{"id":742781,"date":"2023-03-27T08:33:47","date_gmt":"2023-03-27T12:33:47","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/"},"modified":"2023-03-27T08:33:47","modified_gmt":"2023-03-27T12:33:47","slug":"ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/","title":{"rendered":"Ambrx to Present Preclinical Data on ARX517 and ARX305 at the 2023 AACR Annual Meeting"},"content":{"rendered":"<h2>\nThree posters will be presented at AACR and include data from preclinical studies of ARX517 and ARX305 and Trial in Progress Poster on APEX-01<br \/>\n<\/h2>\n<div class=\"mw_release\">\n<p align=\"left\">SAN DIEGO, March  27, 2023  (GLOBE NEWSWIRE) &#8212; Ambrx Biopharma Inc., or Ambrx (NASDAQ: AMAM), announced the presentation of three posters featuring preclinical data at the upcoming 2023 American Association for Cancer Research (AACR) Annual Meeting in Orlando, Florida, from April 14 to 19, 2023. The two preclinical posters will provide data from Ambrx\u2019s preclinical studies of ARX517 (anti-PSMA ADC) and ARX305 (anti-CD70 ADC). Further, a clinical trial in progress poster will be presented from APEX-01 (<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=uXeideWNXUmfKkpTMlghvVnmbEZkiouiGEFTAT2osiXpsfB-MKGtUqBPToRG8FQhE60i39KiMBBfu_ALeqFg4D1uSTkv5W0DqL1ZW3pQS4E=\" rel=\"nofollow noopener\" target=\"_blank\">NCT04662580<\/a>), the Company\u2019s Phase 1, first-in-human, open label dose escalation and dose expansion trial of ARX517 enrolling patients with advanced prostate cancer whose tumors have progressed on at least two prior FDA-approved treatments. ARX517 is the only anti-PSMA ADC in active clinical development.<\/p>\n<p>Ambrx\u2019s abstracts are posted on the AACR Annual Meeting website. The posters will be posted on the Ambrx website during the conference.<\/p>\n<p>\n        <strong>Presentation details:<\/strong>\n      <\/p>\n<p>\n        <strong>Poster Title: <\/strong>ARX517, a Next-Generation anti-PSMA Antibody Drug Conjugate for the Treatment of Metastatic Castration-Resistant Prostate Cancer, Demonstrates Anti-Tumor Activity in Enzalutamide-Resistant and Enzalutamide-Sensitive Models and a Clear Therapeutic Index in a Non-Human Primate Model<\/p>\n<p>\n        <strong>Session Date and Time:\u00a0<\/strong>Tuesday Apr 18, 2023, 9:00 AM &#8211; 12:30 PM<br \/><strong>Session Category:\u00a0<\/strong>Experimental and Molecular Therapeutics<br \/><strong>Session Title:\u00a0<\/strong>Oncogenes and Tumor Suppressor Genes as Targets for Therapy 3<br \/><strong>Location:\u00a0<\/strong>Poster Section 19<br \/><strong>Poster Board Number:\u00a0<\/strong>20<br \/><strong>Published Abstract Number:\u00a0<\/strong>3997<\/p>\n<p>\n        <strong>Poster title:<\/strong> ARX517, an anti-PSMA ADC targeting mCRPC resistant or refractory to standard therapies: A phase 1 dose escalation and dose expansion study (APEX-01 NCT04662580)<br \/><strong>Session Date and Time:<\/strong>\u00a0Monday Apr 17, 2023, 1:30 PM &#8211; 5:00 PM<br \/><strong>Session Title:<\/strong>\u00a0Phase I Clinical Trials in Progress<br \/><strong>Location:<\/strong>\u00a0Poster Section 46<br \/><strong>Poster Board Number:<\/strong>\u00a09<br \/><strong>Abstract Presentation Number:<\/strong>\u00a0CT121<\/p>\n<p>\n        <strong>Poster Title:\u00a0<\/strong>Preclinical characterization of ARX305, a next-generation anti-CD70 antibody drug conjugate for the treatment of CD70-expressing cancers<br \/><strong>Session Date and Time:\u00a0<\/strong>Wednesday Apr 19, 2023, 9:00 AM &#8211; 12:30 PM<br \/><strong>Session Category:\u00a0<\/strong>Experimental and Molecular Therapeutics<br \/><strong>Session Title:\u00a0<\/strong>Growth Factor Receptors as Therapeutic Targets<br \/><strong>Location:\u00a0<\/strong>Poster Section 21<br \/><strong>Poster Board Number:\u00a0<\/strong>25<br \/><strong>Published Abstract Number:\u00a0<\/strong>6318<\/p>\n<p>\n        <strong>About Ambrx Biopharma Inc.