{"id":761705,"date":"2023-06-05T16:38:03","date_gmt":"2023-06-05T20:38:03","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/janux-therapeutics-appoints-zachariah-mciver-d-o-ph-d-vice-president-clinical-development\/"},"modified":"2023-06-05T16:38:03","modified_gmt":"2023-06-05T20:38:03","slug":"janux-therapeutics-appoints-zachariah-mciver-d-o-ph-d-vice-president-clinical-development","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/janux-therapeutics-appoints-zachariah-mciver-d-o-ph-d-vice-president-clinical-development\/","title":{"rendered":"Janux Therapeutics Appoints Zachariah McIver, D.O., Ph.D., Vice President, Clinical Development"},"content":{"rendered":"

<\/p>\n

Janux Therapeutics Appoints Zachariah McIver, D.O., Ph.D., Vice President, Clinical Development<\/b><\/p>\n

SAN DIEGO–(BUSINESS WIRE<\/a>)–Janux Therapeutics, Inc.<\/a> (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr) and Tumor Activated Immunomodulator (TRACIr) platforms, today announced the appointment of Dr. Zachariah (\u201cZach\u201d) McIver as Vice President, Clinical Development. An accomplished physician-scientist with more than 15 years of experience in clinical research, Dr. McIver joins Janux after serving as Amgen\u2019s Executive Medical Director, where he led cross-functional teams in the design, implementation, and execution of clinical and correlative study strategies.<\/p>\n

\n\u201cZach has extensive clinical research experience including leading the clinical development to maximize the value of bispecific T-cell engager assets across multiple hematologic and solid tumor malignancies,\u201d said David Campbell, Ph.D., President and CEO of Janux Therapeutics. \u201cAt Janux, Zach will play a key role in clinical development oversight as we advance our novel immunotherapy programs through clinical trials.\u201d<\/p>\n

\n\u201cWe\u2019re excited to have Zach join the team as his experience with advanced T-cell engager programs will be especially important as we continue to advance our drug candidates in clinical trials,\u201d said Wayne Godfrey, M.D., Chief Medical Officer at Janux.<\/p>\n

\n\u201cWith TRACTr and TRACIr, Janux has built two very powerful platforms designed to overcome the toxicity and efficacy limitations of earlier generations of bispecific immunotherapies,\u201d said Dr. McIver. \u201cI look forward to working with the team at Janux to advance the Company\u2019s deep portfolio of next-generation bispecific immunotherapies to improve cancer treatment and help more patients.\u201d<\/p>\n

\nA board-certified hematologist and physician-scientist, Dr. McIver began his career specializing in hematological malignancies and immunotherapy working as a principal investigator at the Hematology Branch of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institute of Health (NIH). He played a key role in developing novel small molecules targeting alloreactive T-cells to prevent graft-versus-host-disease (GVHD) and established a stem cell transplant program for racial minority populations at the Wake Forest University School of Medicine. Dr. McIver also served as an attending physician at Wake Forest in the hematology\/oncology department. Prior to this, he was an attending physician and a research investigator in the department of hematology\/oncology at Tulane University School of Medicine.<\/p>\n

\nDr. McIver earned a B.S. in Physics and General Sciences from the University of Oregon, a Doctor of Osteopathic Medicine (D.O.) from Ohio University College of Osteopathic Medicine and a Ph.D. in Molecular Medicine and Translational Sciences at the Wake Forest University School of Medicine. He completed his internal medicine residency at the Cleveland Clinic, and his clinical fellowship in hematology and oncology at the NHLBI at the NIH. In addition, Dr. McIver is an active member of professional societies such as the American Society of Clinical Oncology, American Society of Hematology, and American College of Physicians.<\/p>\n

