{"id":786869,"date":"2023-09-28T15:14:17","date_gmt":"2023-09-28T19:14:17","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\/"},"modified":"2023-09-28T15:14:17","modified_gmt":"2023-09-28T19:14:17","slug":"synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\/","title":{"rendered":"Synlogic Announces Publication of Synpheny-1 Phase 2 Study of Synthetic Biotic for Phenylketonuria in Nature Metabolism"},"content":{"rendered":"
\n

CAMBRIDGE, Mass., Sept. 28, 2023 (GLOBE NEWSWIRE) — Synlogic, Inc. (Nasdaq: SYBX), a clinical-stage biotechnology company advancing novel, oral, non-systemically absorbed biotherapeutics to transform the care of serious diseases, today announced the publication of results from its Synpheny-1 Phase 2 study of its drug candidates, labafenogene marselecobac (SYNB1934) and SYNB1618 in patients with phenylketonuria (PKU) in the journal Nature Metabolism.<\/em><\/p>\n

The publication, entitled \u201cEfficacy and Safety of a Synthetic Biotic for Treatment of Phenylketonuria: a Phase 2 Clinical Trial\u201d is now available online at https:\/\/www.nature.com\/articles\/s42255-023-00897-6<\/a>. The paper includes a comprehensive review of the data, showing clinically meaningful, dose-dependent reductions in plasma phenylalanine (Phe).<\/p>\n

\u201cThese positive results build on a body of data supporting the role of labafenogene marselecobac for patients with PKU,\u201d said Dr. Neal Sondheimer, Head of Clinical Development at Synlogic. \u201cThese findings re-enforce our urgency to complete Synpheny-3, the pivotal trial now underway, and advance this potential new treatment to the many patients who need it.\u201d<\/p>\n

The study was completed with the participation of clinical teams at University of Pittsburgh, Mount Sinai Hospital, Washington University, Oregon Health & Science University, University of Texas-Houston, Vanderbilt University, University of Colorado and University of Florida.<\/p>\n

\n About labafenogene marselecobac (SYNB1934) <\/strong>\n <\/p>\n

Labafenogene marselecobac (SYNB1934) is an orally administered, non-systemically absorbed, potential treatment for phenylketonuria (PKU), a rare metabolic disease caused by inherited mutations that impair the breakdown of phenylalanine (Phe), an amino acid found in all protein-containing foods. The goal of PKU management is to reduce plasma Phe below neurotoxic levels, reducing risk of neurocognitive complications. Current treatment options for PKU are limited due to safety and efficacy, leaving the majority of people living with PKU without medical management and with uncontrolled Phe. Synlogic\u00a0designed labafenogene marselecobac by applying precision genetic engineering to a well-characterized probiotic to target and consume Phe in the GI tract. Results to date indicate the potential for labafenogene marselecobac as the first therapeutic for PKU approved as both a monotherapy and adjunctive medical treatment, and following successful Phase 2 results, it has advanced to Synpheny-3, a global, pivotal Phase 3 study. Labafenogene marselecobac has received Orphan Drug Designation (ODD), Fast Track designation and Rare Pediatric Disease Designation (RPDD) from the\u00a0FDA in addition to orphan designation from the\u00a0European Medicines Agency\u00a0(EMA).<\/p>\n

