{"id":746566,"date":"2023-04-11T08:25:32","date_gmt":"2023-04-11T12:25:32","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/"},"modified":"2023-04-11T08:25:32","modified_gmt":"2023-04-11T12:25:32","slug":"in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/","title":{"rendered":"IN8bio to Present New Positive Clinical Data from Phase 1 Trial of INB-100 at EBMT 2023 Annual Meeting"},"content":{"rendered":"<div class=\"mw_release\">\n<ul type=\"disc\">\n<li>\n          <em>Updated data on durability of responses and long-term complete responses (CRs) in leukemia patients treated with INB-100 will be presented; no dose-limiting toxicities have been observed<\/em><\/p>\n<\/li>\n<li>\n          <em>New correlative data on immune reconstitution and gamma-delta T cell proliferation for Cohorts 1 and 2 will be presented<\/em><br \/>\n          \n        <\/li>\n<\/ul>\n<p align=\"justify\">NEW YORK, April  11, 2023  (GLOBE NEWSWIRE) &#8212; IN8bio, Inc. (Nasdaq: INAB), a clinical-stage biopharmaceutical company discovering and developing innovative gamma-delta T cell therapies, today announced that new data from the ongoing Phase 1 trial evaluating INB-100, an allogeneic, gamma-delta T cell therapy, in patients with hematologic malignancies undergoing haploidentical stem cell transplantation (HSCT), will be presented at the 49th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), being held in Paris, France April 23-26.<\/p>\n<p align=\"justify\">Four patients received dose level (DL) 1 of INB-100 (1 x 10<sup>6<\/sup> cells\/kg) and two patients received DL2 (3 x 10<sup>6<\/sup> cells\/kg) as of the abstract data cutoff of December 18, 2022. All four patients who received DL1 remain on study and in durable complete remission (CR), with one patient remaining progression free for nearly three years at 32.2 months and the others remaining progression free for 29.8, 18.1 and 3.8 months respectively. Immune system reconstitution through the first 100-days post-treatment was robust and durable, with observed elevations in T cells, NK cells, and gamma-delta T cells. Updated data from this Phase 1 study will be presented at the meeting on April 23<sup>rd<\/sup>, 2023.<\/p>\n<p align=\"justify\">\n        <strong>Details for the EBMT 2023 presentation are as follows:<\/strong>\n      <\/p>\n<p>\n        <strong>Title<\/strong>: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=R9DVhZGwNmCjjGTKmWFweBrjdlMqLO3FuIZndESqOb3l9EHtu_hV9CdTLB3rqPwvSGSe30DoOHyZqwmutz5L0HuQTCMrWUUYfIF7XpCdCRoCwcUH3p_nImhI6q03hkxt_9oRwSjWXTKUHtjBabuUKhKatM9Qun320mD6FQJUnjgqWdq6NLaZH2Av2qd2VQM2wMfs8loj8adDIHagJsVG_frGE6ldCP0mqmLIPLyRjYQX8G0fP0y37EMxwHsQrYtfCLNIZPe2o_tXvjvwmlP8bdOm7BEbQpA6-j6apKQLre1gnLRfT3B9Ev7l515Q5oD-FP-vIKgxBY0dQv1WAVs7QHbuvEl7kRxXGHeQdD3iC__sZ_FTQfs_UF-YEcosuylLK0zknoswFnzOJdbiP3XUaw==\" rel=\"nofollow noopener\" target=\"_blank\">INB-100: Relapse Prophylaxis Post-Haploidentical Bone Marrow Transplantation and Cyclophosphamide (Haplo\/Cy) by Infusion of Donor-Derived Expanded\/Activated Gamma-Delta (\u03b3\u03b4) T Cells: A Phase I Trial<\/a><br \/><strong>Presenter<\/strong>: Joseph McGuirk, DO, The University of Kansas Cancer Center<br \/><strong>Abstract<\/strong><strong>#<\/strong>: P239<br \/><strong>Date and time<\/strong>: Sunday, April 23, 8:30 a.m. CET<br \/><strong>Session<\/strong>: ePoster Viewing<\/p>\n<p align=\"justify\">\n        <strong>About the INB-100 Phase 1 Trial<\/strong>\n      <\/p>\n<p align=\"justify\">The Phase 1 clinical trial (<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=6KsbenjQRZSQU7D3dR4cpmoYqsFyWNY3c5ZA-4UGbYAwlUhB02p2fDoJZyItrDVLsIAczOJfXo56ZaCzt-J0si2BJ4yR-3B4rITzyF_lemurHcLKKGlxbnE0Lh9gDzZnq-zpD2HHAaGGWMCKI-aZObk5O2JbOOHSsOnyn_0dPkbzXjTlnsVuPrya6Rzs0UhgTPg1c3l2xqi3_Vhn9Lxkoxquil9B0ArSbcR__ba5X4SOLzDhhoW8SpYYhtO_ayj-HUGZaoMFQQ0crB1dc8_M7Vr3NlMHCQjwk0LtLWPMsQehs_J9Iy1ednXeuxrXstXW\" rel=\"nofollow noopener\" target=\"_blank\">NCT03533816<\/a>) is a dose-escalation trial of allogeneic gamma-delta T cells from matched related donors that have been expanded and activated <em>ex vivo<\/em> and administered systemically to patients with leukemia following HSCT. The single-institution clinical trial is currently being conducted at The University of Kansas Cancer Center (KUCC). The primary endpoints of this trial are safety and tolerability, and secondary endpoints include rates of GvHD, relapse rate and overall survival.