{"id":727063,"date":"2023-01-31T07:08:47","date_gmt":"2023-01-31T12:08:47","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/"},"modified":"2023-01-31T07:08:47","modified_gmt":"2023-01-31T12:08:47","slug":"first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/","title":{"rendered":"First Wave BioPharma Announces Initiation of Phase 2 Trial Investigating Enhanced Adrulipase Formulation in Exocrine Pancreatic Insufficiency in Patients with Cystic Fibrosis"},"content":{"rendered":"<h2>\nPatient screening to initiate; topline data expected by mid-2023<br \/>\n<\/h2>\n<div class=\"mw_release\">\n<p align=\"left\">BOCA RATON, Fla., Jan.  31, 2023  (GLOBE NEWSWIRE) &#8212; First Wave BioPharma, Inc. (NASDAQ:FWBI) (\u201cFirst Wave BioPharma\u201d or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for\u00a0gastrointestinal (GI) diseases, today announced that the Company will initiate its planned Phase 2 clinical trial of an enhanced enteric microgranule delivery formulation for adrulipase for the treatment of exocrine pancreatic insufficiency (EPI) in patients with cystic fibrosis (CF). The U.S. Food and Drug Administration (FDA) has reviewed the Investigational New Drug (IND) amendment and after requesting and receiving a modified protocol, has not provided any further comments in the 60 day period of review.<\/p>\n<p>The Phase 2 multi-center study is designed to investigate the safety, tolerability and efficacy of an enteric microgranule delivery formulation for adrulipase in a titrated dose-escalation study involving an estimated twelve (12) patients. The primary efficacy endpoint is the coefficient of fat absorption (CFA), with secondary endpoints of stool weight, signs and symptoms of malabsorption and coefficient of nitrogen absorption (CNA).<\/p>\n<p>First Wave BioPharma expects to initiate patient screening in early February 2023, with topline data anticipated by mid-2023. Three clinical trial sites in the U.S. will be participating in the trial.<\/p>\n<p>\u201cWe are very pleased to announce the initiation of the Phase 2 clinical trial investigating our new formulation of adrulipase as a potential treatment for EPI associated with cystic fibrosis and chronic pancreatitis,\u201d said James Sapirstein, President and CEO of First Wave BioPharma. \u201cPreclinical research has demonstrated the new adrulipase formulation is able to deliver the drug in the intended area of the gastrointestinal tract where it can provide the desired therapeutic effect. This Phase 2 clinical trial is designed to test that capability as a key step in our goal to provide patients with a more effective and convenient therapeutic option for EPI associated with cystic fibrosis and chronic pancreatitis.\u201d<\/p>\n<p>\n        <em>In vitro<\/em> data suggest the microgranule drug delivery formulation offers improved protection against the acidic pH in the stomach followed by the rapid release of adrulipase in the small intestine where the drug is expected to mix with food and deliver its therapeutic benefit. Additionally, <em>in vitro<\/em> research indicates the enhanced formulation has the potential to significantly decrease the number of pills a patient would need to take to achieve the desired therapeutic effect. The pill burden for current commercial porcine pancreatic enzyme replacement therapy (PERT) can be as high as 40 capsules per day, creating a substantial challenge for EPI patients.<\/p>\n<p>\n        <strong>Phase 2 SPAN Trial Design<\/strong><br \/>\n        <br \/>The Phase 2 SPAN trial is designed to investigate the safety, tolerability and efficacy of a new enteric microgranule formulation of adrulipase. The SPAN trial is an open-label study that will be conducted at three sites in the U.S. A total of 12 cystic fibrosis patients, 18 years or older are expected to be enrolled. The trial design employs a dose titration strategy. Patients will be screened at baseline to ensure that they have a coefficient of fat absorption (CFA) of at least 80%. Eligible patients will then be switched from their commercial enzyme product to adrulipase. Each patient will be started on a low dose of adrulipase. If the patient is not clinically controlled, the patient will be switched to a medium dose, and if not controlled on this dose, the patient will be advanced to a high dose. The titrations will be carried out over a three week period, after which a CFA will be obtained. End of study CFAs will be compared to the baseline CFAs in a descriptive fashion. A post-treatment safety visit will be conducted one week after completing the treatment period.