{"id":753711,"date":"2023-05-02T10:42:21","date_gmt":"2023-05-02T14:42:21","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\/"},"modified":"2023-05-02T10:42:21","modified_gmt":"2023-05-02T14:42:21","slug":"horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\/","title":{"rendered":"Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis"},"content":{"rendered":"

<\/p>\n

Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis<\/b><\/p>\n

DUBLIN–(BUSINESS WIRE<\/a>)–
\nHorizon Therapeutics plc (Nasdaq: HZNP) today announced the first patient has enrolled in a Phase 2 randomized placebo-controlled trial to evaluate its development-stage medicine daxdilimab, a potentially first-in-class, fully human monoclonal antibody targeting immunoglobulin-like transcript 7 (ILT7) that depletes certain dendritic cells, to treat people with active proliferative lupus nephritis (LN).<\/p>\n

\nLN is a rare, autoimmune and inflammatory condition of the kidney and represents a common organ manifestation of systemic lupus erythematosus (SLE), a multisystem autoimmune disease. Between 31 and 60 percent of SLE patients live with LN1<\/sup> and in the United States, Horizon estimates that approximately 60,000 patients with LN are appropriate for treatment with novel therapies, including biologics. The disease is more prevalent in certain ethnic groups such as African American, Asian and Hispanic populations.2<\/sup><\/p>\n

\n\u201cFor individuals living with LN, evaluating a safe and effective treatment that can prevent worsening kidney damage and decrease the risk of kidney failure and end-stage renal disease is a key objective,\u201d said Kenneth Kalunian, M.D., professor of medicine, division of rheumatology, allergy and immunology, University of California, San Diego. \u201cCurrent treatment regimens include intensive immunosuppressive therapy that can be associated with several adverse events. There is a need to identify a more specific medicine for those with proliferative LN.\u201d<\/p>\n

\nApproximately 210 participants who meet trial eligibility are expected to be enrolled. The primary endpoint is the proportion of participants who achieve a sustained complete renal response (CRR) between Week 48 and Week 52. This is a composite endpoint defined as a reduction in proteinuria and preservation or improvement of renal function.3 <\/sup>Secondary endpoints include the proportion of participants achieving overall renal response (ORR), which is defined as CRR combined with partial renal response (PRR). To evaluate the steroid-sparing effects of daxdilimab, the proportion of participants who are able to effectively taper oral corticosteroids by Week 24 and maintain a low dose through Week 52 will also be evaluated.<\/p>\n

\n\u201cLN is a serious manifestation of SLE and requires urgent treatment to avoid chronic kidney disease, dialysis or kidney transplantation,\u201d said Theresa Podrebarac, M.D., M.Sc., senior vice president, clinical development, Horizon. \u201cEarly studies point to the role of plasmacytoid dendritic cells (pDCs) and type 1 interferons in its pathogenesis. As a part of our commitment to addressing better treatment options for autoimmune diseases, we are currently evaluating daxdilimab in SLE as well as a variety of other conditions.\u201d<\/p>\n

About Daxdilimab<\/b><\/p>\n

Daxdilimab<\/a> is an anti-ILT7 human monoclonal antibody that depletes certain dendritic cells. Depleting these cells may interrupt the cycle of inflammation that causes tissue damage in a variety of autoimmune conditions. Horizon is also investigating daxdilimab in alopecia areata,<\/a>discoid lupus erythematosus,<\/a>systemic lupus erythematosus<\/a> and plans to investigate it in dermatomyositis or anti-synthetase inflammatory myositis.<\/p>\n

About Horizon<\/b><\/p>\n

\nHorizon is a global biotechnology company focused on the discovery, development and commercialization of medicines that address critical needs for people impacted by rare, autoimmune and severe inflammatory diseases. Our pipeline is purposeful: We apply scientific expertise and courage to bring clinically meaningful therapies to patients. We believe science and compassion must work together to transform lives. For more information on how we go to incredible lengths to impact lives, visit www.horizontherapeutics.com<\/a> and follow us on Twitter<\/a>, LinkedIn<\/a>, Instagram<\/a> and Facebook<\/a>.<\/p>\n

Forward-Looking Statements<\/b><\/p>\n

\nThis press release contains forward-looking statements, including, but not limited to, statements related to the potential benefits of daxdilimab; the expected scope, endpoints and timing of Horizon\u2019s Phase 2 clinical trial of daxdilimab in proliferative lupus nephritis and other statements that are not historical facts. These forward-looking statements are based on Horizon\u2019s current expectations and inherently involve significant risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks related to clinical trials, including the fact that prior results may not predict future clinical trial outcomes; impacts of pandemics and geopolitical conflicts and related disruptions to healthcare activities, including potential delays in clinical trials; regulatory obligations and oversight, including any changes in the legal and regulatory environment in which Horizon operates and those risks detailed from time-to-time under the caption “Risk Factors” and elsewhere in Horizon\u2019s filings and reports with the SEC. Horizon undertakes no duty or obligation to update any forward-looking statements contained in this press release as a result of new information.<\/p>\n

