{"id":784448,"date":"2023-09-18T07:06:09","date_gmt":"2023-09-18T11:06:09","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/"},"modified":"2023-09-18T07:06:09","modified_gmt":"2023-09-18T11:06:09","slug":"aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/","title":{"rendered":"Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\/JAK3 Inhibitor"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <strong><br \/>\n          <em>\u2013\u00a0Preliminary Data Support Progression to Phase 2a Proof of Concept Trials in T cell-mediated Autoimmune Diseases\u00a0\u2013<\/em><br \/>\n        <\/strong><br \/>\n        \n      <\/p>\n<p>WAYNE, Pa., Sept.  18, 2023  (GLOBE NEWSWIRE) &#8212; Aclaris Therapeutics, Inc. (NASDAQ: ACRS), a clinical-stage biopharmaceutical company focused on developing novel drug candidates for immuno-inflammatory diseases, today announced positive results from ATI-2138-PKPD-102, a Phase 1 Multiple Ascending Dose (MAD) trial of the investigational compound ATI-2138.<\/p>\n<p>Preliminary data from the MAD trial demonstrated:<\/p>\n<ul>\n<li>that ATI-2138 was generally well tolerated at all doses tested in the trial;<\/li>\n<li>that ATI-2138 had dose proportional pharmacokinetics (PK); and<\/li>\n<li>a dose-dependent inhibition of both ITK and JAK3 exploratory pharmacodynamic (PD) biomarkers, with near maximal inhibition achieved at the 30 mg total daily dose.<\/li>\n<\/ul>\n<p>Based on these results, Aclaris will progress this program into a Phase 2a proof of concept study in patients with ulcerative colitis, its previously announced intended first clinical development target, and anticipates initiation of the trial in early 2024. Aclaris is also exploring the potential of conducting a second proof of concept trial in an additional T cell-mediated autoimmune disease.<\/p>\n<p>ATI-2138-PKPD-102 was a two-week Phase 1 MAD trial to investigate the safety, tolerability, PK and PD of ATI-2138 in healthy volunteers. The study enrolled 60 healthy subjects across 6 dosing cohorts ranging from 10 to 80 mg of total daily doses, with 8 active\/2 placebo controlled per arm. No serious adverse events were reported. The most common adverse events in subjects treated with ATI-2138, and the only events occurring in more than 1 subject, were headache (assessed as mild, 2 subjects on 5 mg BID, 1 on 40 mg BID) and diarrhea (assessed as mild, 2 subjects on 5 mg BID).<\/p>\n<p>\u201cThe advancement of ATI-2138 to proof-of-concept stage of development marks yet another example of the strength of our world class discovery group and the KINect<sup>\u00ae<\/sup> platform,\u201d stated Doug Manion, M.D., Aclaris\u2019 Chief Executive Officer. \u201cIt is a rarity for a biotech company of our size to be armed with a productive discovery engine and expertise that rivals larger pharmaceutical companies.\u201d<\/p>\n<p>Continued Manion, \u201cWith so much unmet medical need remaining in immuno-inflammatory diseases such as ulcerative colitis, it is gratifying for all of us at Aclaris to progress the development of ATI-2138 for patients who remain underserved by the existing treatment options for the disease. Additionally, we look forward to the data from our two most advanced programs \u2013 zunsemetinib (ATI-450) in rheumatoid arthritis and ATI-1777 in atopic dermatitis \u2013 expected later this year.\u201d<\/p>\n<p>Aclaris has made available a related presentation for the ATI-2138 MAD trial data which can be found on the \u201cInvestors\u201d section of its website, <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=zPJS4h6rELM3UxE1HJSs01gEdc8eLYbPfgUlsjlNOHkdgbtEUX8DGBoTcsNnVk07rPann-pq5nvrw-rHDOTMq-Be9GtCz-LcN1UEefPHrvU=\" rel=\"nofollow noopener\" target=\"_blank\">www.aclaristx.com<\/a>.<\/p>\n<p>\n        <strong>About ATI-2138<\/strong>\n      <\/p>\n<p>ATI-2138 is an investigational oral covalent ITK\/JAK3 inhibitor that is being developed as a potential therapeutic option across a variety of T cell-mediated diseases. ITK is a T cell receptor activated kinase involved in driving T cell effector functions while JAK3 is a non-receptor tyrosine kinase responsible for the signal transduction of common gamma receptor cytokines, IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. In blocking both T cell receptor function and cytokine signaling, ATI-2138 has potential utility in T cell driven diseases. ATI-2138 is currently in clinical development and its safety and efficacy has not been evaluated by regulatory authorities.<\/p>\n<p>\n        <strong>About Aclaris Therapeutics, Inc.<\/strong>\n      <\/p>\n<p>Aclaris Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing a pipeline of novel drug candidates to address the needs of patients with immuno-inflammatory diseases who lack satisfactory treatment options. The company has a multi-stage portfolio of drug candidates powered by a robust R&amp;D engine exploring protein kinase regulation. For additional information, please visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=zPJS4h6rELM3UxE1HJSs05F3d9yIB13cuWXl2Ow3mZYbcMrnQzLW82j-A7SIRVhLgfOQxhd9d2siqnuQEiUVUDyn5nMq1-d4lvhgW8MEu98=\" rel=\"nofollow noopener\" target=\"_blank\">www.aclaristx.com<\/a>.