{"id":701770,"date":"2022-10-27T08:11:25","date_gmt":"2022-10-27T12:11:25","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/melt-pharmaceuticals-announces-dosing-of-last-patient-in-phase-2-pivotal-efficacy-and-safety-study-for-melt-300\/"},"modified":"2022-10-27T08:11:25","modified_gmt":"2022-10-27T12:11:25","slug":"melt-pharmaceuticals-announces-dosing-of-last-patient-in-phase-2-pivotal-efficacy-and-safety-study-for-melt-300","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/melt-pharmaceuticals-announces-dosing-of-last-patient-in-phase-2-pivotal-efficacy-and-safety-study-for-melt-300\/","title":{"rendered":"Melt Pharmaceuticals Announces Dosing of Last Patient in Phase 2 Pivotal Efficacy and Safety Study for MELT-300"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>Melt Pharmaceuticals Announces Dosing of Last Patient in Phase 2 Pivotal Efficacy and Safety Study for MELT-300<\/b><\/p>\n<p class=\"bwalignc\"><b>Top-Line Results Expected by Year-End<\/b><\/p>\n<p>NASHVILLE, Tenn.&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nMelt Pharmaceuticals, Inc., a clinical-stage pharmaceutical company developing novel approaches for procedural sedation and analgesia, today announced the dosing of the last patient in its Phase 2 pivotal efficacy and safety study for its lead product candidate, MELT-300, a sublingual, needle- and opioid-free patented formulation for procedural sedation and analgesia during cataract surgery. Top-line results from this study are expected before the end of the year.\n<\/p>\n<p>\nMELT-300 combines fixed doses of midazolam (3mg) and ketamine (50mg) in one dissolvable tablet that is administered sublingually for procedural sedation and analgesia during cataract surgery. This product candidate utilizes Catalent\u2019s proprietary fast-dissolving Zydis\u00ae delivery technology to rapidly dissolve the tablet for absorption across the very thin sublingual mucosa.\n<\/p>\n<p>\nThe factorial-designed, randomized, double-blind, placebo-controlled, parallel-cohort Phase 2 study was designed to evaluate the efficacy and safety of MELT-300 and the contribution of midazolam and ketamine components to sedation and intraoperative ocular analgesia in subjects undergoing cataract extraction with lens replacement (CELR). The trial compared MELT-300 against (i) placebo alone, (ii) sublingually delivered midazolam alone, and (iii) sublingually delivered ketamine alone, with the primary efficacy endpoints of appropriate sedation during the cataract surgery and management of intraoperative pain during the surgery. The study was conducted at nine sites and enrolled over 330 subjects.\n<\/p>\n<p>\n\u201cWith the dosing of the last patient in our MELT-300 Phase 2 study, we anticipate reporting top-line results by the end of 2022, representing a significant step forward towards the achievement of our mission to provide procedural sedation and analgesia that is needle- and opioid-free, enhancing the patient experience and their clinical outcome,\u201d said Larry Dillaha, M.D., CEO of Melt Pharmaceuticals. \u201cWe are grateful to the investigators and patients who have participated in this pivotal efficacy and safety study, which, to our knowledge, is the first serious attempt to advance the standard of anesthesia care for the nearly 5 million Americans each year who undergo cataract surgery. We are excited to learn and share the findings of the MELT-300 study, and, if the study is successful, we look forward to discussing with the U.S. Food and Drug Administration (FDA) the study results and next steps in the continued development of MELT-300 and its components as a needle- and opioid-free option for sedation and analgesia.\u201d\n<\/p>\n<p><b>About Melt Pharmaceuticals<\/b><\/p>\n<p>\nMelt Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company focused on the development and commercialization of proprietary non-opioid, non-IV, sedation and analgesia therapeutics for human medical procedures in hospital, outpatient and in-office settings. Melt intends to seek regulatory approval through the FDA\u2019s 505(b)(2) regulatory pathway for these proprietary, patented small-molecule product candidates, where possible. The core IP that Melt owns is a patented series of combination non-opioid sedation drug formulations that Melt believes has multiple clinical applications for potential indications of use. Melt Pharmaceuticals, Inc. is a former subsidiary of Harrow Health, Inc. (Nasdaq: HROW) and was carved out as a separately managed business in 2019. To learn more about Melt, please visit their website, <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.meltpharma.com&amp;esheet=52953975&amp;newsitemid=20221027005245&amp;lan=en-US&amp;anchor=www.meltpharma.com&amp;index=1&amp;md5=1ab54bc17cb8c71a35b3f9fdb327edf3\">www.meltpharma.com<\/a>.