{"id":740084,"date":"2023-03-14T16:48:17","date_gmt":"2023-03-14T20:48:17","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/nurix-therapeutics-announces-presentations-at-the-american-association-for-cancer-research-aacr-2023-annual-meeting\/"},"modified":"2023-03-14T16:48:17","modified_gmt":"2023-03-14T20:48:17","slug":"nurix-therapeutics-announces-presentations-at-the-american-association-for-cancer-research-aacr-2023-annual-meeting","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/nurix-therapeutics-announces-presentations-at-the-american-association-for-cancer-research-aacr-2023-annual-meeting\/","title":{"rendered":"Nurix Therapeutics Announces Presentations at the American Association for Cancer Research (AACR) 2023 Annual Meeting"},"content":{"rendered":"<h2>\nNurix to report additional preclinical data for its targeted BTK degraders NX-2127 and NX-5948<br \/>\n<\/h2>\n<div class=\"mw_release\">\n<p align=\"left\">SAN FRANCISCO, March  14, 2023  (GLOBE NEWSWIRE) &#8212; Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company developing targeted protein modulation drugs designed to treat patients with hematologic malignancies and solid tumors, today announced that preclinical data from its targeted protein degradation programs, NX-2127 and NX-5948, will be presented at the American Association for Cancer Research (AACR) 2023 Annual Meeting, which is being held from April 14-19, 2023, in Orlando, FL. NX-2127 and NX-5948 are orally available targeted protein degraders of Bruton\u2019s tyrosine kinase (BTK) that are being evaluated in ongoing Phase 1 clinical trials in patients with relapsed or refractory B cell malignancies.<\/p>\n<p>\n        <strong>Details of the AACR Presentation Abstracts<\/strong><br \/>\n        \n      <\/p>\n<p>\n        <strong>Title:\u00a0<\/strong><br \/>\n        <em>NX-2127: A first-in-class clinical-stage degrader of BTK and IKZF1\/3 for the treatment of patients with B cell malignancies<\/em>\n      <\/p>\n<p>\n        <strong>Session Type:\u00a0<\/strong>Minisymposium<br \/><strong>Presenting Author:<\/strong> Jeffrey Mihalic, Ph.D., Senior Director, Medicinal Chemistry<br \/><strong>Session Category:<\/strong> Chemistry<br \/><strong>Session Title:\u00a0<\/strong>New Targeted Protein Degraders and Novel Design Strategies<br \/><strong>Session Date and Time:\u00a0<\/strong>Monday April 17, 2023, 2:30 PM \u2013 4:30 PM ET<br \/><strong>Published Abstract Number:<\/strong>\u00a03423<\/p>\n<p>\n        <strong>Title:\u00a0<\/strong><br \/>\n        <em>NX-5948 promotes selective, sub-nanomolar degradation of inhibitor-resistant BTK mutants<\/em>\n      <\/p>\n<p>\n        <strong>Session Category:\u00a0<\/strong>Experimental and Molecular Therapeutics<br \/><strong>Presenting Author:<\/strong> Mark Noviski, Ph.D., Senior Scientist, Cell Biology &amp; Project Lead<br \/><strong>Session Title:\u00a0<\/strong>Strategies for Reversal of Drug Resistance<br \/><strong>Session Date and Time:\u00a0<\/strong>Monday April 17, 2023, 1:30 PM &#8211; 5:00 PM ET<br \/><strong>Location:\u00a0<\/strong>Section 20<br \/><strong>Poster Board Number:\u00a0<\/strong>8<br \/><strong>Abstract Presentation Number:<\/strong>\u00a02850<\/p>\n<p>All presentations and posters will be available to registered attendees for on-demand viewing on the AACR website on April 14, 2023, beginning at 4:30 PM ET. Upon release at AACR, Nurix\u2019s presentations will also be available on the <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=KyRIxZAFD8fPIKCAWuuzJs_Y1nCfPX8tjXvUIPAPecYfEoWP8NJv3dY96GDEdC7lGLBCqJIKPimoTdokinT0P9RuStpWPLuIr-TkMirY17UL3JV86l5I7jDSdPR092-4\" rel=\"nofollow noopener\" target=\"_blank\">Posters and Presentations<\/a> section of the scientific resources page of Nurix\u2019s website.<\/p>\n<p>\n        <strong>About NX-2127<\/strong><br \/>\n        <br \/>NX-2127 is a novel bifunctional molecule that degrades BTK and cereblon neosubstrates Ikaros (IKZF1) and Aiolos (IKZF3). NX-2127 is currently being evaluated in a Phase 1 clinical trial in patients with relapsed or refractory B cell malignancies. Additional information on the ongoing clinical trial can be accessed at www.clinicaltrials.gov (<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=A4lgOimWAHNdpzu8aQYSDfT2OGeQQwLj4DDPGU8jWXtDQN-fA1zCwGi38g82Jug_ICokRkEBiLU9PmcwUxrYMUldsxTZhPvLtjQcOibOlao=\" rel=\"nofollow noopener\" target=\"_blank\">NCT04830137<\/a>).