{"id":823483,"date":"2025-03-10T08:12:22","date_gmt":"2025-03-10T12:12:22","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/corcept-therapeutics-initiates-momentum-trial-to-determine-prevalence-of-hypercortisolism-in-patients-with-resistant-hypertension\/"},"modified":"2025-03-10T08:12:22","modified_gmt":"2025-03-10T12:12:22","slug":"corcept-therapeutics-initiates-momentum-trial-to-determine-prevalence-of-hypercortisolism-in-patients-with-resistant-hypertension","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/corcept-therapeutics-initiates-momentum-trial-to-determine-prevalence-of-hypercortisolism-in-patients-with-resistant-hypertension\/","title":{"rendered":"Corcept Therapeutics Initiates MOMENTUM Trial to Determine Prevalence of Hypercortisolism in Patients with Resistant Hypertension"},"content":{"rendered":"

<\/p>\n

Corcept Therapeutics Initiates MOMENTUM Trial to Determine <\/b>Prevalence of Hypercortisolism in Patients with Resistant Hypertension<\/b><\/p>\n

REDWOOD CITY, Calif.–(BUSINESS WIRE<\/a>)–
\nCorcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, today announced the initiation of MOMENTUM, a clinical trial examining the prevalence of endogenous hypercortisolism (Cushing\u2019s syndrome) in patients with resistant hypertension.\n<\/p>\n

\nThe MOMENTUM trial, which will enroll 1,000 patients across 45 sites in the U.S., will establish the prevalence of endogenous hypercortisolism in patients with resistant hypertension. Resistant hypertension is defined by the American Heart Association<\/a> as elevated blood pressure despite the use of three or more antihypertensive medications in different classes, including a diuretic. Patients with a dexamethasone suppression test (DST) value greater than 1.8 \u00b5g\/dL and dexamethasone levels greater than 140 ng\/dL will be identified as having hypercortisolism and will undergo additional testing and adrenal imaging.\n<\/p>\n

\nMOMENTUM\u2019s design is similar to Corcept\u2019s CATALYST<\/a> clinical trial, which demonstrated that one in four patients with difficult-to-control type 2 diabetes has hypercortisolism. The trial results also showed that hypercortisolism was even more common in patients who also had cardiovascular disease, particularly in those who needed three or more medications to manage their hypertension.\n<\/p>\n

\n\u201cResistant hypertension is a serious public health challenge. Patients whose hypertension remains in poor control despite receiving optimal care, including multiple medications, are at greater risk of cardiovascular morbidity and mortality,\u201d said Deepak L. Bhatt, M.D., M.P.H., M.B.A., Director of Mount Sinai Fuster Heart Hospital and the Dr. Valentin Fuster Professor of Cardiovascular Medicine at the Icahn School of Medicine at Mount Sinai. \u201cWe hope the data from this MOMENTUM trial will expand our understanding of the challenges these patients face and open up new opportunities for treatment.\u201d Dr. Bhatt is a lead investigator and steering committee member for MOMENTUM and a paid consultant to Corcept Therapeutics.\n<\/p>\n

\n\u201cThe MOMENTUM trial will provide a deeper understanding of hypercortisolism as a potential underlying issue for patients with resistant hypertension,\u201d said Bill Guyer, PharmD, Corcept\u2019s Chief Development Officer. \u201cEstablishing the prevalence of hypercortisolism in this patient population will help clinicians better understand and address their patients\u2019 needs. We expect results from this study by year-end.\u201d\n<\/p>\n

About Hypercortisolism (Cushing\u2019s Syndrome)<\/b><\/p>\n

\nHypercortisolism is caused by excessive activity of the hormone cortisol. Symptoms vary, but most patients experience one or more of the following manifestations: hypertension, central obesity, elevated blood sugar and difficult-to-control type 2 diabetes, severe fatigue and weak muscles. Irritability, anxiety, depression and cognitive disturbances are common. Hypercortisolism can affect every organ system and can be lethal if not treated effectively.\n<\/p>\n

About Corcept Therapeutics<\/b><\/p>\n

\nFor over 25 years, Corcept\u2019s focus on cortisol modulation and its potential to treat patients with a wide variety of serious disorders has led to the discovery of more than 1,000 proprietary selective cortisol modulators. Corcept is conducting advanced clinical trials in patients with hypercortisolism, solid tumors, ALS and liver disease. In February 2012, the company introduced Korlym\u00ae<\/sup>, the first medication approved by the U.S. Food and Drug Administration for the treatment of patients with endogenous hypercortisolism. Corcept is headquartered in Redwood City, California. For more information, visit Corcept.com<\/a>.\n<\/p>\n

Forward-Looking Statements<\/b><\/p>\n

\nStatements in this press release, other than statements of historical fact, are forward-looking statements based on our current plans and expectations and are subject to risks and uncertainties that might cause our actual results to differ materially from those such statements express or imply. These risks and uncertainties are set forth in our SEC filings, which are available at our website and the SEC\u2019s website.\n<\/p>\n

\nIn this press release, forward-looking statements include, among others: the design, timing, results and expectations regarding our MOMENTUM trial. We disclaim any intention or duty to update forward-looking statements made in this press release.\n<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20250310835894\/en\/<\/a><\/span><\/p>\n

\nInvestor inquiries:
\n
ir@corcept.com
\n<\/a><\/p>\n

Media inquiries:
\n
communications@corcept.com
\n<\/a>
www.corcept.com<\/a><\/p>\n

KEYWORDS:<\/b> United States North America California<\/p>\n

INDUSTRY KEYWORDS:<\/b> Health Clinical Trials Research Science Pharmaceutical Cardiology Biotechnology<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
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\"Logo\"<\/td>\n<\/tr>\n
<\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Corcept Therapeutics Initiates MOMENTUM Trial to Determine Prevalence of Hypercortisolism in Patients with Resistant Hypertension REDWOOD CITY, Calif.–(BUSINESS WIRE)– Corcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, today announced the initiation of MOMENTUM, a clinical trial examining the prevalence of endogenous hypercortisolism (Cushing\u2019s syndrome) in patients with resistant hypertension. The MOMENTUM trial, which will enroll 1,000 patients across 45 sites in the U.S., will establish the prevalence of endogenous hypercortisolism in patients with resistant hypertension. Resistant hypertension is defined by the American Heart Association as elevated blood pressure despite the use of three or more … <\/p>\n

Continue reading “Corcept Therapeutics Initiates MOMENTUM Trial to Determine Prevalence of Hypercortisolism in Patients with Resistant Hypertension”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-823483","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nCorcept Therapeutics Initiates MOMENTUM Trial to Determine Prevalence of Hypercortisolism in Patients with Resistant Hypertension - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/corcept-therapeutics-initiates-momentum-trial-to-determine-prevalence-of-hypercortisolism-in-patients-with-resistant-hypertension\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Corcept Therapeutics Initiates MOMENTUM Trial to Determine Prevalence of Hypercortisolism in Patients with Resistant Hypertension - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Corcept Therapeutics Initiates MOMENTUM Trial to Determine Prevalence of Hypercortisolism in Patients with Resistant Hypertension REDWOOD CITY, Calif.–(BUSINESS WIRE)– Corcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, today announced the initiation of MOMENTUM, a clinical trial examining the prevalence of endogenous hypercortisolism (Cushing\u2019s syndrome) in patients with resistant hypertension. The MOMENTUM trial, which will enroll 1,000 patients across 45 sites in the U.S., will establish the prevalence of endogenous hypercortisolism in patients with resistant hypertension. 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