\n About\u00a0Synlogic\u00a0<\/strong>\n <\/p>\n

Synlogic is a clinical-stage biotechnology company advancing novel, oral, non-systemically absorbed biotherapeutics to transform the care of serious diseases in need of new treatment options. The Company\u2019s late-stage pipeline is focused on rare metabolic diseases, led by labafenogene marselecobac (SYNB1934), currently being studied as a potential treatment for phenylketonuria (PKU) in Synpheny-3, a global, pivotal Phase 3 study. Additional product candidates address diseases including homocystinuria (HCU), enteric hyperoxaluria, gout, and cystinuria. This pipeline is fueled by the Synthetic Biotic platform, which applies precision genetic engineering to well-characterized probiotics. This enables Synlogic to create GI-restricted, oral medicines designed to consume or modify disease-specific metabolites \u2013 an approach well suited for PKU and HCU, both inborn errors of metabolism, as well as other disorders in which the disease\u2013specific metabolites transit through the GI tract, providing validated targets for these Synthetic Biotics. Research activities include a partnership with Roche focused on inflammatory bowel disease (IBD), and a collaboration with Ginkgo Bioworks in synthetic biology, which has contributed to two pipeline programs to date. For more information, please visit www.synlogictx.com or follow us on Twitter<\/a>, LinkedIn<\/a>, Facebook<\/a> or Instagram<\/a>.<\/p>\n

This press release contains “forward-looking statements” that involve substantial risks and uncertainties for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this press release regarding strategy, future operations, clinical development plans, future financial position, future revenue, projected expenses, prospects, plans and objectives of management are forward-looking statements. In addition, when or if used in this press release, the words “may,” “could,” “should,” “anticipate,” “believe,” “look forward,” “estimate,” “expect,” “intend,” “on track,” “plan,” “predict” and similar expressions and their variants, as they relate to\u00a0Synlogic, may identify forward-looking statements. Examples of forward-looking statements, include, but are not limited to, statements regarding the potential of\u00a0Synlogic’s\u00a0approach to Synthetic Biotics to develop therapeutics to address a wide range of diseases including: inborn errors of metabolism and inflammatory and immune disorders; our expectations about sufficiency of our existing cash balance; the future clinical development of Synthetic Biotics; the approach\u00a0Synlogic\u00a0is taking to discover and develop novel therapeutics using synthetic biology; and the expected timing of\u00a0Synlogic’s\u00a0clinical trials of labafenogene marselecobac (SYNB1934), SYNB1353, SYNB8802 and SYNB2081 and availability of clinical trial data. Actual results could differ materially from those contained in any forward-looking statements as a result of various factors, including: the uncertainties inherent in the clinical and preclinical development process; the ability of\u00a0Synlogic\u00a0to protect its intellectual property rights; and legislative, regulatory, political and economic developments, as well as those risks identified under the heading “Risk Factors” in\u00a0Synlogic’s\u00a0filings with the\u00a0U.S. Securities and Exchange Commission. The forward-looking statements contained in this press release reflect\u00a0Synlogic’s\u00a0current views with respect to future events.\u00a0Synlogic\u00a0anticipates that subsequent events and developments will cause its views to change. However, while\u00a0Synlogic\u00a0may elect to update these forward-looking statements in the future,\u00a0Synlogic\u00a0specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing\u00a0Synlogic’s\u00a0view as of any date subsequent to the date hereof.<\/p>\n

\n Media Contact: <\/strong>
\n media@synlogictx.com<\/a>\n <\/p>\n

\n Investor Relations:<\/strong>
\n investor@synlogictx.com<\/a>\n <\/p>\n


\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

CAMBRIDGE, Mass., Sept. 28, 2023 (GLOBE NEWSWIRE) — Synlogic, Inc. (Nasdaq: SYBX), a clinical-stage biotechnology company advancing novel, oral, non-systemically absorbed biotherapeutics to transform the care of serious diseases, today announced the publication of results from its Synpheny-1 Phase 2 study of its drug candidates, labafenogene marselecobac (SYNB1934) and SYNB1618 in patients with phenylketonuria (PKU) in the journal Nature Metabolism. The publication, entitled \u201cEfficacy and Safety of a Synthetic Biotic for Treatment of Phenylketonuria: a Phase 2 Clinical Trial\u201d is now available online at https:\/\/www.nature.com\/articles\/s42255-023-00897-6. The paper includes a comprehensive review of the data, showing clinically meaningful, dose-dependent reductions in plasma phenylalanine (Phe). \u201cThese positive results build on a body of data supporting the role of labafenogene marselecobac for patients … <\/p>\n

