{"id":799496,"date":"2025-01-10T08:06:01","date_gmt":"2025-01-10T13:06:01","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/cargo-therapeutics-provides-corporate-update-and-anticipated-milestones-for-2025\/"},"modified":"2025-01-10T08:06:01","modified_gmt":"2025-01-10T13:06:01","slug":"cargo-therapeutics-provides-corporate-update-and-anticipated-milestones-for-2025","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/cargo-therapeutics-provides-corporate-update-and-anticipated-milestones-for-2025\/","title":{"rendered":"CARGO Therapeutics Provides Corporate Update and Anticipated Milestones for 2025"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"left\">\n        <em>&#8211;<\/em><br \/>\n        <em>71 patients dosed in the potentially pivotal Phase 2 clinical study of <\/em><br \/>\n        <em>firicabtagene autoleucel (<\/em><br \/>\n        <em>firi-cel); Interim analysis results expected to be reported in 1H\u201925 &#8211;<\/em>\n      <\/p>\n<p>\n        <em>&#8211; IND application for CRG-023, CARGO\u2019s tri-specific CAR T, cleared by the FDA; Phase 1 study enrollment expected to initiate mid-year 2025 &#8211; <\/em>\n      <\/p>\n<p>\n        <em>&#8211; CARGO announces novel allogeneic platform based on a universal allogeneic-enabling vector intended to be paired with any new or existing CAR vector to create an allogeneic CAR T-cell therapy while leveraging existing autologous drug product processes &#8211; <\/em>\u00a0\u00a0<\/p>\n<p align=\"justify\">\n        <br \/>SAN CARLOS, Calif., Jan.  10, 2025  (GLOBE NEWSWIRE) &#8212; <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ARZMJrK8j2BjKZzS_L10hQx5YAo4VCSXKkxHEiE4gMCdpf6MR9EnLIv9y1XRPZkFK1RH_JTLy8h9_CM7AuErzA3FqHObWkzEp5_hPSseszA=\" rel=\"nofollow\" target=\"_blank\"><strong>CARGO Therapeutics, Inc<\/strong><\/a><strong>. (NASDAQ: CRGX)<\/strong>, a clinical-stage biotechnology company positioned to advance next-generation, potentially curative cell therapies for cancer patients, today provided a corporate update and anticipated milestones for 2025.<\/p>\n<p align=\"justify\">\u201c2024 highlighted our excellence in execution and innovation. We now have three programs \u2013 two clinical-stage with another advancing quickly \u2013 all driven by our strong capabilities designing, developing, and delivering next-generation, and potentially curative cell therapies,\u201d said Gina Chapman, President and Chief Executive Officer of CARGO. \u201cWe are on track to report our interim analysis results for FIRCE-1 in first half 2025. I am also delighted to announce the clearance of our IND for CRG-023, a potentially best-in-class CAR T-cell therapy with Phase 1 enrollment to initiate mid-year. Rapid progression of CRG-023 from lead construct to IND submission in less than 12 months was enabled by our robust CMC and pre-clinical development capabilities. Finally, I\u2019m very excited to announce our novel allogeneic platform, which I believe can meaningfully improve the availability of potentially curative cell therapies for patients by realizing the promise of an allogeneic solution in a universally applicable way. I\u2019d like to thank the entire CARGO organization for their tenacity and innovative spirit, positioning us for our important milestones this year.\u201d<\/p>\n<p align=\"justify\">\u201cThe challenges that limit a broader impact for autologous cell therapy include the quality of T cells derived from sick patients and availability of product. For allogeneic cell therapy, durable efficacy has been difficult to achieve,\u201d said Michael Ports, Chief Scientific Officer of CARGO. \u201cOver the past three years, we set out to solve these limitations through sophisticated cell therapy design and engineering, starting with CRG-023 and now with our novel allogenic platform that is intended to address immune-based rejection of allogeneic CAR T. The allogeneic CAR T platform is comprised of a universal vector with multiple transgene \u201ccargo\u201d to limit T and NK rejection and downregulate TCR. Importantly, the vector can be paired with pre-existing CAR vectors across targets and indications and can leverage existing autologous drug product processes. We are encouraged by our preclinical results which suggest the potential of a universal approach to creating off-the-shelf allogeneic CAR T products to provide more life-saving therapies for patients.