{"id":758015,"date":"2023-05-11T11:53:42","date_gmt":"2023-05-11T15:53:42","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/"},"modified":"2023-05-11T11:53:42","modified_gmt":"2023-05-11T15:53:42","slug":"allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/","title":{"rendered":"Allogene Therapeutics Announces Encore Presentation of Phase 1 Data from the ALLO-501\/501A Trials in Large B Cell Lymphoma at the European Hematology Association (EHA) Hybrid Congress"},"content":{"rendered":"<div class=\"mw_release\">\n<ul>\n<li style=\"text-align:left\">Data Will Also Be Presented in a Poster Session at the American Society of Clinical Oncology (ASCO) Annual Meeting on June 3, 2023<\/li>\n<\/ul>\n<p>SOUTH SAN FRANCISCO, Calif., May  11, 2023  (GLOBE NEWSWIRE) &#8212; Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T\u2122) products for cancer,\u00a0today announced an encore presentation of data from the Phase 1 ALPHA\/ALPHA2 trials of ALLO-501\/501A at the European Hematology Association (EHA) Hybrid Congress on June\u00a08\u201311, 2023 in\u00a0Frankfurt, Germany.<\/p>\n<p>The ALPHA\/ALPHA2 trials were designed to assess the safety, tolerability, and preliminary efficacy at increasing dose levels of ALLO-501 and ALLO-501A, allogeneic CAR T cell product candidates that target CD19. In addition to exploring cell doses, these studies evaluated escalating doses of ALLO-647, Allogene\u2019s proprietary investigational lymphodepleting antibody designed to prevent premature rejection of AlloCAR T cells, in combination with fludarabine and cyclophosphamide.<\/p>\n<p>Allogene is conducting ALPHA2 and EXPAND, two potentially pivotal Phase 2 trials of ALLO-501A in large B cell lymphoma (LBCL) in sites across the U.S. and is expected to extend its clinical research footprint to Europe, Canada and Australia in 2023.<\/p>\n<p>\n        <u>Allogene Presentation at the 2023 EHA Hybrid Congress:<\/u>\n      <\/p>\n<p>\n        <strong>Title: Durable Responses Achieved with Anti-CD19 Allogeneic CAR T ALLO-501\/501A in Phase 1 Trials of Autologous CAR T Na\u00efve Patients with Relapsed\/Refractory Large B Cell Lymphoma (R\/R LBCL)<\/strong>\n      <\/p>\n<p>Presenter: Dr. Javier Munoz, M.D., M.B.A, Director of the Lymphoma Program at Mayo Clinic in Phoenix, Arizona<br \/>Abstract:\u00a0P1125<br \/>Poster Session Display Date and Time: Friday, June 9, 2023, 18:00 &#8211; 19:00 CEST\/ 9:00AM &#8211; 10:00AM PT\/ 12:00PM &#8211; 1:00PM ET<\/p>\n<p>\n        <strong>About ALLO-501 and ALLO-501A<\/strong><br \/>\n        <br \/>ALLO-501 and ALLO-501A are anti-CD19 AlloCAR T\u2122 investigational products for the treatment of large B cell lymphoma. ALLO-501A, a next-generation anti-CD19 AlloCAR T\u2122, eliminates the rituximab recognition domains in ALLO-501, which could allow for use in a broader patient population, including NHL patients with recent rituximab exposure.\u00a0This product candidate is currently being studied in an ongoing Phase 2 trial. In June 2022, the\u00a0U.S. Food and Drug Administration granted Regenerative Medicine Advanced Therapy (RMAT) designation to ALLO-501A in r\/r LBCL.<\/p>\n<p>\n        <strong>About Allogene Therapeutics<\/strong><br \/>\n        <br \/>Allogene Therapeutics, with headquarters in\u00a0South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T\u2122) products for cancer. Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of \u201coff-the-shelf\u201d CAR T product candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. For more information, please visit\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=_f_MEco3s-yw0dk_8K-3yP-2_zBoykmfEo2Ge4AsZ3U7fLNHseRP9vW6y4F8g_t9VqvAkYbANeVxuQuaDcDFnbv4xuwEd-yWsSfZ0Jmak-05DvbForB8-49Hk4ZA2LhHxuqdZs1UNLgl5iiXAB24Z1nLKP-l7rFAOm7KqyKlfwQQHe1dMhS84W2-SFeN56i7szJRSjjPDTQt3PGLuu7U8G1CamZcljLnXM77cutMnjs=\" rel=\"nofollow noopener\" target=\"_blank\">www.allogene.com<\/a>, and follow @AllogeneTx on Twitter and LinkedIn.<\/p>\n<p>\n        <strong>Cautionary Note on Forward-Looking Statements for Allogene<\/strong><br \/>\n        <br \/>This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The press release may, in some cases, use terms such as \u201ccould,\u201d \u201cdesigned,\u201d \u201cexpects,\u201d \u201cpotential,\u201d \u201cpreliminary,\u201d \u201cwill\u201d or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements include statements regarding intentions, beliefs, projections, outlook, analyses, or current expectations concerning, among other things: the potential of the Phase 2 ALPHA2 trial to be a pivotal trial; expectations with respect to expansion of Allogene\u2019s clinical research footprint to Europe, Canada, and Australia; data results that may be implied from prior results; and the potential benefits