Janux\u2019s TRACTr and TRACIr Pipeline<\/b><\/p>\n

\nJANX008 is a TRACTr that targets epidermal growth factor receptor (EGFR) and is being studied in a Phase 1 clinical trial for the treatment of multiple solid cancers including colorectal cancer, squamous cell carcinoma of the head and neck, non-small cell lung cancer, and renal cell carcinoma. Janux\u2019s first clinical candidate, JANX007, is a TRACTr that targets prostate-specific membrane antigen (PSMA) and is being investigated in a Phase 1 clinical trial in adult subjects with metastatic castration-resistant prostate cancer (mCRPC). Janux\u2019s TRACIr drug candidate, JANX009, is designed for targeting both the programmed death-ligand 1 (PD-L1) receptor as well as the costimulatory CD28 receptor on T cells and is being investigated in preclinical studies for the treatment of solid tumors. Janux is also applying its proprietary technology to develop a TRACTr designed to target trophoblast cell surface antigen 2 (TROP2), a clinically validated anti-tumor target that is overexpressed in various cancer types, such as breast, lung, urothelial, endometrial, ovarian, prostate, pancreatic, gastric, colon, head and neck, and glioma. In addition to named programs, Janux is generating a number of unnamed TRACTr and TRACIr programs for potential future development.<\/p>\n

About Janux Therapeutics<\/b><\/p>\n

\nJanux is a clinical-stage biopharmaceutical company developing next-generation bispecific immunotherapies with the goal of fighting cancers by killing tumor cells while allowing healthy tissues to remain unharmed. Janux\u2019s proprietary platforms develop unique Tumor Activated T Cell Engagers (TRACTr) and Tumor Activated Immunomodulators (TRACIr) and support the building of a broad pipeline of drugs designed to direct and guide the patient\u2019s immune system to eradicate tumors while minimizing safety concerns. The company’s innovative technology currently focuses on the engineering of bispecific antibodies functional only in the tumor, designed to provide safety advantages compared to earlier generations of bispecific immunotherapies. Currently, Janux\u2019s two lead TRACTr compounds for PSMA and EGFR are in the clinic. For more information, please visit www.januxrx.com<\/a> and follow us on LinkedIn<\/a>.<\/p>\n

Forward-Looking Statements<\/b><\/p>\n

\nThis news release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements. Such forward-looking statements include statements regarding, among other things, Janux\u2019s ability to bring new treatments to cancer patients in need, expectations regarding the timing, scope and results of Janux\u2019s development activities, including its ongoing and planned clinical trials, the timing of and plans for regulatory filings, the potential benefits of Janux\u2019s product candidates and platform technologies, and expectations regarding the use of Janux\u2019s platform technologies to generate novel product candidates. Factors that may cause actual results to differ materially include the risk that compounds that appear promising in early research do not demonstrate safety and\/or efficacy in later preclinical studies or clinical trials, the risk that Janux may not obtain approval to market its product candidates, uncertainties associated with performing clinical trials, regulatory filings and applications, risks associated with reliance on third parties to successfully conduct clinical trials, the risks associated with reliance on outside financing to meet capital requirements, and other risks associated with the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. You are urged to consider statements that include the words \u201cmay,\u201d \u201cwill,\u201d \u201cwould,\u201d \u201ccould,\u201d \u201cshould,\u201d \u201cbelieves,\u201d \u201cestimates,\u201d \u201cprojects,\u201d \u201cpromise,\u201d \u201cpotential,\u201d \u201cexpects,\u201d \u201cplans,\u201d \u201canticipates,\u201d \u201cintends,\u201d \u201ccontinues,\u201d \u201cdesigned,\u201d \u201cgoal,\u201d or the negative of those words or other comparable words to be uncertain and forward-looking. For a further list and description of the risks and uncertainties Janux faces, please refer to Janux\u2019s periodic and other filings with the Securities and Exchange Commission, which are available at www.sec.gov<\/a>. Such forward-looking statements are current only as of the date they are made, and Janux assumes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20230605005059\/en\/<\/a><\/span><\/p>\n

Investors:
\n<\/b>
Andy Meyer
\n
Janux Therapeutics
\n
ameyer@januxrx.com
\n<\/a>
(202) 215-2579<\/p>\n

