{"id":684793,"date":"2022-09-13T11:59:30","date_gmt":"2022-09-13T15:59:30","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/update-seqll-announces-peer-reviewed-publication-of-novel-single-molecule-liquid-biopsy-method-in-nature-biotechnology\/"},"modified":"2022-09-13T11:59:30","modified_gmt":"2022-09-13T15:59:30","slug":"update-seqll-announces-peer-reviewed-publication-of-novel-single-molecule-liquid-biopsy-method-in-nature-biotechnology","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/update-seqll-announces-peer-reviewed-publication-of-novel-single-molecule-liquid-biopsy-method-in-nature-biotechnology\/","title":{"rendered":"UPDATE &#8212; SeqLL Announces Peer-Reviewed Publication of Novel Single-Molecule Liquid Biopsy Method in Nature Biotechnology"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"left\">BILLERICA, Mass., Sept.  13, 2022  (GLOBE NEWSWIRE) &#8212; SeqLL Inc. (\u201cSeqLL\u201d or the \u201cCompany\u201d) (NASDAQ: SQL), a technology company providing life sciences instrumentation and research services, today announced a new study demonstrating early cancer detection using SeqLL\u2019s single-molecule technology was published in the peer-reviewed journal <em>Nature Biotechnology<\/em>.<\/p>\n<p>The paper, entitled: \u201c<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=f5vNIKh6TrHL1Rv9ysLwlKNTDW33WVp7qVWBxzsRoNLsZ6-w3VNGvBPCxQ7Ky9rNZ4OgXjLLc8FN7UltQi8wHioRuNqalx0HjQdXhTeevibc8NhCa7KL9WnIYM2SryqZUbmXqi1sVXQGpmzLimxhVBuM6CitKXeKZ-_5JgjVjcotwvDoiUFj5u3M7OEvrvJN5UEvZ-eWVKlYyTOFrzp8A--E1gnMHRk9_mpyNti-zO4=\" rel=\"nofollow noopener\" target=\"_blank\"><em>&#8216;Multiplexed, single-molecule, epigenetic analysis of plasma-isolated nucleosomes for cancer diagnostics<\/em><\/a><em>,<\/em>\u201d applied SeqLL\u2019s tSMS\u00ae platform to generate multiplexed single-molecule measurements of protein biomarkers, epigenetic modifications and their combinations for cancer diagnostics. This liquid biopsy approach, termed EPINUC, allowed researchers to analyze multiple parameters from less than 1 ml of plasma sample and to demonstrate its value for colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) diagnosis. The study\u2019s predictive model displayed high diagnostic potential by generating a 0.96 AUC, sensitivity of 92% at 85% specificity, and 92% precision when analyzing CRC samples. Additionally, Stage I\/II CRC samples were readily distinguishable from Stage III\/IV and resected Stage III\/IV CRC samples.<\/p>\n<p>The publication\u2019s lead authors, Vadim Fedyk and Nir Erez, are graduate students in Dr. Efrat Shema\u2019s Laboratory in the Department of Immunology and Regenerative Biology at the Weizmann Institute of Science. The single molecule-based liquid biopsy approach allowed them to assess and decode cell-free nucleosomes to provide a highly-informative view of histone post-translational modifications, mutant p53, and DNA methylation differences across the cohort of approximately 100 patient samples.<\/p>\n<p>CRC is the third most common cancer worldwide, causing approximately 700,000 deaths every year. PDAC is a devastating disease with a 5-year overall survival of only 11%.<\/p>\n<p>\u201cOur algorithm could tell the difference between the healthy and the patient groups at a record level of certainty for studies of this type, with 92% precision,\u201d stated Dr. Efrat Shema, Principal Investigator and Assistant Professor at the Weizmann Institute of Science. \u201cIn the future, our multiparameter approach may serve to diagnose not only various cancers but also additional diseases that leave traces in the blood, such as autoimmune disorders or heart disease.\u201d<\/p>\n<p>Daniel Jones, the Chief Executive Officer of SeqLL and co-author of the publication, added, \u201cThe development of this groundbreaking EPINUC technology, in collaboration with Dr. Shema and colleagues, demonstrates the value of our tSMS platform in the early detection of disease. We have only begun to explore histone post-translational modifications and their impact on a host of diseases impacting global health. This study further highlights the role PCR-free, ligation-free technologies have in the development of new epigenetic-based approaches for early detection, monitoring, and treatment of disease.