{"id":825868,"date":"2025-03-14T08:33:35","date_gmt":"2025-03-14T12:33:35","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/palisade-bio-commences-dosing-in-first-ulcerative-colitis-patient-cohort-in-ongoing-phase-1a-b-study-of-pali-2108\/"},"modified":"2025-03-14T08:33:35","modified_gmt":"2025-03-14T12:33:35","slug":"palisade-bio-commences-dosing-in-first-ulcerative-colitis-patient-cohort-in-ongoing-phase-1a-b-study-of-pali-2108","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/palisade-bio-commences-dosing-in-first-ulcerative-colitis-patient-cohort-in-ongoing-phase-1a-b-study-of-pali-2108\/","title":{"rendered":"Palisade Bio Commences Dosing in First Ulcerative Colitis Patient Cohort in Ongoing Phase 1a\/b Study of PALI-2108"},"content":{"rendered":"
\n

\n Positive preliminary data from all five single ascending dose (SAD) cohorts and first three completed multiple ascending dose (MAD) cohorts support safety and tolerability of PALI-2108<\/em>\n <\/p>\n

\n No serious adverse events (SAEs) and no treatment-emergent adverse events (TEAEs) related to laboratory values or EKGs seen to date<\/em>\n <\/p>\n

\n On track to report topline data in first half of 2025<\/em>\n <\/p>\n

\n Carlsbad, CA, March 14, 2025 (GLOBE NEWSWIRE) — <\/strong>
\n
\n Palisade Bio, Inc.<\/strong>
\n <\/a> (Nasdaq: PALI) (\u201cPalisade\u201d, \u201cPalisade Bio\u201d, or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases, today provided an update on its ongoing Phase 1a\/b study of PALI-2108 for the treatment of Ulcerative Colitis (UC).<\/p>\n

The Company has commenced dosing of the first UC patient in the final cohort of its Phase 1a\/b study of PALI-2108. In addition to completing the five previous Phase 1a SAD cohorts, the first three of four MAD cohorts have now been completed. Importantly, there have been no SAEs and no TEAEs related to laboratory values or EKGs. The majority of observed TEAEs were considered mild, with a single withdrawal at the highest MAD dose level. Two of the MAD cohorts were completed within the expected therapeutic dose range, again showing no SAEs or TEAEs related to laboratory values or EKGs. One of these cohorts was completed with no TEAEs, underscoring the excellent tolerability of PALI-2108 at these dose levels.<\/p>\n

\u201cWe are pleased with the initiation of the final MAD and UC cohorts in our Phase 1a\/b study of PALI-2108. Of particular note is our successful transition from healthy volunteers to dosing our first cohort of patients with UC. The preliminary results from our SAD and MAD cohorts align with management\u2019s expectations. We look forward to further evaluations, and we remain on track to report topline data in the first half of 2025,\u201d said Dr. Mitch Jones, Chief Medical Officer of Palisade.<\/p>\n

The primary aim of this single-center Phase 1a\/b study is to evaluate the safety, tolerability, and PK of PALI-2108 in healthy volunteers as well as to evaluate the safety, tolerability, PK and pharmacodynamics PD in patients with UC. Several PDE4 inhibitors have received market approval in both inflammatory and fibrotic disease; however, PALI-2108 represents a new chemical entity that has not been previously administered to humans. Biomarkers, including serum high sensitivity C-reactive protein (hsCRP), and fecal calprotectin (CalPro), along with colonic tissue histological assessments, will be employed to provide further insights into the drug\u2019s effects. The analysis of colon tissue will include the study drug and metabolite levels, PDE4 expression, cyclic adenosine monophosphate (cAMP) levels, Absolute Lymphocyte Count (ALC), and related PD biomarkers, which are crucial for understanding the drug\u2019s mechanism and efficacy.<\/p>\n

For more information about the Phase 1a\/b clinical study, visit clinicaltrials.gov<\/a> and reference identifier NCT06663605<\/a>.<\/p>\n

\n About Palisade Bio<\/strong>\n <\/p>\n

Palisade Bio is a clinical-stage biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases. The Company believes that by using a targeted approach with its novel therapeutics it will transform the treatment landscape. For more information, please go to\u00a0www.palisadebio.com<\/a>.<\/p>\n