\n<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20221027005245r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20221027005245\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20221027005245\/en\/<\/a><\/span><\/p>\n<p><b>Investor Contact<\/b>:<br \/>\n<br \/>Larry Dillaha, M.D.<br \/>\n<br \/>Chief Executive Officer<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:ldillaha@meltpharma.com\">ldillaha@meltpharma.com<\/a><\/p>\n<p><b>KEYWORDS:<\/b> Tennessee United States North America<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Surgery Medical Supplies Hospitals FDA Clinical Trials Other Health Biotechnology Pharmaceutical Health Optical<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20221027005245\/en\/1153481\/3\/MELT_logo.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Melt Pharmaceuticals Announces Dosing of Last Patient in Phase 2 Pivotal Efficacy and Safety Study for MELT-300 Top-Line Results Expected by Year-End NASHVILLE, Tenn.&#8211;(BUSINESS WIRE)&#8211; Melt Pharmaceuticals, Inc., a clinical-stage pharmaceutical company developing novel approaches for procedural sedation and analgesia, today announced the dosing of the last patient in its Phase 2 pivotal efficacy and safety study for its lead product candidate, MELT-300, a sublingual, needle- and opioid-free patented formulation for procedural sedation and analgesia during cataract surgery. Top-line results from this study are expected before the end of the year. MELT-300 combines fixed doses of midazolam (3mg) and ketamine (50mg) in one dissolvable tablet that is administered sublingually for procedural sedation and analgesia during cataract surgery. This product candidate &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/melt-pharmaceuticals-announces-dosing-of-last-patient-in-phase-2-pivotal-efficacy-and-safety-study-for-melt-300\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Melt Pharmaceuticals Announces Dosing of Last Patient in Phase 2 Pivotal Efficacy and Safety Study for MELT-300&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-701770","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Melt Pharmaceuticals Announces Dosing of Last Patient in Phase 2 Pivotal Efficacy and Safety Study for MELT-300 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/melt-pharmaceuticals-announces-dosing-of-last-patient-in-phase-2-pivotal-efficacy-and-safety-study-for-melt-300\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Melt Pharmaceuticals Announces Dosing of Last Patient in Phase 2 Pivotal Efficacy and Safety Study for MELT-300 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Melt Pharmaceuticals Announces Dosing of Last Patient in Phase 2 Pivotal Efficacy and Safety Study for MELT-300 Top-Line Results Expected by Year-End NASHVILLE, Tenn.&#8211;(BUSINESS WIRE)&#8211; Melt Pharmaceuticals, Inc., a clinical-stage pharmaceutical company developing novel approaches for procedural sedation and analgesia, today announced the dosing of the last patient in its Phase 2 pivotal efficacy and safety study for its lead product candidate, MELT-300, a sublingual, needle- and opioid-free patented formulation for procedural sedation and analgesia during cataract surgery. Top-line results from this study are expected before the end of the year. MELT-300 combines fixed doses of midazolam (3mg) and ketamine (50mg) in one dissolvable tablet that is administered sublingually for procedural sedation and analgesia during cataract surgery. 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Top-line results from this study are expected before the end of the year. MELT-300 combines fixed doses of midazolam (3mg) and ketamine (50mg) in one dissolvable tablet that is administered sublingually for procedural sedation and analgesia during cataract surgery. 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