lung Metastasis with Bria-OTS\u2122"},"content":{"rendered":"<div class=\"mw_release\">\n<ul>\n<li>\n          <strong><br \/>\n            <em>(IMAGES BELOW) Complete resolution of lung metastasis confirmed at 4 month follow-up in hormone receptor positive (HR+) breast cancer patient<\/em><br \/>\n          <\/strong>\n        <\/li>\n<li>\n          <strong><br \/>\n            <em>Treatment well-tolerated and patient remains on study<\/em><br \/>\n          <\/strong><br \/>\n          <strong><br \/>\n            <em> with stable disease elsewhere<\/em><br \/>\n          <\/strong>\n        <\/li>\n<li>\n          <strong><br \/>\n            <em>Sustained clinical response supports Bria-OTS personalized, off-the-shelf immunotherapy approach in Phase 1\/2a metastatic breast cancer study<\/em><br \/>\n          <\/strong><br \/>\n          \n        <\/li>\n<\/ul>\n<p align=\"justify\">PHILADELPHIA and VANCOUVER, British Columbia, April  24, 2025  (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, confirms the sustained complete resolution of the lung metastasis, <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=leg6N6aPW-Gac_KubDoyhQh1nsge4c8mco77dPSsdGbUs8cKOXRjJTDq8Z_YrrTQFmDTsOEo7yTHbMxoQmrnXHHTGFSf1g5t9VP_qBPonKeY47k-MEtEwq5RA_0-bLdCGcLRBGv-UB5dSm2ezgI8L2YA8q8Ep3XU0iUZxWbbTgESEdg43P9dL8JROYbDuLHM\" rel=\"nofollow\" target=\"_blank\">first reported in February 2025<\/a>, two months after initial treatment in the ongoing Phase 1\/2 Bria-OTS study. The latest data at four months also demonstrates stable disease elsewhere.<\/p>\n<p align=\"justify\">\n        <strong>Figure 1: Treatment with Bria-OTS monotherapy resulted in 100% resolution of tumor in the lung of the metastatic breast cancer (MBC) patient following 2 months of therapy and confirmed at 4 months of therapy<\/strong><br \/>\n        <sup><br \/>\n          <strong>1<\/strong><br \/>\n        <\/sup><br \/>\n        <strong> (axial and coronal views)<\/strong>\n      <\/p>\n<p align=\"center\">\n        \n      <\/p>\n<p align=\"justify\">As shown, the lesion in the patient\u2019s right lung is undetectable after two months and confirmed resolved at 4 months. The updated images supersede those previously reported.<\/p>\n<p align=\"justify\">The patient, a 78-year-old woman with metastatic breast cancer (hormone receptor positive, HER2 negative), had failed several prior lines of therapy and received the lowest dose level in the Phase 1\/2a Bria-OTS study. At enrollment on November 21, 2024, she had extensive metastases including bone, lymph node and lung involvement.\u00a0Following Bria-OTS intradermal injections every 2 weeks for six weeks (4 total doses), and subsequent dosing every 3 weeks, the lung metastasis completely resolved with stable disease elsewhere. This response is now confirmed and shows the potentially promising activity of the Bria-OTS platform as monotherapy.<\/p>\n<p align=\"justify\">\u201cDespite recent advancements with Antibody-drug-conjugates (ADCs) and immune check point inhibitors (CPIs), many patients, including those with HR+ disease, like BriaCell\u2019s first OTS patient, have very few options,\u201d stated Neal S. Chawla MD, Director at the Sarcoma Oncology Center, Santa Monica, Ca., and Principal Investigator for the Bria-OTS study. \u201cWe are thrilled with our initial data with single agent Bria-OTS showing rapid and strong anti-tumor activity in an HR+ patient and look forward to continuing this novel approach in patients with MBC, and other cancers.\u201d<\/p>\n<p align=\"justify\">\u201cThis unprecedented anti-cancer response in the first patient dosed with Bria-OTS is an important milestone for us and provides early validation of BriaCell\u2019s personalized immunotherapy approach,\u201d stated Dr. William V. Williams, BriaCell\u2019s President and CEO.<\/p>\n<p align=\"justify\">Bria-OTS is a personalized off-the-shelf immunotherapy, currently under investigation in a Phase 1\/2a dose escalation study (ClinicalTrials.gov identifier: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=VBNYuW1GjAk_AQDP4T8lZbLL-JWtuuTpWQWz-RXAwKK-iy9m6ZpdxedMJC21pyJuGWOXXj1gdhcRfTs_oCnph0Hlq9NRcgpTDBRg3pK6AxysiuN2j3mzvIhcT78sA3FIaw9sncqmzADGPrqshIuzOg==\" rel=\"nofollow\" target=\"_blank\">NCT06471673<\/a>) in metastatic recurrent breast cancer. Bria-OTS represents a personalized, next generation, advancement of BriaCell\u2019s lead candidate Bria-IMT\u2122 which is currently in a pivotal Phase 3 study for metastatic breast cancer. The Phase 1\/2a clinical trial in metastatic breast cancer is a dose escalation study initially evaluating the safety and efficacy of Bria-OTS as monotherapy and will be followed by Bria-OTS in combination with an immune checkpoint inhibitor.