{"id":784575,"date":"2023-09-18T11:09:34","date_gmt":"2023-09-18T15:09:34","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas\/"},"modified":"2023-09-18T11:09:34","modified_gmt":"2023-09-18T15:09:34","slug":"lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas\/","title":{"rendered":"Lantern Pharma Receives IND Clearance from FDA Enabling Phase 1 Initiation for Drug Candidate LP-284 in Non-Hodgkin\u2019s Lymphomas"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }\n.bwlistdisc { list-style-type: disc }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>Lantern Pharma Receives IND Clearance from FDA Enabling Phase 1 Initiation for Drug Candidate LP-284 in Non-Hodgkin\u2019s Lymphomas<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nThis is the second IND Clearance over the last 100 days for drug candidates that are being developed using guidance from Lantern\u2019s AI Platform, RADR<sup>\u00ae<\/sup>.<\/p>\n<\/li>\n<li>\nLP-284 is the second of Lantern\u2019s synthetic-lethal franchise of molecules that have shown to be synthetically lethal in DNA damage repair deficient cancers and are entering into first-in-human clinical trials.<\/p>\n<\/li>\n<li>\nLantern estimates that LP-284 can have the potential to improve outcomes for 40,000 to 80,000 patients with blood cancers annually, with a global annual market potential of $4 Billion USD.<\/p>\n<\/li>\n<\/ul>\n<p>DALLAS&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nLantern Pharma Inc. (NASDAQ: LTRN), an artificial intelligence (AI) company developing targeted and transformative cancer therapies using its proprietary AI and machine learning (ML) platform, RADR<sup>\u00ae<\/sup>, with multiple clinical stage drug programs, today announced that the United States Food and Drug Administration (FDA) has cleared the investigational new drug (IND) application for LP-284. LP-284 is being developed for the treatment of relapsed or refractory non-Hodgkin\u2019s lymphoma (NHL), including mantle cell lymphoma (MCL) and double hit lymphoma (DHL) and other high-grade B-cell lymphomas (HGBL). Lantern expects to commence enrollment of patients for the first-in-human Phase 1 trial for LP-284 during the fourth quarter of 2023.<\/p>\n<p>\n&#8220;This is now our second novel drug candidate to receive IND clearance from the FDA in the past 100 days, further validating our approach of leveraging AI and machine learning to accelerate the development of our pipeline,&#8221; stated Panna Sharma, Lantern&#8217;s President and CEO. &#8220;LP-284 holds blockbuster potential, and we have been able to expedite its journey from a concept to a first-in-human clinical trial in a highly efficient and cost-effective manner &#8211; less than 2.5 years and under approximately $2.7 million &#8211; underscoring the power and potential of our AI platform RADR\u00ae to accelerate oncology drug discovery and development. RADR<sup>\u00ae<\/sup> was used to unravel the mechanism of action of LP-284, prioritize its cancer indications, and generate machine-learning biomarker signatures that may be pivotal in selecting patients for future phases of the clinical trials. Our success-to-date with LP-284 reaffirms our commitment to harnessing the power of AI to transform cancer treatment and save lives.&#8221;<\/p>\n<p>\nLP-284 is a novel small molecule with a synthetically lethal mechanism of action that preferentially damages cancer cells that harbor mutations in DNA damage repair pathways. Lantern\u2019s LP-284 program has been accelerated and focused using AI insights and biological modeling powered by RADR<sup>\u00ae<\/sup>.<\/p>\n<p>\nNHL is the leading hematological malignancy in the US and remains one of the leading causes of cancer deaths globally, with an estimated 500,000 new cases annually worldwide. Despite advances in NHL using combination and targeted therapies, nearly 20% to 40% of patients with certain subtypes still relapse after treatment. In aggressive subtypes of NHL, like MCL, nearly all patients relapse from standard-of-care (SOC) therapies. Globally, the annual market potential of LP-284 in NHL is estimated to be approximately $4 billion USD.<\/p>\n<p><b>About Lantern Pharma:<\/b><\/p>\n<p>\nLantern Pharma (NASDAQ: LTRN) is an AI company transforming the cost, pace, and timeline of oncology drug discovery and development. Our proprietary AI and machine learning (ML) RADR<sup>\u00ae<\/sup> platform leverages over 34 billion oncology-focused data points and a library of 200+ advanced ML algorithms to help solve billion-dollar, real-world problems in oncology drug development. By harnessing the power of AI and with input from world-class scientific advisors and collaborators, we have accelerated the development of our growing pipeline of therapies including eleven cancer indications and an antibody-drug conjugate (ADC) program. On average, our newly developed drug programs have been advanced from initial AI insights to first-in-human clinical trials in 2-3 years and at approximately $1.0-2.0 million per program.