{"id":757176,"date":"2023-05-10T07:33:11","date_gmt":"2023-05-10T11:33:11","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/vigil-neuroscience-reports-first-quarter-2023-financial-results-and-provides-business-update\/"},"modified":"2023-05-10T07:33:11","modified_gmt":"2023-05-10T11:33:11","slug":"vigil-neuroscience-reports-first-quarter-2023-financial-results-and-provides-business-update","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/vigil-neuroscience-reports-first-quarter-2023-financial-results-and-provides-business-update\/","title":{"rendered":"Vigil Neuroscience Reports First Quarter 2023 Financial Results and Provides Business Update"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>&#8211; Partial clinical hold lifted by FDA on VGL101 &#8211;<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>&#8211; Launched ALSPAware to provide access to no-cost genetic testing and counseling for ALSP &#8211;<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>&#8211; Appointed distinguished biopharmaceutical industry leader, Samantha Budd Haeberlein, Ph.D., to Board of Directors &#8211;<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>&#8211; Interim data from IGNITE Phase 2 clinical trial of VGL101 in patients with ALSP expected in the fourth quarter of 2023 &#8211;<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>&#8211; Small molecule TREM2 agonist IND submission and initiation of the Phase 1 clinical trial planned for the fourth quarter of 2023 &#8211; <\/em>\n      <\/p>\n<p align=\"center\">\n        <em>&#8211; On track to report full data analysis from Phase 1 healthy volunteer trial of VGL101 in the second half of 2023 &#8211; <\/em>\n      <\/p>\n<p>WATERTOWN, Mass., May  10, 2023  (GLOBE NEWSWIRE) &#8212; Vigil Neuroscience, Inc. (Nasdaq: VIGL), a clinical-stage biotechnology company committed to harnessing the power of microglia for the treatment of neurodegenerative diseases, today announced financial results for the first quarter ended March 31, 2023, and provided an update on recent progress.<\/p>\n<p>\u201cWe continue to make considerable progress in advancing VGL101 and our small molecule TREM2 agonist program and believe we are well-positioned to execute on multiple value enhancing milestones in 2023. Our IGNITE Phase 2 trial evaluating VGL101 in patients with ALSP is enrolling as expected and we plan to report our first interim update from the first six patients treated for six months with VGL101 in the fourth quarter of this year. We also remain on track to present the full data analysis from the VGL101 Phase 1 trial in the second half of this year. In addition, we are proud of the recent launch of <em>ALSPAware<\/em> as part of our continued efforts to support the ALSP community. Given that only one-third of those living with ALSP receive a correct initial diagnosis, we believe this new program will help both physicians and individuals reach an accurate diagnosis earlier,\u201d said Ivana Magov\u010devi\u0107-Liebisch, Ph.D., J.D., President and Chief Executive Officer of Vigil. \u201cWe have also continued to advance our lead small molecule candidate toward the clinic and expect to submit an IND and initiate a Phase 1 trial in healthy volunteers in the fourth quarter of 2023. We are committed to achieving these important milestones as part of our patient-centered mission of developing potentially transformative treatments for rare and common neurodegenerative diseases.\u201d<\/p>\n<p>\n        <strong><br \/>\n          <u>Recent Highlights and Anticipated Milestones<\/u><br \/>\n        <\/strong>\n      <\/p>\n<p>\n        <strong>VGL101, Monoclonal Antibody TREM2 Agonist <\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>\n          <strong>Announced FDA lifted partial clinical hold on doses greater than 20 mg\/kg for<\/strong><br \/>\n          <strong>VGL101:<\/strong> In March 2023, Vigil announced that the U.S. Food and Drug Administration (FDA) lifted its partial clinical hold on doses greater than 20 mg\/kg for VGL101 in its ongoing and future clinical trials in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP).<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>\n          <strong>Presented multiple presentations on ALSP at the 2023 American Academy of Neurology (AAN) Annual Meeting:<\/strong> In April 2023, Vigil presented three oral presentations and two poster presentations on ALSP, including previously reported VGL101 Phase 1 interim top-line data and the ILLUMINATE natural history study interim data. The Company also presented key findings on the diverse phenotype, radiological features, and reasons for misdiagnosis and disease progression of ALSP. These presentations can be accessed on the <a href=\"https:\/\/www.vigilneuro.com\/press-releases-publications\" rel=\"nofollow noopener\" target=\"_blank\">publications page<\/a> of the Company\u2019s website.<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>\n          <strong>Launched <\/strong><br \/>\n          <strong><br \/>\n            <em>ALSPAware<\/em><br \/>\n          <\/strong><br \/>\n          <strong> program to provide access to no-cost genetic testing and counseling for ALSP: <\/strong> In May 2023, Vigil launched <em>ALSPAware<\/em>, a new genetic testing and counseling initiative designed to enable improved patient diagnosis of ALSP. Developed with both patients and healthcare providers in mind, the program includes a single gene confirmatory test for individuals with a family history of ALSP, as well as a custom gene panel available for physicians to use in diagnosing adult-onset neurological diseases. By increasing access to genetic testing for both individuals and healthcare providers, we believe <em>ALSPAware <\/em>has the potential to help reduce initial misdiagnosis of this disease, while also providing appropriate disease management services for those living with ALSP.