of AlloCAR T products. Various factors may cause material differences between Allogene\u2019s expectations and actual results, including, risks and uncertainties related to: our product candidates are based on novel technologies, which makes it difficult to predict the time and cost of product candidate development and obtaining regulatory approval; Phase 1 data from our clinical trials is limited and may change as more patient data become available or may not be validated in any future or advanced clinical trial; our ability to maintain intellectual property rights necessary for the continued development of our product candidates, including pursuant to our license agreements; our product candidates may cause undesirable side effects or have other properties that could halt their clinical development, prevent their regulatory approval or limit their commercial potential; the extent to which COVID-19 adversely impacts our business, including our clinical trials; the extent to which the\u00a0FDA\u00a0disagrees with our clinical or regulatory plans, which could cause future delays to our clinical trials or require additional clinical trials; we may encounter difficulties enrolling patients in our clinical trials; we may not be able to demonstrate the safety and efficacy of our product candidates in our clinical trials, which could prevent or delay regulatory approval and commercialization; challenges with manufacturing or optimizing manufacturing of our product candidates; and our ability to obtain additional financing to develop our products and implement our operating plans. These and other risks are discussed in greater detail in Allogene\u2019s filings with the\u00a0SEC, including without limitation under the \u201cRisk Factors\u201d heading of its Form 10-Q for the quarter ended\u00a0March 31, 2023. Any forward-looking statements that are made in this press release speak only as of the date of this press release. Allogene assumes no obligation to update the forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release.<\/p>\n<p>AlloCAR T\u2122 is a trademark of\u00a0Allogene Therapeutics, Inc.<\/p>\n<p>Allogene\u2019s AlloCAR T\u2122 programs utilize the Cellectis TALEN<sup>\u00ae<\/sup> technologies. ALLO-501 and ALLO-501A are anti-CD19 products being jointly developed under a collaboration agreement between Servier and Allogene based on an exclusive license granted by Cellectis to Servier. Servier grants to Allogene exclusive rights to ALLO-501 and ALLO-501A in the U.S.<\/p>\n<p>\n        <strong>Allogene Media\/Investor Contact:<\/strong><br \/>\n        <br \/>Christine Cassiano<br \/>Chief Communications Officer<br \/>(714) 552-0326<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=pbBo_w3xSfSycnxweeQ0cdJvG7oW6MYlQINY1JE5-91XFdm2bOeKjGbq_UbT60P9OLIt38lAu1YjZdUrUGBy1M6mdXJzQjYfwM8pyVB7mMF2sLa75RsTctUPDT28jt9L\" rel=\"nofollow noopener\" target=\"_blank\">Christine.Cassiano@allogene.com<\/a><\/p>\n<p>\n        <strong>Additional Allogene Media Contact:<\/strong><br \/>\n        <br \/>Madeleine Goldstein<br \/>Manager, Corporate &amp; Pipeline Communications<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=MrcXl7psTgmbKOYqjXcED0NWpsht_5cJ82HBzTL_u0lXSgtyT7lv9ULwDsVjrghZN3oSxxAVide7v97JnKAqZzQElhT-XYq4uFiP1CgQnZSMx5NjFIDY553Kv6WID5fW\" rel=\"nofollow noopener\" target=\"_blank\">Madeleine.Goldstein@allogene.com<\/a><\/p>\n<p>      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgzNzU0NSM1NTg4ODczIzIxMjQyNDc=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/YzQ2NzQxZmItMDQxOS00MWI1LTg3ZjEtYzA2MDI4NmQ1OGNkLTExMzU4MTg=\/tiny\/Allogene-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Data Will Also Be Presented in a Poster Session at the American Society of Clinical Oncology (ASCO) Annual Meeting on June 3, 2023 SOUTH SAN FRANCISCO, Calif., May 11, 2023 (GLOBE NEWSWIRE) &#8212; Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T\u2122) products for cancer,\u00a0today announced an encore presentation of data from the Phase 1 ALPHA\/ALPHA2 trials of ALLO-501\/501A at the European Hematology Association (EHA) Hybrid Congress on June\u00a08\u201311, 2023 in\u00a0Frankfurt, Germany. The ALPHA\/ALPHA2 trials were designed to assess the safety, tolerability, and preliminary efficacy at increasing dose levels of ALLO-501 and ALLO-501A, allogeneic CAR T cell product candidates that target CD19. In addition to exploring cell doses, these studies evaluated &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Allogene Therapeutics Announces Encore Presentation of Phase 1 Data from the ALLO-501\/501A Trials in Large B Cell Lymphoma at the European Hematology Association (EHA) Hybrid Congress&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-758015","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Allogene