{"id":692332,"date":"2022-10-05T08:06:36","date_gmt":"2022-10-05T12:06:36","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/"},"modified":"2022-10-05T08:06:36","modified_gmt":"2022-10-05T12:06:36","slug":"xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/","title":{"rendered":"Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting"},"content":{"rendered":"<p>        <!--.bwlistdisc { list-style-type: disc }\n.bwuline { text-decoration: underline }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p><b>Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting<\/b><\/p>\n<p>MONROVIA, Calif.&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nXencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced seven poster presentations at the 37th Annual Meeting of the Society for Immunotherapy of Cancer, being held in Boston, November 10-12, 2022.\n<\/p>\n<p>\nData from the first patients enrolled in a Phase 2 study of vudalimab, Xencor\u2019s selective PD-1 x CTLA-4 bispecific antibody, plus chemotherapy in patients with metastatic castration-resistant prostate cancer, will be presented in abstract 668.\n<\/p>\n<p><b>Presentation Details<\/b><\/p>\n<p><span class=\"bwuline\">Clinical Trials in Progress<\/span><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nAbstract 667, \u201cA Phase 1, multiple-dose study to evaluate the safety and tolerability of XmAb<sup>\u00ae<\/sup>819 (ENPP3 x CD3) in subjects with relapsed or refractory clear cell renal cell carcinoma (RCC)\u201d\n<\/li>\n<li>\nAbstract 668, \u201cA Phase 2 study of vudalimab, a PD-1 x CTLA-4 bispecific antibody, plus chemotherapy or targeted therapy in patients with molecularly defined subtypes of metastatic castration-resistant prostate cancer\u201d\n<\/li>\n<li>\nAbstract 733, \u201cA Phase 2 study of vudalimab (XmAb<sup>\u00ae<\/sup>20717), an anti-PD-1\/CTLA-4 bispecific antibody, in patients with selected gynecological malignancies and high-risk metastatic castration-resistant prostate-cancer\u201d\n<\/li>\n<\/ul>\n<p><span class=\"bwuline\">Preclinical Programs<\/span><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nAbstract 1067, \u201cSynergistic combination of Natural Killer cell engagers (NKEs) with proinflammatory cytokines\u201d\n<\/li>\n<li>\nAbstract 1073, \u201cCostimulatory CD28 trispecific antibodies targeting PDL1 and PDL2 enhance T cell activation in solid tumors\u201d\n<\/li>\n<li>\nAbstract 1079, \u201cLAG3-targeted IL15\/IL15R\u03b1-Fc (LAG3 x IL15) fusion proteins for preferential TIL expansion via cis delivery of IL15 to LAG3+ cells\u201d\n<\/li>\n<li>\nAbstract 1372, \u201cXmAb143, an engineered IL18 heterodimeric Fc-fusion, features improved stability, reduced potency, and insensitivity to IL18BP\u201d\n<\/li>\n<\/ul>\n<p>\nPosters will be available in the poster hall and virtually to registrants of the SITC Annual Meeting, beginning at 9:00 a.m. ET on Thursday, November 10. In the poster hall, odd numbered posters will be displayed on Thursday, November 10, and even numbered posters will be displayed on Friday, November 11. Posters will be archived under &#8220;Events &amp; Presentations&#8221; in the Investors section of the Company&#8217;s website located at <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.xencor.com&amp;esheet=52937069&amp;newsitemid=20221005005321&amp;lan=en-US&amp;anchor=www.xencor.com&amp;index=1&amp;md5=6d126a00a784532589018f16a42b2dfb\">www.xencor.com<\/a>.\n<\/p>\n<p><b>About Vudalimab<\/b><\/p>\n<p>\nVudalimab is an XmAb bispecific antibody that simultaneously targets immune checkpoint receptors PD-1 and CTLA-4 and is designed to promote tumor-selective T-cell activation. Xencor\u2019s approach to dual checkpoint inhibition reduces the need for multiple antibodies and allows for more selective targeting of T cells with high checkpoint expression of both targets, which may potentially improve the therapeutic index of combination immunotherapies. In preclinical studies, dual blockade of PD-1 and CTLA-4 with vudalimab significantly enhanced T cell proliferation and activation, and anti-tumor activity in vivo. Xencor is conducting a Phase 2 clinical study of vudalimab in patients with metastatic castration resistant prostate cancer (mCRPC), plus chemotherapy for certain patient populations, and a Phase 2 clinical study in patients with advanced gynecologic and genitourinary malignancies, as well as high-risk mCRPC.