References<\/b><\/p>\n

    \n
  1. \nBorchers AT, Naguwa SM, Shoenfeld Y, Gershwin ME. The geoepidemiology of systemic lupus erythematosus. Autoimmun Rev<\/i>. 2010;9(5):A277-A287.<\/p>\n<\/li>\n
  2. \nHanly JG, O’Keeffe AG, Su L, et al. The frequency and outcome of lupus nephritis: results from an international inception cohort study. Rheumatology (Oxford)<\/i>. 2016;55(2):252-262.<\/p>\n<\/li>\n
  3. \nU.S. Food and Drug Administration, Center for Drug Evaluation and Research. Table of Surrogate Endpoints That Were the Basis of Drug Approval or Licensure. U.S. Food and Drug Administration.<\/i>https:\/\/www.fda.gov\/drugs\/development-resources\/table-surrogate-endpoints-were-basis-drug-approval-or-licensure<\/a>. Accessed July 18, 2022.<\/p>\n<\/li>\n
  4. \nEstimated glomerular filtration rate (egfr): Definition & results. Cleveland Clinic. https:\/\/my.clevelandclinic.org\/health\/diagnostics\/21593-estimated-glomerular-filtration-rate-egfr<\/a>. Accessed June 28, 2022.<\/p>\n<\/li>\n<\/ol>\n

    \n\u00a0<\/p>\n

    \"\"<\/p>\n

    View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20230502005802\/en\/<\/a><\/span><\/p>\n

    \nTina Ventura
    \n
    Senior Vice President, Chief Investor Relations Officer
    \n
    Investor-relations@horizontherapeutics.com<\/a><\/p>\n

    \nErin Linnihan
    \n
    Executive Director, Investor Relations
    \n
    Investor-relations@horizontherapeutics.com<\/a><\/p>\n

    \nU.S. Media:
    \n
    Geoff Curtis
    \n
    Executive Vice President, Corporate Affairs & Chief Communications Officer
    \n
    media@horizontherapeutics.com<\/a><\/p>\n

    \nIreland Media:
    \n
    Eimear Rigby
    \n
    Associate Director, Corporate Communications
    \n
    media@horizontherapeutics.com<\/a><\/p>\n

    KEYWORDS:<\/b> New York Europe Ireland United States North America<\/p>\n

    INDUSTRY KEYWORDS:<\/b> Health Genetics Other Health Clinical Trials Pharmaceutical Biotechnology<\/p>\n

    MEDIA:<\/b><\/p>\n\n\n\n\n
    Logo<\/b><\/font><\/td>\n<\/tr>\n
    \"Logo\"<\/td>\n<\/tr>\n
    <\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

    Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis DUBLIN–(BUSINESS WIRE)– Horizon Therapeutics plc (Nasdaq: HZNP) today announced the first patient has enrolled in a Phase 2 randomized placebo-controlled trial to evaluate its development-stage medicine daxdilimab, a potentially first-in-class, fully human monoclonal antibody targeting immunoglobulin-like transcript 7 (ILT7) that depletes certain dendritic cells, to treat people with active proliferative lupus nephritis (LN). LN is a rare, autoimmune and inflammatory condition of the kidney and represents a common organ manifestation of systemic lupus erythematosus (SLE), a multisystem autoimmune disease. Between 31 and 60 percent of SLE patients live with LN1 and in the United States, Horizon estimates that approximately 60,000 patients … <\/p>\n

    Continue reading “Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-753711","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nHorizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis DUBLIN–(BUSINESS WIRE)– Horizon Therapeutics plc (Nasdaq: HZNP) today announced the first patient has enrolled in a Phase 2 randomized placebo-controlled trial to evaluate its development-stage medicine daxdilimab, a potentially first-in-class, fully human monoclonal antibody targeting immunoglobulin-like transcript 7 (ILT7) that depletes certain dendritic cells, to treat people with active proliferative lupus nephritis (LN). LN is a rare, autoimmune and inflammatory condition of the kidney and represents a common organ manifestation of systemic lupus erythematosus (SLE), a multisystem autoimmune disease. Between 31 and 60 percent of SLE patients live with LN1 and in the United States, Horizon estimates that approximately 60,000 patients … Continue reading "Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-05-02T14:42:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20230502005802r1&sid=flmnd&distro=nx&lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis\",\"datePublished\":\"2023-05-02T14:42:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\\\/\"},\"wordCount\":945,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&sty=20230502005802r1&sid=flmnd&distro=nx&lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\\\/\",\"name\":\"Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis - 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LN is a rare, autoimmune and inflammatory condition of the kidney and represents a common organ manifestation of systemic lupus erythematosus (SLE), a multisystem autoimmune disease. Between 31 and 60 percent of SLE patients live with LN1 and in the United States, Horizon estimates that approximately 60,000 patients … Continue reading \"Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\/","og_site_name":"Market Newsdesk","article_published_time":"2023-05-02T14:42:21+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20230502005802r1&sid=flmnd&distro=nx&lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis","datePublished":"2023-05-02T14:42:21+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\/"},"wordCount":945,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20230502005802r1&sid=flmnd&distro=nx&lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/horizon-therapeutics-plc-announces-first-patient-enrolled-in-phase-2-trial-evaluating-daxdilimab-for-the-treatment-of-lupus-nephritis\/","name":"Horizon Therapeutics plc Announces First Patient Enrolled in Phase 2 Trial Evaluating Daxdilimab for the Treatment of Lupus Nephritis - 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