{"id":822123,"date":"2025-03-05T15:23:09","date_gmt":"2025-03-05T20:23:09","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/"},"modified":"2025-03-05T15:23:09","modified_gmt":"2025-03-05T20:23:09","slug":"natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/","title":{"rendered":"Natural Alternatives International and CarnoSyn\u00ae Brands\u00a0Publish Clinical Research Demonstrating TriBsyn\u2122 Delivering\u00a0Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"left\">CARLSBAD, Calif., March  05, 2025  (GLOBE NEWSWIRE) &#8212; Natural Alternatives International, Inc. (NAI) and CarnoSyn\u00ae Brands today announced the publication of positive clinical trial results in the journal <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=wPGCrgCO8GfsXcN4HqFdTf5B3zF90RiE1i06Ei-uIVDYNl_32isGI6TLIE9fDM3Yb7zhnuE8-n8KzOELHS_kw8NiMO7K3gp58pc7nXDQdpOKt12QPRGoxT377bnYbJUcKPsQWDNf_Ltx63JId3-A_zD7z7jp_7gHw4MoK0lzo8U=\" rel=\"nofollow\" target=\"_blank\"><em>Food Hydrocolloids for Health<\/em><\/a> showing that TriBsyn\u2122 supplementation led to significantly greater bioavailability and efficiency of beta-alanine along with the elimination of paresthesia, a common beta-alanine side effect.<\/p>\n<p align=\"justify\">\n        <strong>Study Highlights:<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">TriBsyn\u2122 is an encapsulated low-dose \u03b2-alanine complex.<\/li>\n<li style=\"text-align:justify\">TriBsyn\u2122 increased plasma \u03b2-alanine 4.5-fold compared to conventional \u03b2-alanine.<\/li>\n<li style=\"text-align:justify\">TriBsyn\u2122 achieved high plasma concentrations without the sensation of paresthesia.<\/li>\n<\/ul>\n<p align=\"justify\">TriBsyn\u2122 is a carnosine booster derived from CarnoSyn<sup>\u00ae<\/sup>\u00a0beta-alanine and formulated using proprietary Hydro Oleo technology. This patent-pending formulation provides higher bioavailability and higher potency, enabling efficacious dosages at lower volumes while effectively eliminating paresthesia. The advanced formulation enables absorption through multiple pathways, including direct cellular uptake and traditional gastrointestinal routes, allowing for superior delivery at both the cellular and systemic levels. Adequate availability of beta-alanine is critical for maintaining muscle and promoting cognitive well-being. Efficacious doses of beta-alanine are often associated with harmless but generally uncomfortable symptoms of paresthesia, discouraging adherence to supplementation.<\/p>\n<p align=\"justify\">This study aimed to evaluate the bioavailability, pharmacokinetics, and tolerability of a 400 mg Hydro Oleo encapsulated beta-alanine complex (TriBsyn\u2122) specifically designed to reduce paresthesia. A randomized, double-blind, single-dose, three-treatment, three-way crossover oral bioavailability study was conducted in healthy older adults under fasting conditions. The study compared TriBsyn\u2122 with low (400 mg) and high (1200 mg) doses of conventional beta-alanine. TriBsyn\u2122 (400 mg) achieved a nearly 4.5-fold and 1.3-fold increase in circulating beta-alanine plasma concentrations compared to 400 mg and 1200 mg of conventional beta-alanine, respectively.<\/p>\n<p align=\"justify\">Using metrics such as the Visual Analogue Score (VAS) and Qualitative Light Symptoms Inventory (QLSI), sensory side effects were assessed. No paresthesia or adverse effects were reported in the TriBsyn\u2122 group, while the conventional beta-alanine groups exhibited increasing paresthesia with dose. TriBsyn\u2122 (400 mg beta-alanine) recorded a VAS score of 0.62 (indicating almost absent symptoms), whereas conventional \u03b2-alanine (400 mg) and conventional \u03b2-alanine (1200 mg) scored 2.02 and 4.01 respectively. These results highlight the reduced sensory discomfort in the TriBsyn\u2122 group, despite its higher bioavailability.<\/p>\n<p align=\"justify\">\u201cThe TriBsyn\u2122 clinical trial results clearly showed the elimination of paresthesia and an increased pharmacokinetic efficiency, confirming enhanced delivery and exceptional bioavailability,\u201d said Ken Wolf, President and COO of Natural Alternatives International. \u201cWith its advanced Hydro Oleo technology and carnosine-boosting effects, TriBsyn\u2122 provides scientifically proven claims to improve muscle vitality, muscle working capacity, and cognitive performance. It truly sets a new standard in beta-alanine supplementation and helps fill the gap for healthy aging and wellness solutions\u2014especially for the active aging population, GLP-1 users, and those with plant-based diets.