{"id":839316,"date":"2025-04-21T08:11:02","date_gmt":"2025-04-21T12:11:02","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/diabetes-care-publishes-results-from-prevalence-phase-of-corcepts-catalyst-trial-in-people-with-difficult-to-control-type-2-diabetes\/"},"modified":"2025-04-21T08:11:02","modified_gmt":"2025-04-21T12:11:02","slug":"diabetes-care-publishes-results-from-prevalence-phase-of-corcepts-catalyst-trial-in-people-with-difficult-to-control-type-2-diabetes","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/diabetes-care-publishes-results-from-prevalence-phase-of-corcepts-catalyst-trial-in-people-with-difficult-to-control-type-2-diabetes\/","title":{"rendered":"Diabetes Care Publishes Results From Prevalence Phase Of Corcept\u2019s CATALYST Trial In People With Difficult-To-Control Type 2 Diabetes"},"content":{"rendered":"

<\/p>\n

Diabetes Care<\/i> Publishes Results From Prevalence Phase Of Corcept\u2019s CATALYST Trial In People With Difficult-To-Control Type 2 Diabetes<\/b><\/p>\n

Hypercortisolism identified in 24 percent of patients with difficult-to-control type 2 diabetes<\/i><\/p>\n

REDWOOD CITY, Calif.–(BUSINESS WIRE<\/a>)–
\nCorcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, today announced the publication of findings from the prevalence phase of the CATALYST trial in Diabetes Care<\/i>, a peer-reviewed journal published by the American Diabetes Association.\n<\/p>\n

\nThe publication, Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes<\/i>, can be accessed at: https:\/\/diabetesjournals.org\/care\/lookup\/doi\/10.2337\/dc24-2841<\/a>.\n<\/p>\n

\nCATALYST was the largest and most rigorous trial ever conducted to assess the prevalence of hypercortisolism (Cushing\u2019s syndrome) in patients with difficult-to-control type 2 diabetes. Part one of the study screened 1,057 patients at 36 sites across the United States. All patients had hemoglobin A1c greater than 7.5 percent, despite receiving multiple glucose-lowering therapies, including GLP-1 receptor agonists. Using a simple, standardized 1-mg dexamethasone suppression test (DST), 24 percent of these patients were found to have hypercortisolism. These findings were first presented at the American Diabetes Association Scientific Sessions in June 2024<\/a>.\n<\/p>\n

\n\u201cMany patients have uncontrolled type 2 diabetes despite the use of the best available medications,\u201d said lead author John Buse, M.D., Ph.D., director of the University of North Carolina\u2019s Diabetes Center. \u201cIt is critical for clinicians to consider and address all factors that can contribute to inadequate glucose control. CATALYST\u2019s results show that, for many patients, hypercortisolism is one of those factors.\u201d\n<\/p>\n

\nPart two of CATALYST\u2013 a randomized, double-blind, placebo-controlled study of Korlym\u00ae<\/sup> in patients with hypercortisolism and difficult-to-control type 2 diabetes \u2013 met its primary endpoint of reduction in hemoglobin A1c. Topline results were announced in December 2024,<\/a> and complete results will be presented at the American Diabetes Association\u2019s 85th<\/sup> Scientific Sessions on June 23, 2025, at a symposium titled: \u201cTreatment of Hypercortisolism in People with Difficult-to-Control Type 2 Diabetes \u2013 Final Results of the CATALYST Trial.\u201d\n<\/p>\n

\n\u201cCATALYST provides valuable insights into an often-unrecognized cause of difficult-to-control type 2 diabetes,\u201d said Bill Guyer, PharmD, Corcept\u2019s Chief Development Officer. \u201cThese prevalence data, in combination with data from the treatment phase of the study, will hopefully help patients with hypercortisolism receive the diagnosis and care they need.\u201d\n<\/p>\n

About Hypercortisolism (Cushing\u2019s Syndrome)<\/b><\/p>\n

\nHypercortisolism is caused by excessive activity of the hormone cortisol. Symptoms vary, but most patients experience one or more of the following manifestations: hypertension, central obesity, elevated blood sugar and difficult-to-control type 2 diabetes, severe fatigue and weak muscles. Irritability, anxiety, depression and cognitive disturbances are common. Hypercortisolism can affect every organ system and can be lethal if not treated effectively.\n<\/p>\n

