{"id":789305,"date":"2023-10-10T11:52:04","date_gmt":"2023-10-10T15:52:04","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/"},"modified":"2023-10-10T11:52:04","modified_gmt":"2023-10-10T15:52:04","slug":"capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/","title":{"rendered":"Capricor Therapeutics Announces Late-Breaking Presentations at 28th Annual Congress of the World Muscle Society"},"content":{"rendered":"
\n

\n -24-Month Open Label Extension Data from HOPE-2 Study Supports CAP-1002\u2019s Sustained Efficacy and Safety in Treating Duchenne Muscular Dystrophy-<\/em>
\n \n <\/p>\n

\n -Company\u2019s StealthX\u2122<\/em>
\n \u00a0Technology Shows Promise of Exosome-Based Delivery of ASOs-<\/em>\n <\/p>\n

SAN DIEGO, Oct. 10, 2023 (GLOBE NEWSWIRE) — Capricor Therapeutics<\/a>\u00a0(NASDAQ: CAPR), a biotechnology company focused on the development of transformative cell and exosome-based therapeutics for the treatment and prevention of muscular and other select diseases, today announced data from two late-breaking posters presented at this year\u2019s 28th<\/sup> International Annual Congress of the World Muscle Society (WMS) which took place in Charleston, South Carolina, from October 3-7, 2023. Presentations included data from the two-year open label extension (OLE) of the HOPE-2 clinical trial highlighting the efficacy of Capricor\u2019s lead asset, CAP-1002 to treat patients with Duchenne muscular dystrophy (DMD), and preclinical data showing the potential of the Company\u2019s proprietary StealthX\u2122 exosome platform to enhance the delivery of antisense oligonucleotides (ASOs).<\/p>\n

\n
\n
\n Late-Breaking Poster<\/u>
\n <\/em>
\n <\/strong>
\n
\n : Capricor\u2019s 24-Month HOPE-2 Results Show CAP-1002\u2019s Long-Term Safety and Efficacy in Patients with Late-Stage DMD<\/em>
\n <\/strong>\n <\/p>\n

Data from the Company\u2019s HOPE-2 OLE study measured by the Performance of the Upper Limb (PUL 2.0) showed a mean PUL 2.0 decline after 24-months of treatment with CAP-1002 was 2.8 points versus a 7.7-point decline on average observed over 24-months in the placebo patient group (delta change=4.9 points, p=0.021). The average rate of decline in CAP-1002 treated patients showed an attenuation of disease progression by approximately 64%. Additionally, CAP-1002 revealed clinically meaningful improvements in ameliorating cardiac function. The data showed that cardiac function, as measured by left ventricular ejection fraction (LVEF%) by MRI at the 24-month timepoint, improved in 67% of patients, compared to a steady decline in a comparable natural history population.<\/p>\n

\n
\n
\n Late-Breaking Poster<\/u>
\n <\/em>
\n <\/strong>
\n
\n : StealthX\u2122<\/em>
\n <\/strong>
\n
\n \u00a0Platform for Enhanced Exosome-Based ASO Delivery <\/em>
\n <\/strong>\n <\/p>\n

One of the predominant strategies for treating DMD has been through the employment of antisense oligonucleotides to exclude exons resulting in DMD proteins with partially restored function. The main challenge of antisense drugs is to improve their delivery to target tissues. To overcome this challenge, a muscle-targeting moiety was engineered on the surface of the exosomes using Capricor\u2019s StealthX\u2122\u00a0technology. The study results showed the presence of exosomes loaded with a labeled ASO in the lower limbs of mice 24 hours post-injection. Notably, the exosomes carrying the muscle-targeting moiety were not detected in any other tissues except for the expected clearance pathways (kidney and liver). This early data suggests that Capricor’s StealthX\u2122\u00a0technology holds promise for enhancing the delivery of ASO therapies to muscle tissues, potentially leading to improved functional restoration.<\/p>\n

\u201cCapricor remains focused on our mission to develop and commercialize therapies for DMD and the data presented at this year\u2019s WMS support that goal,\u201d said Linda Marb\u00e1n, Ph.D., Capricor\u2019s Chief Executive Officer. \u201cThe 24-month OLE data show long-term efficacy and attenuation of disease progression, which demonstrate its potentially broad therapeutic use across all stages of DMD. Most importantly, CAP-1002 continues to show a favorable safety profile. Building on this momentum, we look forward to delivering on important milestones for this program, including the completion of enrollment of our HOPE-3, Phase 3 study, reporting the outcome of the interim futility analysis in the fourth quarter of 2023 and reporting top-line data in late 2024. While our major focus is on commercializing CAP-1002, we continue to progress our proprietary StealthX\u2122\u00a0program by demonstrating that we can target, load and deliver exosomes. This is part of our long-term plan to leverage our exosome platform for the development of therapeutics.\u201d<\/p>\n

