{"id":770295,"date":"2023-07-17T12:51:35","date_gmt":"2023-07-17T16:51:35","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial\/"},"modified":"2023-07-17T12:51:35","modified_gmt":"2023-07-17T16:51:35","slug":"immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial\/","title":{"rendered":"Immix Biopharma Reports 2nd Positive Interim Clinical Trial Data Readout in Relapsed\/Refractory Metastatic Colorectal Cancer in Ongoing Phase 1b\/2a IMX-110 IMMINENT-01 Clinical Trial"},"content":{"rendered":"<div class=\"mw_release\">\n<ul>\n<li>Tumor shrinkage was observed in 3 out of 4 (75%) patients; 1 out of 4 (25%) experienced tumor control as of the July 7, 2023 clinical data cutoff date. All patients had stage IV relapsed\/refractory metastatic colorectal cancer and received 8 median lines of therapy prior to IMX-110 + tislelizumab<\/li>\n<li>Dose Escalation Proceeding: dosing of 2nd dose cohort complete; no drug-related severe adverse events were observed, enabling enrollment of the next higher dose cohort with the goal of establishing the recommended phase 2 dose<\/li>\n<li>The colorectal cancer market is estimated to reach approximately $31 billion by 2025 according to IndustryARC<\/li>\n<\/ul>\n<p>LOS ANGELES, July  17, 2023  (GLOBE NEWSWIRE) &#8212; Immix Biopharma,\u00a0Inc. (Nasdaq: IMMX) (\u201cImmixBio\u201d, \u201cCompany\u201d, \u201cWe\u201d or \u201cUs\u201d),\u00a0a biopharmaceutical company pioneering CAR-T cell therapies and tissue specific therapeutics targeting oncology and immuno-dysregulated diseases, today announced its 2<sup>nd<\/sup> positive IMX-110 interim update from the Company\u2019s ongoing Phase 1b\/2a IMMINENT-01 (NCT05840835) study of IMX-110 in combination with BeiGene&#8217;s anti-PD-1 antibody tislelizumab. As of the July 7, 2023 data cutoff date, out of 4 relapsed\/refractory metastatic colorectal cancer patients treated with IMX-110 + tislelizumab:<\/p>\n<ul>\n<li>3 out of 4 (75%) patients experienced tumor shrinkage at 2 months<\/li>\n<li>1 out of 4 (25%) patients experienced tumor control at 2 months<\/li>\n<li>1 out of 4 patients remain on IMX-110 + tislelizumab therapy as of July 7, 2023<\/li>\n<li>Median progression-free survival and overall survival not yet reached<\/li>\n<li>Patients received a median of 8 earlier anti-cancer treatments that failed to halt cancer growth (lines of therapy) prior to receiving IMX-110 + tislelizumab and all 4 had proficient mismatch repair (pMMR) relapsed\/refractory mCRC<\/li>\n<li>IMMINENT-01 continues to enroll the next cohort of patients at a higher dose <\/li>\n<\/ul>\n<p>\u201cWe are encouraged that in these early cohorts of patients receiving just a fraction of what we believe will be the optimal dose, we continue to see signals of activity of IMX-110 in relapsed\/refractory metastatic colorectal cancer patients that received a median of 8 lines of anti-cancer therapies that failed to halt cancer growth prior to receiving IMX-110 + tislelizumab,\u201d said Ilya Rachman, MD PhD, Chief Executive Officer of Immix Biopharma. \u201cIn the subsequent higher dose cohorts of IMMINENT-01, we are hopeful that clinical results will further improve. The optimal dose identified in IMMINENT-01 will be utilized in our upcoming Phase 2 IMMINENT-02 clinical trial.\u201d<\/p>\n<p>Dosing of the second cohort of three relapsed\/refractory cancer patients is complete, as of July 7, 2023, for the ongoing Phase 1b portion of the IMMINENT-01 Phase 1b\/2a clinical trial investigating IMX-110 in combination with BeiGene anti-PD-1 antibody tislelizumab in relapsed\/refractory solid tumors, including relapsed\/refractory colorectal cancer. No dose limiting toxicities have been observed in the first 2 cohorts; the trial is now enrolling the next cohort of three patients at a higher dose of IMX-110 in combination with anti-PD-1 antibody tislelizumab. The efficacy evaluable population in IMMINENT-01 includes patients who have completed at least 1 follow-up RECIST assessment. Tumor growth is assessed every 2 months.