{"id":814828,"date":"2025-02-19T08:09:04","date_gmt":"2025-02-19T13:09:04","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker\/"},"modified":"2025-02-19T08:09:04","modified_gmt":"2025-02-19T13:09:04","slug":"alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker\/","title":{"rendered":"Alto Neuroscience Announces U.S. Patent Granted Covering ALTO-300 as a Treatment for Patients with Major Depressive Disorder Characterized by an Electroencephalogram Biomarker"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>Alto Neuroscience Announces U.S. Patent Granted Covering ALTO-300 as a Treatment for Patients with Major Depressive Disorder Characterized by an Electroencephalogram Biomarker<\/b><\/p>\n<p class=\"bwalignc\"><i>\u2013 Patent supports Alto\u2019s precision approach to improve patient selection \u2013<\/i><\/p>\n<p>MOUNTAIN VIEW, Calif.&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nAlto Neuroscience, Inc. (\u201cAlto\u201d) (NYSE: ANRO) a clinical-stage biopharmaceutical company focused on the development of novel precision medicines for neuropsychiatric disorders, today announced that the U.S. Patent and Trademark Office has granted U.S. Patent Number 12,226,375, with method claims pertaining to treatment of major depressive disorder (MDD) in patients with inadequate response to an antidepressant. The method includes treatment with ALTO-300 as an adjunctive therapy and patient selection using specific electroencephalogram (EEG) measures. As granted, not accounting for any potential patent term extensions, the patent is expected to cover the use of ALTO-300 in the EEG-defined patient population until 2044.\n<\/p>\n<p>\nALTO-300, also known agomelatine, is an oral, small molecule designed to act as a melatonin agonist and 5-HT2C antagonist and is being developed as an adjunctive treatment in the United States for biomarker-characterized patients with MDD who have had an inadequate response to current standard of care antidepressants.\n<\/p>\n<p>\n\u201cThe granting of this patent underscores our novel approach to patient selection in neuropsychiatric treatment using objective biomarkers,\u201d said Amit Etkin, M.D., Ph.D., founder and chief executive officer of Alto Neuroscience. \u201cWe are dedicated to developing more effective, targeted treatments for patients with MDD and deepening our understanding of the patient phenotype that is most likely to benefit, based on our unique ALTO-300 biomarker.\u201d\n<\/p>\n<p><b>About Alto Neuroscience<\/b><\/p>\n<p>\nAlto Neuroscience is a clinical-stage biopharmaceutical company with a mission to redefine psychiatry by leveraging neurobiology to develop personalized and highly effective treatment options. Alto\u2019s Precision Psychiatry Platform\u2122 measures brain biomarkers by analyzing EEG activity, neurocognitive assessments, wearable data, and other factors to better identify which patients are more likely to respond to Alto product candidates. Alto\u2019s clinical-stage pipeline includes novel drug candidates in depression, schizophrenia, and other mental health conditions. For more information, visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.altoneuroscience.com&amp;esheet=54209516&amp;newsitemid=20250219461532&amp;lan=en-US&amp;anchor=www.altoneuroscience.com&amp;index=1&amp;md5=0b457fb00e21a309e117d24b12e493c7\">www.altoneuroscience.com<\/a> or <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fx.com%2FAltoNeuro&amp;esheet=54209516&amp;newsitemid=20250219461532&amp;lan=en-US&amp;anchor=follow+Alto+on+X&amp;index=2&amp;md5=8c520cf999eddcc6b4656a22adda69f2\">follow Alto on X<\/a>.\n<\/p>\n<p><b>Forward-Looking Statements<\/b><\/p>\n<p><i>This press release may contain forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as \u201cexpects,\u201d \u201cplans,\u201d \u201cwill\u201d and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements regarding Alto\u2019s expectations about the potential benefits, activity, effectiveness and safety of its product candidates and Precision Psychiatry Platform (\u201cPlatform\u201d); Alto\u2019s expectations with regard to the design and results of its clinical trials and other statements that are not historical fact. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, including uncertainties inherent in the progress and completion of clinical trials and clinical development of Alto\u2019s product candidates and other important factors, any of which could cause Alto\u2019s actual results to differ from those contained in the forward-looking statements, which are described in greater detail in the section titled \u201cRisk Factors\u201d in Alto\u2019s Quarterly Report on Form 10-Q for the fiscal quarter ended September 30, 2024 filed with the Securities and Exchange Commission (\u201cSEC\u201d) as well as in other filings Alto may make with the SEC in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and Alto expressly disclaims any obligation to update any forward-looking statements contained herein, whether because of any new information, future events, changed circumstances or otherwise, except as required by law.<\/i><\/p>\n<p><b>Availability of Information on Alto\u2019s Website<\/b><\/p>\n<p>\nAlto routinely uses its investor relations <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Finvestors.altoneuroscience.com%2Foverview%2Fdefault.aspx&amp;esheet=54209516&amp;newsitemid=20250219461532&amp;lan=en-US&amp;anchor=website&amp;index=3&amp;md5=16055d000ec8e2b2f68c2ccf7f7c8891\">website<\/a> to post presentations to investors and other important information, including information that may be material. Accordingly, Alto encourages investors and others interested in Alto to review the information it makes public on its investor relations website.