{"id":792970,"date":"2024-12-05T16:36:51","date_gmt":"2024-12-05T21:36:51","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/"},"modified":"2024-12-05T16:36:51","modified_gmt":"2024-12-05T21:36:51","slug":"monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/","title":{"rendered":"Monopar Announces First Patient Dosed with its Novel Therapeutic Radiopharmaceutical MNPR-101-Lu"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"left\">WILMETTE, Ill., Dec.  05, 2024  (GLOBE NEWSWIRE) &#8212; Monopar Therapeutics Inc. (Nasdaq: MNPR), a clinical-stage biotechnology company focused on developing innovative treatments for patients with unmet medical needs, today announced the first patient\u00a0ever dosed with MNPR-101-Lu. This novel therapeutic radiopharmaceutical combines MNPR-101, Monopar\u2019s antibody that selectively targets the urokinase plasminogen activator receptor (uPAR), with the therapeutic radioisotope lutetium-177. uPAR is involved in tumor growth and metastasis, and is found in some of the most aggressive, deadly cancers, including pancreatic, ovarian, triple negative breast, and colorectal cancers.<\/p>\n<p>The MNPR-101-Lu intravenous infusion was well-tolerated with no serious adverse reactions reported. This patient, dosed under a compassionate use protocol in the US, has metastatic pancreatic cancer, and prior to dosing, the cancer was imaged using MNPR-101-Zr (a zirconium-89 imaging radioisotope conjugated to MNPR-101) with a PET\/CT scanner and showed uPAR expression.<\/p>\n<p>\u201cAs a result of encouraging biodistribution and dosimetry clinical data\u00a0we recently reported (<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=UXVOkWiGGft6AWBxRLHJolI5oaONFsJ5qAK1V2HK4I7MrQkf1MA9yMtRyG2l4OSdbP73IVHiTEJea3EburkmSIsylczrIw1fSJo0AwQdhiToWPV2grxcdoo4N68o_O10TzdLxz7qSbET4F0paNCpBgAZRccm8DnAtHF1xevCzeKGG_itG9cnVhqJ-IpmV8ZZa86GOLSC46exz0Mie9_m3TZqrpRF6MrLkamZKaZp_xQ=\" rel=\"nofollow\" target=\"_blank\">link<\/a>) with our radiodiagnostic, MNPR-101-Zr, we have been eagerly\u00a0looking forward to initiating treatment of patients with MNPR-101-Lu, hopeful it may provide an important therapeutic benefit to a group of cancer patients very much in need,\u201d said Chandler Robinson, MD, Monopar\u2019s Chief Executive Officer.<\/p>\n<p>\u201cWe are thrilled to have dosed this patient with MNPR-101-Lu, and believe this may be the world\u2019s first dosing of a patient with a uPAR-targeted therapeutic radiopharmaceutical,\u201d said Andrew Cittadine, Monopar\u2019s Chief Operating Officer. <\/p>\n<p>Monopar is actively enrolling participants in two Phase 1 clinical studies in Australia, evaluating MNPR-101-Zr for imaging and MNPR-101-Lu for treatment of advanced solid tumors. Further information about the MNPR-101-Lu Phase 1a trial is available at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ynyIp3kLwTlUv2QNsB2VRIu_qxzen-uFLyeXYhHQLoRCvB4K9EMXjBC4Za-NCP16oLh6zlCmZZ-GHhXAKi453_59yrqUv2xFXOu6kUQOuWg=\" rel=\"nofollow\" target=\"_blank\">www.ClinicalTrials.gov<\/a>\u00a0under study identifier <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=L4_C0f4gp2PSjcHtc6JiyPbgHgjspDopGN8UrxWNLOEq0anC9ne8Gudv5i3XzFw5u97xvhQXc5-qVuai0-FPxHwEAU2ndqi3Cid6Xp9IhsM=\" rel=\"nofollow\" target=\"_blank\"><strong>NCT06617169<\/strong><\/a>. Further information about the MNPR-101-Zr Phase 1 imaging and dosimetry clinical trial is available at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ynyIp3kLwTlUv2QNsB2VRIu_qxzen-uFLyeXYhHQLoRboScbJeouQLnZnyjTgng5wXturDBYxr9b9i6t3Phfwe_2shdwLEJ0AiZwPc7H92E=\" rel=\"nofollow\" target=\"_blank\">www.ClinicalTrials.gov<\/a>\u00a0under study identifier <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=L4_C0f4gp2PSjcHtc6JiyEmZ9GSYFPHRZkjgCUqPOSMlAmLHEJJ-BxgXWPe2F5hLM2qKVzQbgUJYQ--lA3YmZv0mxTmtiTqAPmyFPAqKl_0=\" rel=\"nofollow\" target=\"_blank\"><strong>NCT06337084<\/strong><\/a>.