{"id":739769,"date":"2023-03-14T07:35:40","date_gmt":"2023-03-14T11:35:40","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/"},"modified":"2023-03-14T07:35:40","modified_gmt":"2023-03-14T11:35:40","slug":"reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/","title":{"rendered":"Reneo Pharmaceuticals Achieves Target Enrollment in the Pivotal STRIDE Study of Mavodelpar (REN001) in Primary Mitochondrial Myopathies"},"content":{"rendered":"<h2>\nTopline data from the STRIDE study expected in the fourth quarter of 2023<br \/>\n<\/h2>\n<div class=\"mw_release\">\n<p align=\"left\">IRVINE, Calif., March  14, 2023  (GLOBE NEWSWIRE) &#8212; Reneo Pharmaceuticals, Inc. (Nasdaq: RPHM), a clinical-stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, today announced that the company has achieved the target enrollment in the pivotal STRIDE study of mavodelpar (REN001) in primary mitochondrial myopathies (PMM). Topline data from the STRIDE study are expected in the fourth quarter of 2023.<\/p>\n<p>\u201cWe are very pleased to announce dosing of the 200<sup>th<\/sup> patient in the ongoing STRIDE study,\u201d said Gregory J. Flesher, President and CEO of Reneo Pharmaceuticals. \u201cWe achieved our target enrollment and have several pending patients that are awaiting their baseline visit. As such, we anticipate total enrollment of more than 200 patients and topline results in the fourth quarter of 2023. We are also pleased to see that approximately 85% of the eligible patients from STRIDE have opted to participate in STRIDE AHEAD, the mavodelpar two-year safety study.\u201d<\/p>\n<p>STRIDE is a global, randomized, double-blind, placebo-controlled pivotal Phase 2b trial of mavodelpar in adult patients with PMM due to mitochondrial (mtDNA) defects. The STRIDE study is designed to assess the efficacy and safety of 100 mg mavodelpar administered orally, once daily for 24 weeks. The primary efficacy endpoint is the change from baseline in the distance walked during the 12-minute walk test at week 24.<\/p>\n<p>STRIDE AHEAD is a 24-month, open-label, long-term safety trial outside of the United States in patients with PMM. The STRIDE AHEAD study was recently amended to allow enrollment of patients with PMM due to both mtDNA and nuclear DNA (nDNA) defects.<\/p>\n<p>Reneo intends to submit the data from STRIDE, together with the long-term safety data from STRIDE AHEAD, to the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) in planned marketing applications in 2024.<\/p>\n<p>\n        <strong>About Reneo Pharmaceuticals<\/strong>\n      <\/p>\n<p>Reneo is a clinical-stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, which are often associated with the inability of mitochondria to produce adenosine triphosphate (ATP). Our lead product candidate, mavodelpar, is a potent and selective agonist of the peroxisome proliferator-activated receptor delta (PPAR\u03b4). Mavodelpar has been shown to increase transcription of genes involved in mitochondrial function and increase fatty acid oxidation (FAO), and may increase production of new mitochondria. For additional information, please see\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=EmU6PaOUStNoKa9MjgklGCdsOZtWLV3R7TS_kybJBypVz0k-9-dHDdZyPrQQtDCcLDMZHGy2qUrp2rYXcEB_JA==\" rel=\"nofollow noopener\" target=\"_blank\">reneopharma.com<\/a>.<\/p>\n<p>\n        <strong>About Mavodelpar<\/strong>\n      <\/p>\n<p>Mavodelpar (REN001) is a potent and selective peroxisome proliferator-activated receptor delta (PPAR\u03b4) agonist currently in clinical development for two rare genetic mitochondrial diseases that typically present with myopathy and have high unmet medical needs: primary mitochondrial myopathies (PMM) and long-chain fatty acid oxidation disorders (LC-FAOD). For additional information, please see\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=5zxnUWpMXF_dC5UkpCAm_A3pU64dp0rptYhyCovgja7YldipbK94_VzLtJh4uxwVpoo5yMLEKpoFv4gajFFc3IdxN9LoZ4gMkXrU0LXScpE=\" rel=\"nofollow noopener\" target=\"_blank\">clinicaltrials.gov<\/a>.