{"id":837358,"date":"2025-04-15T08:24:05","date_gmt":"2025-04-15T12:24:05","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/"},"modified":"2025-04-15T08:24:05","modified_gmt":"2025-04-15T12:24:05","slug":"predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/","title":{"rendered":"Predictive Oncology Develops Novel Approach to Identifying Clinically Viable Abandoned Drugs"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>New indications discovered by applying active machine learning and using samples from the company\u2019s vast biobank of live-cell tumors specimens<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>Builds upon Predictive\u2019s biomarker discovery platform to select targeted patient cohorts to significantly de-risk clinical trials <\/em>\n      <\/p>\n<p>PITTSBURGH, April  15, 2025  (GLOBE NEWSWIRE) &#8212; Predictive Oncology Inc. (NASDAQ: POAI), a leader in AI-driven drug discovery, announced today that it has made significant progress along the continuum of biomarker discovery, drug discovery and drug repurposing. These latest developments build upon Predictive\u2019s ongoing initiative to combine its in-house biomarker identification platform with its AI screening capabilities.<\/p>\n<p>Identifying new indications using active machine learning and a biobank of patient derived dissociated tumor cells (DTCs) represents a novel and commercially sustainable approach to repurposing abandoned oncology drugs.<\/p>\n<p>\u201cThis efficient screening approach on a small, curated cohort of abandoned drugs identified three compounds that warrant further exploration in tumor indications that have never been examined in this way,\u201d said Dr. Arlette Uihlein, SVP of Translational Medicine and Drug Discovery and Medical Director at Predictive Oncology. \u201cThe work that we have done successfully demonstrates our ability to utilize our active machine learning and biobank of tumor samples to capture patient response heterogeneity in less than 12 weeks.\u201d<\/p>\n<p>The results of Predictive\u2019s novel approach to identifying clinically viable abandoned drugs are compelling.<\/p>\n<p>Three drugs gave strong results for both ovarian and colon tumors. Specifically, Afuresertib, Alisertib and Entinosta demonstrated the highest proportion of hits within those two tumor types. Notably, Alisertib and Entinostat outperformed Oxaliplatin, a standard of care drug in the colon tumor type, while Alisertib also outperformed Ribociclib, a standard of care in breast cancer.<\/p>\n<p>Afuresertib, is an Akt inhibitor that was previously studied in esophageal cancer, multiple myeloma, and more recently, attempted in combination with paclitaxel in platinum resistant ovarian cancer.<\/p>\n<p>Alisertib, a selective Aurora A Inhibitor previously studied for use in both EGFR-mutated non-small cell lung cancer (NSCLC) and metastatic breast cancer, showed strong tumor drug response in ovarian and colon tumors based on both Predictive\u2019s wet lab testing and AI models. This drug is currently being evaluated in clinical trials for recurrent\/metastatic breast cancer and lung cancer.<\/p>\n<p>Entinostat, an HDAC1\/3 inhibitor which was previously studied in solid tumor types, including breast and pancreatic, had a strong tumor drug response in the company\u2019s colon sample models. This drug is currently in clinical trials for use as a combination therapy in patients with NSCLC and for the purpose of biomarker development.<\/p>\n<p>Of particular significance to Predictive Oncology, this drug class was previously shown to induce mitochondrial dysfunction in colorectal cancer, which is a possible target for further exploration combining the company\u2019s high content imaging (HCI) assay and its proprietary and internally derived HCI analysis pipeline.<\/p>\n<p>\u201cApplying this approach to other sets of publicly available abandoned drugs is a next logical step,\u201d said Raymond Vennare, CEO of Predictive Oncology. \u201cBut, more importantly, from the perspective of partnering opportunities with pharmaceutical companies to retain or repurpose their own abandoned drugs, our methodology would be advantageous in terms of efficiently transitioning their abandoned drugs back to clinical trial readiness.\u201d<\/p>\n<p>\n        <strong>About Predictive Oncology <\/strong>\n      <\/p>\n<p>Predictive Oncology is on the cutting edge of the rapidly growing use of artificial intelligence and machine learning to expedite early drug discovery and enable drug development for the benefit of cancer patients worldwide. The company\u2019s scientifically validated AI platform, PEDAL, is able to predict with 92% accuracy if a tumor sample will respond to a certain drug compound, allowing for a more informed selection of drug\/tumor type combinations for subsequent in-vitro testing. Together with the company\u2019s vast biobank of more than 150,000 assay-capable heterogenous human tumor samples, Predictive Oncology offers its academic and industry partners one of the industry\u2019s broadest AI-based drug discovery solutions, further complimented by its wholly owned CLIA laboratory facility. Predictive Oncology is headquartered in Pittsburgh, PA.