<\/p>\n<p>\nOur lead development programs include two Phase 2 clinical programs and recently initiated Phase 1 clinical programs for two additional product candidates with potential in multiple important cancer indications. We have also established a wholly-owned subsidiary, Starlight Therapeutics Inc., to focus exclusively on the clinical execution of our promising therapies for CNS and brain cancers, many of which have no effective treatment options. Our AI-driven pipeline of innovative product candidates is estimated to have a combined annual market potential of over $15 billion USD and have the potential to provide life-changing therapies to hundreds of thousands of cancer patients across the world.<\/p>\n<p><b>Forward-looking Statements:<\/b><\/p>\n<p>\nThis press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These forward-looking statements include, among other things, statements relating to: future events or our future financial performance; the potential advantages of our RADR<sup>\u00ae<\/sup> platform in identifying drug candidates and patient populations that are likely to respond to a drug candidate; our strategic plans to advance the development of our drug candidates and antibody drug conjugate (ADC) development program; estimates regarding the development timing for our drug candidates and ADC development program; expectations and estimates regarding clinical trial timing and patient enrollment; our research and development efforts of our internal drug discovery programs and the utilization of our RADR<sup>\u00ae<\/sup> platform to streamline the drug development process; our intention to leverage artificial intelligence, machine learning and biomarker data to streamline and transform the pace, risk and cost of oncology drug discovery and development and to identify patient populations that would likely respond to a drug candidate; estimates regarding patient populations, potential markets and potential market sizes; sales estimates for our drug candidates and our plans to discover and develop drug candidates and to maximize their commercial potential by advancing such drug candidates ourselves or in collaboration with others. Any statements that are not statements of historical fact (including, without limitation, statements that use words such as &#8220;anticipate,&#8221; &#8220;believe,&#8221; &#8220;contemplate,&#8221; &#8220;could,&#8221; &#8220;estimate,&#8221; &#8220;expect,&#8221; &#8220;intend,&#8221; &#8220;seek,&#8221; &#8220;may,&#8221; &#8220;might,&#8221; &#8220;plan,&#8221; &#8220;potential,&#8221; &#8220;predict,&#8221; &#8220;project,&#8221; &#8220;target,&#8221; &#8220;model,&#8221; &#8220;objective,&#8221; &#8220;aim,&#8221; &#8220;upcoming,&#8221; &#8220;should,&#8221; &#8220;will,&#8221; &#8220;would,&#8221; or the negative of these words or other similar expressions) should be considered forward-looking statements. There are a number of important factors that could cause our actual results to differ materially from those indicated by the forward-looking statements, such as (i) the risk that our research and the research of our collaborators may not be successful, (ii) the risk that none of our product candidates has received FDA marketing approval, and we may not be able to successfully initiate, conduct, or conclude clinical testing for or obtain marketing approval for our product candidates, (iii) the risk that no drug product based on our proprietary RADR<sup>\u00ae<\/sup> AI platform has received FDA marketing approval or otherwise been incorporated into a commercial product, and (iv) those other factors set forth in the Risk Factors section in our Annual Report on Form 10-K for the year ended December 31, 2022, filed with the Securities and Exchange Commission on March 20, 2023. You may access our Annual Report on Form 10-K for the year ended December 31, 2022 under the investor SEC filings tab of our website at <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.lanternpharma.com%2F&amp;esheet=53556289&amp;newsitemid=20230918509354&amp;lan=en-US&amp;anchor=www.lanternpharma.com&amp;index=1&amp;md5=8818432f67bffd6be512d7a9dca19727\">www.lanternpharma.com<\/a> or on the SEC&#8217;s website at <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.sec.gov%2F&amp;esheet=53556289&amp;newsitemid=20230918509354&amp;lan=en-US&amp;anchor=www.sec.gov&amp;index=2&amp;md5=382ec8de063921eac1520185008bbc24\">www.sec.gov<\/a>. Given these risks and uncertainties, we can give no assurances that our forward-looking statements will prove to be accurate, or that any other results or events projected or contemplated by our forward-looking statements will in fact occur, and we caution investors not to place undue reliance on these statements. All forward-looking statements in this press release represent our judgment as of the date hereof, and, except as otherwise required by law, we disclaim any obligation to update any forward-looking statements to conform the statement to actual results or changes in our expectations.