{"id":840805,"date":"2025-04-23T12:08:01","date_gmt":"2025-04-23T16:08:01","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025\/"},"modified":"2025-04-23T12:08:01","modified_gmt":"2025-04-23T16:08:01","slug":"agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025\/","title":{"rendered":"Agenus Announces Botensilimab and Balstilimab Presentations at ASCO 2025"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }\n.bwuline { text-decoration: underline }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>Agenus Announces Botensilimab and Balstilimab Presentations at ASCO 2025<\/b><\/p>\n<p>LEXINGTON, Mass.&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nAgenus Inc. (Nasdaq: AGEN), a leader in immuno-oncology, today announced three upcoming presentations at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place May 30 \u2013 June 3 in Chicago, Illinois. A poster presentation will highlight new translational data monitoring induced T-cell dynamics from the botensilimab and balstilimab (BOT\/BAL) program in mismatch repair\u2013proficient (pMMR)\/microsatellite stable (MSS) metastatic colorectal cancer (mCRC). In addition, two trials-in-progress presentations will showcase the design and scientific rationale of ongoing clinical studies evaluating botensilimab-based combinations in advanced pancreatic cancer.\n<\/p>\n<p><b><span class=\"bwuline\">Presentation Details:<\/span><\/b><\/p>\n<p><b>Presentation Title:<\/b> Monitoring botensilimab and balstilimab induced T cell dynamics in refractory mismatch repair proficient metastatic colorectal cancer.<br \/>\n<br \/><b>Presenting Author: <\/b>Dr. Gertjan Rasschaert<br \/>\n<br \/><b>Poster Session:<\/b> Gastrointestinal Cancer\u2014Colorectal and Anal<br \/>\n<br \/><b>Session Date and Time:<\/b> May 31<sup>st<\/sup>, 2025; 9:00 AM-12:00 PM CDT<br \/>\n<br \/><b>Abstract Number: <\/b>3527<br \/>\n<br \/><b>Poster Number:<\/b> 196\n<\/p>\n<p><b>Presentation Title:<\/b> A phase 2 study of botensilimab and AGEN1423, an anti-CD73-TGF\u03b2-trap bifunctional antibody, with or without chemotherapy in subjects with advanced pancreatic cancer. (NCT05632328)<br \/>\n<br \/><b>Presenting Author: <\/b>Dr. Bruno Bockorny<br \/>\n<br \/><b>Poster Session:<\/b> Gastrointestinal Cancer\u2014Gastroesophageal, Pancreatic, and Hepatobiliary<br \/>\n<br \/><b>Session Date and Time:<\/b> May 31<sup>st<\/sup>, 2025; 9:00 AM-12:00 PM CDT<br \/>\n<br \/><b>Abstract Number: <\/b>TPS423<br \/>\n<br \/><b>Poster Number:<\/b> 506a\n<\/p>\n<p><b>Presentation Title:<\/b> An open-label, phase 1 trial with expansion cohort of botensilimab (AGEN1181) + balstilimab (AGEN2034) + nab-paclitaxel + gemcitabine + cisplatin + chloroquine + celecoxib in adult patients with previously untreated metastatic pancreatic cancer. (NCT06076837)<br \/>\n<br \/><b>Presenting Author: <\/b>Dr. Dan Van Hoff<br \/>\n<br \/><b>Poster Session:<\/b> Gastrointestinal Cancer\u2014Gastroesophageal, Pancreatic, and Hepatobiliary<br \/>\n<br \/><b>Session Date and Time:<\/b> May 31<sup>st<\/sup>, 2025; 9:00 AM-12:00 PM CDT<br \/>\n<br \/><b>Abstract Number: <\/b>507b<br \/>\n<br \/><b>Poster Number:<\/b> TPS4234\n<\/p>\n<p><b>About Botensilimab (BOT)<\/b><\/p>\n<p>\nBotensilimab is a human Fc enhanced CTLA-4 blocking antibody designed to boost both innate and adaptive anti-tumor immune responses. Its novel design leverages mechanisms of action to extend immunotherapy benefits to \u201ccold\u201d tumors which generally respond poorly to standard of care or are refractory to conventional PD-1\/CTLA-4 therapies and investigational therapies. Botensilimab augments immune responses across a wide range of tumor types by priming and activating T cells, downregulating intratumoral regulatory T cells, activating myeloid cells and inducing long-term memory responses.