{"id":740201,"date":"2023-03-15T07:34:52","date_gmt":"2023-03-15T11:34:52","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-announces-development-plans-for-oral-ct1812-in-geographic-atrophy-secondary-to-dry-amd\/"},"modified":"2023-03-15T07:34:52","modified_gmt":"2023-03-15T11:34:52","slug":"cognition-therapeutics-announces-development-plans-for-oral-ct1812-in-geographic-atrophy-secondary-to-dry-amd","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-announces-development-plans-for-oral-ct1812-in-geographic-atrophy-secondary-to-dry-amd\/","title":{"rendered":"Cognition Therapeutics Announces Development Plans for Oral CT1812 in Geographic Atrophy Secondary to Dry AMD"},"content":{"rendered":"
\n

NEW YORK, March 15, 2023 (GLOBE NEWSWIRE) — Cognition Therapeutics, Inc.<\/a> (NASDAQ: CGTX) announced that its Investigational New Drug (IND) application for\u00a0the investigation of CT1812 for geographic atrophy (GA) secondary to dry age-related macular degeneration (dry AMD) has been cleared by the U.S. Food and Drug Administration (FDA). Cognition plans to initiate the Phase 2 MAGNIFY trial of its oral drug candidate, CT1812 in 2023 in individuals with dry AMD who have measurable GA.<\/p>\n

\u201cWe enjoyed a collaborative dialogue with the ophthalmology division of the FDA during our pre-IND meeting and are excited to assess the potential of CT1812 to impact GA and slow the decline in visual acuity in people with dry AMD,\u201d said Anthony Caggiano, M.D., Ph.D.<\/a>, Cognition\u2019s chief medical officer and head of R&D. \u201cWe believe that CT1812’s oral systemic delivery combined with its potential to protect the retinal pigment epithelium (RPE) from damage in both the affected and fellow eyes, may represent a significant advantage to the millions of people with dry AMD who are at risk for permanent vision loss.\u201d<\/p>\n

The MAGNIFY study (COG2201) is a randomized, placebo-controlled phase 2 trial expected to enroll approximately 246 people who have been diagnosed with dry AMD with measurable GA. Over the treatment period, change in GA lesion size and best-corrected visual acuity, as well as other measures of safety and efficacy will be assessed to determine if treatment can slow vision loss.<\/p>\n

\u201cExpansion of our pipeline programs into GA is an excellent example of how we are leveraging our scientific expertise to tackle some of the most challenging diseases,\u201d added Lisa Ricciardi<\/a>, president and CEO of Cognition. \u201cLooking ahead, I\u2019m excited by our continued clinical progress as we advance CT1812 through ongoing studies and now into this new indication.\u201d<\/p>\n

\n About CT1812<\/strong>
\n
\n CT1812<\/a> is an experimental orally delivered small molecule designed to penetrate the blood-brain and blood-retina barriers and bind selectively to the sigma-2 (\u03c3-2) receptor complex. The \u03c3-2 receptor complex is involved in the regulation of key cellular processes such as membrane trafficking and autophagy that are damaged by toxic interaction with soluble beta amyloid (A\u03b2) oligomers, oxidative stress and other stressors. Such damage to sensitive cells in the central nervous system (CNS) such as neurons and RPE cells can progress to a loss of function. In dry AMD, this can result in a loss of visual acuity and eventual vision loss.<\/p>\n

Early proof-of-concept studies with CT1812 indicate a role of \u03c3-2 receptor modulators in rescuing sensitive RPE cells from damage by stressors such as pathogenic proteins and oxidative stress, thus preserving this crucial component of the macula.<\/p>\n

In addition to Cognitions\u2019 new Phase 2 MAGNIFY clinical trial, CT1812 is being studied in three ongoing Phase 2 clinical trials<\/a>: the SEQUEL study, which recently concluded enrollment of adults with mild-to-moderate Alzheimer\u2019s disease; the SHINE study in individuals with mild-to-moderate Alzheimer\u2019s disease; and the SHIMMER study in individuals with dementia with Lewy bodies. CT1812 has not been approved by the U.S. FDA or other regulatory agency.<\/p>\n