<\/p>\n<p align=\"justify\">\n        <strong>About BriaCell Therapeutics Corp.<\/strong>\n      <\/p>\n<p align=\"justify\">BriaCell is a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care. More information is available at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Q8R7LqbIyHi7RiORwp9cOBhI5GwBlW31JOlwC6CWKeR3zbEAOEpT-hQ0QKoMsP5g7WtpjuUDxfp9BSaG5JXPwzCGQ1M3M5hw2-Mb5goQCG4=\" rel=\"nofollow\" target=\"_blank\">https:\/\/briacell.com\/<\/a>.<\/p>\n<p align=\"justify\">\n        <strong>Safe Harbor<\/strong>\n      <\/p>\n<p align=\"justify\">This press release contains \u201cforward-looking statements\u201d that are subject to substantial risks and uncertainties. All statements, other than statements of historical fact, contained in this press release are forward-looking statements. Forward-looking statements contained in this press release include statements regarding: BriaCell continuing the Phase 1\/2a Bria-OTS study and reproducing similar results in patients with MBC and other cancers; the use of the Bria-OTS platform as monotherapy; and Bria-OTS\u2019s validation as a personalized immunotherapy approach. Forward-looking statements may be identified by the use of words such as \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccontemplate,\u201d \u201ccould,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cseek,\u201d \u201cmay,\u201d \u201cmight,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201ctarget,\u201d \u201caim,\u201d \u201cshould,\u201d \u201cwill,\u201d \u201cwould,\u201d or the negative of these words or other similar expressions, although not all forward-looking statements contain these words. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. These and other risks and uncertainties are described more fully under the heading \u201cRisks and Uncertainties\u201d in the Company\u2019s most recent Management\u2019s Discussion and Analysis, under the heading \u201cRisk Factors\u201d in the Company\u2019s most recent Annual Information Form, and under \u201cRisks and Uncertainties\u201d in the Company\u2019s other filings with the Canadian securities regulatory authorities and the U.S. Securities and Exchange Commission, all of which are available under the Company\u2019s profiles on SEDAR+ at\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=96TT1NY1FLUH330xP1MEr-hSPy_S64oZIJRI-t8JKpFSl2_ulspwUeXsJ6pgswAjo6ZrihLNdz5yRxqsOVOPUeyqcM5dtX-OIYRckzXtpb796LJSKpIpPLptfC94D2xwcHv3882n5jX3EZHH9uA0cbFR7CyVD0lYHl9nCNZsQe3YRRNUBrEfIuGhq-bIe0Be0IAwIqyeWoH5gaRS35d2519ScCqDLcrg1vBx2FybPE0=\" rel=\"nofollow\" target=\"_blank\"><strong>www.sedarplus.ca<\/strong><\/a><b>\u00a0<\/b>and on EDGAR at\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=96TT1NY1FLUH330xP1MEr7ZuIsTIb7gmynFujZBqcrrsRsBc2olvGZrVY_2dcwBWDWr7fjn8oYp-cS7V2gHZG9A01ar6yYJEkSuDEC4fhwn2LML7vw9oYhtWiSyUJXa_MAe8TU-Frq5AYGFTEGJyrIYLZ7JvgNL-XYdkm-mzuroM9eoT6hAdDU4uWOtJudf9pWCyQ-n8qErzvhOXKNbAgiEZ44ILXcpibQWUuQaskGU=\" rel=\"nofollow\" target=\"_blank\"><strong>www.sec.gov<\/strong><\/a>. Forward-looking statements contained in this announcement are made as of this date, and BriaCell Therapeutics Corp. undertakes no duty to update such information except as required under applicable law.<\/p>\n<p align=\"justify\">Neither the Toronto Stock Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Toronto Stock Exchange) accepts responsibility for the adequacy or accuracy of this release.<\/p>\n<p align=\"left\">\n        <strong>Contact Information<\/strong>\n      <\/p>\n<p align=\"left\">\n        <strong>Company Contact:<\/strong><br \/>\n        <br \/>William V. Williams, MD<br \/>President &amp; CEO<br \/>1-888-485-6340<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=NZlNAlKGIXIEY1Oq1oKZp2CsexqouniNeppNEoUu__UX6Fj3EO4V3lWz_rkGtH_QALtb3u5AVHFY90pHhMdpm08dsWPsAKrxWottD6KUzpU=\" rel=\"nofollow\" target=\"_blank\">info@briacell.com<\/a>\u00a0<\/p>\n<p align=\"left\">\n        <strong>Investor Relations Contact:<\/strong><br \/>\n        <br \/>\n        <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Dy2ftV6d33b1z586ty6mbKkeku8ushCvwAO3HGNCuY_S_iw3YzvCLEUoqjOpa79yVKScTGuouipF7TsBrEJaz62xaoM8MfovspfbUhXo0Bk=\" rel=\"nofollow\" target=\"_blank\">investors@briacell.com<\/a>\n      <\/p>\n<p align=\"justify\">\n        <sup>1<\/sup> Note that the other white dots in the lungs are blood vessels.