\u201d\u00a0\u00a0<\/p>\n<p align=\"justify\">\n        <strong>Corporate Update and Anticipated Milestones for 2025:<\/strong>\n      <\/p>\n<p align=\"justify\">\n        <strong>Firi-cel<\/strong>:<\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">As of December 31, 2024, 71 patients have been dosed in the potentially pivotal Phase 2 study of firi-cel, FIRCE-1.<\/li>\n<li style=\"margin-top:6pt;text-align:justify\">CARGO continues to achieve strong manufacturing success of firi-cel. The Company is partnering with National Resilience, Inc. and ElevateBio to manufacture drug product for the FIRCE-1 study.<\/li>\n<li style=\"margin-top:6pt;text-align:justify\">CARGO expects to share topline data from an interim analysis for a meaningful patient sample size with at least 3 months of follow-up in 1H\u201925.<\/li>\n<\/ul>\n<p align=\"justify\">\n        <strong>CRG-023<\/strong>:<\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">In January, the FDA cleared the Investigational New Drug (IND) application for CRG-023, CARGO\u2019s novel tri-specific CAR T that is designed to address several known causes of relapse, resulting in a potential best-in-class CAR T-cell therapy across a broad range of B-cell malignancies with the goal of providing more patients with a durable complete response. CRG-023 is a first-of-its-kind CAR T to express three independent CARs (CD19, CD20, CD22) from a single vector, with each CAR having a distinct co-stimulatory domain. CRG-023 lentiviral vector is produced using suspension culture process which provides a line of sight to commercially suitable expression level. CRG-023 drug product is produced leveraging CARGO\u2019s internally developed process and analytical methods.<\/li>\n<li style=\"margin-top:6pt;text-align:justify\">Given the encouraging pre-clinical data of CRG-023, CARGO intends to demonstrate the product candidate\u2019s best-in-class potential through a Phase 1 dose escalation study in 3L+ LBCL including CAR T-na\u00efve patients. The Company plans to leverage proof-of-concept data to support moving quickly into earlier lines of therapy and additional indications in B-cell malignancies for CRG-023.<\/li>\n<li style=\"margin-top:6pt;text-align:justify\">The Phase 1, open-label, multi-center, dose escalation and dose expansion study is expected to evaluate the safety, tolerability, pharmacokinetics, and efficacy of CRG-023 and to establish the recommended Phase 2 dose of CRG-023. Dose escalation will begin at a dose level of 25 million cells, which was informed by preclinical data that demonstrated in vivo tumor clearance at low dose levels. Enrollment for the Phase 1 study, including CAR T-na\u00efve patients, is expected to initiate mid-year 2025. CARGO plans to leverage its established manufacturing and supply chain infrastructure to accelerate readiness for its Phase 1 study.<\/li>\n<\/ul>\n<p align=\"justify\">\n        <strong>Novel Allogeneic Platform: <\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">CARGO\u2019s novel allogeneic platform is a universal vector solution designed to limit immune-based rejection and enable durable response of CAR T-cell therapy. Through sophisticated engineering, the differentiated platform aims to transform potentially curative autologous CAR T-cell therapies into allogeneic products for broader patient benefit. The universal, allogeneic-enabling vector is intended to pair with new or clinically established CAR vectors, which can be accomplished while leveraging existing autologous drug product processes. The result is intended to be an off-the-shelf allogeneic CAR T product designed to limit rejection, promote safety, improve the starting quality of T cells, and maintain comparable CAR-mediated activity.