<\/p>\n<p>\n        <strong>Cautionary Note Regarding Forward-Looking Statements<\/strong>\n      <\/p>\n<p>Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as \u201canticipate,\u201d \u201cbelieve,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cwill,\u201d and similar expressions, and are based on Aclaris\u2019 current beliefs and expectations. These forward-looking statements include Aclaris\u2019 expectations regarding the timing of the Phase 2a trial of ATI-2138 in ulcerative colitis as well the potential future opportunities for the clinical development of ATI-2138, and the timing of reporting results from other clinical trials. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements. Risks and uncertainties that may cause actual results to differ materially include uncertainties inherent in the conduct of clinical trials, Aclaris\u2019 reliance on third parties over which it may not always have full control, Aclaris\u2019 ability to enter into strategic partnerships on commercially reasonable terms and other risks and uncertainties that are described in the Risk Factors section of Aclaris\u2019 Annual Report on Form 10-K for the year ended December 31, 2022 and other filings Aclaris makes with the U.S. Securities and Exchange Commission from time to time. These documents are available under the \u201cSEC Filings\u201d page of the \u201cInvestors\u201d section of Aclaris\u2019 website at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=zPJS4h6rELM3UxE1HJSs01tzlLiS-KrXVGZqI-uemZ-riXbF36NjOj2HUYXtszZ0MJAdt-PurNjTSw_TChNDzE0WVYYW5yJhCMH-HbNtTCY=\" rel=\"nofollow noopener\" target=\"_blank\">www.aclaristx.com<\/a>. Any forward-looking statements speak only as of the date of this press release and are based on information available to Aclaris as of the date of this release, and Aclaris assumes no obligation to, and does not intend to, update any forward-looking statements, whether as a result of new information, future events or otherwise.<\/p>\n<p>\n        <strong>Aclaris Therapeutics Contact:<\/strong>\n      <\/p>\n<p>Robert A. Doody Jr.<br \/>Vice President, Investor Relations<br \/>484-639-7235<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ezB6hIIgpFJ_CBs35tPW-nsUGV9gZEuZ6CB1OZETGgMJN0X5WFiUY2oPnhy5-pQ9PTojJxPm5-dKs-34yqbXrjTqKrLq7L4gYAjfxtIWGLY=\" rel=\"nofollow noopener\" target=\"_blank\">rdoody@aclaristx.com<\/a><\/p>\n<p>      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODkyMzQwNCM1ODE3MzMwIzIwMjAxODM=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/YjE2MjJmYjQtMTk4NC00YzdhLWFlMzEtYTNiMGE1OGJlNDVhLTEwMzE3NTU=\/tiny\/Aclaris-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u2013\u00a0Preliminary Data Support Progression to Phase 2a Proof of Concept Trials in T cell-mediated Autoimmune Diseases\u00a0\u2013 WAYNE, Pa., Sept. 18, 2023 (GLOBE NEWSWIRE) &#8212; Aclaris Therapeutics, Inc. (NASDAQ: ACRS), a clinical-stage biopharmaceutical company focused on developing novel drug candidates for immuno-inflammatory diseases, today announced positive results from ATI-2138-PKPD-102, a Phase 1 Multiple Ascending Dose (MAD) trial of the investigational compound ATI-2138. Preliminary data from the MAD trial demonstrated: that ATI-2138 was generally well tolerated at all doses tested in the trial; that ATI-2138 had dose proportional pharmacokinetics (PK); and a dose-dependent inhibition of both ITK and JAK3 exploratory pharmacodynamic (PD) biomarkers, with near maximal inhibition achieved at the 30 mg total daily dose. Based on these results, Aclaris will progress &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\/JAK3 Inhibitor&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-784448","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\/JAK3 Inhibitor - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\/JAK3 Inhibitor - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"\u2013\u00a0Preliminary Data Support Progression to Phase 2a Proof of Concept Trials in T cell-mediated Autoimmune Diseases\u00a0\u2013 WAYNE, Pa., Sept. 18, 2023 (GLOBE NEWSWIRE) &#8212; Aclaris Therapeutics, Inc. (NASDAQ: ACRS), a clinical-stage biopharmaceutical company focused on developing novel drug candidates for immuno-inflammatory diseases, today announced positive results from ATI-2138-PKPD-102, a Phase 1 Multiple Ascending Dose (MAD) trial of the investigational compound ATI-2138. Preliminary data from the MAD trial demonstrated: that ATI-2138 was generally well tolerated at all doses tested in the trial; that ATI-2138 had dose proportional pharmacokinetics (PK); and a dose-dependent inhibition of both ITK and JAK3 exploratory pharmacodynamic (PD) biomarkers, with near maximal inhibition achieved at the 30 mg total daily dose. Based on these results, Aclaris will progress &hellip; Continue reading &quot;Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\/JAK3 Inhibitor&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-18T11:06:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODkyMzQwNCM1ODE3MzMwIzIwMjAxODM=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\\\/JAK3 