\n<\/p>\n<p>\nBotensilimab alone, or in combination with Agenus\u2019 investigational PD-1 antibody, balstilimab, has shown clinical responses across nine metastatic, late-line cancers. Approximately 1,100 patients have been treated across the botensilimab\/balstilimab program in phase 1 and phase 2 clinical trials. For more information about botensilimab trials, visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.clinicaltrials.gov&amp;esheet=54242508&amp;newsitemid=20250423929145&amp;lan=en-US&amp;anchor=www.clinicaltrials.gov&amp;index=1&amp;md5=94ab3055d56a3578e7d716ab2cf9bdd0\">www.clinicaltrials.gov<\/a>.\n<\/p>\n<p><b>About Balstilimab (BAL)<\/b><\/p>\n<p>\nBalstilimab is a novel, fully human monoclonal immunoglobulin G4 (IgG4) designed to block PD-1 (programmed cell death protein 1) from interacting with its ligands PD-L1 and PD-L2. It has been evaluated in &gt;900 patients to date and has demonstrated clinical activity and a favorable tolerability profile in several tumor types.\n<\/p>\n<p><b>About Agenus<\/b><\/p>\n<p>\nAgenus is a leading immuno-oncology company targeting cancer with a comprehensive pipeline of immunological agents. The company was founded in 1994 with a mission to expand patient populations benefiting from cancer immunotherapy through combination approaches, using a broad repertoire of antibody therapeutics, adoptive cell therapies (through MiNK Therapeutics) and adjuvants (through SaponiQx). Agenus has robust end-to-end development capabilities, across commercial and clinical cGMP manufacturing facilities, research and discovery, and a global clinical operations footprint. Agenus is headquartered in Lexington, MA. For more information, visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.agenusbio.com&amp;esheet=54242508&amp;newsitemid=20250423929145&amp;lan=en-US&amp;anchor=www.agenusbio.com&amp;index=2&amp;md5=be8cebd6034ea18e7bb76ecdbc307b39\">www.agenusbio.com<\/a> or @agenus_bio. Information that may be important to investors will be routinely posted on our website and social media channels.\n<\/p>\n<p><b>Forward-Looking Statements<\/b><\/p>\n<p>\nThis press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding its botensilimab and balstilimab programs, expected regulatory timelines and filings, and any other statements containing the words &#8220;may,&#8221; &#8220;believes,&#8221; &#8220;expects,&#8221; &#8220;anticipates,&#8221; &#8220;hopes,&#8221; &#8220;intends,&#8221; &#8220;plans,&#8221; &#8220;forecasts,&#8221; &#8220;estimates,&#8221; &#8220;will,&#8221; \u201cestablish,\u201d \u201cpotential,\u201d \u201csuperiority,\u201d \u201cbest in class,\u201d and similar expressions are intended to identify forward-looking statements. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include, among others, the factors described under the Risk Factors section of our most recent Annual Report on Form 10-K for 2024, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission. Agenus cautions investors not to place considerable reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this press release, and Agenus undertakes no obligation to update or revise the statements, other than to the extent required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.\n<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20250423929145r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20250423929145\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20250423929145\/en\/<\/a><\/span><\/p>\n<p><b>Investors<br \/>\n<\/b><br \/>917-362-1370<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:investor@agenusbio.com\">investor@agenusbio.com<br \/>\n<\/a><\/p>\n<p><b>Media<br \/>\n<\/b><br \/>510-323-5188<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:communications@agenusbio.com\">communications@agenusbio.com<\/a><\/p>\n<p><b>KEYWORDS:<\/b> United States North America Illinois Massachusetts<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Biotechnology Health Pharmaceutical Clinical Trials Oncology<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20250423929145\/en\/381089\/3\/2_Agenus-Logo.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Agenus Announces Botensilimab and Balstilimab Presentations at ASCO 2025 LEXINGTON, Mass.