\u00a0 To put this clinical trial update in perspective, multi-kinase inhibitor regorafenib (marketed as STIVARGA\u00ae by Bayer) combined with best supportive care in relapsed\/refractory metastatic colorectal cancer patients with median 3 prior lines of therapy produced progression free survival of 2 months and a 1% response rate according to the FDA approval label. This study was not a head-to-head evaluation with IMX-110 and differences exist between trial designs, subject characteristics, and caution should be exercised when evaluating clinical data across studies. <\/p>\n<p>\n        <strong>About IMMINENT-01<\/strong><br \/>\n        <br \/>IMMINENT-01 (NCT05840835) is an ongoing phase 1b\/2a clinical trial combining tissue specific therapeutic IMX-110 with BeiGene anti-PD-1 antibody tislelizumab, in patients with relapsed\/refractory solid tumors. The novel approach combining TSTx IMX-110 with anti-PD-1 antibody tislelizumab is designed to expand the population of cancer patients experiencing extended remissions from immunotherapies by converting immunologically \u201ccold\u201d tumors \u201chot\u201d.<\/p>\n<p>In Phase 1b of IMMINENT-01, cohorts of 3 patients will receive escalating doses of IMX-110 until the maximum tolerated dose is reached and the recommended phase 2 dose is determined.<\/p>\n<p>Phase 2a will then begin, treating patients in certain solid tumor indications selected based on Phase 1b clinical data collected in a variety of tumor types. 30 patients are expected to be enrolled in IMMINENT-01.<\/p>\n<p>The primary endpoints of IMMINENT-01 are to identify the maximum tolerated dose and recommended Phase 2 dose of IMX-110 + anti-PD-1 antibody tislelizumab, and to evaluate safety. The secondary endpoints of IMMINENT-01 are to evaluate preliminary efficacy and the pharmacokinetics and preliminary efficacy of IMX-110 + anti-PD-1 antibody tislelizumab.<\/p>\n<p>As of the data cutoff of July 7, 2023, the 2<sup>nd<\/sup> cohort dosing at the lowest dose of IMX-110 + anti-PD-1 antibody tislelizumab has reached full enrollment.<\/p>\n<p>Immix Biopharma is currently enrolling the 3<sup>rd<\/sup>, next higher dose cohort of IMX-110 + anti-PD-1 antibody tislelizumab in advanced solid tumors.<\/p>\n<p>\n        <strong>About Colorectal Cancer<\/strong>\n      <\/p>\n<p>According to NIH SEER, there were an estimated 1,388,422 people living with colorectal cancer in the United States as of 2020 and there were roughly 153,020 new cases of colorectal cancer in the United States in 2022. Globally, there are roughly 1,930,000 new cases of colorectal cancer each year, of which 519,500 are in Europe, 148,500 are in Japan, 20,500 are in Australia and New Zealand, and 555,000 are in China. The five-year survival rate in the United States for relapsed\/refractory advanced metastatic CRC is 15.6% according to NIH SEER.\u00a0 The colorectal cancer market is estimated to reach approximately $31.2 billion by 2025 from the estimated $26.3 billion in 2019 according to IndustryARC.<\/p>\n<p>\n        <strong>About Immix Biopharma, Inc.<\/strong><br \/>\n        <br \/>Immix Biopharma, Inc. (ImmixBio) (Nasdaq: IMMX) is a clinical-stage biopharmaceutical company pioneering a novel class of CAR-T cell therapies and Tissue-Specific Therapeutics (TSTx) targeting oncology and immuno-dysregulated diseases with &gt;75 patients treated to-date. Our lead cell therapy asset is NXC-201 in relapsed\/refractory multiple myeloma and relapsed\/refractory AL Amyloidosis, which we believe could be the world\u2019s first out-patient CAR-T. Our lead TSTx asset IMX-110, currently in Phase 1b\/2a clinical trials as a monotherapy and IMMINENT-01 combination clinical trial with BeiGene\u2019s anti-PD-1 antibody tislelizumab, holds Orphan Drug Designation (ODD) and Rare Pediatric Disease Designation (RPDD) by the FDA. ImmixBio subsidiary Nexcella, Inc develops CAR-T NXC-201 for multiple myeloma and AL amyloidosis, with 92% and 100% response rates in each indication, respectively, as of February 9, 2023, currently being trialed in NEXICART-1. Learn more at www.immixbio.com.