<\/p>\n<p>\n        <strong>About Adrulipase\u00a0<\/strong><br \/>\n        <br \/>Adrulipase is a recombinant lipase enzyme administered as an oral, non-systemic biologic capsule for the treatment of exocrine pancreatic insufficiency (EPI) associated with cystic fibrosis (CF) and chronic pancreatitis (CP). Adrulipase is derived from the <em>Yarrowia lipolytica<\/em> yeast lipase and is designed to break up fat molecules in the digestive tract of EPI patients so that they can be absorbed as nutrients. EPI is a condition characterized by deficiency of the exocrine pancreatic enzymes, resulting in a patient\u2019s inability to digest food properly, or maldigestion. The deficiency in this enzyme can be responsible for greasy diarrhea, fecal urge and weight loss. There are more than 30,000 patients in the U.S. with EPI caused by cystic fibrosis according to the Cystic Fibrosis Foundation and approximately 90,000 patients in the U.S. with EPI caused by chronic pancreatitis according to the National Pancreas Foundation.<\/p>\n<p align=\"justify\">\n        <strong>About First Wave BioPharma, Inc.<\/strong><br \/>\n        <br \/>First Wave BioPharma is a clinical-stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for gastrointestinal (GI) diseases. The Company is currently advancing a therapeutic development pipeline with multiple clinical stage programs built around its two proprietary technologies \u2013 the biologic adrulipase, a recombinant lipase enzyme designed to enable the digestion of fats and other nutrients, and niclosamide, an oral small molecule with anti-inflammatory properties. First Wave is advancing two Phase 2 clinical programs built around adrulipase for the treatment of exocrine pancreatic insufficiency (FW-EPI) in patients with cystic fibrosis (CF) and chronic pancreatitis (CP). In developing adrulipase, First Wave is seeking to provide CF and CP patients with a safe and effective therapy to control EPI that is non-animal derived and offers the potential to dramatically reduce their daily pill burden. The company is also advancing multiple programs involving niclosamide, including FW-UP for ulcerative proctitis and ulcerative proctosigmoiditis, FW-UC for ulcerative colitis, and FW-CD for Crohn\u2019s disease. First Wave BioPharma is headquartered in Boca Raton, Florida. For more information visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=GtwVY40ff-cW8YPrYTsUJCmA9VhtBLulmdeV1KY0pjIYYZW2U6nGSF91BDkJxqxV7Z0eqyhmy4ECh89YGeAc6GJJ3jE8-pSMMpofgd3kd2w=\" rel=\"nofollow noopener\" target=\"_blank\">www.firstwavebio.com<\/a>.<\/p>\n<p>\n        <strong>Forward-Looking Statement<\/strong>\n      <\/p>\n<p align=\"justify\">\n        <em>This press release may contain certain statements relating to future results which are forward-looking statements. It is possible that the Company\u2019s actual results and financial condition may differ, possibly materially, from the anticipated results and financial condition indicated in these forward-looking statements, depending on factors including whether results obtained in preclinical and nonclinical studies and clinical trials will be indicative of results obtained in future clinical trials; whether preliminary or interim results from a clinical trial will be indicative of the final results of the trial; whether the contemplated offering will be successful and whether the Company will be able to regain and maintain compliance with Nasdaq\u2019s continued listing criteria; the size of the potential markets for the Company\u2019s drug candidates and its ability to service those markets; the effects of the First Wave Bio, Inc. acquisition, the related