{"id":797258,"date":"2024-12-30T15:48:09","date_gmt":"2024-12-30T20:48:09","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/noble-registry-update-tlx599-cdx-psma-spect-imaging-of-prostate-cancer-published-in-ejnmmi-reports\/"},"modified":"2024-12-30T15:48:09","modified_gmt":"2024-12-30T20:48:09","slug":"noble-registry-update-tlx599-cdx-psma-spect-imaging-of-prostate-cancer-published-in-ejnmmi-reports","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/noble-registry-update-tlx599-cdx-psma-spect-imaging-of-prostate-cancer-published-in-ejnmmi-reports\/","title":{"rendered":"NOBLE Registry Update: TLX599-CDx PSMA SPECT Imaging of Prostate Cancer Published in EJNMMI Reports"},"content":{"rendered":"
\n

MELBOURNE, Australia and BRUSSELS, Dec. 31, 2024 (GLOBE NEWSWIRE) — Telix Pharmaceuticals Limited (ASX: TLX; Nasdaq: TLX, Telix, the Company) and the Brussels-based Oncidium foundation today announce that results for the NOBLE Registry of TLX599-CDx\u00a0(99m<\/sup>Tc-iPSMA) have been published in the European Journal of Nuclear Medicine and Molecular Imaging (EJNMMI) Reports<\/em>.<\/p>\n

The NOBLE (Nob<\/u>ody\u00a0Le<\/u>ft Behind) Registry (NOBLE) is a global real-world evidence (RWE) study that aims to improve equity of access to state-of-the-art prostate cancer imaging. NOBLE is a collaboration combining the oncology and prostate cancer expertise of the Oncidium foundation as registry sponsor, Telix\u2019s intellectual property, and partnered clinical and operational support. An international network of sites support the registry locally through Principal Investigators (PIs), who are responsible for initiating and conducting research. Investigators collect patient\u00a0data\u00a0that will inform\u00a0the\u00a0development\u00a0of TLX599-CDx, an investigational prostate cancer imaging agent that targets PSMA 1<\/sup> using 99m-technetium (99m<\/sup>Tc)-based SPECT2<\/sup> imaging.<\/p>\n

SPECT cameras are being clinically evaluated in this application because they are more widely available than the PET\/CT3<\/sup> scanners used for gallium- or fluorine-based PSMA imaging, where access can be limited by socio-economic or geographic factors, as well as healthcare funding models. For every PET scanner available globally, there are four SPECT machines4<\/sup>, making them a more accessible option when used with 99<\/sup>m<\/sup>Tc \u2013 a radionuclide with a well-established supply chain, which can be produced in a bench-top generator.<\/p>\n

In the publication, the investigators report initial results based on a study of 40 patients in six countries5<\/sup>, who received TLX599-CDx followed by planar and SPECT imaging. Investigators reported a change in management for 17 patients (42.5%) due to the use of SPECT-based PSMA imaging. No adverse events were reported. The authors conclude that technetium-based imaging \u201cis a promising option to identify PSMA-positive prostate cancer on SPECT and could improve patient access to PSMA imaging worldwide\u201d, fulfilling an unmet need for millions of patients with prostate cancer who do not have straightforward access to PET imaging.<\/p>\n

Pete Tually, lead author, Director, TeleMed Remote Nuclear Medicine, and Principal Investigator for the Australian arm of NOBLE said, \u201cThe NOBLE Registry is an important initiative for increasing access to medicine globally, particularly for men in regional and remote locations. The interim results reported in our manuscript are promising, and we believe they provide a compelling basis for the further clinical study of technetium-99m-based PSMA imaging of prostate cancer.\u201d<\/p>\n

Rebecca Lo bue, CEO, Oncidium foundation, added, \u201cPSMA-PET6<\/sup> imaging is today widely used in many countries worldwide, helping to extend life and improve treatment outcomes for men with prostate cancer through earlier diagnosis and better disease management. However, millions of men do not have access to this technology. These results from NOBLE represent an exciting milestone in bringing to market a powerful, cost-effective, and widely available alternative imaging tool that uses PSMA-SPECT technology.\u201d<\/p>\n

Dr. David N. Cade, Group Chief Medical Officer, Telix, continued, \u201cTelix is proud to support the NOBLE Registry, which aims to improve access for patients who face geographic or economic barriers to state-of-the-art prostate cancer imaging. This publication by Pete Tually and his co-authors7<\/sup> signals a positive future for technetium-99m-based PSMA imaging, and we are excited to be part of this innovative program. As established leaders in PSMA imaging, Telix is committed to exploring multiple avenues to help men with prostate cancer get the diagnoses and treatments they need. We would like to thank all NOBLE investigators and the patients who have contributed towards this study.\u201d<\/p>\n

The EJNMMI Reports publication is available online at:\u00a0
https:\/\/link.springer.com\/article\/10.1186\/s41824-024-00226-4<\/u><\/a><\/p>\n