<\/strong>\n      <\/p>\n<p>Ambrx is a clinical stage biopharmaceutical company using an expanded genetic code technology platform to discover and develop next generation antibody drug conjugates (ADCs) and other engineered therapies to modulate the immune system. Ambrx is advancing a focused portfolio of clinical and preclinical programs designed to optimize efficacy and safety in multiple cancer indications, including ARX517, its proprietary antibody-drug conjugate (ADC) targeting the prostate-specific membrane antigen (PSMA) and ARX788, its proprietary ADC targeting HER2. In addition, Ambrx has preclinical and clinical collaborations with multiple partners on drug candidates generated using Ambrx technology. Ambrx spun out of The Scripps Research Institute in 2003 and has several other product candidates involving ADCs and other aspects of Ambrx\u2019s protein engineering technology. For more information, please visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=h90d2hQ3ubvHvTl8WOhzcX2uH_z-7e0A0NvC5fETO_tBf6FQJt9aRcGtcSTeeCNudLR23rWm3t8Ex328Udlbgw==\" rel=\"nofollow noopener\" target=\"_blank\">www.ambrx.com<\/a>. Ambrx routinely posts information that may be important to investors on its website.<\/p>\n<p>\n        <strong>Forward-Looking Statements<\/strong>\n      <\/p>\n<p>This press release includes certain \u201cforward-looking statements\u201d intended to qualify for the \u201csafe harbor\u201d from liability established by the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements may be identified by the words \u201cintend,\u201d \u201cplan,\u201d and similar expressions, and include, without limitation, express or implied statements regarding Ambrx\u2019s preliminary estimates of cash, cash equivalents and marketable debt securities, available-for-sale, as of December 31, 2022, Ambrx\u2019s estimated cash runway and Ambrx\u2019s clinical trial and product candidate plans and strategy. Forward-looking statements are based on Ambrx\u2019s current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the continuing impact of the COVID-19 pandemic and other public health-related risks and events on Ambrx\u2019s business, operations, strategy, goals and anticipated milestones; Ambrx\u2019s ability to execute on its strategy including with respect to the timing of its R&amp;D efforts, initiation of clinical trials and other anticipated milestones; risks associated with development and marketing approval of novel therapeutics, including potential delays in clinical trials and regulatory submissions and the fact that future clinical trial results\/data may not be consistent with interim, initial or preliminary results\/data or results\/data from prior preclinical studies or clinical trials; Ambrx\u2019s ability to fund operations as anticipated; and the additional risks and uncertainties set forth more fully under the caption \u201cRisk Factors\u201d in Ambrx\u2019s Annual Report on Form 20-F filed with the SEC on April 26, 2022, and elsewhere in Ambrx\u2019s filings and reports with the SEC. Forward-looking statements contained in this press release are made as of this date, and Ambrx undertakes no duty to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.<\/p>\n<p align=\"justify\">\n        <strong>Contacts<\/strong>\n      <\/p>\n<p align=\"justify\">INVESTORS<br \/>Mike Moyer<br \/>LifeSci Advisors<br \/>617-308-4306<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Rv8e_hneu9K7O6l0kKF0KV2PmFgXgBbAsnxjdpl1JF9sUuDEHi2v5BREnbn7LJggpCg84xfPHcTyhQP-7TWC_rObnHEIBUwnq-jHfThmuaVwcJwvc-V70GjsQVho7nUk\" rel=\"nofollow noopener\" target=\"_blank\">mmoyer@lifesciadvisors.com<\/a><\/p>\n<p align=\"justify\">MEDIA<br \/>Mike Tattory<br \/>Account Supervisor<br \/>LifeSci Communications<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=2AtxW70VR0dUiGATB0NNvRqhFRuP7XBLOW1-98Thth3zH7LDKw6OF4-G2iVKX4hSZ47hhIW2wcdxJGwVqqIzhA==\" rel=\"nofollow noopener\" target=\"_blank\">media@ambrx.com<\/a><\/p>\n<p align=\"justify\">Source: Ambrx Biopharma Inc.