<\/p>\n<p>\n        <strong>About NX-5948 <\/strong><br \/>\n        <br \/>NX-5948 is an investigational, orally bioavailable, small molecule degrader of BTK that, differentiated from NX-2127, has been designed to lack cereblon immunomodulatory activity. NX-5948 is currently being evaluated in a Phase 1 clinical trial in patients with relapsed or refractory B cell malignancies. Additional information on the ongoing clinical trial can be accessed at clinicaltrials.gov (<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=rza5_ZyY6Tu-vGHyAbFJqzZjMK6W55gW7ZKnznXIkjkd-Rf5CPMrPJ4hb2z4AkEXCRvdWr4jKGACnrRJIyf39CStHZ4MpeLINuMJS2-kNvc=\" rel=\"nofollow noopener\" target=\"_blank\">NCT05131022<\/a>).<\/p>\n<p>\n        <strong>About Nurix Therapeutics, Inc. <\/strong><br \/>\n        <br \/>Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of small molecule and cell therapies based on the modulation of cellular protein levels as a novel treatment approach for cancer and other challenging diseases. Leveraging extensive expertise in E3 ligases together with proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix\u2019s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix\u2019s wholly owned pipeline includes targeted protein degraders of Bruton\u2019s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California. For additional information visit <br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=aV55v1Jtc5EA0rH2Rd_XMcntuBOhcyp8PP-XALcT5uJHyESZd2mR0jld7HnZxuhhjI9fzytT0PZnCRp2jSDRPYFRswR5FqmvU07nBfQ6VVA=\" rel=\"nofollow noopener\" target=\"_blank\">http:\/\/www.nurixtx.com<\/a>.<\/p>\n<p>\n        <strong>Forward-Looking Statements<br \/><\/strong>This press release contains statements that relate to future events and expectations and as such constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. When or if used in this press release, the words \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccould,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201coutlook,\u201d \u201cplan,\u201d \u201cpredict,\u201d \u201cshould,\u201d \u201cwill,\u201d and similar expressions and their variants, as they relate to Nurix, may identify forward-looking statements. All statements that reflect Nurix\u2019s expectations, assumptions or projections about the future, other than statements of historical fact, are forward-looking statements, including, without limitation, statements regarding the planned timing for the provision of preclinical data and initial findings from our clinical studies. Forward-looking statements reflect Nurix\u2019s current beliefs, expectations, and assumptions. Forward-looking statements are not guarantees of future performance and are subject to risks, uncertainties and changes in circumstances that are difficult to predict, which could cause Nurix\u2019s actual activities and results to differ materially from those expressed in any forward-looking statement. Such risks and uncertainties include, but are not limited to, the timing and results of preclinical studies and clinical trials and other risks and uncertainties described under the heading \u201cRisk Factors\u201d in Nurix\u2019s Annual Report on Form 10-K for the fiscal year ended November 30, 2022, and other SEC filings. Accordingly, readers are cautioned not to place undue reliance on these forward-looking statements. The statements in this press release speak only as of the date of this press release, even if subsequently made available by Nurix on its website or otherwise. Nurix disclaims any intention or obligation to update publicly any forward-looking statements, whether in response to new information, future events, or otherwise, except as required by applicable law.