Telix and the Oncidium foundation are planning follow-on clinical activity for NOBLE. This may include collaboration with Rhine Pharma<\/a> on expanded access or compassionate use programs, exploring the use of technetium-99m and rhenium-188 as a theranostic pair for prostate cancer. This initiative reflects Telix\u2019s global commitment to access to medicine.<\/p>\n

\n About the Oncidium foundation<\/strong>\n <\/p>\n

The Oncidium foundation is a nonprofit organisation dedicated to advancing global access to radioligand therapy for cancer care. The foundation’s priorities include raising awareness about radiotheranostics among patients and physicians, supporting and financing the development of new radiopharmaceuticals for therapy, supporting clinical best practice, and improving access to patients, globally. For more information visit http:\/\/www.oncidiumfoundation.org<\/a>.<\/p>\n

\n About <\/strong>
\n Telix Pharmaceuticals Limited <\/strong>\n <\/p>\n

Telix is a biopharmaceutical company focused on the development and commercialization of therapeutic and diagnostic radiopharmaceuticals and associated medical technologies. Telix is headquartered in Melbourne, Australia, with international operations in the United States, Europe (Belgium and Switzerland), and Japan. Telix is developing a portfolio of clinical and commercial stage products that aims to address significant unmet medical needs in oncology and rare diseases. Telix is listed on the Australian Securities Exchange (ASX: TLX) and the Nasdaq Global Select Market (Nasdaq: TLX).<\/p>\n

Telix\u2019s lead imaging product, gallium-68 (68<\/sup>Ga) gozetotide injection (also known as 68<\/sup>Ga PSMA-11 and marketed under the brand name Illuccix\u00ae), has been approved by the U.S. Food and Drug Administration (FDA)8<\/sup>, by the Australian Therapeutic Goods Administration (TGA) 9<\/sup>, and by Health Canada10<\/sup>. No other Telix product has received a marketing authorization in any jurisdiction.<\/p>\n

Visit www.telixpharma.com<\/a> for further information about Telix, including details of the latest share price, announcements made to the ASX, investor and analyst presentations, news releases, event details and other publications that may be of interest. You can also follow Telix on X<\/a> and LinkedIn<\/a>.<\/p>\n

\n Telix Investor Relations<\/strong>\n <\/p>\n

Ms. Kyahn Williamson
Telix Pharmaceuticals Limited
SVP Investor Relations and Corporate Communications
Email: kyahn.williamson@telixpharma.com<\/a><\/p>\n

Legal Notices<\/p>\n

\n You should read this announcement together with our risk factors, as disclosed in our most recently filed reports with the Australian Securities Exchange (ASX), U.S. Securities and Exchange Commission (SEC), including our registration statement on Form 20-F filed with the SEC, or on our website. <\/em>\n <\/p>\n

\n The information contained in this announcement is not intended to be an offer for subscription, invitation or recommendation with respect to securities of Telix Pharmaceuticals Limited (Telix) in any jurisdiction, including the United States. The information and opinions contained in this announcement are subject to change without notification. \u00a0To the maximum extent permitted by law, Telix disclaims any obligation or undertaking to update or revise any information or opinions contained in this announcement, including any forward-looking statements (as referred to below), whether as a result of new information, future developments, a change in expectations or assumptions, or otherwise. No representation or warranty, express or implied, is made in relation to the accuracy or completeness of the information contained or opinions expressed in the course of this announcement. <\/em>\n <\/p>\n

\n This announcement may contain forward-looking statements, including within the meaning of the U.S. Private Securities Litigation Reform Act of 1995, that relate to anticipated future events, financial performance, plans, strategies or business developments. Forward-looking statements can generally be identified by the use of words such as \u201cmay\u201d, \u201cexpect\u201d, \u201cintend\u201d, \u201cplan\u201d, \u201cestimate\u201d, \u201canticipate\u201d, \u201cbelieve\u201d, \u201coutlook\u201d, \u201cforecast\u201d and \u201cguidance\u201d, or the negative of these words or other similar terms or expressions. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to differ materially from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking statements. Forward-looking statements are based on Telix\u2019s good-faith assumptions as to the financial, market, regulatory and other risks and considerations that exist and affect Telix\u2019s business and operations in the future and there can be no assurance that any of the assumptions will prove to be correct. In the context of Telix\u2019s business, forward-looking statements may include, but are not limited to, statements about: the initiation, timing, progress and results of Telix\u2019s preclinical and clinical trials, and Telix\u2019s research and development programs; Telix\u2019s ability to advance product candidates into, enrol and successfully complete, clinical studies, including multi-national clinical trials; the timing or likelihood of regulatory filings and approvals for Telix\u2019s product candidates, manufacturing activities and product marketing activities; Telix\u2019s sales, marketing and distribution and manufacturing capabilities and strategies; the commercialisation of Telix\u2019s product candidates, if or when they have been approved; Telix\u2019s ability to obtain an adequate supply of raw materials at reasonable costs for its products and product candidates; estimates of Telix\u2019s expenses, future revenues and capital requirements; Telix\u2019s financial performance; developments relating to Telix\u2019s competitors and industry; and the pricing and reimbursement of Telix\u2019s product candidates, if and after they have been approved. Telix\u2019s actual results, performance or achievements may be materially different from those which may be expressed or implied by such statements, and the differences may be adverse. Accordingly, you should not place undue reliance on these forward-looking statements. <\/em>\n <\/p>\n