\n<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20250219461532r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20250219461532\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20250219461532\/en\/<\/a><\/span><\/p>\n<p><b>Investor Contact:<br \/>\n<\/b><br \/>Nick Smith<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:investors@altoneuroscience.com\">investors@altoneuroscience.com<\/a><\/p>\n<p><b>Media Contact:<br \/>\n<\/b><br \/>Mari Purpura<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:media@altoneuroscience.com\">media@altoneuroscience.com<\/a><\/p>\n<p><b>KEYWORDS:<\/b> United States North America California<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Mental Health Health Biometrics Neurology Pharmaceutical Biotechnology<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20250219461532\/en\/1266385\/3\/Alto_Neuroscience.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Alto Neuroscience Announces U.S. Patent Granted Covering ALTO-300 as a Treatment for Patients with Major Depressive Disorder Characterized by an Electroencephalogram Biomarker \u2013 Patent supports Alto\u2019s precision approach to improve patient selection \u2013 MOUNTAIN VIEW, Calif.&#8211;(BUSINESS WIRE)&#8211; Alto Neuroscience, Inc. (\u201cAlto\u201d) (NYSE: ANRO) a clinical-stage biopharmaceutical company focused on the development of novel precision medicines for neuropsychiatric disorders, today announced that the U.S. Patent and Trademark Office has granted U.S. Patent Number 12,226,375, with method claims pertaining to treatment of major depressive disorder (MDD) in patients with inadequate response to an antidepressant. The method includes treatment with ALTO-300 as an adjunctive therapy and patient selection using specific electroencephalogram (EEG) measures. As granted, not accounting for any potential patent term extensions, &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Alto Neuroscience Announces U.S. Patent Granted Covering ALTO-300 as a Treatment for Patients with Major Depressive Disorder Characterized by an Electroencephalogram Biomarker&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-814828","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Alto Neuroscience Announces U.S. Patent Granted Covering ALTO-300 as a Treatment for Patients with Major Depressive Disorder Characterized by an Electroencephalogram Biomarker - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alto Neuroscience Announces U.S. Patent Granted Covering ALTO-300 as a Treatment for Patients with Major Depressive Disorder Characterized by an Electroencephalogram Biomarker - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Alto Neuroscience Announces U.S. Patent Granted Covering ALTO-300 as a Treatment for Patients with Major Depressive Disorder Characterized by an Electroencephalogram Biomarker \u2013 Patent supports Alto\u2019s precision approach to improve patient selection \u2013 MOUNTAIN VIEW, Calif.&#8211;(BUSINESS WIRE)&#8211; Alto Neuroscience, Inc. (\u201cAlto\u201d) (NYSE: ANRO) a clinical-stage biopharmaceutical company focused on the development of novel precision medicines for neuropsychiatric disorders, today announced that the U.S. Patent and Trademark Office has granted U.S. Patent Number 12,226,375, with method claims pertaining to treatment of major depressive disorder (MDD) in patients with inadequate response to an antidepressant. The method includes treatment with ALTO-300 as an adjunctive therapy and patient selection using specific electroencephalogram (EEG) measures. As granted, not accounting for any potential patent term extensions, &hellip; Continue reading &quot;Alto Neuroscience Announces U.S. Patent Granted Covering ALTO-300 as a Treatment for Patients with Major Depressive Disorder Characterized by an Electroencephalogram Biomarker&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-02-19T13:09:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20250219461532r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Alto Neuroscience Announces U.S. Patent Granted Covering ALTO-300 as a Treatment for Patients with Major Depressive Disorder Characterized by an Electroencephalogram Biomarker\",\"datePublished\":\"2025-02-19T13:09:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker\\\/\"},\"wordCount\":734,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20250219461532r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/alto-neuroscience-announces-u-s-patent-granted-covering-alto-300-as-a-treatment-for-patients-with-major-depressive-disorder-characterized-by-an-electroencephalogram-biomarker\\\/\",\"name\":\"Alto Neuroscience Announces U.S. Patent Granted Covering ALTO-300 as a Treatment for Patients with Major Depressive Disorder Characterized by an Electroencephalogram Biomarker - 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(\u201cAlto\u201d) (NYSE: ANRO) a clinical-stage biopharmaceutical company focused on the development of novel precision medicines for neuropsychiatric disorders, today announced that the U.S. Patent and Trademark Office has granted U.S. Patent Number 12,226,375, with method claims pertaining to treatment of major depressive disorder (MDD) in patients with inadequate response to an antidepressant. The method includes treatment with ALTO-300 as an adjunctive therapy and patient selection using specific electroencephalogram (EEG) measures. 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