<\/p>\n<p>\n        <strong>About PMM<\/strong>\n      <\/p>\n<p>PMM are a group of rare, genetic metabolic disorders caused by mutations or deletions in the mitochondrial DNA (mtDNA) or nuclear DNA (nDNA). These genetic alterations hamper the ability of mitochondria to generate energy from nutrient sources, resulting in energy deficits that are most pronounced in tissues with high energy demand such as muscle, brain, and heart. The symptoms of PMM include muscle weakness, exercise intolerance, movement disorder, deafness, blindness, and droopy eyelids among others. The prognosis for these disorders ranges in severity from progressive weakness to death.<\/p>\n<p>\n        <strong>Forward-Looking Statements<\/strong>\u00a0<\/p>\n<p>\n        <em>Statements contained in this press release regarding matters that are not historical facts are \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include statements regarding, among other things, the completion of enrollment of clinical trials, announcement of topline data from the STRIDE study, and the submission of marketing applications. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Words such as \u201cplans,\u201d \u201cwill,\u201d \u201cbelieves,\u201d \u201canticipates,\u201d \u201cexpects,\u201d \u201cintends,\u201d \u201cgoal,\u201d \u201cpotential\u201d and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon Reneo\u2019s current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with Reneo\u2019s business in general, and the other risks described in Reneo\u2019s filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Reneo undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.<\/em>\u00a0<\/p>\n<p>\n        <strong>Contacts:<\/strong>\u00a0<\/p>\n<p>Danielle Spangler\u00a0<br \/>Investor Relations\u00a0<br \/>Reneo Pharmaceuticals, Inc.\u00a0<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=0J73pUTbfrPn5-Y0ic4oGN_3BD1RMnzfqOhK9ac95qMeUN3poifnyeBJ_RfbvTLdbW4Earg9q4b50WUg6zgGkaywaHqpH_vZoarH9D9yi-4=\" rel=\"nofollow noopener\" target=\"_blank\">dspangler@reneopharma.com<\/a>\u00a0<\/p>\n<p>David Melamed, Ph.D.\u00a0<br \/>Media Inquiries\u00a0<br \/>Russo Partners, LLC\u00a0<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=oW7bHeJm6H3-oBbZfvMhRL1eS1XmWFaxIOgsVaqXUcKrDnawqhKn08TsNXOkuJQu74ElHx_sjMqe96LDSmXy2FC5C8hAsZ7hqho5iYpMwsbPDaU5ZT1yMTiZvEXR2FWNJI9vEXSVJjxWH4Vrm1nlMQ==\" rel=\"nofollow noopener\" target=\"_blank\">david.melamed@russopartnersllc.com<\/a>\u00a0<\/p>\n<p>      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODc4NzQ1MyM1NDU5Mzk1IzIyMDcyMTA=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/NGU4NTAzZDMtOTA3MC00YjE1LWE5M2MtZjZkYTRhMDI0YTg1LTEyMTg3NjM=\/tiny\/Reneo-Pharmaceuticals-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Topline data from the STRIDE study expected in the fourth quarter of 2023 IRVINE, Calif., March 14, 2023 (GLOBE NEWSWIRE) &#8212; Reneo Pharmaceuticals, Inc. (Nasdaq: RPHM), a clinical-stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, today announced that the company has achieved the target enrollment in the pivotal STRIDE study of mavodelpar (REN001) in primary mitochondrial myopathies (PMM). Topline data from the STRIDE study are expected in the fourth quarter of 2023. \u201cWe are very pleased to announce dosing of the 200th patient in the ongoing STRIDE study,\u201d said Gregory J. Flesher, President and CEO of Reneo Pharmaceuticals. \u201cWe achieved our target enrollment and have several pending patients that are &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Reneo Pharmaceuticals Achieves Target Enrollment in the Pivotal STRIDE Study of Mavodelpar (REN001) in Primary Mitochondrial