<\/p>\n<p>\n        <strong>About IN8bio<\/strong>\n      <\/p>\n<p align=\"justify\">IN8bio is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of gamma-delta T cell product candidates for solid and liquid tumors. Gamma-delta T cells are a specialized population of T cells that possess unique properties, including the ability to differentiate between healthy and diseased tissue. IN8bio\u2019s DeltEx platform employs allogeneic, autologous, iPSC and genetically modified approaches to develop cell therapies, designed to effectively identify and eradicate tumor cells.<\/p>\n<p align=\"justify\">IN8bio is currently conducting two investigator-initiated Phase 1 clinical trials for its lead gamma-delta T cell product candidates: INB-200 for the treatment of newly diagnosed glioblastoma and INB-100 for the treatment of patients with leukemia undergoing hematopoietic stem cell transplantation. IN8bio is initiating INB-400, a company-sponsored Phase 2 clinical trial in newly diagnosed glioblastoma following IND clearance in late 2022. IN8bio also has a broad portfolio of preclinical programs focused on addressing other solid tumor types. For more information about IN8bio and its programs, please visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=PGboZqqiCR4Wu1nwenHDxSDg_gc4d1IUiUyz51IfFSd1wYXwAX39hVonU-C1-z8F4AFplQYFPBz7KtUXENpDfg==\" rel=\"nofollow noopener\" target=\"_blank\">www.IN8bio.com.<\/a><\/p>\n<p align=\"justify\">\n        <strong>Forward Looking Statements<\/strong>\n      <\/p>\n<p align=\"justify\">This press release may contain forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as \u201caims,\u201d \u201canticipates,\u201d \u201cbelieves,\u201d \u201ccould,\u201d \u201cestimates,\u201d \u201cexpects,\u201d \u201cforecasts,\u201d \u201cgoal,\u201d \u201cintends,\u201d \u201cmay,\u201d \u201cplans,\u201d \u201cpossible,\u201d \u201cpotential,\u201d \u201cseeks,\u201d \u201cwill\u201d and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements regarding: future positive results in clinical data relating to the INB-100 study, including results relating to durable CR and immune system reconstitution in patients in this study. IN8bio may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, which are described in greater detail in the section entitled \u201cRisk Factors\u201d in our Annual Report on Form 10-K filed with the Securities and Exchange Commission (SEC) on March 30, 2023, as well as in other filings IN8bio may make with the SEC in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and IN8bio expressly disclaims any obligation to update any forward-looking statements contained herein, whether because of any new information, future events, changed circumstances or otherwise, except as otherwise required by law.<\/p>\n<p>\n        <strong>Company Contact:<\/strong><br \/>\n        <br \/>IN8bio, Inc.<br \/>Patrick McCall<br \/>+ 1 646.600.6GDT (6438)<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=O6QYIE-oPRL-xe2B-cdZD6xJmFs26AJO98HLv9TJCa2DLaxdL-dgip_gKoro-1dxl-iDNO4eK3cUemVKIgHI1g==\" rel=\"nofollow noopener\" target=\"_blank\"><u>info@IN8bio.com<\/u><\/a><\/p>\n<p>\n        <strong>Investors &amp; Media Contact: <\/strong><br \/>\n        <br \/>Argot Partners<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=18MXCf9qI4vieoQC9dPqRZv9RI6wXZyIIPae9W2hcoIkd9fTPWMebayNNqXSWLcQ9edDCUckela-_Id5-5d5btuEcnyAzgJ9rtTStN3bYsM=\" rel=\"nofollow noopener\" target=\"_blank\">IN8bio@argotpartners.com<\/a><\/p>\n<p>      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgwNTEzNiM1NTE3ODUzIzIxMjMwMDY=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/ODc5NDk1YTUtYmM5Mi00ZGNlLTk0NGQtNDdhNWE5ZWQ2YWExLTExMzQ1Nzc=\/tiny\/IN8bio-Inc.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Updated data on durability of responses and long-term complete responses (CRs) in leukemia patients treated with INB-100 will be presented; no dose-limiting toxicities have been observed New correlative data on immune reconstitution and gamma-delta T cell proliferation for Cohorts 1 and 2 will be presented NEW YORK, April 11, 2023 (GLOBE NEWSWIRE) &#8212; IN8bio, Inc. (Nasdaq: INAB), a clinical-stage biopharmaceutical company discovering and developing innovative gamma-delta T cell therapies, today announced that new data from the ongoing Phase 1 trial evaluating INB-100, an allogeneic, gamma-delta T cell therapy, in patients with hematologic malignancies undergoing haploidentical