{"id":758697,"date":"2023-05-15T07:14:24","date_gmt":"2023-05-15T11:14:24","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/"},"modified":"2023-05-15T07:14:24","modified_gmt":"2023-05-15T11:14:24","slug":"fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/","title":{"rendered":"Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for the First Quarter 2023"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>\u2015 <\/em><br \/>\n        <em>Appointed Alex C. Sapir CEO &amp; President, effective July 1st, 2023<\/em><br \/>\n        <em> \u2015<\/em><br \/>\n        \n      <\/p>\n<p align=\"center\">\n        <em>\u2015 On track to complete enrollment in Phase 3 REACH trial of losmapimod\u00a0<\/em><br \/>\n        <em>in facioscapulohumeral muscular dystrophy (FSHD) during 2H\u201923 \u2015<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>\u2015 Active discussions continue with the U.S. Food and Drug Administration (FDA)\u00a0<\/em><br \/>\n        <em>to resolve clinical hold for FTX-6058 in sickle cell disease (SCD) \u2015<\/em>\n      <\/p>\n<p align=\"center\">\u00a0<em>\u2015 Conference call and webcast scheduled for 8:00 a.m. ET today \u2015<\/em><\/p>\n<p>CAMBRIDGE, Mass., May  15, 2023  (GLOBE NEWSWIRE) &#8212; <strong>Fulcrum Therapeutics, Inc.\u00ae<\/strong> (the \u201cCompany\u201d) (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases, today reported financial results for the first quarter 2023 and provided a business update.<\/p>\n<p>\u201cWith today\u2019s announcement of Alex as our next CEO and President, Fulcrum has ended the first quarter of 2023 in a position of strength and with great promise for the future,\u201d said Robert J. Gould, Ph.D., Fulcrum\u2019s interim president and chief executive officer. \u201cWe continue to engage in productive dialogue with the FDA, as we work diligently to address the clinical hold for FTX-6058. Additionally, we remain on track to complete enrollment in the Phase 3 REACH trial in the second half of 2023, which will bring us one step closer to potentially delivering the first FDA-approved therapy for FSHD patients.\u201d<\/p>\n<p>\n        <strong><br \/>\n          <u>Key Business Updates<\/u><br \/>\n        <\/strong>\n      <\/p>\n<p>\n        <strong>FTX-6058<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>On February 23, 2023, the FDA placed the investigational new drug (IND) application for FTX-6058 for the potential treatment of SCD on full clinical hold.\n<ul type=\"circle\">\n<li>In its communication, the Agency noted preclinical data previously submitted in April, October and December 2022, a response to an early February 2023 information request from the FDA about data that we submitted in mid-February 2023, and non-clinical and clinical evidence of hematological malignancies observed with other inhibitors of polycomb repressive complex 2 (PRC2).<\/li>\n<li>Active discussions with the Agency regarding the clinical hold of FTX-6058 are ongoing.<\/li>\n<\/ul>\n<\/li>\n<li>Initial data reported in March 2023 but obtained prior to the clinical hold showed a 10.0% absolute fetal hemoglobin (HbF) increase from baseline in one subject in the 12 mg dose cohort of the Phase 1b clinical trial in SCD, resulting in a total HbF level of 24.9% after 42 days of treatment.<\/li>\n<li>FTX-6058 was generally well-tolerated, as of the March 2023 data cutoff date, with no drug-related treatment emergent serious adverse events and no discontinuations due to treatment emergent adverse events.\n<\/li>\n<\/ul>\n<p>\n        <strong>Losmapimod<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li style=\"margin-bottom:8pt\">Enrollment is ongoing in the REACH Phase 3 pivotal trial evaluating losmapimod in FSHD at sites in the United States, Canada and Europe.<\/li>\n<li>On track to complete enrollment in the second half of 2023.\n<\/li>\n<\/ul>\n<p>\n        <strong><br \/>\n          <u>Corporate Updates<\/u><br \/>\n        <\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>Announced that Alex C. Sapir will join as president and CEO, and member of the Fulcrum board of directors, effective July 1, 2023. Prior to assuming his new role, Mr. Sapir will serve as Special Advisor to the interim president and CEO, effective May 12, 2023.\u00a0\u00a0<\/li>\n<li>Completed underwritten public offering of common stock in January 2023, raising approximately $117.3 million in net proceeds.<\/li>\n<li>Esther Rajavelu resigned as chief financial officer, effective April 21, 2023. Ms. Rajavelu is serving in a consulting role to ensure the continuity of Fulcrum\u2019s financial operations.