<\/li>\n<li style=\"margin-top:6pt;text-align:justify\">To date, CARGO has advanced several lead allogeneic constructs and demonstrated proof of concept in limiting immune rejection, preventing graft vs. host disease (GvHD), and preserving comparable CAR activity when co-transduced with CAR vector utilized for autologous CAR T-cell therapy.<\/li>\n<li style=\"margin-top:6pt;text-align:justify\">CARGO expects to select the lead vector candidate in 1H\u201925.<\/li>\n<\/ul>\n<p align=\"justify\">\n        <strong>Financial Outlook<\/strong>:<\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">As of December 31, 2024, the Company\u2019s preliminary cash, cash equivalents and marketable securities were $368.1 million<sup>(<\/sup><sup>1)<\/sup>, which we believe will be sufficient to fund our expected operations through 2026.<\/li>\n<\/ul>\n<p align=\"justify\">Gina Chapman, President and Chief Executive Officer, is scheduled to present at the 43rd Annual J.P. Morgan Healthcare Conference on Monday, January 13, at 10:30 a.m. PT. Interested parties can access the live webcast for the presentation in the Investors section of CARGO\u2019s website under <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Yw-onzRwaAJG9SiaAjH3NA7uYAMX6MTlMFsa-I3MKeukIRA2g_o6puDxWFSggjbM7ZbpDgyiNGF0h7f4xG8spSfJ54_irBjA1eqwoddglUwlMpPpLiSRHHA5jFNNF-h5\" rel=\"nofollow\" target=\"_blank\">News &amp; Events<\/a>. A replay of the webcast will be available after the conclusion of the live presentation for approximately 30 days.<\/p>\n<p align=\"justify\">\n        <strong>About CARGO Therapeutics <\/strong><br \/>\n        <br \/>CARGO Therapeutics, Inc. is a clinical-stage biotechnology company positioned to advance next-generation, best-in-class, and potentially curative cell therapies for cancer patients. CARGO\u2019s programs, platform technologies, and manufacturing strategy are designed to directly address the limitations of approved cell therapies, including limited durability of effect, safety concerns and availability. CARGO has a growing and focused pipeline that includes firicabtagene autoleucel (firi-cel), an autologous CD22 chimeric antigen receptor (CAR) T-cell therapy candidate currently in a potentially pivotal Phase 2 clinical study in patients with large B-cell lymphoma (LBCL) whose disease relapsed or was refractory (R\/R) to CD19 CAR T-cell therapy. CARGO is also preparing to initiate a Phase 1 study for its CRG-023 product candidate, a CD19\/CD20\/CD22 tri-specific CAR T developed using a tri-cistronic construct and designed to address several known causes of relapse, resulting in a potential best-in-class CAR T-cell therapy across a broad range of B-cell malignancies with the goal of providing more patients with a durable complete response. CARGO\u2019s latest program advancement, a novel allogeneic platform, is a universal vector solution designed to limit immune-based rejection and enable durable response of CAR T-cell therapy. The universal allogeneic-enabling vector is intended to be paired with any CAR vector to create an allogeneic CAR T-cell therapy, with the potential to maintain the efficacy, durability, and safety of autologous cell therapy while broadening availability to more people with cancer. CARGO\u2019s leadership and team have significant experience in designing, developing and delivering oncology and cell therapy products. For more information, please visit the CARGO Therapeutics website at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=DZ5I32zHToxbaHQjjG5vr5Qqmq-IRYEAt1LnN0s3xDMG0w4JrqVs-0b94ze2IXJAdas7a53Nj6JS5VIVB4HSAW0U2VPObbfkRjjhMZG_RHQ=\" rel=\"nofollow\" target=\"_blank\">https:\/\/cargo-tx.com\/<\/a>.