\n About Geographic Atrophy Secondary to Dry AMD<\/strong>
\n
Dry AMD, one of two forms of AMD, is common among people over 50 and is caused by a degeneration and thinning of the macula, the part of the retina responsible for central vision. The gradual loss of central vision associated with dry AMD can present limitations in reading and driving. As the disease progresses in severity into geographic atrophy, which affects approximately 5 million people worldwide and 1 million in the United States, degeneration of retinal pigment epithelial cells can result in permanent vision loss.<\/p>\n

\n About Cognition Therapeutics, Inc.<\/strong>
\n
Cognition Therapeutics, Inc. is a clinical-stage biopharmaceutical company engaged in the discovery and development of innovative, small molecule therapeutics targeting age-related degenerative disorders of the central nervous system and retina. We are currently investigating our lead candidate CT1812 in clinical programs in Alzheimer\u2019s disease, dementia with Lewy bodies (DLB) and dry age-related macular degeneration (dry AMD). We believe CT1812 and our pipeline of \u03c3-2 receptor modulators can regulate pathways that are impaired in these diseases. We believe that targeting the \u03c3-2 receptor with CT1812 represents a mechanism functionally distinct from other current approaches in clinical development for the treatment of degenerative diseases. More about Cognition Therapeutics and its pipeline can be found at\u00a0https:\/\/cogrx.com<\/a>.<\/p>\n

\n Forward-Looking Statements<\/strong>
\n
\n This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. All statements contained in this press release, other than statements of historical facts or statements that relate to present facts or current conditions, including, but not limited to, statements regarding our product candidates, including CT1812, and any expected or implied benefits or results, our clinical development plans, including statements regarding our expected timing of the Phase 2 MAGNIFY trial, are forward-looking statements. These statements involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. In some cases, you can identify forward-looking statements by terms such as \u201cmay,\u201d \u201cmight,\u201d \u201cwill,\u201d \u201cshould,\u201d \u201cexpect,\u201d \u201cplan,\u201d \u201caim,\u201d \u201cseek,\u201d \u201canticipate,\u201d \u201ccould,\u201d \u201cintend,\u201d \u201ctarget,\u201d \u201cproject,\u201d \u201ccontemplate,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cpredict,\u201d \u201cforecast,\u201d \u201cpotential\u201d or \u201ccontinue\u201d or the negative of these terms or other similar expressions. We have based these forward-looking statements largely on our current expectations and projections about future events and financial trends that we believe may affect our business, financial condition, and results of operations. These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions, some of which cannot be predicted or quantified and some of which are beyond our control. These and other risks and uncertainties are described more fully in the \u201cRisk Factors\u201d section of our most recent filings with the Securities and Exchange Commission and are available at <\/em>
\n www.sec.gov<\/em>
\n . Factors that may cause actual results to differ materially from current expectations include, but are not limited to: competition; our ability to secure new (and retain existing) grant funding; our ability to grow and manage growth, maintain relationships with suppliers and retain our management and key employees; our ability to successfully advance our current and future product candidates through development activities, preclinical studies and clinical trials and costs related thereto; uncertainties inherent in the results of preliminary data and pre-clinical studies being predictive of the results of clinical trials; the timing, scope and likelihood of regulatory filings and approvals, including regulatory approval of our product candidates; changes in applicable laws or regulations; the possibility that the we may be adversely affected by other economic, business or competitive factors, including ongoing economic uncertainty; our estimates of expenses and profitability; the evolution of the markets in which we compete; our ability to implement our strategic initiatives and continue to innovate our existing products; our ability to defend our intellectual property; the impact of the ongoing COVID-19 pandemic on our business, supply chain and labor force; and the risks and uncertainties described in the \u201cRisk Factors\u201d section of our annual and quarterly reports filed the Securities Exchange Commission. These risks are not exhaustive and we face both known and unknown risks. You should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected in our forward-looking statements may not be achieved or occur, and actual results could differ materially from those projected in the forward-looking statements. Moreover, we operate in a dynamic industry and economy. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict all risk factors and uncertainties that we may face. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.<\/em>\n <\/p>\n

\n Contact Information:<\/strong>\u00a0
Cognition Therapeutics, Inc.\u00a0
info@cogrx.com<\/a><\/p>\n

Aline Sherwood (media)\u00a0
Scienta Communications\u00a0
asherwood@scientapr.com<\/a><\/p>\n