<\/p>\n<p>      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODc5NTU5NSM1NDkyMTk4IzIyNTIyMTI=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/YTNjZDVhZWItZDcyYS00MTc2LWJmZGQtYjVjNDhhNzRiMjVlLTEyNjM3NjU=\/tiny\/Ambrx-Biopharma-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Three posters will be presented at AACR and include data from preclinical studies of ARX517 and ARX305 and Trial in Progress Poster on APEX-01 SAN DIEGO, March 27, 2023 (GLOBE NEWSWIRE) &#8212; Ambrx Biopharma Inc., or Ambrx (NASDAQ: AMAM), announced the presentation of three posters featuring preclinical data at the upcoming 2023 American Association for Cancer Research (AACR) Annual Meeting in Orlando, Florida, from April 14 to 19, 2023. The two preclinical posters will provide data from Ambrx\u2019s preclinical studies of ARX517 (anti-PSMA ADC) and ARX305 (anti-CD70 ADC). Further, a clinical trial in progress poster will be presented from APEX-01 (NCT04662580), the Company\u2019s Phase 1, first-in-human, open label dose escalation and dose expansion trial of ARX517 enrolling patients with advanced &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Ambrx to Present Preclinical Data on ARX517 and ARX305 at the 2023 AACR Annual Meeting&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-742781","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ambrx to Present Preclinical Data on ARX517 and ARX305 at the 2023 AACR Annual Meeting - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ambrx to Present Preclinical Data on ARX517 and ARX305 at the 2023 AACR Annual Meeting - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Three posters will be presented at AACR and include data from preclinical studies of ARX517 and ARX305 and Trial in Progress Poster on APEX-01 SAN DIEGO, March 27, 2023 (GLOBE NEWSWIRE) &#8212; Ambrx Biopharma Inc., or Ambrx (NASDAQ: AMAM), announced the presentation of three posters featuring preclinical data at the upcoming 2023 American Association for Cancer Research (AACR) Annual Meeting in Orlando, Florida, from April 14 to 19, 2023. The two preclinical posters will provide data from Ambrx\u2019s preclinical studies of ARX517 (anti-PSMA ADC) and ARX305 (anti-CD70 ADC). Further, a clinical trial in progress poster will be presented from APEX-01 (NCT04662580), the Company\u2019s Phase 1, first-in-human, open label dose escalation and dose expansion trial of ARX517 enrolling patients with advanced &hellip; Continue reading &quot;Ambrx to Present Preclinical Data on ARX517 and ARX305 at the 2023 AACR Annual Meeting&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-03-27T12:33:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODc5NTU5NSM1NDkyMTk4IzIyNTIyMTI=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Ambrx to Present Preclinical Data on ARX517 and ARX305 at the 2023 AACR Annual Meeting\",\"datePublished\":\"2023-03-27T12:33:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\\\/\"},\"wordCount\":832,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODc5NTU5NSM1NDkyMTk4IzIyNTIyMTI=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\\\/\",\"name\":\"Ambrx to Present Preclinical Data on ARX517 and ARX305 at the 2023 AACR Annual Meeting - 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The two preclinical posters will provide data from Ambrx\u2019s preclinical studies of ARX517 (anti-PSMA ADC) and ARX305 (anti-CD70 ADC). Further, a clinical trial in progress poster will be presented from APEX-01 (NCT04662580), the Company\u2019s Phase 1, first-in-human, open label dose escalation and dose expansion trial of ARX517 enrolling patients with advanced &hellip; Continue reading \"Ambrx to Present Preclinical Data on ARX517 and ARX305 at the 2023 AACR Annual Meeting\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/","og_site_name":"Market Newsdesk","article_published_time":"2023-03-27T12:33:47+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODc5NTU5NSM1NDkyMTk4IzIyNTIyMTI=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Ambrx to Present Preclinical Data on ARX517 and ARX305 at the 2023 AACR Annual Meeting","datePublished":"2023-03-27T12:33:47+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/"},"wordCount":832,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODc5NTU5NSM1NDkyMTk4IzIyNTIyMTI=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/ambrx-to-present-preclinical-data-on-arx517-and-arx305-at-the-2023-aacr-annual-meeting\/","name":"Ambrx to Present Preclinical Data on ARX517 and ARX305 at the 2023 AACR Annual Meeting - 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