\n<\/li>\n<\/ul>\n<p>\n        <strong><br \/>\n          <u>First Quarter 2023 Financial Results <\/u><br \/>\n        <\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>\n          <strong>Cash Position:<\/strong> As of March 31, 2023, cash, cash equivalents, and marketable securities were $297.8 million, as compared to $202.9 million as of December 31, 2022.<\/li>\n<li>\n          <strong>Collaboration Revenue:<\/strong> Collaboration revenue was $0.3 million for the first quarter of 2023 as compared to $2.6 million for the first quarter of 2022.<\/li>\n<li>\n          <strong>R&amp;D Expenses:<\/strong> Research and development expenses were $16.7 million for the first quarter of 2023 as compared to $17.8 million for the first quarter of 2022. The decrease of $1.1 million was primarily due to decreased research and development headcount, partially offset by increased costs associated with the advancement of REACH.<\/li>\n<li>\n          <strong>G&amp;A Expenses:<\/strong> General and administrative expenses were $11.5 million for the first quarter of 2023 as compared to $10.8 million for the first quarter of 2022. The increase of $0.7 million was primarily due to increased stock-based compensation expense.<\/li>\n<li>\n          <strong>Net Loss:<\/strong> Net loss was $24.8 million for the first quarter of 2023 as compared to $25.9 million for the first quarter of 2022.<\/p>\n<\/li>\n<\/ul>\n<p>\n        <strong><br \/>\n          <u>Financial Guidance<\/u><br \/>\n        <\/strong>\n      <\/p>\n<p>Fulcrum expects that its existing cash, cash equivalents, and marketable securities will be sufficient to fund its operating expenses and capital expenditure requirements into mid-2025.<\/p>\n<p>\n        <strong><br \/>\n          <u>Conference Call and Webcast<\/u><br \/>\n        <\/strong>\n      <\/p>\n<p>Fulcrum Therapeutics, Inc. will host a conference call and webcast today at 8:00 a.m. ET to review the first quarter and 2023 recent business highlights and financial results. Individuals may register for the conference call by clicking the link <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=e_NsNF7oXrjmQl1ZmWoVi9WcjoaVKYrfRX3eVo_WqRvWUsEnBMMG0H657kmea5kO7Lin_6szG2Z0cTbZ5lDDFwC_emfnygh9iwTgpUyCm4n1SUng6SCD-gR7EfLJ8dQkTnWVVHbk1YpOZaTeepcQJA==\" rel=\"nofollow noopener\" target=\"_blank\">here<\/a>. Once registered participants will receive dials and a unique pin which will allow them to access the call. The webcast will be accessible through the Investor Relations section of Fulcrum\u2019s website at www.fulcrumtx.com or by clicking <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=I7s_ZK0XOE-OTzZoPmjJDWPom1wN52YVoQgmYGl9N5tqa4e4k7U9F6YOZKbF-voYzE0tC2Z3xwOUiFSoIX7JKi244YCi0tcRVtR0tN8tuco=\" rel=\"nofollow noopener\" target=\"_blank\">here<\/a>. Following the live webcast, an archived replay will also be available for 90 days.<\/p>\n<p>\n        <strong>About Fulcrum Therapeutics<\/strong><br \/>\n        <br \/>Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum\u2019s two lead programs in clinical development are losmapimod, a small molecule for the treatment of facioscapulohumeral muscular dystrophy (FSHD), and FTX-6058, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease (SCD) and other hemoglobinopathies, which is currently under a full clinical hold issued by the U.S. Food and Drug Administration. The company\u2019s proprietary product engine, FulcrumSeek\u2122, identifies drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. For more information, visit www.fulcrumtx.com and follow us on Twitter\u00a0<strong>@FulcrumTx<\/strong>\u00a0and\u00a0<strong>LinkedIn<\/strong>.<\/p>\n<p>\n        <strong>About FTX-6058<\/strong><br \/>\n        <br \/>FTX-6058 is an investigational oral small-molecule inhibitor of Embryonic Ectoderm Development (EED) that was discovered using FulcrumSeek\u2122, Fulcrum\u2019s proprietary discovery engine. Inhibition of EED leads to potent downregulation of key fetal globin repressors, including BCL11A, thereby causing an increase in fetal hemoglobin (HbF). FTX-6058 is being developed for the treatment of sickle cell disease (SCD) and other hemoglobinopathies. Initial data in SCD demonstrated proof-of-concept and achieved absolute levels of HbF increases associated with potential overall patient benefit. Through the March 2023 data cutoff date, FTX-6058 has been generally well-tolerated in people with SCD with up to three months of exposure, with no serious treatment-emergent adverse events reported. FTX-6058 has been granted U.S. Food and Drug Administration (FDA) Fast Track designation and Orphan Drug Designation for the treatment of SCD. FTX-6058 is currently under a full clinical hold issued by the FDA.