{"id":746531,"date":"2023-04-11T08:07:46","date_gmt":"2023-04-11T12:07:46","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/maia-biotechnology-reports-positive-topline-data-from-part-a-safety-lead-in-of-thio-101-phase-2-trial-for-non-small-cell-lung-cancer\/"},"modified":"2023-04-11T08:07:46","modified_gmt":"2023-04-11T12:07:46","slug":"maia-biotechnology-reports-positive-topline-data-from-part-a-safety-lead-in-of-thio-101-phase-2-trial-for-non-small-cell-lung-cancer","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/maia-biotechnology-reports-positive-topline-data-from-part-a-safety-lead-in-of-thio-101-phase-2-trial-for-non-small-cell-lung-cancer\/","title":{"rendered":"MAIA Biotechnology Reports Positive Topline Data from Part A Safety Lead-In of THIO-101 Phase 2 Trial for Non-Small Cell Lung Cancer"},"content":{"rendered":"

<\/p>\n

MAIA Biotechnology Reports Positive Topline Data from Part A Safety Lead-In of THIO-101 Phase 2 Trial for Non-Small Cell Lung Cancer<\/b><\/p>\n

CHICAGO–(BUSINESS WIRE<\/a>)–
\nMAIA Biotechnology, Inc. (NYSE American: MAIA<\/a>) today announced positive topline data from the completed Part A safety lead-in of the Company\u2019s THIO-101 Phase 2 go-to-market trial in advanced Non-Small Cell Lung Cancer (NSCLC) and has commenced recruitment in Part B randomized efficacy\/dose selection.<\/p>\n

\nTopline data from Part A demonstrated that MAIA\u2019s telomere-targeting agent, THIO, administered in sequential combination with Regeneron\u2019s anti-PD-1 therapy, Libtayo\u00ae<\/sup> (cemiplimab), were generally well-tolerated. No dose-limiting toxicities (DLTs) or significant treatment-related adverse events were observed.<\/p>\n

\nPart A was designed to assess the safety and tolerability of the highest dose of 360 mg\/cycle in six patients. Mild toxicities, such as grade 1 fatigue, and muscle pain, were reported, as well as only one occurrence of grade 3 nausea, but no grade 4 adverse events, reported.<\/p>\n

\n\u201cPart A\u2019s safety profile is in sharp contrast with the typical safety profile of chemotherapy treatment where 70-80% of NSCLC patients experience grade 3 and 4 toxicities,\u201d said MAIA\u2019s Chief Medical Officer Mihail Obrocea, M.D. \u201cThe next dose levels of THIO in Part B are lower compared to Part A. Based on the initial safety profile seen at the highest dose in Part A, we are optimistic about the safety profile of THIO.\u201d<\/p>\n

\n\u201cWe are pleased with the completion of the safety lead-in portion, which is a very important milestone and catalyst that marks the continued progression of our Phase 2 THIO-101 trial. Recruitment has commenced in the Part B efficacy\/dose selection portion of our go-to-market trial, and we anticipate reporting preliminary efficacy data later this year,\u201d said MAIA\u2019s Chairman and Chief Executive Officer Vlad Vitoc, M.D.<\/p>\n

\nPart B of the study will allow randomization of patients to three THIO dose levels, including 60 mg, 180 mg and 360 mg, followed by cemiplimab treatment every 3 weeks. Safety and tolerability will continue to be monitored across all THIO doses. The objective of Part B is to determine the most efficacious and safe dose, which will guide Part C of the trial.<\/p>\n

\nTHIO-101 is a multicenter, open-label, dose-finding Phase 2 clinical trial designed to evaluate THIO\u2019s potential direct anticancer and immune system activation effects in NSCLC patients by administering THIO in advance of Regeneron\u2019s anti-PD-1 therapy, Libtayo\u00ae (cemiplimab), thus allowing for immune system activation and sensitivity to the PD-1 inhibitor to take effect. The primary objectives of the trial are to evaluate the safety and tolerability of THIO administered as a direct anti-cancer and priming immune system agent followed by cemiplimab administration, as well as preliminary clinical efficacy of THIO in patients with advanced NSCLC, who either progressed or relapsed through the initial treatments with an immune-check point inhibitor alone, or in combination with chemotherapy. The clinical trial is currently enrolling patients in Australia and the European Union. For more information on this Phase II trial, please visit ClinicalTrials.gov<\/a> using the identifier NCT05208944.<\/p>\n

About Toxicity Grading in Cancer Treatments<\/b><\/p>\n

\nToxicity is graded 0-5. Toxicity of grade 1 is mild, grade 2 is moderate, grade 3 is severe, grade 4 is life-threatening, and grade 5 is death.<\/p>\n

