\n\u201cWe look forward to presenting positive new data from patients with Dravet syndrome who were already receiving the best available anti-seizure medicines and then were treated with initial doses of 70mg followed by 45mg maintenance dosing of zorevunersen,\u201d said Barry Ticho, M.D., Ph.D., Chief Medical Officer of Stoke Therapeutics. \u201cThese data underscore the potential for zorevunersen as a disease-modifying medicine and support the proposed Phase 3 dosing regimen under discussion with global regulatory agencies.\u201d<\/p>\n
\nNew data will include the nine patients who received two or three initial doses of 70mg of zorevunersen in a Phase 1\/2 study and then continued treatment in an open-label extension (OLE) study where they received at least two doses of 45mg. In addition, data from patients treated in the OLEs (n=73) were consistent with earlier findings and showed durable reductions in seizures and continuous improvements in multiple subdomains of the Vineland-3 through 24 months. Treatment was generally well tolerated.<\/p>\n
\nDetails of the Company\u2019s presentations at AES are as follows:<\/p>\n
- \n
- Title: <\/b>Zorevunersen (STK-001) Demonstrates Potential for Disease Modification Including Reductions in Seizures and Improvements in Cognition and Behavior in Children and Adolescents with Dravet Syndrome (DS)
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Poster Session Date & Time: <\/b>Sunday, December 8 at 12:00 PM PST
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Oral Presentation Date & Time: <\/b>Monday, December 9 at 3:15 PM PST
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Presenter:<\/b> Linda Laux, M.D., Associate professor of Pediatrics (Neurology and Epilepsy) at Northwestern University Feinberg School of Medicine and Attending Physician at Ann & Robert H. Lurie Children\u2019s Hospital of Chicago
\n
Poster Number:<\/b> 2.379<\/p>\n<\/li>\n- Title: <\/b>Patients with Dravet Syndrome in Open-Label Extension Studies of Zorevunersen (STK-001) Have Durable Reductions in Seizure Frequency and Clinically Meaningful Improvements in Cognition and Behavior
\n
Poster Session Date & Time: <\/b>Sunday, December 8 at 12:00 PM PST
\n
Presenter: <\/b>Joseph Sullivan, M.D., FAES, Professor of Neurology and Pediatrics and Director of the Pediatric Epilepsy Center of Excellence at the University of California San Francisco
\n
Poster Number:<\/b> 2.364<\/p>\n<\/li>\n- Title: <\/b>Small Changes on the Vineland-3 are Meaningful to Caregivers of Patients with Dravet Syndrome
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Poster Session Date & Time: <\/b>Sunday, December 8 at 12:00 PM PST
\n
Presenter: <\/b>Carrie Condon, Director of Clinical Science at Stoke Therapeutics
\n
Poster Number:<\/b> 3.383<\/p>\n<\/li>\n- Title: <\/b>Spectral EEG Analysis Demonstrates Decreased Slow-wave Activity in Patients with Dravet Syndrome after Treatment with Zorevunersen, an Antisense Oligonucleotide
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Poster Session Date & Time: <\/b>Monday, December 9 at 12:00 PM PST
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Presenter: <\/b>Nigel Colenbier, Senior Data Scientist, Epilog, Clouds of Care NV
\n
Poster Number:<\/b> 3.407<\/p>\n<\/li>\n<\/ul>\nStoke Therapeutics Corporate Symposium<\/b><\/p>\n
\nStoke Therapeutics will host a symposium for clinicians to review new data from the Dravet syndrome program and discuss the clinical need for disease-modifying therapies that extend beyond seizure reduction. The session will focus on the behavioral, cognitive, and seizure-related impacts of the disease and what improvements are considered meaningful for clinicians and caregivers.<\/p>\n
Title: <\/b>The Potential of Disease-Modifying Treatments for Dravet Syndrome: Entering a New Era
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Date and Time: <\/b>Sunday, December 8, 6:00-9:00 PM PST (9:00 PM-12:00 AM EST)
\n
Presenters: <\/b>Joseph Sullivan, Andreas Brunklaus, Ingrid Scheffer, Helen Cross<\/p>\nStoke Therapeutics Investor and Analyst Virtual Event<\/b><\/p>\n
\nStoke will also host a virtual event led by leading clinicians and patient advocates to discuss the effects of Dravet syndrome, the current treatment landscape, including the latest data from studies of zorevunersen, and the potential real-world impacts of a disease-modifying medicine. The presentation will be conducted virtually and include an opportunity for research analysts to ask questions of the clinician presenters.<\/p>\n
Title:<\/b> Understanding Dravet Syndrome: The Unmet Need and Potential for Disease-Modification
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Date and Time:<\/b> Monday, December 9, 8:30-9:30 AM EST (5:30-6:30 AM PST)
\n
Presenters: <\/b>Edward M. Kaye, M.D., CEO of Stoke Therapeutics, Joseph Sullivan, M.D., FAES, Professor of Neurology and Pediatrics and Director of the Pediatric Epilepsy Center of Excellence at the University of California San Francisco; Andreas Brunklaus, Consultant Paediatric Neurologist at the Royal Hospital for Children, Glasgow, Honorary Professor at the University of Glasgow, member of Dravet Syndrome UK’s Medical Advisory Board; Mary Anne Meskis, Executive Director, Dravet Syndrome Foundation; and Veronica Hood, PhD, Scientific Director, Dravet Syndrome Foundation
\n
Webcast Link:<\/b>https:\/\/edge.media-server.com\/mmc\/p\/bv6h2oxs<\/a><\/p>\nAbout Dravet Syndrome<\/b><\/p>\n
\nDravet syndrome is a severe and progressive genetic epilepsy characterized by frequent, prolonged and refractory seizures, beginning within the first year of life. Dravet syndrome is difficult to treat and has a poor long-term prognosis. Complications of the disease often contribute to a poor quality of life for patients and their caregivers. The effects of the disease go beyond seizures and often include intellectual disability, developmental delays, movement and balance issues, language and speech disturbances, growth defects, sleep abnormalities, disruptions of the autonomic nervous system and mood disorders. The disease is classified as a developmental and epileptic encephalopathy due to the developmental delays and cognitive impairment associated with the disease. Compared with the general epilepsy population, people living with Dravet syndrome have a higher risk of sudden unexpected death in epilepsy, or SUDEP. There are no approved disease-modifying therapies for people living with Dravet syndrome. One out of 16,000 babies are born with Dravet syndrome, which is not concentrated in a particular geographic area or ethnic group.<\/p>\n
