{"id":791802,"date":"2024-12-03T07:07:11","date_gmt":"2024-12-03T12:07:11","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept\/"},"modified":"2024-12-03T07:07:11","modified_gmt":"2024-12-03T12:07:11","slug":"keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept\/","title":{"rendered":"Keros Therapeutics Announces Global License Agreement with Takeda to Advance Elritercept"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"justify\">\n        <em>Keros Therapeutics to receive upfront payment of $200 million and is eligible to receive development, approval and commercial milestone payments with the potential to exceed $1.1 billion and tiered royalties on net sales<\/em>\n      <\/p>\n<p>LEXINGTON, Mass., Dec.  03, 2024  (GLOBE NEWSWIRE) &#8212; Keros Therapeutics, Inc. (\u201cKeros\u201d or the \u201cCompany\u201d) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (\u201cTGF-\u00df\u201d) family of proteins, today announced an exclusive global development and commercialization license agreement with Takeda (TSE:4502\/NYSE:TAK) to advance elritercept. Elritercept is currently in two ongoing Phase 2 clinical trials; one in patients with very low-, low-, or intermediate-risk myelodysplastic syndrome (\u201cMDS\u201d) and one in patients with myelofibrosis (\u201cMF\u201d). The Phase 3 RENEW clinical trial evaluating elritercept in adult patients with transfusion-dependent anemia with very low-, low-, or intermediate-risk MDS will begin enrollment soon.<\/p>\n<p>Under the terms of the agreement, Takeda will obtain an exclusive license to further develop, manufacture and commercialize elritercept worldwide outside of mainland China, Hong Kong and Macau. Takeda will be responsible for all development, manufacturing and commercialization as of the effective date of the agreement. Subject to the terms of the agreement, Keros will receive a $200 million upfront cash payment and is eligible to receive development, approval and commercial milestones with the potential to exceed $1.1 billion. Keros will also be eligible to receive tiered royalties on net sales.<\/p>\n<p>\u201cWe are thrilled to announce this agreement with Takeda, a leader in the hematologic oncology treatment space,\u201d said Jasbir S. Seehra, Ph.D., Chair and Chief Executive Officer of Keros. \u201cWe believe this global license further validates Keros\u2019 position as a leader in understanding the role of the TGF-\u00df family of proteins and the broad potential of this biological pathway.\u201d<\/p>\n<p>\u201cWe believe Takeda is an ideal partner to maximize the potential of elritercept\u2019s differentiated profile and continue to build on the great progress our team has accomplished with elritercept,\u201d said Chris Rovaldi, President and Chief Operating Officer of Keros. \u201cWe expect that the net proceeds from the upfront payment will enable us to extend our operational runway into the fourth quarter of 2028, facilitating the continued advancement of cibotercept (KER-012) and KER-065, both of which are wholly-owned assets with near term clinical updates.\u201d<\/p>\n<p>\u201cWe are excited to partner with Keros, an accomplished team with exceptional expertise in TGF-\u00df biology,\u201d said P.K. Morrow, Head of the Oncology Therapeutic Area Unit at Takeda. \u201cBuilding on the promising results elritercept has shown in the clinic to date, we look forward to continuing to explore its potential and to having the opportunity to potentially deliver it to patients with hematologic disorders. This agreement aligns with our goal of advancing therapies that may shift the treatment paradigm for underserved patient populations.\u201d<\/p>\n<p>The effectiveness of the agreement is subject to clearance under the Hart-Scott-Rodino Antitrust Improvements Act (\u201cHSR Act\u201d).<\/p>\n<p>\n        <strong>About Elritercept<\/strong>\n      <\/p>\n<p>Elritercept is an engineered ligand trap comprised of a modified ligand-binding domain of the TGF-\u00df receptor known as activin receptor type IIA that is fused to the portion of the human antibody known as the Fc domain. Elritercept is being developed for the treatment of low blood cell counts, or cytopenias, including anemia and thrombocytopenia, in patients with MDS and in patients with MF.<\/p>\n<p>\n        <strong>About Keros Therapeutics, Inc.<\/strong>\n      <\/p>\n<p>Keros is a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the TGF-\u00df family of proteins. Keros is a leader in understanding the role of the TGF-\u00df family of proteins, which are master regulators of the growth, repair and maintenance of a number of tissues, including blood, bone, skeletal muscle, adipose and heart tissue. By leveraging this understanding, Keros has discovered and is developing protein therapeutics that have the potential to provide meaningful and potentially disease-modifying benefit to patients. Elritercept is being developed for the treatment of low blood cell counts, or cytopenias, including anemia and thrombocytopenia, in patients with MDS and in patients with MF. Cibotercept is being developed for the treatment of pulmonary arterial hypertension and for the treatment of cardiovascular disorders. KER-065 is being developed for the treatment of obesity and for the treatment of neuromuscular diseases.