<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>\n          <strong>On track to present the full data analysis from the Phase 1 single and multiple ascending dose (SAD and MAD) healthy volunteer trial in the second half of 2023: <\/strong>The Company has completed dosing of the 60 mg\/kg SAD and MAD cohorts in Australia in which VGL101 continued to be safe and well tolerated and expects to report the full data analysis from the Phase 1 trial during the second half of 2023.<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>\n          <strong>First interim data readout from ongoing IGNITE Phase 2 clinical trial expected in the fourth quarter of 2023: <\/strong>IGNITE, the first-ever interventional trial in ALSP, is a global Phase 2, open-label trial designed to evaluate the safety and tolerability of VGL101 in up to 15 patients with symptomatic ALSP who have a <em>CSF1R<\/em> gene mutation. Patients enrolled in the trial receive an intravenous (IV) infusion of 20 mg\/kg of VGL101 approximately every four weeks, for a treatment duration of one year. The Company expects to report six-month interim data from the first six patients in the trial in the fourth quarter of 2023.<\/li>\n<\/ul>\n<p>\n        <strong>Small Molecule TREM2 Agonist Program <\/strong><br \/>\n        \n      <\/p>\n<ul type=\"disc\">\n<li>\n          <strong>Presented small molecule TREM2 agonist program preclinical data at the AD\/PD, Alzheimer\u2019s &amp; Parkinson\u2019s Diseases International Conference:<\/strong> In April 2023, Vigil presented an oral presentation highlighting preclinical data from the characterization of its small molecule TREM2 agonist program supporting further development as a potential treatment of Alzheimer\u2019s disease (AD). This presentation can be accessed on the <a href=\"https:\/\/www.vigilneuro.com\/press-releases-publications\" rel=\"nofollow noopener\" target=\"_blank\">publications page<\/a> of the Company\u2019s website.<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>\n          <strong>Continued advancement of small molecule TREM2 agonist program toward the clinic:<\/strong> Vigil\u2019s highly active, selective and brain-penetrant small molecule agonists are designed to act as a molecular glue that potentiates the TREM2 signaling response to natural damage ligands. Vigil has established that its small molecule agonists demonstrate on-target TREM2 activation across both common and rare TREM2 variants. Additionally, the Company has demonstrated that its small molecule agonists were able to deliver <em>in vivo<\/em> TREM2 responses within the central nervous system at a magnitude and specificity similar to VGL101. The Company expects to submit an Investigational New Drug (IND) application to the FDA and, subject to FDA clearance of the IND, initiate clinical development for its lead small molecule TREM2 agonist, with an initial focus in genetically defined Alzheimer\u2019s disease subpopulations, in the fourth quarter of 2023.<\/li>\n<\/ul>\n<p>\n        <strong>Corporate<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>\n          <strong>Added distinguished leader in biopharmaceutical industry to Board of Directors:<\/strong> In May 2023, Vigil appointed Samantha Budd Haeberlein, Ph.D. to its Board of Directors. Dr. Budd Haeberlein brings more than 20 years of biopharmaceutical industry experience across research, translational medicine, and clinical development with a focus on CNS indications, including rare and common neurological disorders.<\/li>\n<\/ul>\n<p>\n        <strong>Upcoming Events<\/strong>\n      <\/p>\n<p>Vigil plans to participate at the following investor conferences:<\/p>\n<ul type=\"disc\">\n<li>Mizuho Neuroscience Summit on May 16, 2023<\/li>\n<li>Jefferies Healthcare Conference from June 7-9, 2023<\/li>\n<\/ul>\n<p>\n        <strong><br \/>\n          <u>First Quarter 2023 Financial Results<\/u><br \/>\n        <\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>\n          <strong>Cash Position: <\/strong>Cash, cash equivalents, and marketable securities were $164.5 million as of March 31, 2023, compared to $186.6 million as of December 31, 2022. The Company expects its cash, cash equivalents and marketable securities to fund its operational plans into the first quarter of 2025.<\/li>\n<li>\n          <strong>Research and Development<\/strong> (<strong>R&amp;D) Expenses: <\/strong>R&amp;D expenses for the first quarter ended March 31, 2023, were $13.8 million, compared to $10.4 million for the same period in 2022. This increase was primarily driven by increased preclinical activity related to the Company\u2019s small molecule program, increased clinical trial related expenses associated with advancing the VGL101 program into a phase 2 clinical trial, and increased headcount to support the Company\u2019s continued growth.