settlement and their effect on the Company\u2019s business, operating results and financial prospects; and the Company\u2019s current and future capital requirements and its ability to raise additional funds to satisfy its capital needs. Additional information concerning the Company and its business, including a discussion of factors that could materially affect the Company\u2019s financial results are contained in the Company\u2019s Annual Report on Form 10-K for the year ended December 31, 2021 under the heading \u201cRisk Factors,\u201d as well as the Company\u2019s subsequent filings with the Securities and Exchange Commission. All forward-looking statements included in this press release are made only as of the date of this press release, and we do not undertake any obligation to publicly update or correct any forward-looking statements to reflect events or circumstances that subsequently occur or of which we hereafter become aware.<\/em>\n      <\/p>\n<p>\n        <strong>For more information:<\/strong><br \/>\n        <br \/>First Wave BioPharma, Inc.<br \/>777 Yamato Road, Suite 502<br \/>Boca Raton, FL 33431<br \/>Phone: (561) 589-7020<br \/>info@firstwavebio.com<\/p>\n<p>\n        <strong>Media contact:<\/strong><br \/>\n        <br \/>\n        <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=oBFXjTsflvBvbnHa9VwvViGZj6bNh1CGdHhO4TPJXEziHcsW-Y8gFJLG2gwbBoABQ69UnAB9cotF_ykUZARsN3_iAcelYgJpGc5hpRgzyrg=\" rel=\"nofollow noopener\" target=\"_blank\">Tiberend Strategic Advisors, Inc.<\/a><br \/>\n        <br \/>David Schemelia<br \/>(609) 468-9325<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=RSIwgDBLANUELcQ4_5RRrXZvyWkbxXEH3mnN4cFr96ZRjuOPUIJL688fLAGnB5XuyZUOfSck_ei4hbxe-cgLjgf-U8t7WfTBP4W-9_iqaFU=\" rel=\"nofollow noopener\" target=\"_blank\">dschemelia@tiberend.com<\/a><\/p>\n<p>Bill Borden<br \/>(732) 910-1620<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=emdpZlhTheKAz0-PI7V8upY3SGvfaaPIDnBYkhYLJVn22V_4xeUUSncDQs7UMPu-WXyNMmnc4enn8KMtPCPeSYkHNtG7-AYosi_JMZ53Gzc=\" rel=\"nofollow noopener\" target=\"_blank\">bborden@tiberend.com<\/a><\/p>\n<\/p>\n<p>      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODczOTMwOSM1MzgyMTI5IzIwODIyMDc=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/NWFiMTIwM2YtN2ZmYi00MTk5LTgzNDUtNjVjYTc2MjFlNzQ3LTEwOTM3Nzg=\/tiny\/First-Wave-BioPharma-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Patient screening to initiate; topline data expected by mid-2023 BOCA RATON, Fla., Jan. 31, 2023 (GLOBE NEWSWIRE) &#8212; First Wave BioPharma, Inc. (NASDAQ:FWBI) (\u201cFirst Wave BioPharma\u201d or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for\u00a0gastrointestinal (GI) diseases, today announced that the Company will initiate its planned Phase 2 clinical trial of an enhanced enteric microgranule delivery formulation for adrulipase for the treatment of exocrine pancreatic insufficiency (EPI) in patients with cystic fibrosis (CF). The U.S. Food and Drug Administration (FDA) has reviewed the Investigational New Drug (IND) amendment and after requesting and receiving a modified protocol, has not provided any further comments in the 60 day period of review. The Phase 2 multi-center &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;First Wave BioPharma Announces Initiation of Phase 2 Trial Investigating Enhanced Adrulipase Formulation in Exocrine Pancreatic Insufficiency in Patients with Cystic Fibrosis&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-727063","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>First Wave BioPharma Announces Initiation of Phase 2 Trial Investigating Enhanced Adrulipase Formulation in Exocrine Pancreatic Insufficiency in Patients with Cystic Fibrosis - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First Wave BioPharma Announces Initiation of Phase 2 Trial Investigating Enhanced Adrulipase Formulation in Exocrine Pancreatic Insufficiency in Patients with Cystic Fibrosis - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Patient screening to initiate; topline data expected by mid-2023 BOCA RATON, Fla., Jan. 31, 2023 (GLOBE NEWSWIRE) &#8212; First Wave