<\/p>\n<p>\n        <strong>About Sickle Cell Disease<\/strong><br \/>\n        <br \/>Sickle cell disease (SCD) is a genetic disorder of the red blood cells caused by a mutation in the\u00a0<em>HBB<\/em>\u00a0gene. This gene encodes a protein that is a key component of hemoglobin, a protein complex whose function is to transport oxygen in the body. The result of the mutation is less efficient oxygen transport and the formation of red blood cells that have a sickle shape. These sickle shaped cells are much less flexible than healthy cells and can block blood vessels or rupture cells. People with SCD typically suffer from serious clinical consequences, which may include anemia, pain, infections, stroke, heart disease, pulmonary hypertension, kidney failure, liver disease, and reduced life expectancy.<\/p>\n<p>\n        <strong>About Losmapimod<\/strong><br \/>\n        <br \/>Losmapimod is a selective p38\u03b1\/\u03b2 mitogen activated protein kinase (MAPK) inhibitor. Fulcrum exclusively in-licensed losmapimod from GSK following Fulcrum\u2019s discovery of the role of p38\u03b1\/\u03b2 inhibitors in the reduction of DUX4 expression and an extensive review of known compounds. Results reported from the Phase 2b ReDUX4 trial demonstrated slowed disease progression and improved function, including positive impacts on upper extremity strength and functional measures supporting losmapimod\u2019s potential to be a transformative therapy for the treatment of FSHD. Although losmapimod had never previously been explored in muscular dystrophies, it had been evaluated in more than 3,600 subjects in clinical trials across multiple other indications, with no safety signals attributed to losmapimod. Losmapimod has been granted U.S. Food and Drug Administration (FDA) Fast Track designation and Orphan Drug Designation for the treatment of FSHD. Losmapimod is currently being evaluated in a Phase 3 multi-center randomized, double-blind, placebo-controlled, 48-week parallel-group study in people with FSHD (NCT05397470).<\/p>\n<p>\n        <strong>About FSHD<\/strong><br \/>\n        <br \/>FSHD is a serious, rare, progressive and debilitating disease for which there are no approved treatments. It is characterized by fat infiltration of skeletal muscle leading to muscular atrophy involving primarily the face, scapula and shoulders, upper arms, and abdomen. Impact on patients includes profound decreases in the ability to perform activities of daily living, loss of upper limb function, loss of mobility and independence and chronic pain. FSHD is one of the most common forms of muscular dystrophy and has an estimated patient population of 16,000 to 38,000 in the United States alone.<\/p>\n<p>\n        <strong>Forward-Looking Statements<\/strong><br \/>\n        <br \/>This press release contains \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this press release are forward-looking statements, including express or implied statements regarding Fulcrum\u2019s clinical trials, including completion of enrollment in REACH; the clinical hold on FTX-6058, including Fulcrum\u2019s ability to resolve such hold; Fulcrum\u2019s cash runway; and Fulcrum\u2019s ability to deliver an FDA-approved therapy for FSHD patients ;; among others. The words \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccontinue,\u201d \u201ccould,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201cshould,\u201d \u201ctarget,\u201d \u201cwill,\u201d \u201cwould\u201d and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements are based on management\u2019s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in, or implied by, such forward-looking statements. These risks and uncertainties include, but are not limited to, risks associated with resolving the clinical hold on FTX-6058 and responding to FDA\u2019s requests; Fulcrum\u2019s ability to continue to advance its product candidates in clinical trials; initiating and enrolling clinical trials on the timeline expected or at all; obtaining and maintaining necessary approvals from the FDA and other regulatory authorities; replicating in clinical trials positive results found in preclinical studies and\/or earlier-stage clinical trials of losmapimod, FTX-6058 (if resumed) and any other product candidates; obtaining, maintaining or protecting intellectual property rights related to its product candidates; managing expenses; realizing the anticipated benefits of the strategic realignment; managing