About Corcept Therapeutics<\/b><\/p>\n

\nFor over 25 years, Corcept has focused on cortisol modulation and its potential to treat patients with a wide variety of serious disorders, leading to the discovery of more than 1,000 proprietary selective cortisol modulators and glucocorticoid receptor antagonists. Corcept is conducting advanced clinical trials in patients with hypercortisolism, solid tumors, ALS and liver disease. In February 2012, the company introduced Korlym\u00ae<\/sup>, the first medication approved by the U.S. Food and Drug Administration for the treatment of patients with endogenous hypercortisolism. Corcept is headquartered in Redwood City, California. For more information, visit Corcept.com<\/a>.\n<\/p>\n

Forward-Looking Statements<\/b><\/p>\n

\nStatements in this press release, other than statements of historical fact, are forward-looking statements based on our current plans and expectations that are subject to risks and uncertainties that might cause our actual results to differ materially from those expressed or implied by such statements. These risks and uncertainties include, but are not limited to, those related to our ability to: operate our business; study and develop Korlym\u00ae, relacorilant, miricorilant, dazucorilant and our other product candidates, as well as those molecules\u2019 clinical attributes, regulatory approvals, mandates, oversight and other requirements; and the scope and protective power of our intellectual property. These and other risks are set forth in our SEC filings, which are available at our website and the SEC\u2019s website.\n<\/p>\n

\nIn this press release, forward-looking statements include: the design, timing, expectations and results of our CATALYST trial and its impact on the medical field\u2019s screening for and treatment of hypercortisolism. We disclaim any intention or duty to update forward-looking statements made in this press release.\n<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20250421854008\/en\/<\/a><\/span><\/p>\n

\nInvestor inquiries:
\n
ir@corcept.com
\n<\/a>
Media inquiries:
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communications@corcept.com
\n<\/a>
www.corcept.com<\/a><\/p>\n

KEYWORDS:<\/b> United States North America California<\/p>\n

INDUSTRY KEYWORDS:<\/b> Biotechnology Diabetes Health Pharmaceutical Clinical Trials<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
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Diabetes Care Publishes Results From Prevalence Phase Of Corcept\u2019s CATALYST Trial In People With Difficult-To-Control Type 2 Diabetes Hypercortisolism identified in 24 percent of patients with difficult-to-control type 2 diabetes REDWOOD CITY, Calif.–(BUSINESS WIRE)– Corcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, today announced the publication of findings from the prevalence phase of the CATALYST trial in Diabetes Care, a peer-reviewed journal published by the American Diabetes Association. The publication, Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes, can be accessed at: https:\/\/diabetesjournals.org\/care\/lookup\/doi\/10.2337\/dc24-2841. CATALYST was the largest and most rigorous trial ever conducted to assess … <\/p>\n

Continue reading “Diabetes Care Publishes Results From Prevalence Phase Of Corcept\u2019s CATALYST Trial In People With Difficult-To-Control Type 2 Diabetes”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-839316","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nDiabetes Care Publishes Results From Prevalence Phase Of Corcept\u2019s CATALYST Trial In People With Difficult-To-Control Type 2 Diabetes - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/diabetes-care-publishes-results-from-prevalence-phase-of-corcepts-catalyst-trial-in-people-with-difficult-to-control-type-2-diabetes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diabetes Care Publishes Results From Prevalence Phase Of Corcept\u2019s CATALYST Trial In People With Difficult-To-Control Type 2 Diabetes - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Diabetes Care Publishes Results From Prevalence Phase Of Corcept\u2019s CATALYST Trial In People With Difficult-To-Control Type 2 Diabetes Hypercortisolism identified in 24 percent of patients with difficult-to-control type 2 diabetes REDWOOD CITY, Calif.–(BUSINESS WIRE)– Corcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, today announced the publication of findings from the prevalence phase of the CATALYST trial in Diabetes Care, a peer-reviewed journal published by the American Diabetes Association. 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The publication, Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes, can be accessed at: https:\/\/diabetesjournals.org\/care\/lookup\/doi\/10.2337\/dc24-2841. 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