BioPharma, Inc. (NASDAQ:FWBI) (\u201cFirst Wave BioPharma\u201d or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for\u00a0gastrointestinal (GI) diseases, today announced that the Company will initiate its planned Phase 2 clinical trial of an enhanced enteric microgranule delivery formulation for adrulipase for the treatment of exocrine pancreatic insufficiency (EPI) in patients with cystic fibrosis (CF). The U.S. Food and Drug Administration (FDA) has reviewed the Investigational New Drug (IND) amendment and after requesting and receiving a modified protocol, has not provided any further comments in the 60 day period of review. The Phase 2 multi-center &hellip; Continue reading &quot;First Wave BioPharma Announces Initiation of Phase 2 Trial Investigating Enhanced Adrulipase Formulation in Exocrine Pancreatic Insufficiency in Patients with Cystic Fibrosis&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2023-01-31T12:08:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODczOTMwOSM1MzgyMTI5IzIwODIyMDc=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"First Wave BioPharma Announces Initiation of Phase 2 Trial Investigating Enhanced Adrulipase Formulation in Exocrine Pancreatic Insufficiency in Patients with Cystic Fibrosis\",\"datePublished\":\"2023-01-31T12:08:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\\\/\"},\"wordCount\":1269,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODczOTMwOSM1MzgyMTI5IzIwODIyMDc=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\\\/\",\"name\":\"First Wave BioPharma Announces Initiation of Phase 2 Trial Investigating Enhanced Adrulipase Formulation in Exocrine Pancreatic Insufficiency in Patients with Cystic Fibrosis - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/","og_locale":"en_US","og_type":"article","og_title":"First Wave BioPharma Announces Initiation of Phase 2 Trial Investigating Enhanced Adrulipase Formulation in Exocrine Pancreatic Insufficiency in Patients with Cystic Fibrosis - Market Newsdesk","og_description":"Patient screening to initiate; topline data expected by mid-2023 BOCA RATON, Fla., Jan. 31, 2023 (GLOBE NEWSWIRE) &#8212; First Wave BioPharma, Inc. (NASDAQ:FWBI) (\u201cFirst Wave BioPharma\u201d or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for\u00a0gastrointestinal (GI) diseases, today announced that the Company will initiate its planned Phase 2 clinical trial of an enhanced enteric microgranule delivery formulation for adrulipase for the treatment of exocrine pancreatic insufficiency (EPI) in patients with cystic fibrosis (CF). The U.S. Food and Drug Administration (FDA) has reviewed the Investigational New Drug (IND) amendment and after requesting and receiving a modified protocol, has not provided any further comments in the 60 day period of review. The Phase 2 multi-center &hellip; Continue reading \"First Wave BioPharma Announces Initiation of Phase 2 Trial Investigating Enhanced Adrulipase Formulation in Exocrine Pancreatic Insufficiency in Patients with Cystic Fibrosis\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/","og_site_name":"Market Newsdesk","article_published_time":"2023-01-31T12:08:47+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODczOTMwOSM1MzgyMTI5IzIwODIyMDc=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"First Wave BioPharma Announces Initiation of Phase 2 Trial Investigating Enhanced Adrulipase Formulation in Exocrine Pancreatic Insufficiency in Patients with Cystic Fibrosis","datePublished":"2023-01-31T12:08:47+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/"},"wordCount":1269,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODczOTMwOSM1MzgyMTI5IzIwODIyMDc=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/first-wave-biopharma-announces-initiation-of-phase-2-trial-investigating-enhanced-adrulipase-formulation-in-exocrine-pancreatic-insufficiency-in-patients-with-cystic-fibrosis\/","name":"First Wave BioPharma Announces Initiation of Phase 2 Trial Investigating Enhanced Adrulipase Formulation in Exocrine Pancreatic Insufficiency in Patients with Cystic Fibrosis - 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