<\/p>\n<p>\n        <strong>Investor Relations Contact: <\/strong>\n      <\/p>\n<p>Mike Moyer<br \/>LifeSci Advisors, LLC <br \/>mmoyer@lifesciadvisors.com<\/p>\n<p>\n        <strong>Forward-Looking Statements<\/strong>\n      <\/p>\n<p>Certain statements made in this press release are \u201cforward-looking statements\u201d within the meaning of the \u201csafe harbor\u201d provisions of the Private Securities Litigation Reform Act of 1995. These forward- looking statements reflect Predictive Oncology\u2019s current expectations and projections about future events and are subject to substantial risks, uncertainties and assumptions about Predictive Oncology\u2019s operations and the investments Predictive Oncology makes. All statements, other than statements of historical facts, included in this press release regarding our strategy, future operations, future financial position, future revenue and financial performance, projected costs, prospects, changes in management, plans and objectives of management are forward-looking statements. The words \u201canticipate,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cplan,\u201d \u201cwould,\u201d \u201ctarget\u201d and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Predictive Oncology\u2019s actual future performance may materially differ from that contemplated by the forward-looking statements as a result of a variety of factors including, among other things, factors discussed under the heading \u201cRisk Factors\u201d in Predictive Oncology\u2019s filings with the SEC. Except as expressly required by law, Predictive Oncology disclaims any intent or obligation to update these forward-looking statements. Predictive Oncology does not give any assurance that Predictive Oncology will achieve its expectations described in this press release.<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQyMTYyNCM2ODYzMzYxIzIwMTkyMjY=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/NDI0NDFjODEtNzBhYy00ODBiLWFjN2QtOWFkZDBjZjU5M2NhLTEwMzA3OTktMjAyNS0wNC0xNS1lbg==\/tiny\/Predictive-Oncology-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>New indications discovered by applying active machine learning and using samples from the company\u2019s vast biobank of live-cell tumors specimens Builds upon Predictive\u2019s biomarker discovery platform to select targeted patient cohorts to significantly de-risk clinical trials PITTSBURGH, April 15, 2025 (GLOBE NEWSWIRE) &#8212; Predictive Oncology Inc. (NASDAQ: POAI), a leader in AI-driven drug discovery, announced today that it has made significant progress along the continuum of biomarker discovery, drug discovery and drug repurposing. These latest developments build upon Predictive\u2019s ongoing initiative to combine its in-house biomarker identification platform with its AI screening capabilities. Identifying new indications using active machine learning and a biobank of patient derived dissociated tumor cells (DTCs) represents a novel and commercially sustainable approach to repurposing abandoned &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Predictive Oncology Develops Novel Approach to Identifying Clinically Viable Abandoned Drugs&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-837358","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Predictive Oncology Develops Novel Approach to Identifying Clinically Viable Abandoned Drugs - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Predictive Oncology Develops Novel Approach to Identifying Clinically Viable Abandoned Drugs - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"New indications discovered by applying active machine learning and using samples from the company\u2019s vast biobank of live-cell tumors specimens Builds upon Predictive\u2019s biomarker discovery platform to select targeted patient cohorts to significantly de-risk clinical trials PITTSBURGH, April 15, 2025 (GLOBE NEWSWIRE) &#8212; Predictive Oncology Inc. (NASDAQ: POAI), a leader in AI-driven drug discovery, announced today that it has made significant progress along the continuum of biomarker discovery, drug discovery and drug repurposing. These latest developments build upon Predictive\u2019s ongoing initiative to combine its in-house biomarker identification platform with its AI screening capabilities. Identifying new indications using active machine learning and a biobank of patient derived dissociated tumor cells (DTCs) represents a novel and commercially sustainable approach to repurposing abandoned &hellip; Continue reading &quot;Predictive Oncology Develops Novel Approach to Identifying Clinically Viable Abandoned Drugs&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-04-15T12:24:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQyMTYyNCM2ODYzMzYxIzIwMTkyMjY=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Predictive Oncology Develops Novel Approach to Identifying Clinically Viable Abandoned Drugs\",\"datePublished\":\"2025-04-15T12:24:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\\\/\"},\"wordCount\":875,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTQyMTYyNCM2ODYzMzYxIzIwMTkyMjY=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\\\/\",\"name\":\"Predictive Oncology Develops Novel Approach to Identifying Clinically Viable Abandoned Drugs - 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(NASDAQ: POAI), a leader in AI-driven drug discovery, announced today that it has made significant progress along the continuum of biomarker discovery, drug discovery and drug repurposing. These latest developments build upon Predictive\u2019s ongoing initiative to combine its in-house biomarker identification platform with its AI screening capabilities. Identifying new indications using active machine learning and a biobank of patient derived dissociated tumor cells (DTCs) represents a novel and commercially sustainable approach to repurposing abandoned &hellip; Continue reading \"Predictive Oncology Develops Novel Approach to Identifying Clinically Viable Abandoned Drugs\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/","og_site_name":"Market Newsdesk","article_published_time":"2025-04-15T12:24:05+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQyMTYyNCM2ODYzMzYxIzIwMTkyMjY=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Predictive Oncology Develops Novel Approach to Identifying Clinically Viable Abandoned Drugs","datePublished":"2025-04-15T12:24:05+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/"},"wordCount":875,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQyMTYyNCM2ODYzMzYxIzIwMTkyMjY=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/predictive-oncology-develops-novel-approach-to-identifying-clinically-viable-abandoned-drugs\/","name":"Predictive Oncology Develops Novel Approach to Identifying Clinically Viable Abandoned Drugs - 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