\n<\/p>\n<p><b>About XmAb<sup>\u00ae<\/sup>819<\/b><\/p>\n<p>\nXmAb<sup>\u00ae<\/sup>819 is a tumor-targeted, T-cell engaging XmAb 2+1 bispecific antibody in development for patients with renal cell carcinoma (RCC). XmAb819 engages the immune system by activating T cells for highly potent and targeted killing of tumor cells expressing ENPP3, an antigen highly expressed on kidney cancers. ENPP3 is differentially expressed between RCC (high expression) and normal tissues (low expression). To attack RCC cells selectively, XmAb819 was engineered as an XmAb 2+1 bispecific antibody with two binding domains against ENPP3 and one cytotoxic T-cell binding domain against CD3, a component of the T-cell receptor (TCR) complex. Xencor\u2019s XmAb Bispecific Fc Domain serves as the scaffold for these binding domains and provides long circulating half-life, stability and ease of manufacture. Xencor is conducting a Phase 1 study of XmAb819 in patients with advanced renal cell carcinoma.\n<\/p>\n<p><b>About Xencor<\/b><\/p>\n<p>\nXencor is a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of patients with cancer and autoimmune diseases. More than 20 candidates engineered with Xencor&#8217;s XmAb\u00ae technology are in clinical development, and three XmAb medicines are marketed by partners. Xencor&#8217;s XmAb engineering technology enables small changes to a protein&#8217;s structure that result in new mechanisms of therapeutic action. For more information, please visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.xencor.com&amp;esheet=52937069&amp;newsitemid=20221005005321&amp;lan=en-US&amp;anchor=www.xencor.com&amp;index=2&amp;md5=4932d3f1777f6b3aadec185b132bc977\">www.xencor.com<\/a>.\n<\/p>\n<p><b>Forward-Looking Statements<\/b><\/p>\n<p>\nCertain statements contained in this press release may constitute forward-looking statements within the meaning of applicable securities laws. Forward-looking statements include statements that are not purely statements of historical fact, and can generally be identified by the use of words such as \u201cpotential,\u201d \u201ccan,\u201d \u201cwill,\u201d \u201cplan,\u201d \u201cmay,\u201d \u201ccould,\u201d \u201cwould,\u201d \u201cexpect,\u201d \u201canticipate,\u201d \u201cseek,\u201d \u201clook forward,\u201d \u201cbelieve,\u201d \u201ccommitted,\u201d \u201cinvestigational,\u201d and similar terms, or by express or implied discussions relating to Xencor\u2019s business, including, but not limited to, statements regarding the timing of data from Xencor\u2019s early and clinical-stage programs and other statements that are not purely statements of historical fact. Such statements are made on the basis of the current beliefs, expectations, and assumptions of the management of Xencor and are subject to significant known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements and the timing of events to be materially different from those implied by such statements, and therefore these statements should not be read as guarantees of future performance or results. Such risks include, without limitation, the risks associated with the process of discovering, developing, manufacturing and commercializing drugs that are safe and effective for use as human therapeutics and other risks, including the ability of publicly disclosed preliminary clinical trial data to support continued clinical development and regulatory approval for specific treatments, in each case as described in Xencor&#8217;s public securities filings. For a discussion of these and other factors, please refer to Xencor&#8217;s annual report on Form 10-K for the year ended December 31, 2021 as well as Xencor&#8217;s subsequent filings with the Securities and Exchange Commission. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. This caution is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, as amended to date. All forward-looking statements are qualified in their entirety by this cautionary statement and Xencor undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof, except as required by law.