Daniel Kontoh-Boateng (investors)\u00a0
Tiberend Strategic Advisors, Inc.\u00a0
dboateng@tiberend.com<\/a><\/p>\n


\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

NEW YORK, March 15, 2023 (GLOBE NEWSWIRE) — Cognition Therapeutics, Inc. (NASDAQ: CGTX) announced that its Investigational New Drug (IND) application for\u00a0the investigation of CT1812 for geographic atrophy (GA) secondary to dry age-related macular degeneration (dry AMD) has been cleared by the U.S. Food and Drug Administration (FDA). Cognition plans to initiate the Phase 2 MAGNIFY trial of its oral drug candidate, CT1812 in 2023 in individuals with dry AMD who have measurable GA. \u201cWe enjoyed a collaborative dialogue with the ophthalmology division of the FDA during our pre-IND meeting and are excited to assess the potential of CT1812 to impact GA and slow the decline in visual acuity in people with dry AMD,\u201d said Anthony Caggiano, M.D., Ph.D., Cognition\u2019s … <\/p>\n

Continue reading “Cognition Therapeutics Announces Development Plans for Oral CT1812 in Geographic Atrophy Secondary to Dry AMD”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-740201","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nCognition Therapeutics Announces Development Plans for Oral CT1812 in Geographic Atrophy Secondary to Dry AMD - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-announces-development-plans-for-oral-ct1812-in-geographic-atrophy-secondary-to-dry-amd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cognition Therapeutics Announces Development Plans for Oral CT1812 in Geographic Atrophy Secondary to Dry AMD - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"NEW YORK, March 15, 2023 (GLOBE NEWSWIRE) — Cognition Therapeutics, Inc. (NASDAQ: CGTX) announced that its Investigational New Drug (IND) application for\u00a0the investigation of CT1812 for geographic atrophy (GA) secondary to dry age-related macular degeneration (dry AMD) has been cleared by the U.S. Food and Drug Administration (FDA). 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(NASDAQ: CGTX) announced that its Investigational New Drug (IND) application for\u00a0the investigation of CT1812 for geographic atrophy (GA) secondary to dry age-related macular degeneration (dry AMD) has been cleared by the U.S. Food and Drug Administration (FDA). Cognition plans to initiate the Phase 2 MAGNIFY trial of its oral drug candidate, CT1812 in 2023 in individuals with dry AMD who have measurable GA. \u201cWe enjoyed a collaborative dialogue with the ophthalmology division of the FDA during our pre-IND meeting and are excited to assess the potential of CT1812 to impact GA and slow the decline in visual acuity in people with dry AMD,\u201d said Anthony Caggiano, M.D., Ph.D., Cognition\u2019s … Continue reading \"Cognition Therapeutics Announces Development Plans for Oral CT1812 in Geographic Atrophy Secondary to Dry AMD\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-announces-development-plans-for-oral-ct1812-in-geographic-atrophy-secondary-to-dry-amd\/","og_site_name":"Market Newsdesk","article_published_time":"2023-03-15T11:34:52+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODc4ODU2NCM1NDYxODkzIzIwODQ4NzU=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-announces-development-plans-for-oral-ct1812-in-geographic-atrophy-secondary-to-dry-amd\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-announces-development-plans-for-oral-ct1812-in-geographic-atrophy-secondary-to-dry-amd\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Cognition Therapeutics Announces Development Plans for Oral CT1812 in Geographic Atrophy Secondary to Dry AMD","datePublished":"2023-03-15T11:34:52+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-announces-development-plans-for-oral-ct1812-in-geographic-atrophy-secondary-to-dry-amd\/"},"wordCount":1352,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-announces-development-plans-for-oral-ct1812-in-geographic-atrophy-secondary-to-dry-amd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODc4ODU2NCM1NDYxODkzIzIwODQ4NzU=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-announces-development-plans-for-oral-ct1812-in-geographic-atrophy-secondary-to-dry-amd\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-announces-development-plans-for-oral-ct1812-in-geographic-atrophy-secondary-to-dry-amd\/","name":"Cognition Therapeutics Announces Development Plans for Oral CT1812 in Geographic Atrophy Secondary to Dry AMD - 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