{"id":688366,"date":"2022-09-23T07:25:07","date_gmt":"2022-09-23T11:25:07","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/artivion-follows-recommendation-to-stop-proact-xa-clinical-trial\/"},"modified":"2022-09-23T07:25:07","modified_gmt":"2022-09-23T11:25:07","slug":"artivion-follows-recommendation-to-stop-proact-xa-clinical-trial","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/artivion-follows-recommendation-to-stop-proact-xa-clinical-trial\/","title":{"rendered":"Artivion Follows Recommendation to Stop PROACT Xa Clinical Trial"},"content":{"rendered":"
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PR Newswire<\/p>\n<\/p><\/div>\n

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\n Study Was Evaluating the Use of Apixaban in Patients Treated with Mechanical Aortic Valves<\/i>\n <\/p>\n

\n ATLANTA<\/span>, Sept. 23, 2022<\/span> \/PRNewswire\/ — Artivion, Inc. (NYSE: AORT)<\/b>, a leading cardiac and vascular surgery company focused on aortic disease, announced today that it has stopped the PROACT Xa clinical trial, a prospective, randomized, trial designed to determine if patients with an On-X mechanical aortic valve can be maintained safely and effectively on apixaban rather than on warfarin. The decision was based on the recommendation of the independent Data and Safety Monitoring Board (DSMB) of the trial due to lack of evidence supporting non-inferiority of apixaban to warfarin for valve thrombosis and thromboembolism.<\/p>\n

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The PROACT Xa trial randomized patients having an On-X aortic valve replacement to receive either warfarin or apixaban as their anticoagulant to prevent blood clots. The trial began enrolling in April 2020<\/span>. The DSMB found that blood clots, resulting in stroke, occurred more frequently in patients receiving apixaban and that continuing the trial was unlikely to achieve the primary endpoint while possibly exposing patients to increased risk. Physician investigators at the trial’s sites are being notified to change patients who are in the apixaban arm of the trial back to warfarin.<\/p>\n

Dr. John Alexander<\/span>, Chair of the PROACT Xa trial and Professor of Medicine\/Cardiology at Duke University<\/span> School of Medicine, said, “The PROACT Xa trial was designed to determine whether apixaban would yield equivalent safety to the standard anticoagulant, warfarin. Unfortunately, it appears that it does not. On behalf of all of the investigators, we appreciate the research effort into the science of managing patients with artificial heart valves.”<\/p>\n

\n Pat Mackin<\/span>, Chairman, President and Chief Executive Officer of Artivion said, “The On-X aortic valve has a long track record of safe and efficacious outcomes and is the leading mechanical aortic valve in the United States<\/span> and in other markets around the globe. Despite this setback, the On-X aortic valve provides significant clinical benefits to patients and remains the only mechanical aortic valve for which patients can be safely managed with reduced blood thinners, leading to a 60 percent reduction in bleeding.”<\/p>\n

Mr. Mackin continued, “We are disappointed to stop the PROACT Xa trial as a successful trial would have significantly benefited patients and significantly increased our addressable market opportunity beginning in 2025. Despite stopping the trial, we are reiterating our 2022 outlook of delivering double-digit top-line growth and we remain committed to delivering the financial expectations we communicated in our March investor meeting: Double digit top-line growth, expanding gross margins, and accelerated adjusted EBITDA growth through 2024. We had committed approximately $10 million<\/span> in annual funding to this study through 2024 and will now redirect these funds to other development opportunities and to incremental EBITDA and cash flow in 2023 and 2024.”<\/p>\n

\n Webcast and Conference Call Information
<\/b>The Company will hold a teleconference call and live webcast later today, September 23, 2022<\/span>, at 8:30 a.m. ET<\/span>. To participate in the conference call dial 201-689-8261 a few minutes prior to 8:30\u00a0a.m. ET. The teleconference replay will be available approximately one hour following the completion of the event and can be accessed by calling (toll free) 877-660-6853 or 201-612-7415. The conference number for the replay is 13733128.<\/p>\n

The live webcast and replay can be accessed by going to the Investors section of the Artivion website at\u00a0www.Artivion.com\u00a0and selecting the heading Webcasts & Presentations.<\/p>\n

\n About Artivion
<\/b>Headquartered in suburban Atlanta, Georgia<\/span>, Artivion, Inc. is a medical device company focused on developing simple, elegant solutions that address cardiac and vascular surgeons’ most difficult challenges in treating patients with aortic diseases. This multinational company’s four major groups of products include: aortic stents and stent grafts, prosthetic heart valves, cryopreserved cardiac and vascular allografts, and surgical sealants. Artivion markets and sells products in more than 100 countries worldwide. For additional information about Artivion, visit our website,\u00a0www.artivion.com<\/a>.<\/p>\n