<\/p>\n<p>\n        <strong>About Monopar Therapeutics Inc.<\/strong><\/p>\n<p>Monopar Therapeutics is a clinical-stage biotechnology company with ALXN-1840 for Wilson disease which has completed a Phase 3 trial, and radiopharma programs including Phase 1-stage MNPR-101-Zr for imaging advanced cancers, and Phase 1a-stage MNPR-101-Lu and late preclinical-stage MNPR-101-Ac225 for the treatment of advanced cancers. For more information, visit: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=fJgZoSG0vhcTbiN4yqrofmhMMQ9y-Ei4XZBOli95VBta_MJNdtbJ7C5Yiood-rbuDx2l9ey8nJQdIP7dlIROphZyTY7brd9Hum-xLzlO0fI=\" rel=\"nofollow\" target=\"_blank\">www.monopartx.com<\/a>.\u00a0<\/p>\n<p><strong>Forward-Looking Statements<\/strong><\/p>\n<p>Statements contained in this press release regarding matters that are not historical facts are &#8220;forward-looking statements&#8221; within the meaning of the Private Securities Litigation Reform Act of 1995. The words \u201cmay,\u201d \u201cwill,\u201d \u201ccould,\u201d \u201cwould,\u201d \u201cshould,\u201d \u201cexpect,\u201d \u201cplan,\u201d \u201canticipate,\u201d \u201cintend,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201cpotential,\u201d \u201ccontinue,\u201d \u201ctarget\u201d and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Examples of these forward-looking statements include statements concerning: the MNPR-101-Lu intravenous infusion was well-tolerated with no serious adverse reactions reported; that as a result of recently reported encouraging biodistribution and dosimetry clinical data with Monopar\u2019s radiodiagnostic, MNPR-101-Zr, the Company has been eagerly looking forward to\u00a0initiating treatment and to seeing if\u00a0the Company can bring an important therapeutic benefit to a group of cancer patients very much in need; and the Company believes this may be the world\u2019s first dosing of a patient with a uPAR-targeted therapeutic radiopharmaceutical. The forward-looking statements involve risks and uncertainties including, but not limited to: that the patient may develop a serious adverse event in the future to MNPR-101-Lu; that radiation dosimetry analytics in the future may not be consistent with the estimated data generated thus far; that Monopar may not find enough patients to successfully enroll its MNPR-101-Lu therapeutic study; that the Phase 1 imaging and dosimetry clinical trial in advanced cancer patients with MNPR-101-Zr may not yield consistently satisfactory results; that future preclinical or clinical data may not be as promising as the data to date; that MNPR-101-Zr and\/or MNPR-101-Lu may cause unexpected serious adverse effects or fail to be effective against the cancer tumors in humans; that the trials could result in a clinical hold should there be a Serious Adverse Event; Monopar\u2019s ability to raise sufficient funds in order for the Company to support continued clinical, regulatory and commercial development of its programs and to make contractual future milestone payments, as well as its ability to further raise additional funds in the future to support any future product candidate programs through completion of clinical trials, the approval processes and, if applicable, commercialization\u037e uncertainties related to the regulatory discussions that Monopar intends to initiate related to ALXN-1840 and the outcome thereof; the rate of market acceptance and competitiveness in terms of pricing, efficacy and safety, of any products for which Monopar receives marketing approval, and Monopar\u2019s ability to competitively market any such products as compared to larger pharmaceutical firms\u037e and the