Therapeutics Announces Encore Presentation of Phase 1 Data from the ALLO-501\/501A Trials in Large B Cell Lymphoma at the European Hematology Association (EHA) Hybrid Congress - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Allogene Therapeutics Announces Encore Presentation of Phase 1 Data from the ALLO-501\/501A Trials in Large B Cell Lymphoma at the European Hematology Association (EHA) Hybrid Congress - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Data Will Also Be Presented in a Poster Session at the American Society of Clinical Oncology (ASCO) Annual Meeting on June 3, 2023 SOUTH SAN FRANCISCO, Calif., May 11, 2023 (GLOBE NEWSWIRE) &#8212; Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T\u2122) products for cancer,\u00a0today announced an encore presentation of data from the Phase 1 ALPHA\/ALPHA2 trials of ALLO-501\/501A at the European Hematology Association (EHA) Hybrid Congress on June\u00a08\u201311, 2023 in\u00a0Frankfurt, Germany. The ALPHA\/ALPHA2 trials were designed to assess the safety, tolerability, and preliminary efficacy at increasing dose levels of ALLO-501 and ALLO-501A, allogeneic CAR T cell product candidates that target CD19. In addition to exploring cell doses, these studies evaluated &hellip; Continue reading &quot;Allogene Therapeutics Announces Encore Presentation of Phase 1 Data from the ALLO-501\/501A Trials in Large B Cell Lymphoma at the European Hematology Association (EHA) Hybrid Congress&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-05-11T15:53:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgzNzU0NSM1NTg4ODczIzIxMjQyNDc=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Allogene Therapeutics Announces Encore Presentation of Phase 1 Data from the ALLO-501\\\/501A Trials in Large B Cell Lymphoma at the European Hematology Association (EHA) Hybrid Congress\",\"datePublished\":\"2023-05-11T15:53:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\\\/\"},\"wordCount\":984,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODgzNzU0NSM1NTg4ODczIzIxMjQyNDc=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\\\/\",\"name\":\"Allogene Therapeutics Announces Encore Presentation of Phase 1 Data from the ALLO-501\\\/501A Trials in Large B Cell Lymphoma at the European Hematology Association (EHA) Hybrid Congress - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/","og_locale":"en_US","og_type":"article","og_title":"Allogene Therapeutics Announces Encore Presentation of Phase 1 Data from the ALLO-501\/501A Trials in Large B Cell Lymphoma at the European Hematology Association (EHA) Hybrid Congress - Market Newsdesk","og_description":"Data Will Also Be Presented in a Poster Session at the American Society of Clinical Oncology (ASCO) Annual Meeting on June 3, 2023 SOUTH SAN FRANCISCO, Calif., May 11, 2023 (GLOBE NEWSWIRE) &#8212; Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T\u2122) products for cancer,\u00a0today announced an encore presentation of data from the Phase 1 ALPHA\/ALPHA2 trials of ALLO-501\/501A at the European Hematology Association (EHA) Hybrid Congress on June\u00a08\u201311, 2023 in\u00a0Frankfurt, Germany. The ALPHA\/ALPHA2 trials were designed to assess the safety, tolerability, and preliminary efficacy at increasing dose levels of ALLO-501 and ALLO-501A, allogeneic CAR T cell product candidates that target CD19. In addition to exploring cell doses, these studies evaluated &hellip; Continue reading \"Allogene Therapeutics Announces Encore Presentation of Phase 1 Data from the ALLO-501\/501A Trials in Large B Cell Lymphoma at the European Hematology Association (EHA) Hybrid Congress\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/","og_site_name":"Market Newsdesk","article_published_time":"2023-05-11T15:53:42+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgzNzU0NSM1NTg4ODczIzIxMjQyNDc=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Allogene Therapeutics Announces Encore Presentation of Phase 1 Data from the ALLO-501\/501A Trials in Large B Cell Lymphoma at the European Hematology Association (EHA) Hybrid Congress","datePublished":"2023-05-11T15:53:42+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/"},"wordCount":984,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgzNzU0NSM1NTg4ODczIzIxMjQyNDc=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-announces-encore-presentation-of-phase-1-data-from-the-allo-501-501a-trials-in-large-b-cell-lymphoma-at-the-european-hematology-association-eha-hybrid-congress\/","name":"Allogene Therapeutics Announces Encore Presentation of Phase 1 Data from the ALLO-501\/501A Trials in Large B Cell Lymphoma at the European Hematology Association (EHA) Hybrid Congress - 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