Myopathies&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-739769","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Reneo Pharmaceuticals Achieves Target Enrollment in the Pivotal STRIDE Study of Mavodelpar (REN001) in Primary Mitochondrial Myopathies - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reneo Pharmaceuticals Achieves Target Enrollment in the Pivotal STRIDE Study of Mavodelpar (REN001) in Primary Mitochondrial Myopathies - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Topline data from the STRIDE study expected in the fourth quarter of 2023 IRVINE, Calif., March 14, 2023 (GLOBE NEWSWIRE) &#8212; Reneo Pharmaceuticals, Inc. (Nasdaq: RPHM), a clinical-stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, today announced that the company has achieved the target enrollment in the pivotal STRIDE study of mavodelpar (REN001) in primary mitochondrial myopathies (PMM). Topline data from the STRIDE study are expected in the fourth quarter of 2023. \u201cWe are very pleased to announce dosing of the 200th patient in the ongoing STRIDE study,\u201d said Gregory J. Flesher, President and CEO of Reneo Pharmaceuticals. \u201cWe achieved our target enrollment and have several pending patients that are &hellip; Continue reading &quot;Reneo Pharmaceuticals Achieves Target Enrollment in the Pivotal STRIDE Study of Mavodelpar (REN001) in Primary Mitochondrial Myopathies&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-03-14T11:35:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODc4NzQ1MyM1NDU5Mzk1IzIyMDcyMTA=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Reneo Pharmaceuticals Achieves Target Enrollment in the Pivotal STRIDE Study of Mavodelpar (REN001) in Primary Mitochondrial Myopathies\",\"datePublished\":\"2023-03-14T11:35:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\\\/\"},\"wordCount\":802,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODc4NzQ1MyM1NDU5Mzk1IzIyMDcyMTA=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\\\/\",\"name\":\"Reneo Pharmaceuticals Achieves Target Enrollment in the Pivotal STRIDE Study of Mavodelpar (REN001) in Primary Mitochondrial Myopathies - 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(Nasdaq: RPHM), a clinical-stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, today announced that the company has achieved the target enrollment in the pivotal STRIDE study of mavodelpar (REN001) in primary mitochondrial myopathies (PMM). Topline data from the STRIDE study are expected in the fourth quarter of 2023. \u201cWe are very pleased to announce dosing of the 200th patient in the ongoing STRIDE study,\u201d said Gregory J. Flesher, President and CEO of Reneo Pharmaceuticals. \u201cWe achieved our target enrollment and have several pending patients that are &hellip; Continue reading \"Reneo Pharmaceuticals Achieves Target Enrollment in the Pivotal STRIDE Study of Mavodelpar (REN001) in Primary Mitochondrial Myopathies\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/","og_site_name":"Market Newsdesk","article_published_time":"2023-03-14T11:35:40+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODc4NzQ1MyM1NDU5Mzk1IzIyMDcyMTA=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Reneo Pharmaceuticals Achieves Target Enrollment in the Pivotal STRIDE Study of Mavodelpar (REN001) in Primary Mitochondrial Myopathies","datePublished":"2023-03-14T11:35:40+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/"},"wordCount":802,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODc4NzQ1MyM1NDU5Mzk1IzIyMDcyMTA=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/reneo-pharmaceuticals-achieves-target-enrollment-in-the-pivotal-stride-study-of-mavodelpar-ren001-in-primary-mitochondrial-myopathies\/","name":"Reneo Pharmaceuticals Achieves Target Enrollment in the Pivotal STRIDE Study of Mavodelpar (REN001) in Primary Mitochondrial Myopathies - 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