{"id":740717,"date":"2023-03-16T08:36:23","date_gmt":"2023-03-16T12:36:23","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/journey-medical-corporation-announces-completion-of-treatment-assessing-impact-of-dfd-29-minocycline-modified-release-capsules-40-mg-on-microbial-flora-in-a-separate-phase-1-clinical-trial\/"},"modified":"2023-03-16T08:36:23","modified_gmt":"2023-03-16T12:36:23","slug":"journey-medical-corporation-announces-completion-of-treatment-assessing-impact-of-dfd-29-minocycline-modified-release-capsules-40-mg-on-microbial-flora-in-a-separate-phase-1-clinical-trial","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/journey-medical-corporation-announces-completion-of-treatment-assessing-impact-of-dfd-29-minocycline-modified-release-capsules-40-mg-on-microbial-flora-in-a-separate-phase-1-clinical-trial\/","title":{"rendered":"Journey Medical Corporation Announces Completion of Treatment Assessing Impact of DFD-29 (Minocycline Modified Release Capsules 40 mg) on Microbial Flora in a Separate Phase 1 Clinical Trial"},"content":{"rendered":"
\n

\n Subjects completed 16-week treatment with no significant safety issues<\/em>
\n \n <\/p>\n

\n Topline results expected in the first half of 2023<\/em>\n <\/p>\n

SCOTTSDALE, Ariz., March 16, 2023 (GLOBE NEWSWIRE) — Journey Medical Corporation (Nasdaq: DERM) (\u201cJourney Medical\u201d), a commercial-stage biopharmaceutical company that focuses on the development and commercialization of pharmaceutical products for the treatment of dermatological conditions, today announced completion of treatment in the Phase 1 clinical trial assessing the impact of DFD-29 (Minocycline Modified Release Capsules 40 mg) on the microbial flora of healthy adults. The clinical trial is also assessing the safety and tolerability of the treatment. DFD-29 is being developed for the treatment of papulopustular rosacea (\u201cPPR\u201d) in collaboration with Dr. Reddy\u2019s Laboratories Ltd.<\/p>\n

DFD-29-CD-006 is a\u00a0multi-center, randomized, double-blind, placebo-controlled, parallel group\u00a0study that enrolled 60 healthy, adult subjects (30 males and 30 females) in a 2:1 randomization between DFD-29 and placebo. Treatment was administered once daily orally over 16 weeks. Microbiological samples were collected from the skin (forehead), stool and vagina at multiple timepoints through the study. No significant safety issues were noted during the study. Additional information on the DFD-29 Phase 1 clinical trial can be found on ClinicalTrials.gov using the identifier: NCT05597462<\/a>.<\/p>\n

Claude Maraoui, Co-Founder, President and Chief Executive Officer of Journey Medical, stated, \u201cDFD-29 continues to make positive progress in the clinic, bringing us closer to potentially providing a new treatment option for the millions of patients suffering from rosacea. We expect to report topline results from the Phase 1 trial in the first half of 2023. In addition, we are pleased that the DFD-29 Phase 3 clinical trials have been fully enrolled as of January 2023. We anticipate topline data from the Phase 3 clinical trials in the first half of 2023, with a New Drug Application filing subsequently expected in the second half of 2023.\u201d<\/p>\n

The DFD-29 Phase 3 clinical program consists of two multicenter, randomized, double-blind, parallel-group, active-comparator and placebo-controlled clinical trials, MVOR-1 and MVOR-2 (Minocycline versus Oracea\u00ae in Rosacea), that are expected to support a New Drug Application (NDA) submission in the United States and a Marketing Authorization Application in Europe. The combined enrollment target of 640 total adult patients with moderate to severe PPR was achieved in the trials; one trial was enrolling patients in the United States, and the other was enrolling patients in both the United States and Europe. The MVOR-1 and MVOR-2 clinical trials are randomized in a 3:3:2 ratio to DFD-29 (Minocycline Hydrochloride Modified Release Capsules, 40 mg), Oracea\u00ae (Doxycycline capsules 40 mg) or placebo once daily for 16 weeks. The primary objective is to evaluate the safety, efficacy and tolerability of DFD-29 compared to placebo for the treatment of PPR. The secondary objective is to evaluate the safety, efficacy and tolerability of DFD-29 compared to Oracea\u00ae (Doxycycline capsules 40 mg). To date, no major safety issues have been reported, and no drug-related serious adverse events have been observed.<\/p>\n

\n About Rosacea<\/strong>
\n
Rosacea is a chronic, relapsing, inflammatory skin condition that most commonly presents with symptoms such as deep facial redness, acne-like inflammatory lesions (papules and pustules) and spider veins (telangiectasia). According to\u00a0The National Rosacea Society<\/a>,<\/em>\u00a0it is estimated that rosacea affects well over 16 million Americans and as many as 415 million worldwide.\u00a0Rosacea is most frequently seen in adults between 30 and 50 years of age. Surveys conducted by\u00a0The National Rosacea Society<\/a>\u00a0report more than 90 percent of rosacea patients said their condition had lowered their self-confidence and self-esteem, and 41 percent reported that it had caused them to avoid public contact or cancel social engagements. Among rosacea patients with severe symptoms, 88 percent said the disorder had adversely affected their professional interactions, and 51 percent said they had missed work because of their condition.<\/p>\n