Media:
\n<\/b>
Jessica Yingling, Ph.D.
\n
Little Dog Communications Inc.
\n
jessica@litldog.com
\n<\/a>
(858) 344-8091<\/p>\n

KEYWORDS:<\/b> United States North America California<\/p>\n

INDUSTRY KEYWORDS:<\/b> Biotechnology Pharmaceutical Health Oncology<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
Logo<\/b><\/font><\/td>\n<\/tr>\n
\"Logo\"<\/td>\n<\/tr>\n
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Janux Therapeutics Appoints Zachariah McIver, D.O., Ph.D., Vice President, Clinical Development SAN DIEGO–(BUSINESS WIRE)–Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr) and Tumor Activated Immunomodulator (TRACIr) platforms, today announced the appointment of Dr. Zachariah (\u201cZach\u201d) McIver as Vice President, Clinical Development. An accomplished physician-scientist with more than 15 years of experience in clinical research, Dr. McIver joins Janux after serving as Amgen\u2019s Executive Medical Director, where he led cross-functional teams in the design, implementation, and execution of clinical and correlative study strategies. \u201cZach has extensive clinical research experience including leading the clinical development to maximize the value of … <\/p>\n

Continue reading “Janux Therapeutics Appoints Zachariah McIver, D.O., Ph.D., Vice President, Clinical Development”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-761705","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nJanux Therapeutics Appoints Zachariah McIver, D.O., Ph.D., Vice President, Clinical Development - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/janux-therapeutics-appoints-zachariah-mciver-d-o-ph-d-vice-president-clinical-development\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Janux Therapeutics Appoints Zachariah McIver, D.O., Ph.D., Vice President, Clinical Development - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Janux Therapeutics Appoints Zachariah McIver, D.O., Ph.D., Vice President, Clinical Development SAN DIEGO–(BUSINESS WIRE)–Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr) and Tumor Activated Immunomodulator (TRACIr) platforms, today announced the appointment of Dr. Zachariah (\u201cZach\u201d) McIver as Vice President, Clinical Development. 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(Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr) and Tumor Activated Immunomodulator (TRACIr) platforms, today announced the appointment of Dr. Zachariah (\u201cZach\u201d) McIver as Vice President, Clinical Development. An accomplished physician-scientist with more than 15 years of experience in clinical research, Dr. McIver joins Janux after serving as Amgen\u2019s Executive Medical Director, where he led cross-functional teams in the design, implementation, and execution of clinical and correlative study strategies. \u201cZach has extensive clinical research experience including leading the clinical development to maximize the value of … Continue reading \"Janux Therapeutics Appoints Zachariah McIver, D.O., Ph.D., Vice President, Clinical Development\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/janux-therapeutics-appoints-zachariah-mciver-d-o-ph-d-vice-president-clinical-development\/","og_site_name":"Market Newsdesk","article_published_time":"2023-06-05T20:38:03+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20230605005059r1&sid=flmnd&distro=nx&lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/janux-therapeutics-appoints-zachariah-mciver-d-o-ph-d-vice-president-clinical-development\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/janux-therapeutics-appoints-zachariah-mciver-d-o-ph-d-vice-president-clinical-development\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Janux Therapeutics Appoints Zachariah McIver, D.O., Ph.D., Vice President, Clinical Development","datePublished":"2023-06-05T20:38:03+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/janux-therapeutics-appoints-zachariah-mciver-d-o-ph-d-vice-president-clinical-development\/"},"wordCount":1206,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/janux-therapeutics-appoints-zachariah-mciver-d-o-ph-d-vice-president-clinical-development\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20230605005059r1&sid=flmnd&distro=nx&lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/janux-therapeutics-appoints-zachariah-mciver-d-o-ph-d-vice-president-clinical-development\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/janux-therapeutics-appoints-zachariah-mciver-d-o-ph-d-vice-president-clinical-development\/","name":"Janux Therapeutics Appoints Zachariah McIver, D.O., Ph.D., Vice President, Clinical Development - 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