executive and employee turnover, including integrating a new CEO; and raising the substantial additional capital needed to achieve its business objectives, among others. For a discussion of other risks and uncertainties, and other important factors, any of which could cause Fulcrum\u2019s actual results to differ from those contained in the forward-looking statements, see the \u201cRisk Factors\u201d section, as well as discussions of potential risks, uncertainties, and other important factors, in Fulcrum\u2019s most recent filings with the Securities and Exchange Commission. In addition, the forward-looking statements included in this press release represent Fulcrum\u2019s views as of the date hereof and should not be relied upon as representing Fulcrum\u2019s views as of any date subsequent to the date hereof. Fulcrum anticipates that subsequent events and developments will cause Fulcrum\u2019s views to change. However, while Fulcrum may elect to update these forward-looking statements at some point in the future, Fulcrum specifically disclaims any obligation to do so.<\/p>\n<table align=\"center\" style=\"border-collapse: collapse;width:100%;border-collapse:collapse\">\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>Fulcrum Therapeutics, Inc.<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>Selected Consolidated Balance Sheet Data<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>(In thousands)<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>(Unaudited)<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>March\u00a031,<\/strong><br \/>\n            <br \/>\n            <strong>2023<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>December\u00a031,<\/strong><br \/>\n            <br \/>\n            <strong>2022<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"max-width:64%;width:64%;min-width:64%;vertical-align: bottom\">Cash, cash equivalents, and marketable securities<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;border-top: solid black 1pt;vertical-align: bottom\">$<\/td>\n<td style=\"max-width:15%;width:15%;min-width:15%;border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">297,840<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;border-top: solid black 1pt;vertical-align: bottom\">$<\/td>\n<td style=\"max-width:15%;width:15%;min-width:15%;border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">202,921<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: bottom\">Working capital<sup>(1)<\/sup><\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">288,423<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">190,794<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: bottom\">Total assets<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">321,120<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">226,685<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: bottom\">Total stockholders\u2019 equity<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">296,256<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">198,942<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<\/table>\n<p>(1) Fulcrum defines working capital as current assets minus current liabilities.<\/p>\n<table align=\"center\" style=\"border-collapse: collapse;width:100%;border-collapse:collapse\">\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle\">\n            <strong>Fulcrum Therapeutics, Inc.<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle\">\n            <strong>Consolidated Statements of Operations<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle\">\n            <strong>(In thousands, except per share data)<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle\">\n            <strong>(Unaudited)<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<td colspan=\"6\" style=\"border-bottom: solid black 1pt;text-align: center;vertical-align: middle\">\n            <strong>Three Months Ended<\/strong><br \/>\n            <br \/>\n            <strong>March\u00a031,<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<td colspan=\"2\" style=\"border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: center;vertical-align: middle\">\n            <strong>2023<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;text-align: center;vertical-align: middle\">\u00a0<\/td>\n<td colspan=\"2\" style=\"border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: center;vertical-align: middle\">\n            <strong>2022<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"max-width:64%;width:64%;min-width:64%\">Collaboration revenue<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;border-top: solid black 1pt\">$<\/td>\n<td style=\"max-width:15%;width:15%;min-width:15%;border-top: solid black 1pt;text-align: right;vertical-align: middle\">295<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;border-top: solid black 1pt\">$<\/td>\n<td style=\"max-width:15%;width:15%;min-width:15%;border-top: solid black 1pt;text-align: right;vertical-align: middle\">2,592<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td>Operating expenses:<\/td>\n<td>\u00a0<\/td>\n<td colspan=\"2\" style=\"text-align: right;vertical-align: middle\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle\">\u00a0<\/td>\n<td>\u00a0<\/td>\n<td colspan=\"2\" style=\"text-align: right;vertical-align: middle\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 15.0px\">Research and development<\/td>\n<td>\u00a0<\/td>\n<td>\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle\">16,715<\/td>\n<td>\u00a0<\/td>\n<td>\u00a0<\/td>\n<td>\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle\">17,831<\/td>\n<td>\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 15.0px\">General and administrative<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;text-align: right;vertical-align: middle\">11,520<\/td>\n<td>\u00a0<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;text-align: right;vertical-align: middle\">10,759<\/td>\n<td>\u00a0<\/td>\n<\/tr>\n<tr>\n<td>Total operating expenses<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;border-bottom: solid black 1pt\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: right;vertical-align: middle\">28,235<\/td>\n<td>\u00a0<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;border-bottom: solid black 1pt\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: right;vertical-align: middle\">28,590<\/td>\n<td>\u00a0<\/td>\n<\/tr>\n<tr>\n<td>Loss from operations<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-top: solid black 1pt\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;text-align: right;vertical-align: middle\">(27,940<\/td>\n<td>)<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-top: solid black 1pt\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;text-align: right;vertical-align: middle\">(25,998<\/td>\n<td>)<\/td>\n<\/tr>\n<tr>\n<td>Other income, net<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;text-align: right;vertical-align: middle\">3,161<\/td>\n<td>\u00a0<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;text-align: right;vertical-align: middle\">70<\/td>\n<td>\u00a0<\/td>\n<\/tr>\n<tr>\n<td>Net loss<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;border-bottom: double 15px 3pt\">$<\/td>\n<td style=\"border-top: solid black 1pt;border-bottom: double 15px 3pt;text-align: right;vertical-align: middle\">(24,779<\/td>\n<td>)<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;border-bottom: double 15px 3pt\">$<\/td>\n<td style=\"border-top: solid black 1pt;border-bottom: double 15px 3pt;text-align: right;vertical-align: middle\">(25,928<\/td>\n<td>)<\/td>\n<\/tr>\n<tr>\n<td>Net loss per share, basic and diluted<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double 15px 3pt\">$<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double 15px 3pt;text-align: right;vertical-align: middle\">(0.41<\/td>\n<td>)<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double 15px 3pt\">$<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double 15px 3pt;text-align: right;vertical-align: middle\">(0.64<\/td>\n<td>)<\/td>\n<\/tr>\n<tr>\n<td>Weighted-average common shares outstanding, basic and diluted<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double 15px 3pt\">\u00a0<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double 15px 3pt;text-align: right;vertical-align: middle\">59,722<\/td>\n<td>\u00a0<\/td>\n<td>\u00a0<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double 15px 3pt\">\u00a0<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double 15px 3pt;text-align: right;vertical-align: middle\">40,644<\/td>\n<td>\u00a0<\/td>\n<\/tr>\n<\/table>\n<p>\n        <strong><br \/>\n          <br \/>Contact:<\/strong>\n      <\/p>\n<p>\n        <em>Investors:<\/em><br \/>\n        <br \/>Chris Calabrese<br \/>LifeSci Advisors, LLC<br \/>ccalabrese@lifesciadvisors.com<br \/>917-680-5608<\/p>\n<p>\n        <em>Media:<\/em><br \/>\n        <br \/>Dee Smith<br \/>Executive Director, Corporate Communications<br \/>Fulcrum Therapeutics, Inc.