\u201d<\/p>\n<p>This research builds upon the 2016 <em>Science<\/em> publication \u201c<em>Single-molecule decoding of combinatorially modified nucleosomes<\/em>,\u201d authored by the laboratory of Dr. Bradley Bernstein at Massachusetts General Hospital, Harvard Medical School, and the Broad Institute. Dr. Shema and Mr. Jones were the lead and second author on that publication and have continued to collaboratively develop the underlying technology. More information regarding this collaboration can be found at the Weizmann Institute\u2019s science news portal, using the following link:<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=0WH2WjyfbWwZ4yXoluqh-w7mChRJ7OJo0WLp2wxZ5vsCxBZy0VX-wHe1MwO18UG9vCDotZnfygn9EyVcbtMQ0nT8896nFPQhuG0gYuUNpopjgodqaWb1FfM8-cs92bEjMBuFL7Z8JZ0k5kaXJYbuJ7vechZa_ITzhUX6JALT8wkzo-zj9hDqWKWF3Exe9hvmY16-zM693blbwETt7-JCZCOyrtiNmlTXX6pewR1SugpXq1delLge5gsMv0hSl_hb-YJ6ksDZ5ZJy8YwlGGTH1ksZcM0p_qxFnu5D4o4nq48_vWqycPd6HBp51yziBor82u7OYFG82oyJozWoAnMvLn-KhxyyF8hSfTF7YQwn7kuUEjPg06VAN2x5RaBJlMTdhPzBpL9zw3wxdNirqznZmg==\" rel=\"nofollow noopener\" target=\"_blank\">Putting Liquid Biopsies on Solid Ground: Cancer Diagnosis from a Milliliter of Blood &#8211; Life Sciences | Weizmann Wonder Wander &#8211; News, Features and Discoveries<\/a><\/p>\n<p>\n        <strong>About SeqLL Inc.<\/strong><br \/>\n        <br \/>SeqLL Inc. (\u201cSeqLL\u201d) is a technology company providing life sciences instrumentation and research services in collaborative partnerships aimed at the development of novel scientific assets and intellectual property across multiple \u201comics\u201d fields. The Company leverages its expertise with the True Single Molecule Sequencing (\u201ctSMS<sup>\u00ae<\/sup>\u201d) platform to empower scientists and researchers with improved genetic tools to better understand the molecular mechanisms of disease that is essential to the continued development of new breakthroughs in genomic medicine, and that hopefully address the critical concerns involved with today\u2019s precision medicine.<\/p>\n<p>\n        <strong>Forward Looking Statements<\/strong><br \/>\n        <br \/>This press release contains certain forward-looking statements, including those related to the applicability and viability of the Company\u2019s\u00a0technology to quantifying RNA molecules from blood\u00a0and other statements that are predictive in nature. Forward-looking statements are based on the Company&#8217;s current expectations and assumptions. The Private Securities Litigation Reform Act of 1995 provides a safe-harbor for forward-looking statements. These statements may be identified by the use of forward-looking expressions, including, but not limited to, &#8220;expect,&#8221; &#8220;anticipate,&#8221; &#8220;intend,&#8221; &#8220;plan,&#8221; &#8220;believe,&#8221; &#8220;estimate,&#8221; &#8220;potential,&#8221; &#8220;predict,&#8221; &#8220;project,&#8221; &#8220;should,&#8221; &#8220;would&#8221; and similar expressions and the negatives of those terms. Prospective investors are cautioned not to place undue reliance on such forward-looking statements, which speak only as of the date of this presentation. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Important factors that could cause actual results to differ materially from those in the forward-looking statements are set forth in the Company&#8217;s filings with the Securities and Exchange Commission, including under the caption &#8220;Risk Factors&#8221; in the Company\u2019s Annual Report on Form 10-K for the year ended December 31, 2021.<\/p>\n<p>Contacts:<\/p>\n<p>Ashley R. Robinson<br \/>LifeSci Advisors, LLC<br \/>Tel: +1 (617) 430-7577<br \/>Email:\u00a0arr@lifesciadvisors.com<\/p>\n<p>      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODY0NTg3MCM1MTUwODE2IzUwMDA4NDI2MA==\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/MTNhMDUxZjQtZDgwMi00YWFjLTlkY2MtN2M0MWViYmFhMzA5LTUwMDA4NDI2MA==\/tiny\/SeqLL-Inc.