significant general risks and uncertainties surrounding the research, development, regulatory approval, and commercialization of imaging agents and therapeutics. Actual results may differ materially from those expressed or implied by such forward-looking statements. Risks are described more fully in Monopar&#8217;s filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Monopar undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made. Any forward-looking statements contained in this press release represent Monopar\u2019s views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.<\/p>\n<p>\n        <strong>CONTACT:\u202f\u202f <\/strong><br \/>\n        <br \/>Monopar Therapeutics Inc. <br \/>Investor Relations<br \/>\u202f\u202f <br \/>Karthik Radhakrishnan\u202f\u202f <br \/>Chief Financial Officer\u202f\u202f <br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=gsk1BYg1ozndlGO7w5ZNMUWXc8WGYa1B0eGKWC4YrMG2wrtX8DGPdX4iLLmMs4j95ErMtyNt7sV1pCFrMmg8uFiWr2pzE-5xfcBrNMymP48=\" rel=\"nofollow\" target=\"_blank\">karthik@monopartx.com<\/a><\/p>\n<p>Follow Monopar on social media for updates:<br \/>Twitter: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=PUmJhPw3icD9pKL4n_2v6eu6PfA2vLIcv0vylY-zAzlNFf6w5Hca0DII0Sig4pwPW6LqxjqzRMHZ_2o0YpJaKcqnTqwqwmI3_pQMp1RXF8ZbG9wKyzFZsXAENti8IUQmJLBOEsXedUP-Vt9f5MXQu_owElrOzYRD7rKW_wrnXfjdXwh5IgVfFE27rIMLhYTMsc41ciLDrn8Z2n3i0inpoEubIZVxDSkdtZ7JP7-gK1Q=\" rel=\"nofollow\" target=\"_blank\">@MonoparTx<\/a>\u2009 LinkedIn: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=A2HvIDVndAkaspI1uIO65_oLxMxTbj18PnpZENVG-uy3HzUIq8nIkQmtZVpNABTVY81q4iDjNaJCTgtlF5QbrmrXjR5aunyCK9rMAFAt8yvo61NzJni-i-NSZ6vHfy-lo7FUmLMiWbQV0OlvhTJJfCbimSH5CtqeXX_D7Wf8w00oE9FhIwdUIXSmeUXNR0wcvRVxyhytt-7_Lwmh-leSooEeg6lxAqPEpYJi-gGwBDG9X3c63Tsuv54CFxjkoATosVPZKQ5eyNLvH3Cetw8RfJR1JOXdD4Ab8XRmTulzBqMVmI3bqBZ9XnWvmSkPKKCz\" rel=\"nofollow\" target=\"_blank\">Monopar Therapeutics <\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTMxNTE1MyM2NjI1MTc1IzIxOTM4NjM=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/NmQ1YjM3MDktZjk1Mi00Nzg4LWE1ZTgtYTE3NDRjNzFiMDY0LTEyMDU0MTY=\/tiny\/Monopar-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>WILMETTE, Ill., Dec. 05, 2024 (GLOBE NEWSWIRE) &#8212; Monopar Therapeutics Inc. (Nasdaq: MNPR), a clinical-stage biotechnology company focused on developing innovative treatments for patients with unmet medical needs, today announced the first patient\u00a0ever dosed with MNPR-101-Lu. This novel therapeutic radiopharmaceutical combines MNPR-101, Monopar\u2019s antibody that selectively targets the urokinase plasminogen activator receptor (uPAR), with the therapeutic radioisotope lutetium-177. uPAR is involved in tumor growth and metastasis, and is found in some of the most aggressive, deadly cancers, including pancreatic, ovarian, triple negative breast, and colorectal cancers. The MNPR-101-Lu intravenous infusion was well-tolerated with no serious adverse reactions reported. This patient, dosed under a compassionate use protocol in the US, has metastatic pancreatic cancer, and prior to dosing, the cancer was &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Monopar Announces First Patient Dosed with its Novel Therapeutic Radiopharmaceutical MNPR-101-Lu&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-792970","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Monopar Announces First Patient Dosed with its Novel Therapeutic Radiopharmaceutical MNPR-101-Lu - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Monopar Announces First Patient Dosed with its Novel Therapeutic Radiopharmaceutical MNPR-101-Lu - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"WILMETTE, Ill., Dec. 05, 2024 (GLOBE NEWSWIRE) &#8212; Monopar Therapeutics Inc. (Nasdaq: MNPR), a clinical-stage