\n<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20221005005321r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20221005005321\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20221005005321\/en\/<\/a><\/span><\/p>\n<p>\nFor Investors:<br \/>\n<br \/>Charles Liles<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:cliles@xencor.com\">cliles@xencor.com<br \/>\n<\/a><br \/>626-737-8118\n<\/p>\n<p>\nFor Media:<br \/>\n<br \/>Jason I. Spark<br \/>\n<br \/>Evoke Canale<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:jason.spark@evokegroup.com\">jason.spark@evokegroup.com<br \/>\n<\/a><br \/>619-849-6005\n<\/p>\n<p><b>KEYWORDS:<\/b> United States North America California Massachusetts<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Biotechnology Health Pharmaceutical Clinical Trials Oncology<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20221005005321\/en\/1222964\/3\/Xencor_logo_BW.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting MONROVIA, Calif.&#8211;(BUSINESS WIRE)&#8211; Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced seven poster presentations at the 37th Annual Meeting of the Society for Immunotherapy of Cancer, being held in Boston, November 10-12, 2022. Data from the first patients enrolled in a Phase 2 study of vudalimab, Xencor\u2019s selective PD-1 x CTLA-4 bispecific antibody, plus chemotherapy in patients with metastatic castration-resistant prostate cancer, will be presented in abstract 668. Presentation Details Clinical Trials in Progress Abstract 667, \u201cA Phase 1, multiple-dose study to evaluate the safety and tolerability of XmAb\u00ae819 &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-692332","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting MONROVIA, Calif.&#8211;(BUSINESS WIRE)&#8211; Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced seven poster presentations at the 37th Annual Meeting of the Society for Immunotherapy of Cancer, being held in Boston, November 10-12, 2022. Data from the first patients enrolled in a Phase 2 study of vudalimab, Xencor\u2019s selective PD-1 x CTLA-4 bispecific antibody, plus chemotherapy in patients with metastatic castration-resistant prostate cancer, will be presented in abstract 668. Presentation Details Clinical Trials in Progress Abstract 667, \u201cA Phase 1, multiple-dose study to evaluate the safety and tolerability of XmAb\u00ae819 &hellip; Continue reading &quot;Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-05T12:06:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20221005005321r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting\",\"datePublished\":\"2022-10-05T12:06:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\\\/\"},\"wordCount\":1075,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20221005005321r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\\\/\",\"name\":\"Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/","og_locale":"en_US","og_type":"article","og_title":"Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting - Market Newsdesk","og_description":"Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting MONROVIA, Calif.&#8211;(BUSINESS WIRE)&#8211; Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced seven poster presentations at the 37th Annual Meeting of the Society for Immunotherapy of Cancer, being held in Boston, November 10-12, 2022. Data from the first patients enrolled in a Phase 2 study of vudalimab, Xencor\u2019s selective PD-1 x CTLA-4 bispecific antibody, plus chemotherapy in patients with metastatic castration-resistant prostate cancer, will be presented in abstract 668. Presentation Details Clinical Trials in Progress Abstract 667, \u201cA Phase 1, multiple-dose study to evaluate the safety and tolerability of XmAb\u00ae819 &hellip; Continue reading \"Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/","og_site_name":"Market Newsdesk","article_published_time":"2022-10-05T12:06:36+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20221005005321r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting","datePublished":"2022-10-05T12:06:36+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/"},"wordCount":1075,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20221005005321r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/xencor-to-present-seven-posters-on-multiple-clinical-trials-and-research-stage-programs-at-the-sitc-annual-meeting\/","name":"Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting - 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