\u201d<\/p>\n<p align=\"justify\">\n        <strong>About CarnoSyn\u00ae\u00a0Brands: <\/strong><br \/>\n        <br \/>CarnoSyn\u00ae\u00a0Brands features three clinically studied, patented and patent pending ingredients available exclusively from Natural Alternatives International, Inc.: CarnoSyn\u00ae\u00a0instant release beta-alanine powder, SR CarnoSyn\u00ae\u00a0sustained release beta-alanine tablets, and TriBsyn\u2122 powder. In 2019, CarnoSyn\u00ae beta-alanine successfully obtained NDI status from the FDA and received Self-Affirmed GRAS (Generally Recognized as Safe) status. SR CarnoSyn\u00ae, an advanced delivery form of CarnoSyn\u00ae, received GRAS affirmation in 2017. The new \u201cparesthesia-free\u201d TriBsyn\u2122 powder allows NAI to broaden their product offerings within the dietary supplement category, medical food and other fortified food products. To learn more about CarnoSyn\u00ae and SR CarnoSyn\u00ae in sports nutrition and wellness, visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=U_fej1T5miv2j2zzz_p3sUCmsQ8kzftjA2HQLITLIBWPk06fHSilQfQSOeYaDXyVUpNT-QK-VVVvnaQa3jldHw==\" rel=\"nofollow\" target=\"_blank\">www.carnosyn.com<\/a> and <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=VCjk_8hTU-BfP-BUMXgIr4VQGvg0i5GbP4NnnZVsL7Q-GKYldA-V3bvQxZXXZIBvnlqr-GpbffNXUxIB4lBj296QVzNiCaVbYGG8OleKaJc=\" rel=\"nofollow\" target=\"_blank\">www.srcarnosyn.com<\/a>. For more information about our latest innovation, TriBsyn\u2122, visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=xwbvXxOi6rvladdK5IwUWcemr4Ep3WXIKqvvVo5Sa0T-WFmNlBJRETtwH7n7hHrEe0JMksRbq-hg-i31zc2yVw==\" rel=\"nofollow\" target=\"_blank\">www.tribsyn.com<\/a>.<\/p>\n<p align=\"justify\">\n        <strong>About NAI:<\/strong><br \/>\n        <br \/>NAI, headquartered in Carlsbad, California, is a leading formulator, manufacturer and marketer of nutritional supplements and provides strategic partnering services to its customers. NAI\u2019s comprehensive partnership approach offers a wide range of innovative nutritional products and services to clients including scientific research, proprietary ingredients, customer-specific nutritional product formulation, product testing and evaluation, marketing management and support, packaging and delivery system design, regulatory review, and international product registration assistance. For more information about NAI, please visit\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=2AROVYUlLIFvQVSCt-QpcwUars5ftjgHTpiH64ozFlXjw5MZ4uh2xqFPII-CbT0W1ctIHKM5Ibnvg9T25meMZ8qTrmMVqDRzkfeSK2nkHnk=\" rel=\"nofollow\" target=\"_blank\">www.nai-online.com<\/a>.<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTM4OTY3MyM2NzkyNjI2IzIwMDgyMTI=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/MTVlMWE2NjMtOTNhNS00NWY0LWI0N2QtZDEyN2U0MDI5ODQ5LTEwMTk3ODU=\/tiny\/Natural-Alternatives-Internati.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\">\n<pre>Contact:\r\nRenee Michaelson\r\nDirector of Global Marketing\r\nNAI\/CarnoSyn\u00ae\u00a0Brands\r\ninfo@nai-online.com\u00a0<\/pre>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>CARLSBAD, Calif., March 05, 2025 (GLOBE NEWSWIRE) &#8212; Natural Alternatives International, Inc. (NAI) and CarnoSyn\u00ae Brands today announced the publication of positive clinical trial results in the journal Food Hydrocolloids for Health showing that TriBsyn\u2122 supplementation led to significantly greater bioavailability and efficiency of beta-alanine along with the elimination of paresthesia, a common beta-alanine side effect. Study Highlights: TriBsyn\u2122 is an encapsulated low-dose \u03b2-alanine complex. TriBsyn\u2122 increased plasma \u03b2-alanine 4.5-fold compared to conventional \u03b2-alanine. TriBsyn\u2122 achieved high plasma concentrations without the sensation of paresthesia. TriBsyn\u2122 is a carnosine booster derived from CarnoSyn\u00ae\u00a0beta-alanine and formulated using proprietary Hydro Oleo technology. This patent-pending formulation provides higher bioavailability and higher potency, enabling efficacious dosages at lower volumes while effectively eliminating paresthesia. The advanced &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Natural Alternatives International and CarnoSyn\u00ae Brands\u00a0Publish Clinical Research Demonstrating TriBsyn\u2122 Delivering\u00a0Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-822123","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Natural Alternatives International and CarnoSyn\u00ae Brands\u00a0Publish Clinical Research Demonstrating TriBsyn\u2122 Delivering\u00a0Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Natural Alternatives International and CarnoSyn\u00ae Brands\u00a0Publish Clinical Research Demonstrating TriBsyn\u2122 Delivering\u00a0Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"CARLSBAD, Calif., March 