<\/li>\n<li>\n          <strong>General and Administrative<\/strong> (<strong>G&amp;A) Expenses: <\/strong>G&amp;A expenses for the first quarter ended March 31, 2023, were $6.9 million, compared to $5.0 million for the same period in 2022. The increase was primarily attributable to increases in headcount-related costs to support the Company\u2019s growth.<\/li>\n<li>\n          <strong>Net Loss: <\/strong>Loss from operations for the first quarter ended March 31, 2023, were $19.8 million, compared to $15.3 million for the same period in 2022.<\/li>\n<\/ul>\n<p>\n        <strong>About Vigil Neuroscience<\/strong><br \/>\n        <br \/>Vigil Neuroscience is a clinical-stage biotechnology company focused on developing treatments for both rare and common neurodegenerative diseases by restoring the vigilance of microglia, the sentinel immune cells of the brain. We are utilizing the tools of modern neuroscience drug development across multiple therapeutic modalities in our efforts to develop precision-based therapies to improve the lives of patients and their families. VGL101, our lead candidate, is a fully human monoclonal antibody agonist targeting human triggering receptor expressed on myeloid cells 2 (TREM2) and is in a Phase 2 proof-of-concept trial in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare and fatal neurodegenerative disease. We are also conducting IND-enabling studies with a novel small molecule TREM2 agonist program to treat common neurodegenerative diseases associated with microglial dysfunction, with an initial focus on Alzheimer\u2019s disease (AD) in genetically defined subpopulations.<\/p>\n<p>\n        <strong>Forward-Looking Statements<\/strong><br \/>\n        <br \/>This press release includes certain disclosures that contain \u201cforward-looking statements\u201d of Vigil Neuroscience\u2019s (\u201cVigil\u201d or the \u201cCompany\u201d) that are made pursuant to the safe harbor provisions of the federal securities laws, including, without limitation, express or implied statements regarding: the Company\u2019s strategy, business plans and focus; the potential design, access, benefits and success of <em>ALSPAware<\/em>, including the belief that the program will ease the diagnostic journey for patients and their families; the progress and timing of the preclinical and clinical development of Vigil\u2019s programs, including the availability of data and expected timing for reporting interim data from IGNITE Phase 2 clinical trial in the fourth quarter of 2023, filing an IND application for its small molecule TREM2 agonist program and the initiation of the Phase 1 clinical trial in the fourth quarter of 2023 and reporting full data analysis from its Phase 1 healthy volunteer trial of VGL101 in the second half of 2023; the success and timing of its interactions with regulatory authorities; expectations regarding the development of VGL101 in ALSP and other indications, its small molecule TREM2 agonist program in AD, and the development of other pipeline candidates, including its expected therapeutic benefits as well as its safety and tolerability profile; the Company\u2019s cash runway into first quarter of 2025; expectations regarding the use of capital, expenses and other financial results in the future. Forward-looking statements are based on Vigil\u2019s current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, risks and uncertainties related to uncertainties inherent in the identification and development of product candidates, including the conduct of research activities and the initiation and completion of preclinical studies and clinical trials; uncertainties as to the availability and timing of results and data from preclinical and clinical studies; the timing of the Company\u2019s ability to submit and obtain regulatory clearance for investigational new drug applications and initiate additional clinical trials; whether results from preclinical studies will be predictive of the results of later preclinical studies and clinical trials; the Company\u2019s ability to initiate and complete its current and expected clinical trials; whether Vigil\u2019s cash resources will be sufficient to fund its foreseeable and unforeseeable operating expenses and capital expenditure requirements; uncertainties associated with the impact of the COVID-19 pandemic on its business and operations; as well as the risks and uncertainties identified in the Company\u2019s filings with the Securities and Exchange Commission (SEC), including Vigil\u2019s Annual Report on Form 10-K for the year ended December 31, 2022 and in any subsequent filings it may make with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Vigil undertakes no duty to update such information except as required under applicable law. Readers should not rely upon the information on this page as current or accurate after its publication date.<\/p>\n<p>\n        \n      <\/p>\n<table align=\"center\" style=\"border-collapse: collapse;width:100%;border-collapse:collapse\">\n<tr>\n<td colspan=\"9\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>VIGIL NEUROSCIENCE, INC.