biotechnology company focused on developing innovative treatments for patients with unmet medical needs, today announced the first patient\u00a0ever dosed with MNPR-101-Lu. This novel therapeutic radiopharmaceutical combines MNPR-101, Monopar\u2019s antibody that selectively targets the urokinase plasminogen activator receptor (uPAR), with the therapeutic radioisotope lutetium-177. uPAR is involved in tumor growth and metastasis, and is found in some of the most aggressive, deadly cancers, including pancreatic, ovarian, triple negative breast, and colorectal cancers. The MNPR-101-Lu intravenous infusion was well-tolerated with no serious adverse reactions reported. This patient, dosed under a compassionate use protocol in the US, has metastatic pancreatic cancer, and prior to dosing, the cancer was &hellip; Continue reading &quot;Monopar Announces First Patient Dosed with its Novel Therapeutic Radiopharmaceutical MNPR-101-Lu&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-05T21:36:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTMxNTE1MyM2NjI1MTc1IzIxOTM4NjM=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Monopar Announces First Patient Dosed with its Novel Therapeutic Radiopharmaceutical MNPR-101-Lu\",\"datePublished\":\"2024-12-05T21:36:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\\\/\"},\"wordCount\":939,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTMxNTE1MyM2NjI1MTc1IzIxOTM4NjM=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\\\/\",\"name\":\"Monopar Announces First Patient Dosed with its Novel Therapeutic Radiopharmaceutical MNPR-101-Lu - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/","og_locale":"en_US","og_type":"article","og_title":"Monopar Announces First Patient Dosed with its Novel Therapeutic Radiopharmaceutical MNPR-101-Lu - Market Newsdesk","og_description":"WILMETTE, Ill., Dec. 05, 2024 (GLOBE NEWSWIRE) &#8212; Monopar Therapeutics Inc. (Nasdaq: MNPR), a clinical-stage biotechnology company focused on developing innovative treatments for patients with unmet medical needs, today announced the first patient\u00a0ever dosed with MNPR-101-Lu. This novel therapeutic radiopharmaceutical combines MNPR-101, Monopar\u2019s antibody that selectively targets the urokinase plasminogen activator receptor (uPAR), with the therapeutic radioisotope lutetium-177. uPAR is involved in tumor growth and metastasis, and is found in some of the most aggressive, deadly cancers, including pancreatic, ovarian, triple negative breast, and colorectal cancers. The MNPR-101-Lu intravenous infusion was well-tolerated with no serious adverse reactions reported. This patient, dosed under a compassionate use protocol in the US, has metastatic pancreatic cancer, and prior to dosing, the cancer was &hellip; Continue reading \"Monopar Announces First Patient Dosed with its Novel Therapeutic Radiopharmaceutical MNPR-101-Lu\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/","og_site_name":"Market Newsdesk","article_published_time":"2024-12-05T21:36:51+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTMxNTE1MyM2NjI1MTc1IzIxOTM4NjM=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Monopar Announces First Patient Dosed with its Novel Therapeutic Radiopharmaceutical MNPR-101-Lu","datePublished":"2024-12-05T21:36:51+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/"},"wordCount":939,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTMxNTE1MyM2NjI1MTc1IzIxOTM4NjM=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/monopar-announces-first-patient-dosed-with-its-novel-therapeutic-radiopharmaceutical-mnpr-101-lu\/","name":"Monopar Announces First Patient Dosed with its Novel Therapeutic Radiopharmaceutical MNPR-101-Lu - 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