stem cell transplantation (HSCT), will be presented at the 49th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), being held in &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;IN8bio to Present New Positive Clinical Data from Phase 1 Trial of INB-100 at EBMT 2023 Annual Meeting&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-746566","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IN8bio to Present New Positive Clinical Data from Phase 1 Trial of INB-100 at EBMT 2023 Annual Meeting - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IN8bio to Present New Positive Clinical Data from Phase 1 Trial of INB-100 at EBMT 2023 Annual Meeting - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Updated data on durability of responses and long-term complete responses (CRs) in leukemia patients treated with INB-100 will be presented; no dose-limiting toxicities have been observed New correlative data on immune reconstitution and gamma-delta T cell proliferation for Cohorts 1 and 2 will be presented NEW YORK, April 11, 2023 (GLOBE NEWSWIRE) &#8212; IN8bio, Inc. (Nasdaq: INAB), a clinical-stage biopharmaceutical company discovering and developing innovative gamma-delta T cell therapies, today announced that new data from the ongoing Phase 1 trial evaluating INB-100, an allogeneic, gamma-delta T cell therapy, in patients with hematologic malignancies undergoing haploidentical stem cell transplantation (HSCT), will be presented at the 49th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), being held in &hellip; Continue reading &quot;IN8bio to Present New Positive Clinical Data from Phase 1 Trial of INB-100 at EBMT 2023 Annual Meeting&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-11T12:25:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgwNTEzNiM1NTE3ODUzIzIxMjMwMDY=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"IN8bio to Present New Positive Clinical Data from Phase 1 Trial of INB-100 at EBMT 2023 Annual Meeting\",\"datePublished\":\"2023-04-11T12:25:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\\\/\"},\"wordCount\":819,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODgwNTEzNiM1NTE3ODUzIzIxMjMwMDY=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\\\/\",\"name\":\"IN8bio to Present New Positive Clinical Data from Phase 1 Trial of INB-100 at EBMT 2023 Annual Meeting - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/","og_locale":"en_US","og_type":"article","og_title":"IN8bio to Present New Positive Clinical Data from Phase 1 Trial of INB-100 at EBMT 2023 Annual Meeting - Market Newsdesk","og_description":"Updated data on durability of responses and long-term complete responses (CRs) in leukemia patients treated with INB-100 will be presented; no dose-limiting toxicities have been observed New correlative data on immune reconstitution and gamma-delta T cell proliferation for Cohorts 1 and 2 will be presented NEW YORK, April 11, 2023 (GLOBE NEWSWIRE) &#8212; IN8bio, Inc. (Nasdaq: INAB), a clinical-stage biopharmaceutical company discovering and developing innovative gamma-delta T cell therapies, today announced that new data from the ongoing Phase 1 trial evaluating INB-100, an allogeneic, gamma-delta T cell therapy, in patients with hematologic malignancies undergoing haploidentical stem cell transplantation (HSCT), will be presented at the 49th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), being held in &hellip; Continue reading \"IN8bio to Present New Positive Clinical Data from Phase 1 Trial of INB-100 at EBMT 2023 Annual Meeting\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/","og_site_name":"Market Newsdesk","article_published_time":"2023-04-11T12:25:32+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgwNTEzNiM1NTE3ODUzIzIxMjMwMDY=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"IN8bio to Present New Positive Clinical Data from Phase 1 Trial of INB-100 at EBMT 2023 Annual Meeting","datePublished":"2023-04-11T12:25:32+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/"},"wordCount":819,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODgwNTEzNiM1NTE3ODUzIzIxMjMwMDY=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-to-present-new-positive-clinical-data-from-phase-1-trial-of-inb-100-at-ebmt-2023-annual-meeting\/","name":"IN8bio to Present New Positive Clinical Data from Phase 1 Trial of INB-100 at EBMT 2023 Annual Meeting - 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