About Zorevunersen<\/b><\/p>\n
\nZorevunersen is an investigational new medicine for the treatment of Dravet syndrome currently being evaluated in ongoing clinical trials. Stoke believes that zorevunersen, a proprietary antisense oligonucleotide (ASO), has the potential to be the first disease-modifying therapy to address the genetic cause of Dravet syndrome. Zorevunersen is designed to upregulate NaV1.1 protein expression by leveraging the non-mutant (wild-type) copy of the SCN1A<\/i> gene to restore physiological NaV1.1 levels, thereby reducing both occurrence of seizures and significant non-seizure comorbidities. Zorevunersen has been granted orphan drug designation by the FDA and the EMA, and rare pediatric disease designation by the FDA as a potential new treatment for Dravet syndrome.<\/p>\n
About Stoke Therapeutics<\/b><\/p>\n
\nStoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body\u2019s potential with RNA medicine. Using Stoke\u2019s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore protein levels. Stoke\u2019s first compound, zorevunersen (STK-001), is in clinical testing for the treatment of Dravet syndrome, a severe and progressive genetic epilepsy. Dravet syndrome is one of many diseases caused by a haploinsufficiency, in which a loss of ~50% of normal protein levels leads to disease. Stoke is pursuing the development of STK-002 for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. Stoke\u2019s initial focus is haploinsufficiencies and diseases of the central nervous system and the eye, although proof of concept has been demonstrated in other organs, tissues, and systems, supporting its belief in the broad potential for its proprietary approach. Stoke is headquartered in Bedford, Massachusetts with offices in Cambridge, Massachusetts. For more information, visit https:\/\/www.stoketherapeutics.com\/<\/a>.<\/p>\n
Cautionary Note Regarding Forward-Looking Statements<\/b><\/p>\n
\nThis press release contains forward-looking statements within the meaning of the \u201csafe harbor\u201d provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to, the ability of zorevunersen to treat the underlying causes of Dravet syndrome and reduce seizures or show improvements in behavior and cognition at the indicated dosing levels or at all, the timing and expected progress of clinical trials, data readouts, regulatory meetings, regulatory decisions and other presentations, and the participation of scientists associated with Stoke making presentations at AES 2024 and the presentation of data at AES 2024. Statements including words such as \u201cplan,\u201d \u201cpotential,\u201d \u201cwill,\u201d \u201ccontinue,\u201d \u201cexpect,\u201d or similar words and statements in the future tense are forward-looking statements. These forward-looking statements involve risks and uncertainties, as well as assumptions, which, if they do not fully materialize or prove incorrect, could cause our results to differ materially from those expressed or implied by such forward-looking statements. Forward-looking statements are subject to risks and uncertainties that may cause the Company\u2019s actual activities or results to differ significantly from those expressed in any forward-looking statement, including risks and uncertainties related to: the Company\u2019s ability to advance, obtain regulatory approval of, and ultimately commercialize its product candidates, including zorevunersen; the timing of data readouts and interim and final results of preclinical and clinical trials; the receipt and timing of potential regulatory decisions; positive results in a clinical trial may not be replicated in subsequent trials or successes in early stage clinical trials may not be predictive of results in later stage trials; the Company\u2019s ability to fund development activities and achieve development goals, including expectations regarding its collaboration with Acadia Pharmaceuticals; the Company\u2019s ability to protect its intellectual property; the direct or indirect impact of global business, political and macroeconomic conditions, including inflation, interest rate volatility, cybersecurity events, uncertainty with respect to the federal budget, instability in the global banking system and volatile market conditions, and global events, including public health crises, and ongoing geopolitical conflicts, such as the conflicts in Ukraine and the Middle East; and other risks and uncertainties described under the heading \u201cRisk Factors\u201d in the Company\u2019s Annual Report on Form 10-K for the year ended December 31, 2023, its quarterly reports on Form 10-Q, and the other documents it files from time to time with the Securities and Exchange Commission. These forward-looking statements speak only as of the date of this press release, and the Company undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date hereof.<\/p>\n
<\/p>\n
View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20241202234043\/en\/<\/a><\/span><\/p>\n
Stoke Media & Investor Contacts:
\n<\/b>
Dawn Kalmar
\n
Chief Communications Officer
\n
dkalmar@stoketherapeutics.com
\n<\/a>
781-303-8302<\/p>\n\nDoug Snow
\n
Director, Communications & Investor Relations
\n
IR@stoketherapeutics.com
\n<\/a>
508-642-6485<\/p>\nKEYWORDS:<\/b> United States North America California Massachusetts<\/p>\n
INDUSTRY KEYWORDS:<\/b> Science Neurology Biotechnology Research Pharmaceutical Health Genetics Clinical Trials<\/p>\n
- Title: <\/b>Patients with Dravet Syndrome in Open-Label Extension Studies of Zorevunersen (STK-001) Have Durable Reductions in Seizure Frequency and Clinically Meaningful Improvements in Cognition and Behavior
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