About THIO<\/b><\/p>\n

\nTHIO (6-thio-dG or 6-thio-2\u2019-deoxyguanosine) is a telomere-targeting agent currently in clinical development to evaluate its activity in non-small cell lung cancer (NSCLC), in sequential administration with Regeneron\u2019s anti-PD-1 therapy, Libtayo\u00ae (cemiplimab). Telomeres play a fundamental role in the survival of cancer cells and their resistance to current therapies. THIO is being developed as a second or later line of treatment for NSCLC for patients that have progressed beyond the standard-of-care regimen of existing checkpoint inhibitors.<\/p>\n

About MAIA Biotechnology, Inc.<\/b><\/p>\n

\nMAIA is a targeted therapy, immuno-oncology company focused on the development and commercialization of potential first-in-class drugs with novel mechanisms of action that are intended to meaningfully improve and extend the lives of people with cancer. Its lead program is THIO, a potential first-in-class cancer telomere targeting agent in clinical development for the treatment of NSCLC patients with telomerase-positive cancer cells. For more information, please visit www.maiabiotech.com<\/a>.<\/p>\n

Forward Looking Statements<\/b><\/p>\n

\nMAIA cautions that all statements, other than statements of historical facts, contained in this press release, are forward-looking statements. Forward-looking statements are subject to known and unknown risks, uncertainties, and other factors that may cause our or our industry\u2019s actual results, levels or activity, performance or achievements to be materially different from those anticipated by such statements. The use of words such as \u201cmay,\u201d \u201cmight,\u201d \u201cwill,\u201d \u201cshould,\u201d \u201ccould,\u201d \u201cexpect,\u201d \u201cplan,\u201d \u201canticipate,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cproject,\u201d \u201cintend,\u201d \u201cfuture,\u201d \u201cpotential,\u201d or \u201ccontinue,\u201d and other similar expressions are intended to identify forward looking statements. However, the absence of these words does not mean that statements are not forward-looking. For example, all statements we make regarding (i) the initiation, timing, cost, progress and results of our preclinical and clinical studies and our research and development programs, (ii) our ability to advance product candidates into, and successfully complete, clinical studies, (iii) the timing or likelihood of regulatory filings and approvals, (iv) our ability to develop, manufacture and commercialize our product candidates and to improve the manufacturing process, (v) the rate and degree of market acceptance of our product candidates, (vi) the size and growth potential of the markets for our product candidates and our ability to serve those markets, and (vii) our expectations regarding our ability to obtain and maintain intellectual property protection for our product candidates, are forward looking. All forward-looking statements are based on current estimates, assumptions and expectations by our management that, although we believe to be reasonable, are inherently uncertain. Any forward-looking statement expressing an expectation or belief as to future events is expressed in good faith and believed to be reasonable at the time such forward-looking statement is made. However, these statements are not guarantees of future events and are subject to risks and uncertainties and other factors beyond our control that may cause actual results to differ materially from those expressed in any forward-looking statement. Any forward-looking statement speaks only as of the date on which it was made. We undertake no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law. In this release, unless the context requires otherwise, \u201cMAIA,\u201d \u201cCompany,\u201d \u201cwe,\u201d \u201cour,\u201d and \u201cus\u201d refers to MAIA Biotechnology, Inc. and its subsidiaries.<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20230411005338\/en\/<\/a><\/span><\/p>\n

Investor Inquiries
\n
<\/b>
MAIA Biotechnology
\n
Joseph McGuire
\n
Chief Financial Officer
\n
jmcguire@maiabiotech.com
\n<\/a>
904-228-2603<\/p>\n

ICR Westwicke
\n
Stephanie Carrington
\n
Stephanie.carrington@westwicke.com
\n<\/a>
646-277-1282<\/p>\n

KEYWORDS:<\/b> Illinois United States North America<\/p>\n

INDUSTRY KEYWORDS:<\/b> Biotechnology Health Pharmaceutical Clinical Trials Oncology<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
Logo<\/b><\/font><\/td>\n<\/tr>\n
\"Logo\"<\/td>\n<\/tr>\n
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MAIA Biotechnology Reports Positive Topline Data from Part A Safety Lead-In of THIO-101 Phase 2 Trial for Non-Small Cell Lung Cancer CHICAGO–(BUSINESS WIRE)– MAIA Biotechnology, Inc. (NYSE American: MAIA) today announced positive topline data from the completed Part A safety lead-in of the Company\u2019s THIO-101 Phase 2 go-to-market trial in advanced Non-Small Cell Lung Cancer (NSCLC) and has commenced recruitment in Part B randomized efficacy\/dose selection. Topline data from Part A demonstrated that MAIA\u2019s telomere-targeting agent, THIO, administered in sequential combination with Regeneron\u2019s anti-PD-1 therapy, Libtayo\u00ae (cemiplimab), were generally well-tolerated. No dose-limiting toxicities (DLTs) or significant treatment-related adverse events were observed. Part A was designed to assess the safety and tolerability of the highest dose of 360 mg\/cycle in six … <\/p>\n

