{"id":687904,"date":"2022-09-22T07:03:54","date_gmt":"2022-09-22T11:03:54","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/revolution-medicines-doses-first-patient-in-phase-1-1b-clinical-trial-of-rmc-6291-companys-first-mutant-selective-rason-inhibitor\/"},"modified":"2022-09-22T07:03:54","modified_gmt":"2022-09-22T11:03:54","slug":"revolution-medicines-doses-first-patient-in-phase-1-1b-clinical-trial-of-rmc-6291-companys-first-mutant-selective-rason-inhibitor","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/revolution-medicines-doses-first-patient-in-phase-1-1b-clinical-trial-of-rmc-6291-companys-first-mutant-selective-rason-inhibitor\/","title":{"rendered":"Revolution Medicines Doses First Patient in Phase 1\/1b Clinical Trial of RMC-6291, Company\u2019s First Mutant-Selective RAS(ON) Inhibitor"},"content":{"rendered":"
\n

\n KRAS<\/em>
\n
\n G12C<\/em>
\n <\/sup>
\n (ON) Inhibitor with highly differentiated mechanism of action being evaluated in patients with cancers harboring KRAS<\/em>
\n
\n G12C<\/em>
\n <\/sup>
\n mutation<\/em>
\n \n <\/p>\n

\n RMC-6291 is first mutant-selective RAS(ON) Inhibitor to enter clinic, following closely behind company\u2019s RAS<\/em>
\n
\n MULTI<\/em>
\n <\/sup>
\n (ON) Inhibitor, RMC-6236 <\/em>\n <\/p>\n

REDWOOD CITY, Calif., Sept. 22, 2022 (GLOBE NEWSWIRE) — Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing targeted therapies for RAS-addicted cancers, today announced the first patient was dosed in its Phase 1\/1b monotherapy clinical trial of RMC-6291, an oral, selective, covalent KRASG12C<\/sup>(ON) Inhibitor designed to treat patients with cancers driven by the KRASG12C<\/sup> mutation. RMC-6291, which exhibits a potential best-in-class preclinical profile, is the first drug candidate from the company\u2019s pipeline of mutant-selective RAS(ON) Inhibitors to enter the clinic. Last quarter, Revolution Medicines initiated clinical development of RMC-6236, its oral RASMULTI<\/sup>(ON) Inhibitor designed to treat patients with cancers driven by a variety of RAS mutations.<\/p>\n

The Phase 1\/1b trial (NCT05462717<\/a>) sponsored by Revolution Medicines is a multicenter, open-label, dose-escalation and dose-expansion study of RMC-6291 in patients with advanced solid tumors harboring the KRASG12<\/sup>C<\/sup> mutation. The primary objectives of the study are to evaluate safety and tolerability and to inform the recommended Phase 2 dose and schedule (RP2DS) for the compound.<\/p>\n

\u201cRMC-6291 is an exciting first drug candidate from our collection of oral, mutant-selective RAS(ON) Inhibitors to advance into clinical development, and we expect learnings from this trial will also inform advancement of our pipeline of innovative compounds. The next mutant-selective RAS(ON) inhibitor we plan to advance into the clinic is RMC-9805, an oral and covalent inhibitor of KRASG12D<\/sup>, the most common mutant RAS driver of human cancers,\u201d said Mark A. Goldsmith, M.D., Ph.D., chief executive officer and chairman of Revolution Medicines. \u201cThe mutant-selective approach exemplified by RMC-6291, RMC-9805 and other assets in our pipeline differs from the profile of RMC-6236, which entered clinical evaluation recently and is designed to inhibit many RAS variants rather than a single RAS mutation. We believe that these complementary approaches, used in monotherapy and\/or combination treatment regimens, will provide a powerful set of tools for countering the complex processes that cause and sustain a wide range of RAS-addicted cancers.\u201d<\/p>\n

\n About Revolution Medicines, Inc.<\/strong>
\n
Revolution Medicines is a clinical-stage oncology company developing novel targeted therapies for RAS-addicted cancers. The company\u2019s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. The company\u2019s RAS(ON) Inhibitors RMC-6236 (RASMULTI<\/sup>) and RMC-6291(KRASG12C<\/sup>) are in clinical development. Additional RAS(ON) Inhibitors in development include RMC-9805 (KRASG12D<\/sup>) and RMC-8839 (KRASG13C<\/sup>), and a pipeline of research compounds targeting additional RAS variants. RAS Companion Inhibitors in clinical development include RMC-4630 (SHP2) and RMC-5552 (mTORC1\/4EBP1).<\/p>\n

\n Forward Looking Statements<\/strong>
\n
This press release contains forward-looking statements within the meaning of\u00a0the U.S. Private Securities Litigation Reform Act of 1995.\u00a0Any statements in this press release that are not historical facts may be considered “forward-looking statements,” including without limitation statements regarding the company\u2019s development plans and timelines and its ability to advance its portfolio and R&D pipeline, including its RAS(ON) inhibitors; dosing and enrollment in the company\u2019s clinical trials and the tolerability, potential efficacy and utility of the company\u2019s candidates being studied; and the ability of the company\u2019s planned complementary treatment approaches to counter the processes that cause and sustain RAS-addicted cancers. Forward-looking statements are typically, but not always, identified by the use of words such as “may,” “will,” “would,” “believe,” “intend,” “plan,” “anticipate,” “estimate,” “expect,” and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause the company\u2019s development programs, future results, performance, or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including the company\u2019s programs\u2019 early stage of development, the process of designing and conducting preclinical and clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, the company\u2019s ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of the company\u2019s capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on the company\u2019s business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Revolution Medicines in general, see Revolution Medicines\u2019 Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 9, 2022, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Revolution Medicines undertakes no obligation to update any forward-looking statements to reflect new information, events, or circumstances, or to reflect the occurrence of unanticipated events.<\/p>\n<\/p>\n


