{"id":800874,"date":"2025-01-15T06:33:21","date_gmt":"2025-01-15T11:33:21","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-additional-update-on-the-phase-2-tropos-trial\/"},"modified":"2025-01-15T06:33:21","modified_gmt":"2025-01-15T11:33:21","slug":"keros-therapeutics-announces-additional-update-on-the-phase-2-tropos-trial","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-additional-update-on-the-phase-2-tropos-trial\/","title":{"rendered":"Keros Therapeutics Announces Additional Update on the Phase 2 TROPOS Trial"},"content":{"rendered":"<div class=\"mw_release\">\n<p>LEXINGTON, Mass., Jan.  15, 2025  (GLOBE NEWSWIRE) &#8212; Keros Therapeutics, Inc. (\u201cKeros\u201d or the \u201cCompany\u201d) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (\u201cTGF-\u00df\u201d) family of proteins, today announced that it has voluntarily halted all dosing in the TROPOS trial, a Phase 2 clinical trial of cibotercept (KER-012) in combination with background therapy in patients with pulmonary arterial hypertension (\u201cPAH\u201d), including the 1.5 mg\/kg and placebo treatment arms, based on the ongoing safety review due to new observations of pericardial effusion adverse events. On December 12, 2024, the Company announced that it had voluntarily halted the 3.0 mg\/kg and 4.5 mg\/kg treatment based on the observation of pericardial effusions at those dose levels.<\/p>\n<p>\u201cWhile we are disappointed in this new development, patient safety is always our top priority. We continue to work with the investigators, the U.S. Food and Drug Administration (\u201cFDA\u201d) and other relevant regulatory authorities, and we look forward to analyzing and presenting TROPOS topline clinical data in the future,\u201d said Jasbir S. Seehra, PhD., Chair and CEO.<\/p>\n<p>The Company has notified investigators and certain regulatory authorities, including the FDA, about this decision, and is in the process of notifying other relevant regulatory authorities. The TROPOS trial is being terminated early, and patients are expected to be monitored through the end-of-trial visits. The Company continues to expect to present topline data from all treatment arms in this trial in the second quarter of 2025.<\/p>\n<p>\n        <strong>About TROPOS (NCT05975905)<\/strong>\n      <\/p>\n<p>TROPOS is a randomized, double-blind, placebo-controlled, global Phase 2 clinical trial to evaluate cibotercept in combination with background therapy in patients with PAH. The primary objective of this trial is to evaluate the effect of cibotercept on pulmonary hemodynamics compared to placebo in participants on background PAH therapy. The key secondary objective of this trial is to evaluate the effect of cibotercept on exercise capacity compared to placebo on participants on background PAH therapy.<\/p>\n<p>\n        <strong>About Cibotercept<\/strong>\n      <\/p>\n<p>Cibotercept is designed to bind to and inhibit the signaling of TGF-\u03b2 ligands that stimulate smooth muscle hypertrophy and fibrosis, including activin A, activin B and myostatin. Keros believes that cibotercept has the potential to increase the signaling of bone morphogenic protein (\u201cBMP\u201d) pathways through this inhibition of activin A and activin B signaling, and consequently treat diseases such as PAH that are associated with reduced BMP signaling due to inactivating mutations in the BMP receptors. Cibotercept is being developed for the treatment of PAH and for the treatment of cardiovascular disorders.<\/p>\n<p>\n        <strong>Cautionary Note Regarding Forward-Looking Statements<\/strong>\n      <\/p>\n<p>Statements contained in this press release regarding matters that are not historical facts are \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Words such as \u201ccontinue,\u201d \u201cexpect\u201d and \u201cforward,\u201d or similar expressions are intended to identify forward-looking statements. Examples of these forward-looking statements include statements concerning: Keros\u2019 expectations regarding its progress and the design, objectives and timing of its clinical trial for cibotercept, including expected timing for data readout for the TROPOS trial; the response of FDA or any regulatory authorities to our voluntary actions with respect to the TROPOS trial; and the potential of cibotercept to increase the signaling of BMP pathways to treat diseases such as PAH. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These risks and uncertainties include, among others: Keros\u2019 limited operating history and historical losses; Keros\u2019 ability to raise additional funding to complete the development and any commercialization of its product candidates; Keros\u2019 dependence on the success of its product candidates, cibotercept, elritercept and KER-065; that Keros may be delayed in initiating, enrolling or completing any clinical trials; the risk that initial or interim results from a clinical trial may not be predictive of the final results of the trial or the results of future trials; competition from third parties that are developing products for similar uses; Keros\u2019 ability to obtain, maintain and protect its intellectual property; and Keros\u2019 dependence on third parties in connection with manufacturing, clinical trials and preclinical studies.<\/p>\n<p>These and other risks are described more fully in Keros\u2019 filings with the Securities and Exchange Commission (\u201cSEC\u201d), including the \u201cRisk Factors\u201d section of the Company\u2019s Quarterly Report on Form 10-Q, filed with the SEC on November 6, 2024, and its other documents subsequently filed with or furnished to the SEC. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except to the extent required by law, Keros undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.<\/p>\n<p>\n        <strong>Investor Contact:<\/strong><br \/>\n        <br \/>Justin Frantz<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=C02bJo60F6dimnb6hT041_R-GBF_wf_H25wdKXOoU3WAAtT8qR0SKmOorb0CwdPPStjqsWAgjIBdGnp8DG51Bvtxz4RDcDfuRscaE2Nm1L0=\" rel=\"nofollow\" target=\"_blank\">jfrantz@kerostx.com<\/a><br \/>617-221-6042<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTMzMjIwNyM2Njk0NTMyIzIxMjU5MzM=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/NGM1YjZjNmQtMjA1Zi00N2I5LTk1NDEtMDVmMGZlNGFiNjRlLTExMzc1MDQ=\/tiny\/Keros-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>LEXINGTON, Mass., Jan. 15, 2025 (GLOBE NEWSWIRE) &#8212; Keros Therapeutics, Inc. (\u201cKeros\u201d or the \u201cCompany\u201d) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (\u201cTGF-\u00df\u201d) family of proteins, today announced that it has voluntarily halted all dosing in the TROPOS trial, a Phase 2 clinical trial of cibotercept (KER-012) in combination with background therapy in patients with pulmonary arterial hypertension (\u201cPAH\u201d), including the 1.5 mg\/kg and placebo treatment arms, based on the ongoing safety review due to new observations of pericardial effusion adverse events. On December 12, 2024, the Company announced that it had voluntarily halted &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-additional-update-on-the-phase-2-tropos-trial\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Keros Therapeutics Announces Additional Update on the Phase 2 TROPOS Trial&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-800874","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Keros Therapeutics Announces Additional Update on the Phase 2 TROPOS Trial - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-additional-update-on-the-phase-2-tropos-trial\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Keros Therapeutics Announces Additional Update on the Phase 2 TROPOS Trial - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"LEXINGTON, Mass., Jan. 15, 2025 (GLOBE NEWSWIRE) &#8212; Keros Therapeutics, Inc. (\u201cKeros\u201d or the \u201cCompany\u201d) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (\u201cTGF-\u00df\u201d) family of proteins, today announced that it has voluntarily halted all dosing in the TROPOS trial, a Phase 2 clinical trial of cibotercept (KER-012) in combination with background therapy in patients with pulmonary arterial hypertension (\u201cPAH\u201d), including the 1.5 mg\/kg and placebo treatment arms, based on the ongoing safety review due to new observations of pericardial effusion adverse events. 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