{"id":819980,"date":"2025-02-28T09:07:40","date_gmt":"2025-02-28T14:07:40","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting\/"},"modified":"2025-02-28T09:07:40","modified_gmt":"2025-02-28T14:07:40","slug":"inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting\/","title":{"rendered":"InflaRx to Showcase Vilobelimab\u2019s Role in Immuno-Dermatology at the 2025 AAD Annual Meeting"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"justify\">JENA, Germany, Feb.  28, 2025  (GLOBE NEWSWIRE) &#8212; InflaRx\u00a0N.V.\u00a0(Nasdaq:\u00a0IFRX), a biopharmaceutical company pioneering anti-inflammatory therapeutics targeting the complement system, today announced acceptance of all submitted abstracts, featuring the role of vilobelimab in pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS), to be presented during the 2025 American Academy of Dermatology (AAD) Annual Meeting, March 7 &#8211; 11, in Orlando, FL.<\/p>\n<p align=\"justify\">\n        <strong>Camilla Chong, MD, Chief Medical Officer of InflaRx<\/strong>, commented: \u201cWe are proud to announce that all of our submitted abstracts have been accepted for presentation at the AAD Annual Meeting, reflecting the considerable scientific work that has gone into the clinical development of vilobelimab in pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS). In HS, we are presenting for the first time the reduction in draining tunnels (dTs) with vilobelimab, and the relevance of our modified HiSCR which weighs the importance of these dTs which have a devastating impact on patients with HS.\u201d<\/p>\n<p align=\"justify\">\n        <strong>#63560<br \/><\/strong><br \/>\n        <strong>Oral poster presentation:<\/strong><br \/>\n        <em>Vilobelimab Safety in Pyoderma Gangrenosum Patients: A Phase 2a Explorative Dose-Finding Study<br \/><\/em><br \/>\n        <strong>Authors:<\/strong> Afsaneh Alavi, Benjamin H. Kaffenberger, Hoda Taw\ufb01k, Camilla Chong, Bruce P. Burnett<br \/><strong>Date\/time:<\/strong> Mar 8, 2025 10:15 AM &#8211; 10:20 AM<\/p>\n<p align=\"justify\">\n        <strong>#63550<br \/><\/strong><br \/>\n        <strong>ePoster<\/strong>:<em> Pharmacokinetic\/Pharmacodynamic Analysis of Vilobelimab and Complement C3 and C5a in a Randomized, Controlled Multidose Phase 2a Study in Pyoderma Gangrenosum<br \/><\/em><strong>Authors:<\/strong> Afsaneh Alavi, Hoda Taw\ufb01k, Camilla Chong, Joseph F. Grippo, Bruce P. Burnett<\/p>\n<p align=\"justify\">\n        <strong>#63490<br \/><\/strong><br \/>\n        <strong>ePoster: <\/strong><br \/>\n        <em>Reduction in Draining Tunnels in Hidradenitis Suppurativa Patients Treated with Vilobelimab in a Randomized, Placebo-Controlled, Double-Blind Multicenter Phase 2b Study<br \/><\/em><br \/>\n        <strong>Authors: <\/strong>Evangelos J. Giamarellos-Bourboulis, Christopher Sayed, Jamie Weisman, Jacek C Szepietowski, Falk Bechara, Hoda Taw\ufb01k, Camilla Chong, Bruce P. Burnett<\/p>\n<p align=\"justify\">\n        <strong>#63505<br \/><\/strong><br \/>\n        <strong>ePoster: <\/strong><br \/>\n        <em>Vilobelimab Post-hoc Ef\ufb01cacy in Hidradenitis Suppurativa using the Modi\ufb01ed-HiSCR with Data from the Phase 2b SHINE Study<br \/><\/em><br \/>\n        <strong>Authors: <\/strong>Evangelos J. Giamarellos-Bourboulis, Christopher Sayed, Camilla Chong, Hoda Taw\ufb01k, Bruce P. Burnett<\/p>\n<p align=\"justify\">\n        <strong>#63527<br \/><\/strong><br \/>\n        <strong>ePoster: <\/strong><br \/>\n        <em>Vilobelimab Safety in Hidradenitis Suppurativa Patients in a Randomized, Placebo-Controlled, Double-Blind Multicenter Phase 2b study<br \/><\/em><br \/>\n        <strong>Authors: <\/strong>Evangelos J. Giamarellos-Bourboulis, Christopher Sayed, Jamie Weisman, Jacek C Szepietowski, Falk Bechara, Hoda Taw\ufb01k, Camilla Chong, Bruce P. Burnett<\/p>\n<p align=\"justify\">\n        <strong>#63454<br \/><\/strong><br \/>\n        <strong>ePoster:<\/strong><br \/>\n        <em> Pharmacokinetic\/Pharmacodynamic Analysis of Vilobelimab Demonstrates a