\n
\n \n <\/div>\n

\n
Contacts:\r\n\r\nFor Investors:\r\nVida Strategic Partners\r\nStephanie Diaz\r\n415-675-7401\r\nsdiaz@vidasp.com\r\n\r\nFor Media:\r\nVida Strategic Partners\r\nTim Brons\r\n415-675-7402\r\ntbrons@vidasp.com<\/pre>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"
KRAS G12C (ON) Inhibitor with highly differentiated mechanism of action being evaluated in patients with cancers harboring KRAS G12C mutation RMC-6291 is first mutant-selective RAS(ON) Inhibitor to enter clinic, following closely behind company\u2019s RAS MULTI (ON) Inhibitor, RMC-6236 REDWOOD CITY, Calif., Sept. 22, 2022 (GLOBE NEWSWIRE) — Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing targeted therapies for RAS-addicted cancers, today announced the first patient was dosed in its Phase 1\/1b monotherapy clinical trial of RMC-6291, an oral, selective, covalent KRASG12C(ON) Inhibitor designed to treat patients with cancers driven by the KRASG12C mutation. RMC-6291, which exhibits a potential best-in-class preclinical profile, is the first drug candidate from the company\u2019s pipeline of mutant-selective RAS(ON) Inhibitors to enter the clinic. … <\/p>\n
Continue reading “Revolution Medicines Doses First Patient in Phase 1\/1b Clinical Trial of RMC-6291, Company\u2019s First Mutant-Selective RAS(ON) Inhibitor”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-687904","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nRevolution Medicines Doses First Patient in Phase 1\/1b Clinical Trial of RMC-6291, Company\u2019s First Mutant-Selective RAS(ON) Inhibitor - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/revolution-medicines-doses-first-patient-in-phase-1-1b-clinical-trial-of-rmc-6291-companys-first-mutant-selective-rason-inhibitor\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Revolution Medicines Doses First Patient in Phase 1\/1b Clinical Trial of RMC-6291, Company\u2019s First Mutant-Selective RAS(ON) Inhibitor - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"KRAS G12C (ON) Inhibitor with highly differentiated mechanism of action being evaluated in patients with cancers harboring KRAS G12C mutation RMC-6291 is first mutant-selective RAS(ON) Inhibitor to enter clinic, following closely behind company\u2019s RAS MULTI (ON) Inhibitor, RMC-6236 REDWOOD CITY, Calif., Sept. 22, 2022 (GLOBE NEWSWIRE) — Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing targeted therapies for RAS-addicted cancers, today announced the first patient was dosed in its Phase 1\/1b monotherapy clinical trial of RMC-6291, an oral, selective, covalent KRASG12C(ON) Inhibitor designed to treat patients with cancers driven by the KRASG12C mutation. 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(Nasdaq: RVMD), a clinical-stage oncology company developing targeted therapies for RAS-addicted cancers, today announced the first patient was dosed in its Phase 1\/1b monotherapy clinical trial of RMC-6291, an oral, selective, covalent KRASG12C(ON) Inhibitor designed to treat patients with cancers driven by the KRASG12C mutation. RMC-6291, which exhibits a potential best-in-class preclinical profile, is the first drug candidate from the company\u2019s pipeline of mutant-selective RAS(ON) Inhibitors to enter the clinic. … Continue reading \"Revolution Medicines Doses First Patient in Phase 1\/1b Clinical Trial of RMC-6291, Company\u2019s First Mutant-Selective RAS(ON) Inhibitor\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/revolution-medicines-doses-first-patient-in-phase-1-1b-clinical-trial-of-rmc-6291-companys-first-mutant-selective-rason-inhibitor\/","og_site_name":"Market Newsdesk","article_published_time":"2022-09-22T11:03:54+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODY1MTM0NCM1MTY2MDE2IzIxOTQwMzQ=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/revolution-medicines-doses-first-patient-in-phase-1-1b-clinical-trial-of-rmc-6291-companys-first-mutant-selective-rason-inhibitor\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/revolution-medicines-doses-first-patient-in-phase-1-1b-clinical-trial-of-rmc-6291-companys-first-mutant-selective-rason-inhibitor\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Revolution Medicines Doses First Patient in Phase 1\/1b Clinical Trial of RMC-6291, Company\u2019s First Mutant-Selective RAS(ON) Inhibitor","datePublished":"2022-09-22T11:03:54+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/revolution-medicines-doses-first-patient-in-phase-1-1b-clinical-trial-of-rmc-6291-companys-first-mutant-selective-rason-inhibitor\/"},"wordCount":869,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/revolution-medicines-doses-first-patient-in-phase-1-1b-clinical-trial-of-rmc-6291-companys-first-mutant-selective-rason-inhibitor\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODY1MTM0NCM1MTY2MDE2IzIxOTQwMzQ=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/revolution-medicines-doses-first-patient-in-phase-1-1b-clinical-trial-of-rmc-6291-companys-first-mutant-selective-rason-inhibitor\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/revolution-medicines-doses-first-patient-in-phase-1-1b-clinical-trial-of-rmc-6291-companys-first-mutant-selective-rason-inhibitor\/","name":"Revolution Medicines Doses First Patient in Phase 1\/1b Clinical Trial of RMC-6291, Company\u2019s First Mutant-Selective RAS(ON) Inhibitor - 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