<\/p>\n<p>A photo accompanying this announcement is available at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Q8R7LqbIyHi7RiORwp9cOIf2ePLPLL3_X_nLKzNIjcUm3xs-Mz7bycsrspC1f2wnGnmyMTRyC0IaBstximPfbn2Tw1v1WVf2rQNSRi7DqYT4HBiqYhzmSwCqfH_iB6PV_KZlhBgTQESHaIr4Wmwiv4IolWBPiE3-03q5LJZWu185_3ARtv38cSi9OtXCP_FFN0mW_Q7XoW7agJ0NTV_RS4PmncUMe3hXdTsFM5_VNUzwX2kmkB6ym0rIbPHDoeLbY-gTp_P1FX0nEIJKI559tA==\" rel=\"nofollow\" target=\"_blank\">https:\/\/www.globenewswire.com\/NewsRoom\/AttachmentNg\/19a24c7d-e793-4f57-b0df-c1605b7395dc<\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQzODAyNSM2OTAyNjI3IzIwOTA2NTg=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/NjdhNTNjODQtYTFhNy00ZTgyLTllMWYtNWFlMjNjZjkzODkzLTExMDIyMjktMjAyNS0wNC0yNC1lbg==\/tiny\/BriaCell-Therapeutics-Corp-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>(IMAGES BELOW) Complete resolution of lung metastasis confirmed at 4 month follow-up in hormone receptor positive (HR+) breast cancer patient Treatment well-tolerated and patient remains on study with stable disease elsewhere Sustained clinical response supports Bria-OTS personalized, off-the-shelf immunotherapy approach in Phase 1\/2a metastatic breast cancer study PHILADELPHIA and VANCOUVER, British Columbia, April 24, 2025 (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, confirms the sustained complete resolution of the lung metastasis, first reported in February 2025, two months after initial treatment in the ongoing Phase 1\/2 Bria-OTS study. The latest data at four months also demonstrates stable disease elsewhere. Figure 1: &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;BriaCell Confirms 100% Resolution of Lung Metastasis with Bria-OTS\u2122&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-841401","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BriaCell Confirms 100% Resolution of Lung Metastasis with Bria-OTS\u2122 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BriaCell Confirms 100% Resolution of Lung Metastasis with Bria-OTS\u2122 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"(IMAGES BELOW) Complete resolution of lung metastasis confirmed at 4 month follow-up in hormone receptor positive (HR+) breast cancer patient Treatment well-tolerated and patient remains on study with stable disease elsewhere Sustained clinical response supports Bria-OTS personalized, off-the-shelf immunotherapy approach in Phase 1\/2a metastatic breast cancer study PHILADELPHIA and VANCOUVER, British Columbia, April 24, 2025 (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, confirms the sustained complete resolution of the lung metastasis, first reported in February 2025, two months after initial treatment in the ongoing Phase 1\/2 Bria-OTS study. The latest data at four months also demonstrates stable disease elsewhere. 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/","og_locale":"en_US","og_type":"article","og_title":"BriaCell Confirms 100% Resolution of Lung Metastasis with Bria-OTS\u2122 - Market Newsdesk","og_description":"(IMAGES BELOW) Complete resolution of lung metastasis confirmed at 4 month follow-up in hormone receptor positive (HR+) breast cancer patient Treatment well-tolerated and patient remains on study with stable disease elsewhere Sustained clinical response supports Bria-OTS personalized, off-the-shelf immunotherapy approach in Phase 1\/2a metastatic breast cancer study PHILADELPHIA and VANCOUVER, British Columbia, April 24, 2025 (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, confirms the sustained complete resolution of the lung metastasis, first reported in February 2025, two months after initial treatment in the ongoing Phase 1\/2 Bria-OTS study. The latest data at four months also demonstrates stable disease elsewhere. Figure 1: &hellip; Continue reading \"BriaCell Confirms 100% Resolution of Lung Metastasis with Bria-OTS\u2122\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/","og_site_name":"Market Newsdesk","article_published_time":"2025-04-24T11:35:53+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQzODAyNSM2OTAyNjI3IzIwOTA2NTg=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"BriaCell Confirms 100% Resolution of Lung Metastasis with Bria-OTS\u2122","datePublished":"2025-04-24T11:35:53+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/"},"wordCount":861,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQzODAyNSM2OTAyNjI3IzIwOTA2NTg=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-confirms-100-resolution-of-lung-metastasis-with-bria-ots\/","name":"BriaCell Confirms 100% Resolution of Lung Metastasis with Bria-OTS\u2122 - 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