<\/p>\n<p>\n        <strong>Cautionary Note Regarding Forward-Looking Statements<\/strong>\n      <\/p>\n<p>Statements contained in this press release regarding matters that are not historical facts are \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Words such as \u201cexpect,\u201d \u201cenable,\u201d \u201cforward,\u201d \u201cpotential\u201d and \u201cwill\u201d or similar expressions are intended to identify forward-looking statements. Examples of these forward-looking statements include statements concerning: the expected upfront payment and other potential milestone and royalty payments and development activities under the license agreement, Keros\u2019 expectations regarding the timing of enrollment for the Phase 3 RENEW clinical trial for elritercept, the potential benefits of elritercept, Takeda\u2019s ability to further develop and advance elritercept, Keros\u2019 expected cash runway, Keros\u2019 ability to advance cibotercept and KER-065, and the clearance of the license agreement under the HSR Act. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These risks and uncertainties include, among others: Keros\u2019 limited operating history and historical losses; Keros\u2019 ability to raise additional funding to complete the development and any commercialization of its product candidates; Keros\u2019 dependence on the success of its product candidates, cibotercept, elritercept and KER-065; that Keros may be delayed in initiating, enrolling or completing any clinical trials; competition from third parties that are developing products for similar uses; Keros\u2019 ability to obtain, maintain and protect its intellectual property; and Keros\u2019 dependence on third parties in connection with manufacturing, clinical trials and preclinical studies.<\/p>\n<p>These and other risks are described more fully in Keros\u2019 filings with the Securities and Exchange Commission (\u201cSEC\u201d), including the \u201cRisk Factors\u201d section of the Company\u2019s Quarterly Report on Form 10-Q, filed with the SEC on November 6, 2024, and its other documents subsequently filed with or furnished to the SEC. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except to the extent required by law, Keros undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.<\/p>\n<p>\n        <strong>Investor Contact:<\/strong>\n      <\/p>\n<p>Justin Frantz<br \/>jfrantz@kerostx.com<br \/>617-221-6042<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTMxMzA1NSM2NjE5ODYzIzIxMjU5MzM=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/N2I2YjJmZTQtZDYzYi00MjU4LWIzNDEtMjZjZDcxZGMzZDgyLTExMzc1MDQ=\/tiny\/Keros-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Keros Therapeutics to receive upfront payment of $200 million and is eligible to receive development, approval and commercial milestone payments with the potential to exceed $1.1 billion and tiered royalties on net sales LEXINGTON, Mass., Dec. 03, 2024 (GLOBE NEWSWIRE) &#8212; Keros Therapeutics, Inc. (\u201cKeros\u201d or the \u201cCompany\u201d) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (\u201cTGF-\u00df\u201d) family of proteins, today announced an exclusive global development and commercialization license agreement with Takeda (TSE:4502\/NYSE:TAK) to advance elritercept. Elritercept is currently in two ongoing Phase 2 clinical trials; one in patients with very low-, low-, or intermediate-risk &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Keros Therapeutics Announces Global License Agreement with Takeda to Advance Elritercept&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-791802","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Keros Therapeutics Announces Global License Agreement with Takeda to Advance Elritercept - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Keros Therapeutics Announces Global License Agreement with Takeda to Advance Elritercept - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Keros Therapeutics to receive upfront payment of $200 million and is eligible to receive development, approval and commercial milestone payments with the potential to exceed $1.1 billion and tiered royalties on net sales LEXINGTON, Mass., Dec. 03, 2024 (GLOBE NEWSWIRE) &#8212; Keros Therapeutics, Inc. (\u201cKeros\u201d or the \u201cCompany\u201d) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (\u201cTGF-\u00df\u201d) family of proteins, today announced an exclusive global development and commercialization license agreement with Takeda (TSE:4502\/NYSE:TAK) to advance elritercept. 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(\u201cKeros\u201d or the \u201cCompany\u201d) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (\u201cTGF-\u00df\u201d) family of proteins, today announced an exclusive global development and commercialization license agreement with Takeda (TSE:4502\/NYSE:TAK) to advance elritercept. Elritercept is currently in two ongoing Phase 2 clinical trials; one in patients with very low-, low-, or intermediate-risk &hellip; Continue reading \"Keros Therapeutics Announces Global License Agreement with Takeda to Advance Elritercept\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept\/","og_site_name":"Market Newsdesk","article_published_time":"2024-12-03T12:07:11+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTMxMzA1NSM2NjE5ODYzIzIxMjU5MzM=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Keros Therapeutics Announces Global License Agreement with Takeda to Advance Elritercept","datePublished":"2024-12-03T12:07:11+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept\/"},"wordCount":1077,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTMxMzA1NSM2NjE5ODYzIzIxMjU5MzM=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/keros-therapeutics-announces-global-license-agreement-with-takeda-to-advance-elritercept\/","name":"Keros Therapeutics Announces Global License Agreement with Takeda to Advance Elritercept - 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