\n Forward Looking Statements<\/strong>\n <\/p>\n

Any statements contained in this communication that are not statements of historical fact may be deemed to be forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements regarding the safety and tolerability, PK and drug release characteristics of PALI-2108 based on the Company\u2019s preclinical studies and preliminary data from the Company\u2019s Phase 1b\/2a clinical study, indications and anticipated benefits of PALI-2108 and the expected timing of the release of topline data from the Phase 1b\/2a clinical study. These forward-looking statements are based on the Company\u2019s current expectations. Forward-looking statements involve risks and uncertainties. The Company\u2019s actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, the Company is heavily dependent on the success of PALI-2108, which is in the early stages of clinical development and may not successfully progress through clinical development or receive regulatory approval; preliminary clinical study results or the results from earlier preclinical studies may not be predictive of final or future results and unexpected adverse side effects or inadequate efficacy of PALI-2108 may limit its development, regulatory approval and\/or commercialization; the Company needs to raise significant additional funds to support its operations and the continued development of PALI-2108; the timing and outcome of the Company\u2019s current and anticipated clinical studies related to its product candidates; indications of use and estimates about the size and growth potential of the markets for the Company\u2019s product candidates, and its ability to serve those markets, including any potential revenue generated; the Company\u2019s ability to maintain the Nasdaq listing of its securities; the Company\u2019s ability to compete effectively in a competitive industry; the Company\u2019s ability to identify and qualify manufacturers to provide API and manufacture drug product; the Company\u2019s ability to enter into commercial supply agreements; the Company\u2019s ability to attract and retain key scientific or management personnel; the accuracy of the Company\u2019s estimates regarding expenses, future revenues, capital requirements and needs for additional financing; and the impact of any global event on the Company\u2019s business, and operations, and supply. Additional risks and uncertainties can be found in the Company\u2019s Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed with the Securities and Exchange Commission (\u201cSEC\u201d) on March 26, 2024, and the Quarterly Reports on Form 10-Q or other SEC filings that are filed thereafter. Investors are cautioned not to put undue reliance on these forward-looking statements. These forward-looking statements speak only as of the date hereof, and the Company expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in the Company\u2019s expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based.<\/p>\n

\n Investor Relations Contact<\/strong>
\n
JTC Team, LLC
Jenene Thomas
908-824-0775
PALI@jtcir.com<\/a><\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Positive preliminary data from all five single ascending dose (SAD) cohorts and first three completed multiple ascending dose (MAD) cohorts support safety and tolerability of PALI-2108 No serious adverse events (SAEs) and no treatment-emergent adverse events (TEAEs) related to laboratory values or EKGs seen to date On track to report topline data in first half of 2025 Carlsbad, CA, March 14, 2025 (GLOBE NEWSWIRE) — Palisade Bio, Inc. (Nasdaq: PALI) (\u201cPalisade\u201d, \u201cPalisade Bio\u201d, or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases, today provided an update on its ongoing Phase 1a\/b study of PALI-2108 for the treatment of Ulcerative Colitis (UC). The Company has commenced dosing … <\/p>\n

Continue reading “Palisade Bio Commences Dosing in First Ulcerative Colitis Patient Cohort in Ongoing Phase 1a\/b Study of PALI-2108”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-825868","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nPalisade Bio Commences Dosing in First Ulcerative Colitis Patient Cohort in Ongoing Phase 1a\/b Study of PALI-2108 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/palisade-bio-commences-dosing-in-first-ulcerative-colitis-patient-cohort-in-ongoing-phase-1a-b-study-of-pali-2108\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Palisade Bio Commences Dosing in First Ulcerative Colitis Patient Cohort in Ongoing Phase 1a\/b Study of PALI-2108 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Positive preliminary data from all five single ascending dose (SAD) cohorts and first three completed multiple ascending dose (MAD) cohorts support safety and tolerability of PALI-2108 No serious adverse events (SAEs) and no treatment-emergent adverse events (TEAEs) related to laboratory values or EKGs seen to date On track to report topline data in first half of 2025 Carlsbad, CA, March 14, 2025 (GLOBE NEWSWIRE) — Palisade Bio, Inc. (Nasdaq: PALI) (\u201cPalisade\u201d, \u201cPalisade Bio\u201d, or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases, today provided an update on its ongoing Phase 1a\/b study of PALI-2108 for the treatment of Ulcerative Colitis (UC). 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(Nasdaq: PALI) (\u201cPalisade\u201d, \u201cPalisade Bio\u201d, or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases, today provided an update on its ongoing Phase 1a\/b study of PALI-2108 for the treatment of Ulcerative Colitis (UC). 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