<\/p>\n<p>\n        <strong>Forward Looking Statements<\/strong><br \/>\n        <br \/>This press release contains \u201cforward-looking statements\u201d Forward-looking statements reflect our current view about future events. When used in this press release, the words \u201canticipate,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cfuture,\u201d \u201cintend,\u201d \u201cplan,\u201d or the negative of these terms and similar expressions, as they relate\u00a0to us or our management, identify forward-looking statements. Such statements, include, but are not limited to, statements contained in this press release relating to our business strategy, our future operating results and liquidity and capital resources outlook. Forward-looking statements are based on our current expectations and assumptions regarding our business, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict. Our actual results may differ materially from those contemplated by the forward-looking statements. They are neither statements of historical fact nor guarantees of assurance of future performance. We caution you therefore against relying on any of these forward-looking statements. Important factors that could cause actual results to differ materially from those in the forward-looking statements include, without limitation, our ability to raise capital to fund continuing operations; our ability to protect our intellectual property rights; the impact of any infringement actions or other litigation brought against us; competition from other providers and products; our ability to develop and commercialize products and services; changes in government regulation; our ability to complete capital raising transactions; and other factors relating to our industry, our operations and results of operations. Actual results may differ significantly from those anticipated, believed, estimated, expected, intended or planned including: the uncertainties related to market conditions and other factors described more fully in the section entitled \u2018Risk Factors\u2019 in Immix Biopharma\u2019s Annual Report on Form 10-K for the year ended December 31, 2022, and other periodic reports filed with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Immix Biopharma, Inc. specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.<\/p>\n<p>Factors or events that could cause our actual results to differ may emerge from time to time, and it is not possible for us to predict all of them. We cannot guarantee future results, levels of activity, performance or achievements. <\/p>\n<p>\n        <strong>Investor Contact<\/strong><br \/>\n        <br \/>Stern Investor Relations<br \/>Alex Lobo<br \/>Managing Director<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=hiI4n927x4fHFFjeHzxO5O4l4AfOIq5lTJRp26qZebzBqVjHLXtXg4qfIrb3l1m4k_psvJwYOFVjsYSNALjOdH2r3r9mq-PjeK-hzgJvwes=\" rel=\"nofollow noopener\" target=\"_blank\"><u>Alex.lobo@sternir.com<\/u><\/a><\/p>\n<p>\n        <strong>Company Contact<\/strong><br \/>\n        <br \/>\n        <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=HH1vTPchw74UU-atlinUTqU9GuwexS_ccO8U6_xv6nGh3SXB8ZHmO_Mric4bSQ1rsc7N-8Mm8hpJS9HZGlJi3wV8KY5BdtvhIB6vUtMU-4E=\" rel=\"nofollow noopener\" target=\"_blank\"><br \/>\n          <u>irteam@immixbio.com<\/u><br \/>\n        <\/a>\n      <\/p>\n<p \/>\n      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODg3NTA2OCM1NjkzNzczIzUwMDA5ODEwNA==\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/MmIxZTY5MWMtZWFjMi00NWMyLWJlN2ItMzFkZDg5NmQ1MTdhLTUwMDA5ODEwNA==\/tiny\/Immix-Biopharma-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Tumor shrinkage was observed in 3 out of 4 (75%) patients; 1 out of 4 (25%) experienced tumor control as of the July 7, 2023 clinical data cutoff date. All patients had stage IV relapsed\/refractory metastatic colorectal cancer and received 8 median lines of therapy prior to IMX-110 + tislelizumab Dose Escalation Proceeding: dosing of 2nd dose cohort complete; no drug-related severe adverse events were