Inhibitor\",\"datePublished\":\"2023-09-18T11:06:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/\"},\"wordCount\":904,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODkyMzQwNCM1ODE3MzMwIzIwMjAxODM=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/\",\"name\":\"Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\\\/JAK3 Inhibitor - Market Newsdesk\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODkyMzQwNCM1ODE3MzMwIzIwMjAxODM=\",\"datePublished\":\"2023-09-18T11:06:09+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODkyMzQwNCM1ODE3MzMwIzIwMjAxODM=\",\"contentUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODkyMzQwNCM1ODE3MzMwIzIwMjAxODM=\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\\\/JAK3 Inhibitor\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#website\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/\",\"name\":\"Market Newsdesk\",\"description\":\"Latest Business News in Real Time\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\",\"name\":\"Newsdesk\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g\",\"caption\":\"Newsdesk\"},\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/author\\\/newsdesk\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\/JAK3 Inhibitor - Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/","og_locale":"en_US","og_type":"article","og_title":"Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\/JAK3 Inhibitor - Market Newsdesk","og_description":"\u2013\u00a0Preliminary Data Support Progression to Phase 2a Proof of Concept Trials in T cell-mediated Autoimmune Diseases\u00a0\u2013 WAYNE, Pa., Sept. 18, 2023 (GLOBE NEWSWIRE) &#8212; Aclaris Therapeutics, Inc. (NASDAQ: ACRS), a clinical-stage biopharmaceutical company focused on developing novel drug candidates for immuno-inflammatory diseases, today announced positive results from ATI-2138-PKPD-102, a Phase 1 Multiple Ascending Dose (MAD) trial of the investigational compound ATI-2138. Preliminary data from the MAD trial demonstrated: that ATI-2138 was generally well tolerated at all doses tested in the trial; that ATI-2138 had dose proportional pharmacokinetics (PK); and a dose-dependent inhibition of both ITK and JAK3 exploratory pharmacodynamic (PD) biomarkers, with near maximal inhibition achieved at the 30 mg total daily dose. Based on these results, Aclaris will progress &hellip; Continue reading \"Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\/JAK3 Inhibitor\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/","og_site_name":"Market Newsdesk","article_published_time":"2023-09-18T11:06:09+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODkyMzQwNCM1ODE3MzMwIzIwMjAxODM=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\/JAK3 Inhibitor","datePublished":"2023-09-18T11:06:09+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/"},"wordCount":904,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODkyMzQwNCM1ODE3MzMwIzIwMjAxODM=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/","name":"Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\/JAK3 Inhibitor - Market Newsdesk","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/#primaryimage"},"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODkyMzQwNCM1ODE3MzMwIzIwMjAxODM=","datePublished":"2023-09-18T11:06:09+00:00","author":{"@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"breadcrumb":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/#primaryimage","url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODkyMzQwNCM1ODE3MzMwIzIwMjAxODM=","contentUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODkyMzQwNCM1ODE3MzMwIzIwMjAxODM="},{"@type":"BreadcrumbList","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/aclaris-therapeutics-announces-positive-results-from-phase-1-multiple-ascending-dose-trial-of-ati-2138-an-investigational-oral-covalent-itk-jak3-inhibitor\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.marketnewsdesk.com\/"},{"@type":"ListItem","position":2,"name":"Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Investigational Oral Covalent ITK\/JAK3 Inhibitor"}]},{"@type":"WebSite","@id":"https:\/\/www.marketnewsdesk.com\/#website","url":"https:\/\/www.marketnewsdesk.com\/","name":"Market Newsdesk","description":"Latest Business News in Real Time","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.marketnewsdesk.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979","name":"Newsdesk","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g","caption":"Newsdesk"},"url":"https:\/\/www.marketnewsdesk.com\/index.php\/author\/newsdesk\/"}]}},"_links":{"self":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/posts\/784448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/comments?post=784448"}],"version-history":[{"count":0,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/posts\/784448\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/media?parent=784448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/categories?post=784448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/tags?post=784448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}