Continue reading “Synlogic Announces Publication of Synpheny-1 Phase 2 Study of Synthetic Biotic for Phenylketonuria in Nature Metabolism”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-786869","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nSynlogic Announces Publication of Synpheny-1 Phase 2 Study of Synthetic Biotic for Phenylketonuria in Nature Metabolism - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Synlogic Announces Publication of Synpheny-1 Phase 2 Study of Synthetic Biotic for Phenylketonuria in Nature Metabolism - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"CAMBRIDGE, Mass., Sept. 28, 2023 (GLOBE NEWSWIRE) — Synlogic, Inc. (Nasdaq: SYBX), a clinical-stage biotechnology company advancing novel, oral, non-systemically absorbed biotherapeutics to transform the care of serious diseases, today announced the publication of results from its Synpheny-1 Phase 2 study of its drug candidates, labafenogene marselecobac (SYNB1934) and SYNB1618 in patients with phenylketonuria (PKU) in the journal Nature Metabolism. The publication, entitled \u201cEfficacy and Safety of a Synthetic Biotic for Treatment of Phenylketonuria: a Phase 2 Clinical Trial\u201d is now available online at https:\/\/www.nature.com\/articles\/s42255-023-00897-6. The paper includes a comprehensive review of the data, showing clinically meaningful, dose-dependent reductions in plasma phenylalanine (Phe). \u201cThese positive results build on a body of data supporting the role of labafenogene marselecobac for patients … Continue reading "Synlogic Announces Publication of Synpheny-1 Phase 2 Study of Synthetic Biotic for Phenylketonuria in Nature Metabolism"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-28T19:14:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODkzMDQ5MSM1ODI3MzAwIzIwODY5ODA=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Synlogic Announces Publication of Synpheny-1 Phase 2 Study of Synthetic Biotic for Phenylketonuria in Nature Metabolism\",\"datePublished\":\"2023-09-28T19:14:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\\\/\"},\"wordCount\":926,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODkzMDQ5MSM1ODI3MzAwIzIwODY5ODA=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\\\/\",\"name\":\"Synlogic Announces Publication of Synpheny-1 Phase 2 Study of Synthetic Biotic for Phenylketonuria in Nature Metabolism - 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(Nasdaq: SYBX), a clinical-stage biotechnology company advancing novel, oral, non-systemically absorbed biotherapeutics to transform the care of serious diseases, today announced the publication of results from its Synpheny-1 Phase 2 study of its drug candidates, labafenogene marselecobac (SYNB1934) and SYNB1618 in patients with phenylketonuria (PKU) in the journal Nature Metabolism. The publication, entitled \u201cEfficacy and Safety of a Synthetic Biotic for Treatment of Phenylketonuria: a Phase 2 Clinical Trial\u201d is now available online at https:\/\/www.nature.com\/articles\/s42255-023-00897-6. The paper includes a comprehensive review of the data, showing clinically meaningful, dose-dependent reductions in plasma phenylalanine (Phe). \u201cThese positive results build on a body of data supporting the role of labafenogene marselecobac for patients … Continue reading \"Synlogic Announces Publication of Synpheny-1 Phase 2 Study of Synthetic Biotic for Phenylketonuria in Nature Metabolism\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\/","og_site_name":"Market Newsdesk","article_published_time":"2023-09-28T19:14:17+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODkzMDQ5MSM1ODI3MzAwIzIwODY5ODA=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Synlogic Announces Publication of Synpheny-1 Phase 2 Study of Synthetic Biotic for Phenylketonuria in Nature Metabolism","datePublished":"2023-09-28T19:14:17+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\/"},"wordCount":926,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODkzMDQ5MSM1ODI3MzAwIzIwODY5ODA=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/synlogic-announces-publication-of-synpheny-1-phase-2-study-of-synthetic-biotic-for-phenylketonuria-in-nature-metabolism\/","name":"Synlogic Announces Publication of Synpheny-1 Phase 2 Study of Synthetic Biotic for Phenylketonuria in Nature Metabolism - 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