Oraycea\u00ae<\/sup>\u00a0and Oracea\u00ae<\/sup>\u00a0are registered trademarks of Galderma Holdings, S.A.<\/p>\n

\n About Journey Medical Corporation<\/strong>
\n
Journey Medical Corporation (Nasdaq: DERM) (\u201cJourney Medical\u201d) is focused on identifying, acquiring, developing and strategically commercializing innovative, differentiated dermatology products through its efficient sales and marketing model. The company currently markets eight products that help treat and heal common skin conditions. The Journey Medical team comprises industry experts with extensive experience in developing and commercializing some of dermatology\u2019s most successful prescription brands. Journey Medical is located in Scottsdale, Arizona and was founded by Fortress Biotech, Inc. (Nasdaq: FBIO). Journey Medical\u2019s common stock is registered under the Securities Exchange Act of 1934, as amended, and it files periodic reports with the U.S. Securities and Exchange Commission (\u201cSEC\u201d). For additional information about Journey Medical, visit www.journeymedicalcorp.com<\/a>.<\/p>\n

\n Forward-Looking Statements<\/strong>
\n
This press release may contain \u201cforward-looking statements\u201d within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, as amended. As used below and throughout this press release, the words \u201cwe\u201d, \u201cus\u201d and \u201cour\u201d may refer to Journey Medical. Such statements include, but are not limited to, any statements relating to our growth strategy and product development programs and any other statements that are not historical facts. The words \u201canticipate,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cmay,\u201d \u201cexpect,\u201d \u201cwill,\u201d \u201ccould,\u201d \u201cproject,\u201d \u201cintend\u201d and similar expressions are generally intended to identify forward-looking statements. Forward-looking statements are based on management\u2019s current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition and stock price. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; uncertainties relating to preclinical and clinical testing; risks relating to the timing of starting and completing clinical trials, including disruptions that may result from hostilities in Europe; our dependence on third-party suppliers; our ability to obtain additional financing on favorable terms or at all; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; potential recovery of funds lost from previously disclosed cyber security breaches; as well as other risks described in Part I, Item 1A, \u201cRisk Factors,\u201d in our Annual Report on Form 10-K filed on March 28, 2022, subsequent Reports on Form 10-Q, and our other filings we make with the SEC. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as may be required by law, and we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995.<\/p>\n

\n Company Contact:<\/strong>
\n
Jaclyn Jaffe
(781) 652-4500
ir@jmcderm.com<\/a><\/p>\n

\n Media Relations Contact:<\/strong>
\n
Tony Plohoros
6 Degrees
(908) 591-2839
tplohoros@6degreespr.com<\/a>\u00a0\u00a0<\/p>\n<\/p>\n


\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Subjects completed 16-week treatment with no significant safety issues Topline results expected in the first half of 2023 SCOTTSDALE, Ariz., March 16, 2023 (GLOBE NEWSWIRE) — Journey Medical Corporation (Nasdaq: DERM) (\u201cJourney Medical\u201d), a commercial-stage biopharmaceutical company that focuses on the development and commercialization of pharmaceutical products for the treatment of dermatological conditions, today announced completion of treatment in the Phase 1 clinical trial assessing the impact of DFD-29 (Minocycline Modified Release Capsules 40 mg) on the microbial flora of healthy adults. The clinical trial is also assessing the safety and tolerability of the treatment. DFD-29 is being developed for the treatment of papulopustular rosacea (\u201cPPR\u201d) in collaboration with Dr. Reddy\u2019s Laboratories Ltd. DFD-29-CD-006 is a\u00a0multi-center, randomized, double-blind, placebo-controlled, parallel … <\/p>\n

Continue reading “Journey Medical Corporation Announces Completion of Treatment Assessing Impact of DFD-29 (Minocycline Modified Release Capsules 40 mg) on Microbial Flora in a Separate Phase 1 Clinical Trial”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-740717","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nJourney Medical Corporation Announces Completion of Treatment Assessing Impact of DFD-29 (Minocycline Modified Release Capsules 40 mg) on Microbial Flora in a Separate Phase 1 Clinical Trial - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/journey-medical-corporation-announces-completion-of-treatment-assessing-impact-of-dfd-29-minocycline-modified-release-capsules-40-mg-on-microbial-flora-in-a-separate-phase-1-clinical-trial\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Journey Medical Corporation Announces Completion of Treatment Assessing Impact of DFD-29 (Minocycline Modified Release Capsules 40 mg) on Microbial Flora in a Separate Phase 1 Clinical Trial - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Subjects completed 16-week treatment with no significant safety issues Topline results expected in the first half of 2023 SCOTTSDALE, Ariz., March 16, 2023 (GLOBE NEWSWIRE) — Journey Medical Corporation (Nasdaq: DERM) (\u201cJourney Medical\u201d), a commercial-stage biopharmaceutical company that focuses on the development and commercialization of pharmaceutical products for the treatment of dermatological conditions, today announced completion of treatment in the Phase 1 clinical trial assessing the impact of DFD-29 (Minocycline Modified Release Capsules 40 mg) on the microbial flora of healthy adults. 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The clinical trial is also assessing the safety and tolerability of the treatment. DFD-29 is being developed for the treatment of papulopustular rosacea (\u201cPPR\u201d) in collaboration with Dr. Reddy\u2019s Laboratories Ltd. 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