Signi\ufb01cant Reduction of C5a Levels in Hidradenitis Suppurativa Patients<br \/><\/em><br \/>\n        <strong>Authors: <\/strong>Evangelos J. Giamarellos-Bourboulis, Theodora Kanni, Hoda Taw\ufb01k, Camilla Chong, Joe F. Grippo, Bruce P. Burnett<\/p>\n<p align=\"justify\">\n        <strong><br \/>\n          <em>About Vilobelimab <\/em><br \/>\n        <\/strong><br \/>\n        <br \/>Vilobelimab is a first-in-class monoclonal anti-human complement factor C5a antibody, which targets the biological activity of C5a and demonstrates high selectivity towards its target in human blood. Unlike upstream blockers e.g. anti-C5, vilobelimab does not alter the membrane attack complex (C5b-9). Thus, vilobelimab leaves the formation of the C5b-9 intact as an important defense mechanism of the innate immune system, which is not the case for molecules blocking C5. In pre-clinical studies, vilobelimab has been shown to control the inflammatory response-driven tissue and organ damage by specifically blocking C5a as a key \u201camplifier\u201d of this response.<\/p>\n<p align=\"justify\">Vilobelimab is being developed for various debilitating or life-threatening inflammatory indications, including a Phase 3 trial for pyoderma gangrenosum (PG). Vilobelimab has been granted orphan drug designation for the treatment of PG by both the FDA and the EMA, as well as fast track designation by the FDA.<\/p>\n<p align=\"justify\">\n        <strong>About GOHIBIC (vilobelimab)<\/strong>\n      <\/p>\n<p align=\"justify\">In the U.S., GOHIBIC (vilobelimab) has been granted an Emergency Use Authorization by the Food and Drug Administration (FDA) for the treatment of COVID-19 in hospitalized adults when initiated within 48 hours of receiving IMV or ECMO. The emergency use of GOHIBIC is only authorized for the duration of the declaration that circumstances exist justifying the authorization of the emergency use of drugs and biological products during the COVID-19 pandemic under Section 564(b)(1) of the Act, 21 U.S.C. \u00a7 360bbb-3(b)(1), unless the declaration is terminated, or authorization revoked sooner.<\/p>\n<p align=\"justify\">GOHIBIC (vilobelimab) is an investigational drug that has not been approved by the FDA for any indication, including for the treatment of COVID-19. There is limited information known about the safety and effectiveness of using GOHIBIC to treat people in the hospital with COVID-19. Please see additional information in the Fact Sheet for Healthcare Providers, Fact Sheet for Patients and Parents\/Caregivers and FDA Letter of Authorization on the GOHIBIC website <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=LQpS48aj_zN6pb3QfC5c9kciMIK6I1CxQWOcO95mEGurEdQ-IzhqySZEdSOsFB1X9n8EkEVdiI5H4a0VstSmPpuHR_3WFsJCiLumBMYwDkc=\" rel=\"nofollow\" target=\"_blank\">http:\/\/www.gohibic.com<\/a>.<\/p>\n<p align=\"justify\">In the EU, GOHIBIC (vilobelimab) has been granted marketing authorization under exceptional circumstances for the treatment of adult patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) who are receiving systemic corticosteroids as part of standard of care and receiving invasive mechanical ventilation (IMV) (with or without extracorporeal membrane oxygenation (ECMO)). The EU approval of GOHIBIC is supported by the previously announced results of the multicenter Phase 3 PANAMO trial, one of the largest 1:1 randomized, double-blind, placebo-controlled trials in invasively mechanically ventilated COVID-19 patients in intensive care units. The results showed that vilobelimab treatment improved survival with a relative reduction in 28-day all-cause mortality of 23.9% compared to placebo in the global data set. The data were published in The Lancet Respiratory Medicine.<\/p>\n<p align=\"justify\">A marketing authorization under exceptional circumstances is recommended when the benefit\/risk assessment is determined to be positive but, due to the rarity of the disease, it\u2019s unlikely that comprehensive data can be obtained under normal conditions of use. Under the terms of GOHIBIC\u2019s approval in the EC, InflaRx will provide annual updates to EMA on the previously announced clinical platform study planned by the Biomedical Advanced Research and Development Authority (BARDA). Vilobelimab is included in this study as one of three new potential therapies for treating ARDS.