<\/p>\n<p>\n        <strong>Contacts:<\/strong>\n      <\/p>\n<p>\n        <strong>Investors<\/strong><br \/>\n        <br \/>Silinda Neou <br \/>Nurix Therapeutics <br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=aE4m9raDgWmO-2SAc67cgvovNxJw2dkJ5tJZSFQNtXU4vWe5NNk0WsXmb7_p_nuU71eqRPlyS_mx1PCMMSF3lQ==\" rel=\"nofollow noopener\" target=\"_blank\">ir@nurixtx.com<\/a><\/p>\n<p>Elizabeth Wolffe, Ph.D. <br \/>Wheelhouse Life Science Advisors <br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=g6qSoNMhZuxQAYPKKX_ECLkC9X68fRvsH8Go2s0M_Lf1iNTiO-fMl7ufkGckeVW1tPRwDtIOgLRGCKA1RuLMp2vIB-2IwB9fDJkUItB-5cY=\" rel=\"nofollow noopener\" target=\"_blank\">lwolffe@wheelhouselsa.com<\/a><\/p>\n<p>\n        <strong>Media<\/strong><br \/>\n        <br \/>Aljanae Reynolds<br \/>Wheelhouse Life Science Advisors <br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=x9tDCg8gjgEZ5K5CnwdHnd3pvkn-wlCXIBzfgnox0nIK74CW403D3wVOBhi6LrhkZrjm0Rjp4Mdp4LQD2BYWUYveod0w0DwoOPBYL45cqksbvZp3xmD_xT1Tt87fznCQ\" rel=\"nofollow noopener\" target=\"_blank\">areynolds@wheelhouselsa.com<\/a><\/p>\n<p>      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODc4ODM4MSM1NDU4OTczIzIyMDA2Njk=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/ZDdiZjJhODAtYmM5MS00MjExLTg5MjktY2FiMDYxYTYxOTdhLTEyMTIyMjI=\/tiny\/Nurix-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nurix to report additional preclinical data for its targeted BTK degraders NX-2127 and NX-5948 SAN FRANCISCO, March 14, 2023 (GLOBE NEWSWIRE) &#8212; Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company developing targeted protein modulation drugs designed to treat patients with hematologic malignancies and solid tumors, today announced that preclinical data from its targeted protein degradation programs, NX-2127 and NX-5948, will be presented at the American Association for Cancer Research (AACR) 2023 Annual Meeting, which is being held from April 14-19, 2023, in Orlando, FL. NX-2127 and NX-5948 are orally available targeted protein degraders of Bruton\u2019s tyrosine kinase (BTK) that are being evaluated in ongoing Phase 1 clinical trials in patients with relapsed or refractory B cell malignancies. Details of &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/nurix-therapeutics-announces-presentations-at-the-american-association-for-cancer-research-aacr-2023-annual-meeting\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Nurix Therapeutics Announces Presentations at the American Association for Cancer Research (AACR) 2023 Annual Meeting&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-740084","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nurix Therapeutics Announces Presentations at the American Association for Cancer Research (AACR) 2023 Annual Meeting - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/nurix-therapeutics-announces-presentations-at-the-american-association-for-cancer-research-aacr-2023-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nurix Therapeutics Announces Presentations at the American Association for Cancer Research (AACR) 2023 Annual Meeting - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Nurix to report additional preclinical data for its targeted BTK degraders NX-2127 and NX-5948 SAN FRANCISCO, March 14, 2023 (GLOBE NEWSWIRE) &#8212; Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company developing targeted protein modulation drugs designed to treat patients with hematologic malignancies and solid tumors, today announced that preclinical data from its targeted protein degradation programs, NX-2127 and NX-5948, will be presented at the American Association for Cancer Research (AACR) 2023 Annual Meeting, which is being held from April 14-19, 2023, in Orlando, FL. NX-2127 and NX-5948 are orally available targeted protein degraders of Bruton\u2019s tyrosine kinase (BTK) that are being evaluated in ongoing Phase 1 clinical trials in patients with relapsed or refractory B cell malignancies. 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(Nasdaq: NRIX), a clinical-stage biopharmaceutical company developing targeted protein modulation drugs designed to treat patients with hematologic malignancies and solid tumors, today announced that preclinical data from its targeted protein degradation programs, NX-2127 and NX-5948, will be presented at the American Association for Cancer Research (AACR) 2023 Annual Meeting, which is being held from April 14-19, 2023, in Orlando, FL. NX-2127 and NX-5948 are orally available targeted protein degraders of Bruton\u2019s tyrosine kinase (BTK) that are being evaluated in ongoing Phase 1 clinical trials in patients with relapsed or refractory B cell malignancies. 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