<br \/>dsmith@fulcrumtx.com<br \/>202-746-1324<\/p>\n<\/p>\n<p>      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgzODc0NSM1NTkzNjU2IzIxODM1NDI=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/YTU0YjczMDYtZjFiZS00Njg2LWEwZGUtYTVmYWY3ZGE3MTQyLTExOTUxMDA=\/tiny\/Fulcrum-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u2015 Appointed Alex C. Sapir CEO &amp; President, effective July 1st, 2023 \u2015 \u2015 On track to complete enrollment in Phase 3 REACH trial of losmapimod\u00a0 in facioscapulohumeral muscular dystrophy (FSHD) during 2H\u201923 \u2015 \u2015 Active discussions continue with the U.S. Food and Drug Administration (FDA)\u00a0 to resolve clinical hold for FTX-6058 in sickle cell disease (SCD) \u2015 \u00a0\u2015 Conference call and webcast scheduled for 8:00 a.m. ET today \u2015 CAMBRIDGE, Mass., May 15, 2023 (GLOBE NEWSWIRE) &#8212; Fulcrum Therapeutics, Inc.\u00ae (the \u201cCompany\u201d) (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases, today reported financial results for the first quarter 2023 and provided a business update. \u201cWith today\u2019s announcement of Alex &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for the First Quarter 2023&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-758697","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for the First Quarter 2023 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for the First Quarter 2023 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"\u2015 Appointed Alex C. Sapir CEO &amp; President, effective July 1st, 2023 \u2015 \u2015 On track to complete enrollment in Phase 3 REACH trial of losmapimod\u00a0 in facioscapulohumeral muscular dystrophy (FSHD) during 2H\u201923 \u2015 \u2015 Active discussions continue with the U.S. Food and Drug Administration (FDA)\u00a0 to resolve clinical hold for FTX-6058 in sickle cell disease (SCD) \u2015 \u00a0\u2015 Conference call and webcast scheduled for 8:00 a.m. ET today \u2015 CAMBRIDGE, Mass., May 15, 2023 (GLOBE NEWSWIRE) &#8212; Fulcrum Therapeutics, Inc.\u00ae (the \u201cCompany\u201d) (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases, today reported financial results for the first quarter 2023 and provided a business update. \u201cWith today\u2019s announcement of Alex &hellip; Continue reading &quot;Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for the First Quarter 2023&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-05-15T11:14:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgzODc0NSM1NTkzNjU2IzIxODM1NDI=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"10 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for the First Quarter 2023\",\"datePublished\":\"2023-05-15T11:14:24+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\\\/\"},\"wordCount\":1963,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODgzODc0NSM1NTkzNjU2IzIxODM1NDI=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\\\/\",\"name\":\"Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for the First Quarter 2023 - 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Sapir CEO &amp; President, effective July 1st, 2023 \u2015 \u2015 On track to complete enrollment in Phase 3 REACH trial of losmapimod\u00a0 in facioscapulohumeral muscular dystrophy (FSHD) during 2H\u201923 \u2015 \u2015 Active discussions continue with the U.S. Food and Drug Administration (FDA)\u00a0 to resolve clinical hold for FTX-6058 in sickle cell disease (SCD) \u2015 \u00a0\u2015 Conference call and webcast scheduled for 8:00 a.m. ET today \u2015 CAMBRIDGE, Mass., May 15, 2023 (GLOBE NEWSWIRE) &#8212; Fulcrum Therapeutics, Inc.\u00ae (the \u201cCompany\u201d) (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases, today reported financial results for the first quarter 2023 and provided a business update. \u201cWith today\u2019s announcement of Alex &hellip; Continue reading \"Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for the First Quarter 2023\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/","og_site_name":"Market Newsdesk","article_published_time":"2023-05-15T11:14:24+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgzODc0NSM1NTkzNjU2IzIxODM1NDI=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"10 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for the First Quarter 2023","datePublished":"2023-05-15T11:14:24+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/"},"wordCount":1963,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgzODc0NSM1NTkzNjU2IzIxODM1NDI=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-announces-recent-business-highlights-and-financial-results-for-the-first-quarter-2023\/","name":"Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for the First Quarter 2023 - 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