<\/p>\n<p align=\"justify\">The COVID-19 related work described herein is partly funded by the German Federal Government through grant number 16LW0113 (VILO-COVID). All responsibility for the content of this work lies with InflaRx.<\/p>\n<p align=\"left\">\n        <strong><br \/>\n          <em>About InflaRx N.V. <\/em><br \/>\n        <\/strong>\n      <\/p>\n<p align=\"justify\">InflaRx (Nasdaq: IFRX) is a biopharmaceutical company pioneering anti-inflammatory therapeutics by applying its proprietary anti-C5a and anti-C5aR technologies to discover, develop and commercialize highly potent and specific inhibitors of the complement activation factor C5a and its receptor C5aR. C5a is a powerful inflammatory mediator involved in the progression of a wide variety of inflammatory diseases. InflaRx\u2019s lead product candidate, vilobelimab, is a novel, intravenously delivered, first-in-class, anti-C5a monoclonal antibody that selectively binds to free C5a and has demonstrated disease-modifying clinical activity and tolerability in multiple clinical studies in different indications. InflaRx is also developing INF904, an orally administered, small molecule inhibitor of the C5a receptor. InflaRx was founded in 2007, and the group has offices and subsidiaries in Jena and Munich, Germany, as well as Ann Arbor, MI, USA. For further information, please visit\u00a0www.inflarx.com.<\/p>\n<p align=\"left\">InflaRx GmbH (Germany) and InflaRx Pharmaceuticals Inc. (USA) are wholly owned subsidiaries of InflaRx N.V. (together, InflaRx).<\/p>\n<p align=\"justify\">\n        <strong><br \/>\n          <em>Contacts:<\/em><br \/>\n        <\/strong>\n      <\/p>\n<table style=\"border-collapse: collapse;width:100%;border-collapse:collapse\">\n<tr>\n<td style=\"max-width:40%;width:40%;min-width:40%;text-align: justify;vertical-align: middle;vertical-align: top\">\n            <strong>InflaRx N.V.<\/strong>\n          <\/td>\n<td style=\"max-width:60%;width:60%;min-width:60%;text-align: justify;vertical-align: middle;vertical-align: top\">\n            <strong>MC Services AG<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: justify;vertical-align: middle;vertical-align: top\">Jan Medina, CFA<br \/>Vice President, Head of Investor Relations<br \/>Email: <a href=\"mailto:IR@inflarx.de\" rel=\"nofollow\" target=\"_blank\">IR@inflarx.de<\/a><\/td>\n<td style=\"text-align: justify;vertical-align: middle;vertical-align: top\">Katja Arnold, Laurie Doyle, Dr. Regina Lutz<br \/>Email: <a href=\"mailto:inflarx@mc-services.eu\" rel=\"nofollow\" target=\"_blank\">inflarx@mc-services.eu<\/a><br \/>Europe: +49 89-210 2280<br \/>U.S.: +1-339-832-0752<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: justify;vertical-align: middle;vertical-align: top\">\u00a0<\/td>\n<td style=\"text-align: justify;vertical-align: middle;vertical-align: top\">\u00a0<\/td>\n<\/tr>\n<\/table>\n<p align=\"justify\">\n        <strong>FORWARD-LOOKING STATEMENTS<\/strong><br \/>\n        <br \/>This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as \u201cmay,\u201d \u201cwill,\u201d \u201cshould,\u201d \u201cexpect,\u201d \u201cplan,\u201d \u201canticipate,\u201d \u201ccould,\u201d \u201cintend,\u201d \u201ctarget,\u201d \u201cproject,\u201d \u201cestimate,\u201d \u201cbelieve,\u201d \u201cpredict,\u201d \u201cpotential\u201d or \u201ccontinue,\u201d among others. Forward-looking statements appear in a number of places throughout this release and may include statements regarding our intentions, beliefs, projections, outlook, analyses, current expectations and the risks, uncertainties and other factors described under the headings, \u201cRisk factors\u201d and \u201cCautionary statement regarding forward looking statements\u201d, in our periodic filings with the SEC. These statements speak only as of the date of this press release and involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTM4NjczMSM2Nzg0MjkwIzIxOTQyNDE=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/YWVlMDIwYjItZDA3My00YTA5LWI2MmEtODVjZTVhZWYzMmI0LTEyMDU3OTQ=\/tiny\/InflaRx-N-V-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>JENA, Germany, Feb. 28, 2025 (GLOBE NEWSWIRE) &#8212; InflaRx\u00a0N.V.