<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20230918509354r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20230918509354\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20230918509354\/en\/<\/a><\/span><\/p>\n<p>\nNicole Leber<br \/>\n<br \/>Investor Relations Associate<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:ir@lanternpharma.com\">ir@lanternpharma.com<br \/>\n<\/a><\/p>\n<p>Please find more information at:<br \/>\n<br \/>Website: <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.lanternpharma.com&amp;esheet=53556289&amp;newsitemid=20230918509354&amp;lan=en-US&amp;anchor=www.lanternpharma.com&amp;index=3&amp;md5=f38454256d16165b7477abc187f3476d\">www.lanternpharma.com<br \/>\n<\/a><br \/>LinkedIn: <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Flanternpharma%2F&amp;esheet=53556289&amp;newsitemid=20230918509354&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Flanternpharma%2F&amp;index=4&amp;md5=99eca6b06fcba4cbcb38fed84cca8725\">https:\/\/www.linkedin.com\/company\/lanternpharma\/<br \/>\n<\/a><br \/>X\/Twitter: <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Ftwitter.com%2FLanternPharma&amp;esheet=53556289&amp;newsitemid=20230918509354&amp;lan=en-US&amp;anchor=%40lanternpharma&amp;index=5&amp;md5=c5996bdab14824722c73e4dc3bad79e7\">@lanternpharma<br \/>\n<\/a><br \/>Newsletter \u2013 The Spark: Sign-up <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Flantern-pharma.read.axioshq.com%2Fsignup%2Flantern-pharma-newsletter&amp;esheet=53556289&amp;newsitemid=20230918509354&amp;lan=en-US&amp;anchor=here&amp;index=6&amp;md5=1068b48ffefb386335e79f2b610dd9fc\">here<\/a><\/p>\n<p><b>KEYWORDS:<\/b> United States North America Texas<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Technology FDA Clinical Trials Biotechnology Other Health Health Pharmaceutical Artificial Intelligence Oncology<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230918509354\/en\/1892344\/3\/Lantern_Pharma_Logo.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Lantern Pharma Receives IND Clearance from FDA Enabling Phase 1 Initiation for Drug Candidate LP-284 in Non-Hodgkin\u2019s Lymphomas This is the second IND Clearance over the last 100 days for drug candidates that are being developed using guidance from Lantern\u2019s AI Platform, RADR\u00ae. LP-284 is the second of Lantern\u2019s synthetic-lethal franchise of molecules that have shown to be synthetically lethal in DNA damage repair deficient cancers and are entering into first-in-human clinical trials. Lantern estimates that LP-284 can have the potential to improve outcomes for 40,000 to 80,000 patients with blood cancers annually, with a global annual market potential of $4 Billion USD. DALLAS&#8211;(BUSINESS WIRE)&#8211; Lantern Pharma Inc. (NASDAQ: LTRN), an artificial intelligence (AI) company developing targeted and transformative cancer &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Lantern Pharma Receives IND Clearance from FDA Enabling Phase 1 Initiation for Drug Candidate LP-284 in Non-Hodgkin\u2019s Lymphomas&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-784575","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lantern Pharma Receives IND Clearance from FDA Enabling Phase 1 Initiation for Drug Candidate LP-284 in Non-Hodgkin\u2019s Lymphomas - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lantern Pharma Receives IND Clearance from FDA Enabling Phase 1 Initiation for Drug Candidate LP-284 in Non-Hodgkin\u2019s Lymphomas - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Lantern Pharma Receives IND Clearance from FDA Enabling Phase 1 Initiation for Drug Candidate LP-284 in Non-Hodgkin\u2019s Lymphomas This is the second IND Clearance over the last 100 days for drug candidates that are being developed using guidance from Lantern\u2019s AI Platform, RADR\u00ae. LP-284 is the second of Lantern\u2019s synthetic-lethal franchise of molecules that have shown to be synthetically lethal in DNA damage repair deficient cancers and are entering into first-in-human clinical trials. Lantern estimates that LP-284 can have the potential to improve outcomes for 40,000 to 80,000 patients with blood cancers annually, with a global annual market potential of $4 Billion USD. DALLAS&#8211;(BUSINESS WIRE)&#8211; Lantern Pharma Inc. (NASDAQ: LTRN), an artificial intelligence (AI) company developing targeted and transformative cancer &hellip; Continue reading &quot;Lantern Pharma Receives IND Clearance from FDA Enabling Phase 1 Initiation for Drug Candidate LP-284 in Non-Hodgkin\u2019s Lymphomas&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-18T15:09:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20230918509354r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Lantern Pharma Receives IND Clearance from FDA Enabling Phase 1 Initiation for Drug Candidate LP-284 in Non-Hodgkin\u2019s Lymphomas\",\"datePublished\":\"2023-09-18T15:09:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas\\\/\"},\"wordCount\":1323,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20230918509354r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/lantern-pharma-receives-ind-clearance-from-fda-enabling-phase-1-initiation-for-drug-candidate-lp-284-in-non-hodgkins-lymphomas\\\/\",\"name\":\"Lantern Pharma Receives IND Clearance from FDA Enabling Phase 1 Initiation for Drug Candidate LP-284 in Non-Hodgkin\u2019s Lymphomas - 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LP-284 is the second of Lantern\u2019s synthetic-lethal franchise of molecules that have shown to be synthetically lethal in DNA damage repair deficient cancers and are entering into first-in-human clinical trials. Lantern estimates that LP-284 can have the potential to improve outcomes for 40,000 to 80,000 patients with blood cancers annually, with a global annual market potential of $4 Billion USD. DALLAS&#8211;(BUSINESS WIRE)&#8211; Lantern Pharma Inc. 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