Continue reading “MAIA Biotechnology Reports Positive Topline Data from Part A Safety Lead-In of THIO-101 Phase 2 Trial for Non-Small Cell Lung Cancer”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-746531","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nMAIA Biotechnology Reports Positive Topline Data from Part A Safety Lead-In of THIO-101 Phase 2 Trial for Non-Small Cell Lung Cancer - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/maia-biotechnology-reports-positive-topline-data-from-part-a-safety-lead-in-of-thio-101-phase-2-trial-for-non-small-cell-lung-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MAIA Biotechnology Reports Positive Topline Data from Part A Safety Lead-In of THIO-101 Phase 2 Trial for Non-Small Cell Lung Cancer - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"MAIA Biotechnology Reports Positive Topline Data from Part A Safety Lead-In of THIO-101 Phase 2 Trial for Non-Small Cell Lung Cancer CHICAGO–(BUSINESS WIRE)– MAIA Biotechnology, Inc. (NYSE American: MAIA) today announced positive topline data from the completed Part A safety lead-in of the Company\u2019s THIO-101 Phase 2 go-to-market trial in advanced Non-Small Cell Lung Cancer (NSCLC) and has commenced recruitment in Part B randomized efficacy\/dose selection. Topline data from Part A demonstrated that MAIA\u2019s telomere-targeting agent, THIO, administered in sequential combination with Regeneron\u2019s anti-PD-1 therapy, Libtayo\u00ae (cemiplimab), were generally well-tolerated. No dose-limiting toxicities (DLTs) or significant treatment-related adverse events were observed. 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(NYSE American: MAIA) today announced positive topline data from the completed Part A safety lead-in of the Company\u2019s THIO-101 Phase 2 go-to-market trial in advanced Non-Small Cell Lung Cancer (NSCLC) and has commenced recruitment in Part B randomized efficacy\/dose selection. Topline data from Part A demonstrated that MAIA\u2019s telomere-targeting agent, THIO, administered in sequential combination with Regeneron\u2019s anti-PD-1 therapy, Libtayo\u00ae (cemiplimab), were generally well-tolerated. No dose-limiting toxicities (DLTs) or significant treatment-related adverse events were observed. Part A was designed to assess the safety and tolerability of the highest dose of 360 mg\/cycle in six … Continue reading \"MAIA Biotechnology Reports Positive Topline Data from Part A Safety Lead-In of THIO-101 Phase 2 Trial for Non-Small Cell Lung Cancer\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/maia-biotechnology-reports-positive-topline-data-from-part-a-safety-lead-in-of-thio-101-phase-2-trial-for-non-small-cell-lung-cancer\/","og_site_name":"Market Newsdesk","article_published_time":"2023-04-11T12:07:46+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20230411005338r1&sid=flmnd&distro=nx&lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/maia-biotechnology-reports-positive-topline-data-from-part-a-safety-lead-in-of-thio-101-phase-2-trial-for-non-small-cell-lung-cancer\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/maia-biotechnology-reports-positive-topline-data-from-part-a-safety-lead-in-of-thio-101-phase-2-trial-for-non-small-cell-lung-cancer\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"MAIA Biotechnology Reports Positive Topline Data from Part A Safety Lead-In of THIO-101 Phase 2 Trial for Non-Small Cell Lung Cancer","datePublished":"2023-04-11T12:07:46+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/maia-biotechnology-reports-positive-topline-data-from-part-a-safety-lead-in-of-thio-101-phase-2-trial-for-non-small-cell-lung-cancer\/"},"wordCount":1130,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/maia-biotechnology-reports-positive-topline-data-from-part-a-safety-lead-in-of-thio-101-phase-2-trial-for-non-small-cell-lung-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20230411005338r1&sid=flmnd&distro=nx&lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/maia-biotechnology-reports-positive-topline-data-from-part-a-safety-lead-in-of-thio-101-phase-2-trial-for-non-small-cell-lung-cancer\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/maia-biotechnology-reports-positive-topline-data-from-part-a-safety-lead-in-of-thio-101-phase-2-trial-for-non-small-cell-lung-cancer\/","name":"MAIA Biotechnology Reports Positive Topline Data from Part A Safety Lead-In of THIO-101 Phase 2 Trial for Non-Small Cell Lung Cancer - 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