\u00a0(Nasdaq:\u00a0IFRX), a biopharmaceutical company pioneering anti-inflammatory therapeutics targeting the complement system, today announced acceptance of all submitted abstracts, featuring the role of vilobelimab in pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS), to be presented during the 2025 American Academy of Dermatology (AAD) Annual Meeting, March 7 &#8211; 11, in Orlando, FL. Camilla Chong, MD, Chief Medical Officer of InflaRx, commented: \u201cWe are proud to announce that all of our submitted abstracts have been accepted for presentation at the AAD Annual Meeting, reflecting the considerable scientific work that has gone into the clinical development of vilobelimab in pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS). In HS, we are presenting for the first time &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;InflaRx to Showcase Vilobelimab\u2019s Role in Immuno-Dermatology at the 2025 AAD Annual Meeting&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-819980","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>InflaRx to Showcase Vilobelimab\u2019s Role in Immuno-Dermatology at the 2025 AAD Annual Meeting - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"InflaRx to Showcase Vilobelimab\u2019s Role in Immuno-Dermatology at the 2025 AAD Annual Meeting - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"JENA, Germany, Feb. 28, 2025 (GLOBE NEWSWIRE) &#8212; InflaRx\u00a0N.V.\u00a0(Nasdaq:\u00a0IFRX), a biopharmaceutical company pioneering anti-inflammatory therapeutics targeting the complement system, today announced acceptance of all submitted abstracts, featuring the role of vilobelimab in pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS), to be presented during the 2025 American Academy of Dermatology (AAD) Annual Meeting, March 7 &#8211; 11, in Orlando, FL. Camilla Chong, MD, Chief Medical Officer of InflaRx, commented: \u201cWe are proud to announce that all of our submitted abstracts have been accepted for presentation at the AAD Annual Meeting, reflecting the considerable scientific work that has gone into the clinical development of vilobelimab in pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS). 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Camilla Chong, MD, Chief Medical Officer of InflaRx, commented: \u201cWe are proud to announce that all of our submitted abstracts have been accepted for presentation at the AAD Annual Meeting, reflecting the considerable scientific work that has gone into the clinical development of vilobelimab in pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS). In HS, we are presenting for the first time &hellip; Continue reading \"InflaRx to Showcase Vilobelimab\u2019s Role in Immuno-Dermatology at the 2025 AAD Annual Meeting\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting\/","og_site_name":"Market Newsdesk","article_published_time":"2025-02-28T14:07:40+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTM4NjczMSM2Nzg0MjkwIzIxOTQyNDE=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"InflaRx to Showcase Vilobelimab\u2019s Role in Immuno-Dermatology at the 2025 AAD Annual Meeting","datePublished":"2025-02-28T14:07:40+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting\/"},"wordCount":1333,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTM4NjczMSM2Nzg0MjkwIzIxOTQyNDE=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/inflarx-to-showcase-vilobelimabs-role-in-immuno-dermatology-at-the-2025-aad-annual-meeting\/","name":"InflaRx to Showcase Vilobelimab\u2019s Role in Immuno-Dermatology at the 2025 AAD Annual Meeting - 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