{"id":827668,"date":"2025-03-19T16:11:29","date_gmt":"2025-03-19T20:11:29","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/fight-dmd-trial-results-selected-for-late-breaking-presentation-at-mda-clinical-scientific-conference\/"},"modified":"2025-03-19T16:11:29","modified_gmt":"2025-03-19T20:11:29","slug":"fight-dmd-trial-results-selected-for-late-breaking-presentation-at-mda-clinical-scientific-conference","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/fight-dmd-trial-results-selected-for-late-breaking-presentation-at-mda-clinical-scientific-conference\/","title":{"rendered":"FIGHT DMD Trial Results Selected for Late-Breaking Presentation at MDA Clinical & Scientific Conference"},"content":{"rendered":"
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PR Newswire<\/p>\n<\/p><\/div>\n

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\n Ifetroban demonstrated significant 5.4% improvement in cardiac function <\/i>\n <\/p>\n

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\n NASHVILLE, Tenn.<\/span>
\n <\/span>, March 19, 2025<\/span><\/span> \/PRNewswire\/ —\u00a0Cumberland Pharmaceuticals Inc. (Nasdaq: CPIX), a specialty pharmaceutical company with development efforts focused on rare diseases, today announced that results from its Phase 2 FIGHT DMD clinical trial were selected for a late-breaking presentation at the Muscular Dystrophy Association (MDA) Clinical & Scientific Conference in Dallas<\/span>. The trial demonstrated significant cardiac benefits for patients with Duchenne muscular dystrophy (DMD), potentially addressing the leading cause of death in this devastating disease.<\/p>\n

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\n \"Cumberland
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The presentation, delivered today by Dr. John Jerry Parent<\/span>, highlighted the breakthrough findings from Cumberland’s<\/span> study of ifetroban in DMD heart disease. For the abstract presented at the meeting, please see the MDA website<\/a><\/u>. \u00a0<\/p>\n

The Phase 2 FIGHT DMD trial demonstrated that high-dose ifetroban treatment resulted in a 3.3% improvement in left ventricular ejection fraction (LVEF) compared to placebo. When compared with propensity-matched natural history controls, the difference was even more pronounced, with high-dose treatment providing a significant 5.4% overall improvement in LVEF, as control patients experienced a 3.6% decline in LVEF. This improvement in cardiac function could translate to meaningful benefits in quality of life and survival for DMD patients. The complete presentation slides are now available on Cumberland’s<\/span>website<\/a><\/u>.<\/p>\n

“The enthusiastic response from MDA conference attendees reinforces the importance of our work in targeting DMD-related heart disease,” said John Jerry Parent<\/span>, MD, Associate Professor of Clinical Pediatrics and Medical Director of the Pediatric Heart Transplant at Indiana University School of Medicine<\/span> and Site Investigator at Riley Children’s Hospital for the FIGHT DMD trial. “These findings represent a potential paradigm shift in how we approach cardiac complications in DMD patients.”<\/p>\n

“We are honored that the MDA recognized the significance of our FIGHT DMD trial by selecting it for a late-breaking presentation,” said A.J. Kazimi, Chief Executive Officer of Cumberland Pharmaceuticals. “This platform allowed us to share our promising results with the global DMD community, including leading researchers, clinicians and patient advocates who are working tirelessly to improve outcomes for those affected by this devastating disease.”<\/p>\n

“These results offer hope to thousands of families affected by DMD,” said Sharon Hesterlee<\/span>, PhD, Chief Research Officer, MDA. “While current therapies focus on preserving muscle function, addressing the cardiac complications of DMD remains an urgent unmet need. Cumberland’s<\/span> work with ifetroban represents a critical step forward in potentially extending and improving the lives of DMD patients.”<\/p>\n

Ifetroban, an oral thromboxane receptor antagonist, has received both Orphan Drug Designation<\/i> and Rare Pediatric Disease Designation <\/i>from the FDA for DMD-related heart disease.<\/p>\n

\n Cumberland<\/span> has secured a growing portfolio of patents with claims associated with the product for this DMD indication. Next steps include further data analysis and completion of a full study report in preparation for an end-of-Phase-2 meeting with the FDA to determine next steps associated with the product’s development and commercialization.<\/p>\n

For more information about the FIGHT DMD trial, please visit www.fightdmdtrial.com<\/a><\/u>.<\/p>\n

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\n About Duchenne muscular dystrophy (DMD)<\/u>
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DMD is a rare and incurable pediatric disease caused by mutations in the gene encoding dystrophin, a protein critical for muscle function, including the heart. Patients with DMD slowly lose muscle function, resulting in the inability to walk, difficulty breathing and heart failure. While current treatments can help manage some DMD symptoms, there are no approved therapies specifically targeting DMD-related heart disease, highlighting a critical unmet medical need.<\/p>\n

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\n About ifetroban<\/u>
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Ifetroban is a once-daily oral medication that works by blocking the thromboxane receptor, which plays a key role in inflammation and fibrosis. The drug has received both Orphan Drug Designation<\/i> and Rare Pediatric Disease Designation<\/i> from the FDA, highlighting its potential significance in treating this devastating condition. If approved, ifetroban would be the first therapy specifically indicated for DMD-related heart disease.<\/p>\n

A previous study conducted at Vanderbilt University<\/span> Medical Center demonstrated that ifetroban is protective against cardiomyopathy in several preclinical models of muscular dystrophy. The results of that study were published in the Journal of the American Heart Association<\/i> (West 2019). Based on those promising results, Cumberland Pharmaceuticals became the first recipient of an FDA Office of Orphan Products Development clinical trial grant for DMD, funding the development of this Phase 2 clinical trial.<\/p>\n

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\n References:<\/u>
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Soslow JH, Xu M, Slaughter JC, et al. Cardiovascular Measures of All-Cause Mortality in Duchenne Muscular Dystrophy. Circ Heart Fail. 2023 Aug;16(8):e010040. doi: 10.1161\/CIRCHEARTFAILURE.122.010040. Epub 2023 Jun 8<\/span>. PMID: 37288563; PMCID: PMC10524475.<\/p>\n

West JD, Galindo CL, Kim K, et al. Antagonism of the thromboxane-prostanoid receptor as a potential therapy for cardiomyopathy of muscular dystrophy. J Am Heart Assoc. 2019;8(21):e011902. doi: 10.1161\/JAHA.118.011902.<\/p>\n

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\n About Cumberland Pharmaceuticals<\/u>
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\n Cumberland Pharmaceuticals <\/b>is the largest biopharmaceutical company founded and headquartered in Tennessee<\/span>. The company is focused on providing unique products that improve the quality of patient care. Cumberland<\/span> develops, acquires, and commercializes products for the hospital acute care, gastroenterology and oncology market segments.<\/p>\n

\n Cumberland’s<\/span> portfolio of FDA-approved brands includes:<\/p>\n