\n Session Details<\/strong>: Session 4 was showcased from 3:30-4:30 ET on October 6, 2023 and data was embargoed until that time. Abstract Numbers: LBP12 and LBP13<\/p>\n

The full WMS Congress program is available\u00a0here<\/a>.<\/p>\n

The Capricor posters are available on the publications section of the Capricor\u00a0website<\/a>.<\/p>\n

\n About Capricor Therapeutics<\/strong>\n <\/p>\n

Capricor Therapeutics, Inc. (NASDAQ: CAPR) is a biotechnology company focused on the development of transformative cell and exosome-based therapeutics for the treatment and prevention of muscular and other select diseases. Capricor\u2019s lead candidate, CAP-1002, is an allogeneic cardiac-derived cell therapy that is currently in late-stage clinical development for treating Duchenne muscular dystrophy. Further, Capricor has entered into a\u00a0partnership\u00a0for the exclusive commercialization and distribution of CAP-1002 for DMD in the United States and Japan with Nippon Shinyaku Co., Ltd. (U.S. subsidiary:\u00a0NS Pharma<\/a>, Inc.), subject to regulatory approval. Capricor is also developing its exosome technology as a next-generation therapeutic platform. Our proprietary StealthX\u2122 exosome platform has potential for a broad range of new therapeutic applications in the field of vaccinology as well as targeted oligonucleotide, protein and small molecule therapeutics to treat or prevent a variety of diseases. For more information, visit\u00a0capricor.com<\/a>, and follow Capricor on\u00a0Facebook<\/a>,\u00a0Instagram<\/a>\u00a0and\u00a0Twitter<\/a>.<\/p>\n

\n Cautionary Note Regarding Forward-Looking Statements<\/strong>\n <\/p>\n

Statements in this press release regarding the efficacy, safety, and intended utilization of Capricor\u2019s product candidates; the initiation, conduct, size, timing and results of discovery efforts and clinical trials; the pace of enrollment of clinical trials; plans regarding regulatory filings, future research and clinical trials; regulatory developments involving products, including the ability to obtain regulatory approvals or otherwise bring products to market; manufacturing capabilities; the ability to achieve product milestones and to receive milestone payments from commercial partners; plans regarding current and future collaborative activities and the ownership of commercial rights; scope, duration, validity and enforceability of intellectual property rights; future royalty streams and revenue projections; expectations with respect to the expected use of proceeds from the recently completed offerings and the anticipated effects of the offerings; and any other statements about Capricor\u2019s management team\u2019s future expectations, beliefs, goals, plans or prospects constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Any statements that are not statements of historical fact (including statements containing the words \u201cbelieves,\u201d \u201cplans,\u201d \u201ccould,\u201d \u201canticipates,\u201d \u201cexpects,\u201d \u201cestimates,\u201d \u201cshould,\u201d \u201ctarget,\u201d \u201cwill,\u201d \u201cwould\u201d and similar expressions) should also be considered to be forward-looking statements. There are a number of important factors that could cause actual results or events to differ materially from those indicated by such forward-looking statements. More information about these and other risks that may impact Capricor\u2019s business is set forth in Capricor\u2019s Annual Report on Form 10-K for the year ended December 31, 2022, as filed with the Securities and Exchange Commission on March 17, 2023 and in our Quarterly Report on Form 10-Q for the quarter ended June 30, 2023, as filed with the Securities and Exchange Commission on August 8, 2023. All forward-looking statements in this press release are based on information available to Capricor as of the date hereof, and Capricor assumes no obligation to update these forward-looking statements.<\/p>\n

\n CAP-1002 is an Investigational New Drug and is not approved for any indications. None of Capricor\u2019s exosome-based candidates have been approved for clinical investigation.<\/em>\n <\/p>\n

\n For more information, please contact:<\/strong>
\n
\n Capricor Media Contact:<\/strong>
\n
Raquel Cona
KCSA Strategic Communications
rcona@kcsa.com<\/u><\/a>
212.896.1204<\/p>\n

\n Capricor Investor Contact:<\/strong>
\n
Joyce Allaire
LifeSci Advisors, LLC
jallaire@lifesciadvisors.com<\/u><\/a>
617.435.6602<\/p>\n

\n Capricor Company Contact:<\/strong>
\n
AJ Bergmann, Chief Financial Officer
abergmann@capricor.com<\/u><\/a>
858.727.1755<\/p>\n<\/p>\n