<br \/>Follow us on LinkedIn: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ARZMJrK8j2BjKZzS_L10hVtDrMT-F2hLmBq4hmx9BILt5SzQl68wMWozdKqTZnnaBEA8wrBv7u06RlHg2GXpKaLtHyFbPhUQnZxMHWCvNI343s4cqb64GdpCF1J5wwYS\" rel=\"nofollow\" target=\"_blank\">CARGO Therapeutics<\/a><br \/>Follow us on X (Twitter): <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=JeQNWwigukC0S77HzYBSxB9QCFUzYGiVb5qTw7_gnqxgH7kx-YarhP6r7vccNsc_E1-eVKDESWdCijjyJs6o6w==\" rel=\"nofollow\" target=\"_blank\">@CARGOTx<\/a><\/p>\n<p align=\"justify\">\n        <sup><br \/>\n          <strong>(1)<\/strong><br \/>\n        <\/sup> The Company\u2019s actual consolidated cash, cash equivalents, marketable securities as of December 31, 2024 may differ from this preliminary estimate due to the completion of the Company\u2019s year-end closing and auditing procedures.<\/p>\n<p align=\"justify\">\n        <strong>Cautionary Note Regarding Forward-Looking Statements<\/strong><br \/>\n        <br \/>This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. In some cases, you can identify forward-looking statements by terminology such as \u201caim,\u201d \u201canticipate,\u201d \u201cassume,\u201d \u201cbelieve,\u201d \u201ccontemplate,\u201d \u201ccontinue,\u201d \u201ccould,\u201d \u201cdesign,\u201d \u201cdue,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cgoal,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cobjective,\u201d \u201cplan,\u201d \u201cpositioned,\u201d \u201cpotential,\u201d \u201cpredict,\u201d \u201cseek,\u201d \u201cshould,\u201d \u201ctarget,\u201d \u201cwill,\u201d \u201cwould\u201d and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology. All statements other than statements of historical facts contained in this press release are forward-looking statements. These forward-looking statements include, but are not limited to, statements about: the initiation, timing, progress, advancement, and results of CARGO\u2019s clinical and preclinical programs; the potential benefits of CARGO\u2019s product candidates; the timing of data reports, including the release of interim data from CARGO\u2019s ongoing Phase 2 clinical trial of firi-cel; CARGO\u2019s strategic plans for its business and product candidates; CARGO\u2019s estimated cash, cash equivalents and marketable securities as of December 31, 2024 and CARGO\u2019s expectations that its current cash, cash equivalents and marketable securities will be sufficient to fund its expected operations through 2026. Forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties that could cause actual results and events to differ materially from those anticipated, including, but not limited to, risks and uncertainties related to: the company\u2019s ability to obtain necessary capital to fund its clinical programs; the early stages of clinical development of the company\u2019s product candidates and the product candidates involving novel technologies; clinical and preclinical development being a lengthy and expensive process with uncertain outcomes; data from the company\u2019s clinical trials and preclinical studies, including the performance and characteristics of the company\u2019s product candidates, including any undesirable side effects or other properties discovered or detected in the company\u2019s clinical trials and preclinical studies; any favorable data from trials conducted by third-parties, including Stanford University or the NCI, may not be replicated in the company\u2019s clinical trials or predictive of future results; the company\u2019s ability to obtain regulatory approval of and successfully commercialize its product candidates; the company\u2019s reliance on third-party suppliers and manufacturers, including CROs; the outcomes of any future collaboration agreements; and the company\u2019s ability to adequately maintain intellectual property rights for its product candidates. For a detailed discussion of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to CARGO\u2019s business in general, please refer to the risk factors identified in the Company\u2019s filings with the Securities and Exchange Commission (SEC), including but not limited to its Quarterly Report on Form 10-Q for the quarter ended September 30, 2024 filed on November 12, 2024. Any forward-looking statements that the company makes in this press release are made pursuant to the Private Securities Litigation Reform Act of 1995, as amended, and speak only as of the date of this press release. Except as required by law, the company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise.<\/p>\n<p>\n        <strong>Contacts<\/strong><br \/>\n        <br \/>\n        <strong>Media Contact:<\/strong><br \/>\n        <br \/>Denise Powell<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=2JbGzZlgBFrnxbB240dLceSaKy6FU52hneV47NOJIRqBxbdYkx0zdJDCALeYLEntbyTwe2_kltc7IDnQFIThSTmk8CWHwWmCm2qLl5mxgyI=\" rel=\"nofollow\" target=\"_blank\">denise@redhousecomms.com<\/a><\/p>\n<p>\n        <strong>Investor Contact:<\/strong><br \/>\n        <br \/>Jessica Serra<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ZlQ6ZVaxs6WEw47BLnD8FgE7y2qO5-EhjE5F0cWUvAQAzptAcUwrq44tc9s2rbkjTMjmV_XAiUWii5ItoDMqdF9B5sOrLf1bv4P4ob1pQEk=\" rel=\"nofollow\" target=\"_blank\">jserra@cargo-tx.com<\/a><br \/>Laurence Watts<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=NzeiCLgC8-ZPROp3jCe_xyubeXr8MDAMINZXppbWXRyoOHkcRl14a4vqlgTZEQwz-EAQm4u5pJ1uCfkVNt857N9V0FR441gNedveqJy2Smo=\" rel=\"nofollow\" target=\"_blank\">laurence@newstreetir.com<\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTMyOTc3NCM2Njg3NzE1IzIyNjI0OTA=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/OWVmYjljMGYtMTU3MC00OGMxLThlMzUtYjgyODJkZTVhNmUyLTEyNzQwNDA=\/tiny\/Cargo-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>&#8211; 71 patients dosed in the potentially pivotal Phase 2 clinical study of firicabtagene autoleucel ( firi-cel); Interim analysis results expected to be reported in 1H\u201925 &#8211; &#8211; IND application for CRG-023, CARGO\u2019s tri-specific CAR T, cleared by the FDA; Phase 1 study enrollment expected to initiate mid-year 2025 &#8211; &#8211; CARGO announces novel allogeneic platform based on a universal allogeneic-enabling vector intended to be paired with any new or existing CAR vector to create an allogeneic CAR T-cell therapy while leveraging existing autologous drug product processes &#8211; \u00a0\u00a0 SAN CARLOS, Calif., Jan. 10, 2025 (GLOBE NEWSWIRE) &#8212; CARGO Therapeutics, Inc. (NASDAQ: CRGX), a clinical-stage biotechnology company positioned to advance next-generation, potentially curative cell therapies for cancer patients, today provided &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/cargo-therapeutics-provides-corporate-update-and-anticipated-milestones-for-2025\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;CARGO Therapeutics Provides Corporate Update and Anticipated Milestones for 2025&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-799496","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CARGO Therapeutics Provides Corporate Update and Anticipated Milestones for 2025 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/cargo-therapeutics-provides-corporate-update-and-anticipated-milestones-for-2025\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CARGO Therapeutics Provides Corporate Update and Anticipated Milestones for 2025 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"&#8211; 71 patients dosed in the potentially pivotal Phase 2 clinical study of firicabtagene autoleucel ( firi-cel); Interim analysis results expected to be reported in 1H\u201925 &#8211; &#8211; IND application for CRG-023, CARGO\u2019s tri-specific CAR T, cleared by the FDA; Phase 1 study enrollment expected to initiate mid-year 2025 &#8211; &#8211; CARGO announces novel allogeneic platform based on a universal allogeneic-enabling vector intended to be paired with any new or existing CAR vector to create an allogeneic CAR T-cell therapy while leveraging existing autologous drug product processes &#8211; \u00a0\u00a0 SAN CARLOS, Calif., Jan. 10, 2025 (GLOBE NEWSWIRE) &#8212; CARGO Therapeutics, Inc. 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