observed, enabling enrollment of the next higher dose cohort with the goal of establishing the recommended phase 2 dose The colorectal cancer market is estimated to reach approximately $31 billion by 2025 according to IndustryARC LOS ANGELES, July 17, 2023 (GLOBE NEWSWIRE) &#8212; Immix Biopharma,\u00a0Inc. (Nasdaq: IMMX) (\u201cImmixBio\u201d, \u201cCompany\u201d, \u201cWe\u201d or \u201cUs\u201d),\u00a0a biopharmaceutical company pioneering &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Immix Biopharma Reports 2nd Positive Interim Clinical Trial Data Readout in Relapsed\/Refractory Metastatic Colorectal Cancer in Ongoing Phase 1b\/2a IMX-110 IMMINENT-01 Clinical Trial&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-770295","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Immix Biopharma Reports 2nd Positive Interim Clinical Trial Data Readout in Relapsed\/Refractory Metastatic Colorectal Cancer in Ongoing Phase 1b\/2a IMX-110 IMMINENT-01 Clinical Trial - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immix Biopharma Reports 2nd Positive Interim Clinical Trial Data Readout in Relapsed\/Refractory Metastatic Colorectal Cancer in Ongoing Phase 1b\/2a IMX-110 IMMINENT-01 Clinical Trial - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Tumor shrinkage was observed in 3 out of 4 (75%) patients; 1 out of 4 (25%) experienced tumor control as of the July 7, 2023 clinical data cutoff date. All patients had stage IV relapsed\/refractory metastatic colorectal cancer and received 8 median lines of therapy prior to IMX-110 + tislelizumab Dose Escalation Proceeding: dosing of 2nd dose cohort complete; no drug-related severe adverse events were observed, enabling enrollment of the next higher dose cohort with the goal of establishing the recommended phase 2 dose The colorectal cancer market is estimated to reach approximately $31 billion by 2025 according to IndustryARC LOS ANGELES, July 17, 2023 (GLOBE NEWSWIRE) &#8212; Immix Biopharma,\u00a0Inc. (Nasdaq: IMMX) (\u201cImmixBio\u201d, \u201cCompany\u201d, \u201cWe\u201d or \u201cUs\u201d),\u00a0a biopharmaceutical company pioneering &hellip; Continue reading &quot;Immix Biopharma Reports 2nd Positive Interim Clinical Trial Data Readout in Relapsed\/Refractory Metastatic Colorectal Cancer in Ongoing Phase 1b\/2a IMX-110 IMMINENT-01 Clinical Trial&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-07-17T16:51:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODg3NTA2OCM1NjkzNzczIzUwMDA5ODEwNA==\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Immix Biopharma Reports 2nd Positive Interim Clinical Trial Data Readout in Relapsed\\\/Refractory Metastatic Colorectal Cancer in Ongoing Phase 1b\\\/2a IMX-110 IMMINENT-01 Clinical Trial\",\"datePublished\":\"2023-07-17T16:51:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial\\\/\"},\"wordCount\":1416,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODg3NTA2OCM1NjkzNzczIzUwMDA5ODEwNA==\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immix-biopharma-reports-2nd-positive-interim-clinical-trial-data-readout-in-relapsed-refractory-metastatic-colorectal-cancer-in-ongoing-phase-1b-2a-imx-110-imminent-01-clinical-trial\\\/\",\"name\":\"Immix Biopharma Reports 2nd Positive Interim Clinical Trial Data Readout in Relapsed\\\/Refractory Metastatic Colorectal Cancer in Ongoing Phase 1b\\\/2a IMX-110 IMMINENT-01 Clinical Trial - 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All patients had stage IV relapsed\/refractory metastatic colorectal cancer and received 8 median lines of therapy prior to IMX-110 + tislelizumab Dose Escalation Proceeding: dosing of 2nd dose cohort complete; no drug-related severe adverse events were observed, enabling enrollment of the next higher dose cohort with the goal of establishing the recommended phase 2 dose The colorectal cancer market is estimated to reach approximately $31 billion by 2025 according to IndustryARC LOS ANGELES, July 17, 2023 (GLOBE NEWSWIRE) &#8212; Immix Biopharma,\u00a0Inc. 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