\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

-24-Month Open Label Extension Data from HOPE-2 Study Supports CAP-1002\u2019s Sustained Efficacy and Safety in Treating Duchenne Muscular Dystrophy- -Company\u2019s StealthX\u2122 \u00a0Technology Shows Promise of Exosome-Based Delivery of ASOs- SAN DIEGO, Oct. 10, 2023 (GLOBE NEWSWIRE) — Capricor Therapeutics\u00a0(NASDAQ: CAPR), a biotechnology company focused on the development of transformative cell and exosome-based therapeutics for the treatment and prevention of muscular and other select diseases, today announced data from two late-breaking posters presented at this year\u2019s 28th International Annual Congress of the World Muscle Society (WMS) which took place in Charleston, South Carolina, from October 3-7, 2023. Presentations included data from the two-year open label extension (OLE) of the HOPE-2 clinical trial highlighting the efficacy of Capricor\u2019s lead asset, CAP-1002 to … <\/p>\n

Continue reading “Capricor Therapeutics Announces Late-Breaking Presentations at 28th Annual Congress of the World Muscle Society”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-789305","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nCapricor Therapeutics Announces Late-Breaking Presentations at 28th Annual Congress of the World Muscle Society - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Capricor Therapeutics Announces Late-Breaking Presentations at 28th Annual Congress of the World Muscle Society - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"-24-Month Open Label Extension Data from HOPE-2 Study Supports CAP-1002\u2019s Sustained Efficacy and Safety in Treating Duchenne Muscular Dystrophy- -Company\u2019s StealthX\u2122 \u00a0Technology Shows Promise of Exosome-Based Delivery of ASOs- SAN DIEGO, Oct. 10, 2023 (GLOBE NEWSWIRE) — Capricor Therapeutics\u00a0(NASDAQ: CAPR), a biotechnology company focused on the development of transformative cell and exosome-based therapeutics for the treatment and prevention of muscular and other select diseases, today announced data from two late-breaking posters presented at this year\u2019s 28th International Annual Congress of the World Muscle Society (WMS) which took place in Charleston, South Carolina, from October 3-7, 2023. Presentations included data from the two-year open label extension (OLE) of the HOPE-2 clinical trial highlighting the efficacy of Capricor\u2019s lead asset, CAP-1002 to … Continue reading "Capricor Therapeutics Announces Late-Breaking Presentations at 28th Annual Congress of the World Muscle Society"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-10-10T15:52:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODk0NjI0MCM1ODY0NDczIzUwMDA2ODU2Ng==\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Capricor Therapeutics Announces Late-Breaking Presentations at 28th Annual Congress of the World Muscle Society\",\"datePublished\":\"2023-10-10T15:52:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\\\/\"},\"wordCount\":1168,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODk0NjI0MCM1ODY0NDczIzUwMDA2ODU2Ng==\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\\\/\",\"name\":\"Capricor Therapeutics Announces Late-Breaking Presentations at 28th Annual Congress of the World Muscle Society - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/","og_locale":"en_US","og_type":"article","og_title":"Capricor Therapeutics Announces Late-Breaking Presentations at 28th Annual Congress of the World Muscle Society - Market Newsdesk","og_description":"-24-Month Open Label Extension Data from HOPE-2 Study Supports CAP-1002\u2019s Sustained Efficacy and Safety in Treating Duchenne Muscular Dystrophy- -Company\u2019s StealthX\u2122 \u00a0Technology Shows Promise of Exosome-Based Delivery of ASOs- SAN DIEGO, Oct. 10, 2023 (GLOBE NEWSWIRE) — Capricor Therapeutics\u00a0(NASDAQ: CAPR), a biotechnology company focused on the development of transformative cell and exosome-based therapeutics for the treatment and prevention of muscular and other select diseases, today announced data from two late-breaking posters presented at this year\u2019s 28th International Annual Congress of the World Muscle Society (WMS) which took place in Charleston, South Carolina, from October 3-7, 2023. Presentations included data from the two-year open label extension (OLE) of the HOPE-2 clinical trial highlighting the efficacy of Capricor\u2019s lead asset, CAP-1002 to … Continue reading \"Capricor Therapeutics Announces Late-Breaking Presentations at 28th Annual Congress of the World Muscle Society\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/","og_site_name":"Market Newsdesk","article_published_time":"2023-10-10T15:52:04+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODk0NjI0MCM1ODY0NDczIzUwMDA2ODU2Ng==","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Capricor Therapeutics Announces Late-Breaking Presentations at 28th Annual Congress of the World Muscle Society","datePublished":"2023-10-10T15:52:04+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/"},"wordCount":1168,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODk0NjI0MCM1ODY0NDczIzUwMDA2ODU2Ng==","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/capricor-therapeutics-announces-late-breaking-presentations-at-28th-annual-congress-of-the-world-muscle-society\/","name":"Capricor Therapeutics Announces Late-Breaking Presentations at 28th Annual Congress of the World Muscle Society - 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