05, 2025 (GLOBE NEWSWIRE) &#8212; Natural Alternatives International, Inc. (NAI) and CarnoSyn\u00ae Brands today announced the publication of positive clinical trial results in the journal Food Hydrocolloids for Health showing that TriBsyn\u2122 supplementation led to significantly greater bioavailability and efficiency of beta-alanine along with the elimination of paresthesia, a common beta-alanine side effect. Study Highlights: TriBsyn\u2122 is an encapsulated low-dose \u03b2-alanine complex. TriBsyn\u2122 increased plasma \u03b2-alanine 4.5-fold compared to conventional \u03b2-alanine. TriBsyn\u2122 achieved high plasma concentrations without the sensation of paresthesia. TriBsyn\u2122 is a carnosine booster derived from CarnoSyn\u00ae\u00a0beta-alanine and formulated using proprietary Hydro Oleo technology. This patent-pending formulation provides higher bioavailability and higher potency, enabling efficacious dosages at lower volumes while effectively eliminating paresthesia. The advanced &hellip; Continue reading &quot;Natural Alternatives International and CarnoSyn\u00ae Brands\u00a0Publish Clinical Research Demonstrating TriBsyn\u2122 Delivering\u00a0Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-03-05T20:23:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTM4OTY3MyM2NzkyNjI2IzIwMDgyMTI=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Natural Alternatives International and CarnoSyn\u00ae Brands\u00a0Publish Clinical Research Demonstrating TriBsyn\u2122 Delivering\u00a0Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination\",\"datePublished\":\"2025-03-05T20:23:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\\\/\"},\"wordCount\":647,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTM4OTY3MyM2NzkyNjI2IzIwMDgyMTI=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\\\/\",\"name\":\"Natural Alternatives International and CarnoSyn\u00ae Brands\u00a0Publish Clinical Research Demonstrating TriBsyn\u2122 Delivering\u00a0Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/","og_locale":"en_US","og_type":"article","og_title":"Natural Alternatives International and CarnoSyn\u00ae Brands\u00a0Publish Clinical Research Demonstrating TriBsyn\u2122 Delivering\u00a0Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination - Market Newsdesk","og_description":"CARLSBAD, Calif., March 05, 2025 (GLOBE NEWSWIRE) &#8212; Natural Alternatives International, Inc. (NAI) and CarnoSyn\u00ae Brands today announced the publication of positive clinical trial results in the journal Food Hydrocolloids for Health showing that TriBsyn\u2122 supplementation led to significantly greater bioavailability and efficiency of beta-alanine along with the elimination of paresthesia, a common beta-alanine side effect. Study Highlights: TriBsyn\u2122 is an encapsulated low-dose \u03b2-alanine complex. TriBsyn\u2122 increased plasma \u03b2-alanine 4.5-fold compared to conventional \u03b2-alanine. TriBsyn\u2122 achieved high plasma concentrations without the sensation of paresthesia. TriBsyn\u2122 is a carnosine booster derived from CarnoSyn\u00ae\u00a0beta-alanine and formulated using proprietary Hydro Oleo technology. This patent-pending formulation provides higher bioavailability and higher potency, enabling efficacious dosages at lower volumes while effectively eliminating paresthesia. The advanced &hellip; Continue reading \"Natural Alternatives International and CarnoSyn\u00ae Brands\u00a0Publish Clinical Research Demonstrating TriBsyn\u2122 Delivering\u00a0Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/","og_site_name":"Market Newsdesk","article_published_time":"2025-03-05T20:23:09+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTM4OTY3MyM2NzkyNjI2IzIwMDgyMTI=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Natural Alternatives International and CarnoSyn\u00ae Brands\u00a0Publish Clinical Research Demonstrating TriBsyn\u2122 Delivering\u00a0Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination","datePublished":"2025-03-05T20:23:09+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/"},"wordCount":647,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTM4OTY3MyM2NzkyNjI2IzIwMDgyMTI=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/natural-alternatives-international-and-carnosyn-brands-publish-clinical-research-demonstrating-tribsyn-delivering-exceptional-bioavailability-increased-efficiency-and-paresth\/","name":"Natural Alternatives International and CarnoSyn\u00ae Brands\u00a0Publish Clinical Research Demonstrating TriBsyn\u2122 Delivering\u00a0Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination - 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