\n \u00a92024 Telix Pharmaceuticals Limited. The Telix Pharmaceuticals\u00ae and Illuccix\u00ae names and logos are trademarks of Telix Pharmaceuticals Limited and its affiliates \u2013 all rights reserved.<\/em>\n <\/p>\n

\n ___________________________________________<\/em>\n <\/p>\n

\n 1<\/sup> Prostate-specific membrane antigen.
2<\/sup> Single photon emission computed tomography.
3<\/sup> Positron emission tomography\/computed tomography.
4<\/sup> MEDraysintell.
5<\/sup> Australia, Azerbaijan, Egypt, Indonesia, Mexico, South Africa.
6<\/sup> Imaging of prostate-specific membrane antigen with positron emission tomography.
7<\/sup> Virginia Garcia Quinto (Hospital Galenia Department of Nuclear Medicine, Cancun, Mexico), Yehia Omar (Misr Radiology Center, Cairo, Egypt), Fuad Novruzov (Department of Nuclear Medicine, Azerbaijan National Centre of Oncology, Baku, Azerbaijan), Ryan Yudistiro (Department of Nuclear Medicine, Siloam Hospital, Jakarta, Indonesia), Mike Sathekge (University of Pretoria Nuclear Medicine Department, Gauteng, South Africa), Geoffrey Currie (School of Dentistry and Medical Sciences, Charles Sturt University, Bathurst, Australia), Paul Galette, Neel Patel, Tracey Brown and David Cade (Telix), Gabriel Bolland and Rebecca Lo bue (Oncidium foundation).
8<\/sup> Telix ASX disclosure 20 December 2021.
9<\/sup> Telix ASX disclosure 2 November 2021.
10<\/sup> Telix ASX disclosure 14 October 2022.<\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

MELBOURNE, Australia and BRUSSELS, Dec. 31, 2024 (GLOBE NEWSWIRE) — Telix Pharmaceuticals Limited (ASX: TLX; Nasdaq: TLX, Telix, the Company) and the Brussels-based Oncidium foundation today announce that results for the NOBLE Registry of TLX599-CDx\u00a0(99mTc-iPSMA) have been published in the European Journal of Nuclear Medicine and Molecular Imaging (EJNMMI) Reports. The NOBLE (Nobody\u00a0Left Behind) Registry (NOBLE) is a global real-world evidence (RWE) study that aims to improve equity of access to state-of-the-art prostate cancer imaging. NOBLE is a collaboration combining the oncology and prostate cancer expertise of the Oncidium foundation as registry sponsor, Telix\u2019s intellectual property, and partnered clinical and operational support. An international network of sites support the registry locally through Principal Investigators (PIs), who are responsible for initiating … <\/p>\n

Continue reading “NOBLE Registry Update: TLX599-CDx PSMA SPECT Imaging of Prostate Cancer Published in EJNMMI Reports”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-797258","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nNOBLE Registry Update: TLX599-CDx PSMA SPECT Imaging of Prostate Cancer Published in EJNMMI Reports - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/noble-registry-update-tlx599-cdx-psma-spect-imaging-of-prostate-cancer-published-in-ejnmmi-reports\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NOBLE Registry Update: TLX599-CDx PSMA SPECT Imaging of Prostate Cancer Published in EJNMMI Reports - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"MELBOURNE, Australia and BRUSSELS, Dec. 31, 2024 (GLOBE NEWSWIRE) — Telix Pharmaceuticals Limited (ASX: TLX; Nasdaq: TLX, Telix, the Company) and the Brussels-based Oncidium foundation today announce that results for the NOBLE Registry of TLX599-CDx\u00a0(99mTc-iPSMA) have been published in the European Journal of Nuclear Medicine and Molecular Imaging (EJNMMI) Reports. The NOBLE (Nobody\u00a0Left Behind) Registry (NOBLE) is a global real-world evidence (RWE) study that aims to improve equity of access to state-of-the-art prostate cancer imaging. NOBLE is a collaboration combining the oncology and prostate cancer expertise of the Oncidium foundation as registry sponsor, Telix\u2019s intellectual property, and partnered clinical and operational support. 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The NOBLE (Nobody\u00a0Left Behind) Registry (NOBLE) is a global real-world evidence (RWE) study that aims to improve equity of access to state-of-the-art prostate cancer imaging. NOBLE is a collaboration combining the oncology and prostate cancer expertise of the Oncidium foundation as registry sponsor, Telix\u2019s intellectual property, and partnered clinical and operational support. 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