\n Forward Looking Statements
<\/b>
\n Statements made in this press release that look forward in time or that express management’s beliefs, expectations, or hopes are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements reflect the views of management at the time such statements are made. These statements include our beliefs that the On-X aortic valve is the leading mechanical aortic valve in the United States<\/span> and in other markets around the globe; that the On-X aortic valve provides significant clinical benefits to patients and remains the only mechanical aortic valve for which patients can be safely managed with reduced blood thinners, leading to a 60 percent reduction in bleeding; and our expectations that we will achieve our 2022 outlook of delivering double-digit top line growth; will deliver on the financial expectations we communicated in our March investor meeting: Double digit top-line growth, expanding gross margins, and accelerated adjusted EBITDA growth through 2022; and will redirect the funds we planned to invest in the PROACT Xa clinical trial into other development opportunities and to incremental EBITDA and cash flow in 2023 and 2024.<\/i>
\n These forward-looking statements are subject to a number of risks, uncertainties, estimates, and assumptions that may cause actual results to differ materially from current expectations. These risks and uncertainties include the risk factors detailed in our Securities and Exchange Commission filings, including our Form 10-K for year ended December 31, 2021<\/span>. Artivion does not undertake to update its forward-looking statements, whether as a result of new information, future events, or otherwise.<\/i>\n <\/p>\n

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\n Artivion <\/b>
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\n Gilmartin\u00a0Group LLC<\/b>
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\n D. Ashley Lee <\/span>\n <\/p>\n<\/td>\n

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\n Brian Johnston \/ Lynn Lewis<\/span>\n <\/p>\n<\/td>\n<\/tr>\n

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\n Executive Vice President & Chief Financial Officer<\/span>\n <\/p>\n<\/td>\n

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\n Phone:\u00a0 631-807-1986<\/span>\n <\/p>\n<\/td>\n<\/tr>\n

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\n Phone: 770-419-3355 <\/span>\n <\/p>\n<\/td>\n

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\n investors@artivion.com<\/span>\n <\/p>\n<\/td>\n<\/tr>\n

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\n \"Cision\" View original content to download multimedia:https:\/\/www.prnewswire.com\/news-releases\/artivion-follows-recommendation-to-stop-proact-xa-clinical-trial-301631774.html<\/a><\/p>\n

SOURCE Artivion, Inc.<\/p>\n<\/p><\/div>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

PR Newswire Study Was Evaluating the Use of Apixaban in Patients Treated with Mechanical Aortic Valves ATLANTA, Sept. 23, 2022 \/PRNewswire\/ — Artivion, Inc. (NYSE: AORT), a leading cardiac and vascular surgery company focused on aortic disease, announced today that it has stopped the PROACT Xa clinical trial, a prospective, randomized, trial designed to determine if patients with an On-X mechanical aortic valve can be maintained safely and effectively on apixaban rather than on warfarin. The decision was based on the recommendation of the independent Data and Safety Monitoring Board (DSMB) of the trial due to lack of evidence supporting non-inferiority of apixaban to warfarin for valve thrombosis and thromboembolism. The PROACT Xa trial randomized patients having an On-X aortic … <\/p>\n

Continue reading “Artivion Follows Recommendation to Stop PROACT Xa Clinical Trial”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-688366","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nArtivion Follows Recommendation to Stop PROACT Xa Clinical Trial - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/artivion-follows-recommendation-to-stop-proact-xa-clinical-trial\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Artivion Follows Recommendation to Stop PROACT Xa Clinical Trial - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"PR Newswire Study Was Evaluating the Use of Apixaban in Patients Treated with Mechanical Aortic Valves ATLANTA, Sept. 23, 2022 \/PRNewswire\/ — Artivion, Inc. (NYSE: AORT), a leading cardiac and vascular surgery company focused on aortic disease, announced today that it has stopped the PROACT Xa clinical trial, a prospective, randomized, trial designed to determine if patients with an On-X mechanical aortic valve can be maintained safely and effectively on apixaban rather than on warfarin. The decision was based on the recommendation of the independent Data and Safety Monitoring Board (DSMB) of the trial due to lack of evidence supporting non-inferiority of apixaban to warfarin for valve thrombosis and thromboembolism. 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