<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"9\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>Consolidated Statements of Operations<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"9\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>(in thousands, except share and per share data)<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"9\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>(unaudited)<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"7\" style=\"border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>Three Months Ended<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>March\u00a031,<\/strong><br \/>\n            <br \/>\n            <strong>2023<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>March\u00a031,<\/strong><br \/>\n            <br \/>\n            <strong>2022<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: top;vertical-align: bottom\">Operating expenses:<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"max-width:64%;width:64%;min-width:64%;vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: top;vertical-align: bottom\">Research and development<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: middle;text-align: left;padding-left: 25.0px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">$<\/td>\n<td style=\"max-width:15%;width:15%;min-width:15%;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">13,834<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">$<\/td>\n<td style=\"max-width:15%;width:15%;min-width:15%;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">10,365<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: top;vertical-align: bottom\">General and administrative<\/td>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 25.0px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">6,941<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">4,967<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 30.0px;vertical-align: top;vertical-align: bottom\">Total operating expenses<\/td>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 30.0px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">20,775<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">15,332<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: top;vertical-align: bottom\">Loss from operations<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">(20,775<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">)<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">(15,332<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">)<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: top;vertical-align: bottom\">Other income (expense):<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: top;vertical-align: bottom\">Interest income, net<\/td>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 25.0px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">985<\/td>\n<td style=\"padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">2<\/td>\n<td style=\"padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: top;vertical-align: bottom\">Other income (expense), net<\/td>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 25.0px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">(5<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">)<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">(4<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">)<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 30.0px;vertical-align: top;vertical-align: bottom\">Total other expense, net<\/td>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 30.0px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">(980<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">)<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">(2<\/td>\n<td style=\"border-bottom: solid black 1pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">)<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: top;vertical-align: bottom\">Net loss and comprehensive loss<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">$<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">(19,795<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">)<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">$<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">(15,334<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">)<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: top;vertical-align: bottom\">Net loss per share attributable to common stockholders, basic and diluted<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">$<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">(0.51<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">)<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">$<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">(0.58<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">)<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: top;vertical-align: bottom\">Weighted\u2014average common shares outstanding, basic, and diluted<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">38,546,012<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">26,660,246<\/td>\n<td style=\"border-bottom: double 15px 3pt;padding-left: 0;text-align: left;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<\/table>\n<p>\n        \n      <\/p>\n<table align=\"center\" style=\"border-collapse: collapse;width:100%;border-collapse:collapse\">\n<tr>\n<td colspan=\"7\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>VIGIL NEUROSCIENCE, INC.