&#8211;(BUSINESS WIRE)&#8211; Agenus Inc. (Nasdaq: AGEN), a leader in immuno-oncology, today announced three upcoming presentations at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place May 30 \u2013 June 3 in Chicago, Illinois. A poster presentation will highlight new translational data monitoring induced T-cell dynamics from the botensilimab and balstilimab (BOT\/BAL) program in mismatch repair\u2013proficient (pMMR)\/microsatellite stable (MSS) metastatic colorectal cancer (mCRC). In addition, two trials-in-progress presentations will showcase the design and scientific rationale of ongoing clinical studies evaluating botensilimab-based combinations in advanced pancreatic cancer. Presentation Details: Presentation Title: Monitoring botensilimab and balstilimab induced T cell dynamics in refractory mismatch repair proficient metastatic colorectal cancer. Presenting Author: &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Agenus Announces Botensilimab and Balstilimab Presentations at ASCO 2025&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-840805","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Agenus Announces Botensilimab and Balstilimab Presentations at ASCO 2025 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Agenus Announces Botensilimab and Balstilimab Presentations at ASCO 2025 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Agenus Announces Botensilimab and Balstilimab Presentations at ASCO 2025 LEXINGTON, Mass.&#8211;(BUSINESS WIRE)&#8211; Agenus Inc. (Nasdaq: AGEN), a leader in immuno-oncology, today announced three upcoming presentations at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place May 30 \u2013 June 3 in Chicago, Illinois. A poster presentation will highlight new translational data monitoring induced T-cell dynamics from the botensilimab and balstilimab (BOT\/BAL) program in mismatch repair\u2013proficient (pMMR)\/microsatellite stable (MSS) metastatic colorectal cancer (mCRC). In addition, two trials-in-progress presentations will showcase the design and scientific rationale of ongoing clinical studies evaluating botensilimab-based combinations in advanced pancreatic cancer. Presentation Details: Presentation Title: Monitoring botensilimab and balstilimab induced T cell dynamics in refractory mismatch repair proficient metastatic colorectal cancer. Presenting Author: &hellip; Continue reading &quot;Agenus Announces Botensilimab and Balstilimab Presentations at ASCO 2025&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-04-23T16:08:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20250423929145r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Agenus Announces Botensilimab and Balstilimab Presentations at ASCO 2025\",\"datePublished\":\"2025-04-23T16:08:01+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025\\\/\"},\"wordCount\":781,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20250423929145r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-botensilimab-and-balstilimab-presentations-at-asco-2025\\\/\",\"name\":\"Agenus Announces Botensilimab and Balstilimab Presentations at ASCO 2025 - 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(Nasdaq: AGEN), a leader in immuno-oncology, today announced three upcoming presentations at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place May 30 \u2013 June 3 in Chicago, Illinois. A poster presentation will highlight new translational data monitoring induced T-cell dynamics from the botensilimab and balstilimab (BOT\/BAL) program in mismatch repair\u2013proficient (pMMR)\/microsatellite stable (MSS) metastatic colorectal cancer (mCRC). In addition, two trials-in-progress presentations will showcase the design and scientific rationale of ongoing clinical studies evaluating botensilimab-based combinations in advanced pancreatic cancer. Presentation Details: Presentation Title: Monitoring botensilimab and balstilimab induced T cell dynamics in refractory mismatch repair proficient metastatic colorectal cancer. 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