{"id":726142,"date":"2023-01-26T08:33:33","date_gmt":"2023-01-26T13:33:33","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/bone-biologics-advances-preparations-for-nb1-pilot-clinical-trial-with-engagement-of-contract-research-organization\/"},"modified":"2023-01-26T08:33:33","modified_gmt":"2023-01-26T13:33:33","slug":"bone-biologics-advances-preparations-for-nb1-pilot-clinical-trial-with-engagement-of-contract-research-organization","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/bone-biologics-advances-preparations-for-nb1-pilot-clinical-trial-with-engagement-of-contract-research-organization\/","title":{"rendered":"Bone Biologics Advances Preparations for NB1 Pilot Clinical Trial with Engagement of Contract Research Organization"},"content":{"rendered":"

<\/p>\n

Bone Biologics Advances Preparations for NB1 Pilot Clinical Trial with Engagement of Contract Research Organization<\/b><\/p>\n

BURLINGTON, Mass.–(BUSINESS WIRE<\/a>)–Bone Biologics Corporation (NASDAQ: BBLG)<\/b>, a developer of orthobiologic products for spine fusion markets, announces it has engaged Avania as the contract research organization (CRO) for the Company\u2019s pilot clinical trial with NB1. Avania is an integrated global, full-service CRO with specialized expertise in medical devices, novel technology and drug-device combination products. The trial will evaluate the safety and effectiveness of Bone Biologic\u2019s novel NB1 in patients with degenerative disc disease undergoing a Transforaminal Lumbar Interbody Fusion (TLIF) procedure.\n<\/p>\n

\nThis multicenter, parallel group, randomized trial is designed to evaluate the safety and preliminary effectiveness of NB1 bone graft in 30 subjects with degenerative disc disease undergoing a TLIF. The trial is expected to be initiated in the second half of 2023, pending approval from the Monash Health system ethics committee in Australia.\n<\/p>\n

\nFor the NB1 bone graft device, the inclusion of rhNELL-1 provides an ancillary osteopromotive effect that is expected to increase both the quantity and maturity of bone and to increase the rate of spinal fusion. The proposed mechanism of action for rhNELL-1 to improve bone formation is based on published research and involves classic receptor binding and intracellular signaling transduction to the nucleus to promote osteogenic gene expression and bone formation.\n<\/p>\n

\n\u201cWe are encouraged by our progress in advancing NB1 into human testing and engaging Avania supports our plans to enter the clinic later this year,\u201d said Jeffrey Frelick, chief executive officer of Bone Biologics. \u201cWe have been steadfastly preparing for this trial, and engaging a prominent CRO builds upon the recent engagement of a contract manufacturer and finalizing the supply agreement with the carrier.\u201d\n<\/p>\n

About Bone Biologics<\/b><\/p>\n

\nBone Biologics was founded to pursue regenerative medicine for bone. The Company is undertaking work with select strategic partners that builds on the preclinical research of the Nell-1 protein. Bone Biologics is currently focusing its development efforts for its bone graft substitute product on bone regeneration in spinal fusion procedures, while additionally having rights to trauma and osteoporosis applications. For more information, please visit www.bonebiologics.com<\/a>.\n<\/p>\n

Forward-looking Statements<\/b><\/p>\n

\nCertain statements contained in this press release, including, without limitation, statements containing the words \u2018’believes,” “anticipates,” “expects” and words of similar import, constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements involve both known and unknown risks and uncertainties. The Company’s actual results may differ materially from those anticipated in its forward-looking statements as a result of a number of factors, including those including the Company’s ability to develop our lead product NELL-1 and other proposed products, its ability to obtain patent protection for its technology, its ability to obtain the necessary financing to develop products and conduct the necessary clinical testing, its ability to obtain Federal Food and Drug Administration approval to market any product it may develop in the United States and to obtain any other regulatory approval necessary to market any product in other countries, its ability to market any product it may develop, its ability to create, sustain, manage or forecast its growth; its ability to attract and retain key personnel; changes in the Company’s business strategy or development plans; competition; business disruptions; adverse publicity and international, national and local general economic and market conditions and risks generally associated with an undercapitalized developing company, as well as the risks contained under “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in the Company’s Form S-1, Form 10-K for the year ended December 31, 2021 and the Company’s other filings with the Securities and Exchange Commission. Except as required by applicable law, we undertake no obligation to revise or update any forward-looking statements to reflect any event or circumstance that may arise after the date hereof.\n<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20230126005289\/en\/<\/a><\/span><\/p>\n

\nLHA Investor Relations
\n
Kim Sutton Golodetz
\n
212-838-3777
\n
kgolodetz@lhai.com<\/a><\/p>\n

KEYWORDS:<\/b> United States North America Massachusetts<\/p>\n

INDUSTRY KEYWORDS:<\/b> Biotechnology Surgery Medical Devices Health Clinical Trials<\/p>\n

MEDIA:<\/b><\/p>\n\n","protected":false},"excerpt":{"rendered":"

Bone Biologics Advances Preparations for NB1 Pilot Clinical Trial with Engagement of Contract Research Organization BURLINGTON, Mass.–(BUSINESS WIRE)–Bone Biologics Corporation (NASDAQ: BBLG), a developer of orthobiologic products for spine fusion markets, announces it has engaged Avania as the contract research organization (CRO) for the Company\u2019s pilot clinical trial with NB1. Avania is an integrated global, full-service CRO with specialized expertise in medical devices, novel technology and drug-device combination products. The trial will evaluate the safety and effectiveness of Bone Biologic\u2019s novel NB1 in patients with degenerative disc disease undergoing a Transforaminal Lumbar Interbody Fusion (TLIF) procedure. This multicenter, parallel group, randomized trial is designed to evaluate the safety and preliminary effectiveness of NB1 bone graft in 30 subjects with degenerative … <\/p>\n

Continue reading “Bone Biologics Advances Preparations for NB1 Pilot Clinical Trial with Engagement of Contract Research Organization”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-726142","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nBone Biologics Advances Preparations for NB1 Pilot Clinical Trial with Engagement of Contract Research Organization - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/bone-biologics-advances-preparations-for-nb1-pilot-clinical-trial-with-engagement-of-contract-research-organization\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bone Biologics Advances Preparations for NB1 Pilot Clinical Trial with Engagement of Contract Research Organization - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Bone Biologics Advances Preparations for NB1 Pilot Clinical Trial with Engagement of Contract Research Organization BURLINGTON, Mass.–(BUSINESS WIRE)–Bone Biologics Corporation (NASDAQ: BBLG), a developer of orthobiologic products for spine fusion markets, announces it has engaged Avania as the contract research organization (CRO) for the Company\u2019s pilot clinical trial with NB1. Avania is an integrated global, full-service CRO with specialized expertise in medical devices, novel technology and drug-device combination products. The trial will evaluate the safety and effectiveness of Bone Biologic\u2019s novel NB1 in patients with degenerative disc disease undergoing a Transforaminal Lumbar Interbody Fusion (TLIF) procedure. 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