<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"7\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>Selected Balance Sheet Data<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"7\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>(in thousands)<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"7\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>(unaudited)<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>March\u00a031, 2023<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>December\u00a031, 2022<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td style=\"max-width:66%;width:66%;min-width:66%;vertical-align: top;vertical-align: bottom\">Cash, cash equivalents, and marketable securities<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">$<\/td>\n<td style=\"max-width:15%;width:15%;min-width:15%;padding-left: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">164,480<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">$<\/td>\n<td style=\"max-width:15%;width:15%;min-width:15%;padding-left: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">186,605<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: top;vertical-align: bottom\">Total assets<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-left: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">192,361<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-left: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">200,393<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: top;vertical-align: bottom\">Total liabilities<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-left: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">21,021<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-left: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">11,312<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: top;vertical-align: bottom\">Total stockholders&#8217; equity<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-left: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">171,340<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-right: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"padding-left: 0;text-align: right;vertical-align: middle;vertical-align: bottom\">189,081<\/td>\n<\/tr>\n<\/table>\n<p>\n        <strong><br \/>\n          <br \/>\n        <\/strong>\n      <\/p>\n<p>\n        <strong>Investor Contact:<\/strong><br \/>\n        <br \/>Stern Investor Relations<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=4gdhw9yoZgCD3J5kipJ4gGeaB-QEQaaXsKbfv1DcNij9IidYJ1cqRTwePeIFAUvvOj9XAZ1W1sO_AKRat6Vm5nMGJGWejnRjhtx1xJWK79U=\" rel=\"nofollow noopener\" target=\"_blank\">investors@vigilneuro.com<\/a><\/p>\n<p>\n        <strong>Media <\/strong><br \/>\n        <strong>Contact:<\/strong><br \/>\n        <br \/>Megan McGrath <br \/>MacDougall Advisors<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=oPPnfgKoQpWMup7LnKgap7xtzALjqtPZAe8rtJoy1xg52H9WYW-bPoRXptPnUJmRhjamxnksXbEqtxYFGwY4gP6SPFuVJSRfWGh825b4EJ4=\" rel=\"nofollow noopener\" target=\"_blank\">mmcgrath@macdougall.bio<\/a><\/p>\n<p>      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgzNTc3NiM1NTg1NjQ4IzIyMjMxMTg=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/ZjI1NDcxYjMtMjE5MS00M2Q5LWFjOTItMzE4NzE2YzAzZDhiLTEyMzQ2NzE=\/tiny\/Vigil-Neuroscience-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>&#8211; Partial clinical hold lifted by FDA on VGL101 &#8211; &#8211; Launched ALSPAware to provide access to no-cost genetic testing and counseling for ALSP &#8211; &#8211; Appointed distinguished biopharmaceutical industry leader, Samantha Budd Haeberlein, Ph.D., to Board of Directors &#8211; &#8211; Interim data from IGNITE Phase 2 clinical trial of VGL101 in patients with ALSP expected in the fourth quarter of 2023 &#8211; &#8211; Small molecule TREM2 agonist IND submission and initiation of the Phase 1 clinical trial planned for the fourth quarter of 2023 &#8211; &#8211; On track to report full data analysis from Phase 1 healthy volunteer trial of VGL101 in the second half of 2023 &#8211; WATERTOWN, Mass., May 10, 2023 (GLOBE NEWSWIRE) &#8212; Vigil Neuroscience, Inc. &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/vigil-neuroscience-reports-first-quarter-2023-financial-results-and-provides-business-update\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Vigil Neuroscience Reports First Quarter 2023 Financial Results and Provides Business Update&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-757176","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Vigil Neuroscience Reports First Quarter 2023 Financial Results and Provides Business Update - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/vigil-neuroscience-reports-first-quarter-2023-financial-results-and-provides-business-update\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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Phase 2 clinical trial of VGL101 in patients with ALSP expected in the fourth quarter of 2023 &#8211; &#8211; Small molecule TREM2 agonist IND submission and initiation of the Phase 1 clinical trial planned for the fourth quarter of 2023 &#8211; &#8211; On track to report full data analysis from Phase 1 healthy volunteer trial of VGL101 in the second half of 2023 &#8211; WATERTOWN, Mass., May 10, 2023 (GLOBE NEWSWIRE) &#8212; Vigil Neuroscience, Inc. &hellip; Continue reading \"Vigil Neuroscience Reports First Quarter 2023 Financial Results and Provides Business Update\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/vigil-neuroscience-reports-first-quarter-2023-financial-results-and-provides-business-update\/","og_site_name":"Market 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