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>BILLERICA, Mass., Sept. 13, 2022 (GLOBE NEWSWIRE) &#8212; SeqLL Inc. (\u201cSeqLL\u201d or the \u201cCompany\u201d) (NASDAQ: SQL), a technology company providing life sciences instrumentation and research services, today announced a new study demonstrating early cancer detection using SeqLL\u2019s single-molecule technology was published in the peer-reviewed journal Nature Biotechnology. The paper, entitled: \u201c&#8216;Multiplexed, single-molecule, epigenetic analysis of plasma-isolated nucleosomes for cancer diagnostics,\u201d applied SeqLL\u2019s tSMS\u00ae platform to generate multiplexed single-molecule measurements of protein biomarkers, epigenetic modifications and their combinations for cancer diagnostics. This liquid biopsy approach, termed EPINUC, allowed researchers to analyze multiple parameters from less than 1 ml of plasma sample and to demonstrate its value for colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) diagnosis. The study\u2019s predictive model displayed &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/update-seqll-announces-peer-reviewed-publication-of-novel-single-molecule-liquid-biopsy-method-in-nature-biotechnology\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;UPDATE &#8212; SeqLL Announces Peer-Reviewed Publication of Novel Single-Molecule Liquid Biopsy Method in Nature Biotechnology&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-684793","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UPDATE - SeqLL Announces Peer-Reviewed Publication of Novel Single-Molecule Liquid Biopsy Method in Nature Biotechnology - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/update-seqll-announces-peer-reviewed-publication-of-novel-single-molecule-liquid-biopsy-method-in-nature-biotechnology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UPDATE - SeqLL Announces Peer-Reviewed Publication of Novel Single-Molecule Liquid Biopsy Method in Nature Biotechnology - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"BILLERICA, Mass., Sept. 13, 2022 (GLOBE NEWSWIRE) &#8212; SeqLL Inc. (\u201cSeqLL\u201d or the \u201cCompany\u201d) (NASDAQ: SQL), a technology company providing life sciences instrumentation and research services, today announced a new study demonstrating early cancer detection using SeqLL\u2019s single-molecule technology was published in the peer-reviewed journal Nature Biotechnology. The paper, entitled: \u201c&#8216;Multiplexed, single-molecule, epigenetic analysis of plasma-isolated nucleosomes for cancer diagnostics,\u201d applied SeqLL\u2019s tSMS\u00ae platform to generate multiplexed single-molecule measurements of protein biomarkers, epigenetic modifications and their combinations for cancer diagnostics. This liquid biopsy approach, termed EPINUC, allowed researchers to analyze multiple parameters from less than 1 ml of plasma sample and to demonstrate its value for colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) diagnosis. 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SeqLL Inc. (\u201cSeqLL\u201d or the \u201cCompany\u201d) (NASDAQ: SQL), a technology company providing life sciences instrumentation and research services, today announced a new study demonstrating early cancer detection using SeqLL\u2019s single-molecule technology was published in the peer-reviewed journal Nature Biotechnology. The paper, entitled: \u201c&#8216;Multiplexed, single-molecule, epigenetic analysis of plasma-isolated nucleosomes for cancer diagnostics,\u201d applied SeqLL\u2019s tSMS\u00ae platform to generate multiplexed single-molecule measurements of protein biomarkers, epigenetic modifications and their combinations for cancer diagnostics. This liquid biopsy approach, termed EPINUC, allowed researchers to analyze multiple parameters from less than 1 ml of plasma sample and to demonstrate its value for colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) diagnosis. 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