{"id":537289,"date":"2021-09-13T08:03:48","date_gmt":"2021-09-13T12:03:48","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/opregen-data-update-will-be-featured-at-54th-annual-retina-society-meeting-in-podium-presentation-by-christopher-d-riemann-m-d\/"},"modified":"2021-09-13T08:03:48","modified_gmt":"2021-09-13T12:03:48","slug":"opregen-data-update-will-be-featured-at-54th-annual-retina-society-meeting-in-podium-presentation-by-christopher-d-riemann-m-d","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/opregen-data-update-will-be-featured-at-54th-annual-retina-society-meeting-in-podium-presentation-by-christopher-d-riemann-m-d\/","title":{"rendered":"Opregen\u00ae Data Update Will Be Featured at 54th Annual Retina Society Meeting in Podium Presentation by Christopher D. Riemann, M.D."},"content":{"rendered":"

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Opregen\u00ae<\/sup> Data Update Will Be Featured at 54th<\/sup> Annual Retina Society Meeting in Podium Presentation by Christopher D. Riemann, M.D.<\/b><\/p>\n

CARLSBAD, Calif.–(BUSINESS WIRE<\/a>)–Lineage Cell Therapeutics, Inc.<\/a> (NYSE American and TASE: LCTX), a clinical-stage biotechnology company developing allogeneic cell therapies for unmet medical needs, reported today that updated interim results from a Phase 1\/2a study of its lead product candidate, OpRegen\u00ae<\/sup><\/a>, a retinal pigment epithelium cell transplant therapy currently in development for the treatment of dry age-related macular degeneration (AMD), will be featured in a podium presentation at the 54th<\/sup> Annual Scientific Meeting of the Retina Society<\/a>, to be held at the Ritz-Carlton Hotel in Chicago, IL (September 29 \u2013 October 2, 2021). The presentation, \u201cPhase 1\/2a Clinical Trial of Transplanted Allogeneic Retinal Pigmented Epithelium (RPE, OpRegen) Cells in Advanced Dry Age-Related Macular Degeneration (AMD): Interim Results<\/i>,\u201d<\/i> will be presented on September 30, 2021 at 9:52 am EDT by Christopher D. Riemann<\/a>, M.D., Vitreoretinal Surgeon and Fellowship Director, Cincinnati Eye Institute<\/a> (CEI) and University of Cincinnati School of Medicine.\n<\/p>\n

\nLineage also intends to present updated interim results from the Phase 1\/2a study later this month, which will include a minimum of 9 months of follow-up in all 24 patients treated with OpRegen, including all 12 patients treated in Cohort 4, which had better baseline vision and smaller areas of GA at baseline than earlier cohorts.\n<\/p>\n

\nThe Retina Society was founded in 1968 exclusively for educational and scientific purposes concerning the diagnosis, care and treatment of diseases and injuries to the retina. For more information on the Retina Society or its annual scientific meeting, please visit https:\/\/www.retinasociety.org\/<\/a> or follow the association on Twitter @RetinaSociety<\/a>.\n<\/p>\n

About OpRegen<\/b><\/p>\n

\nOpRegen is currently being evaluated in a Phase 1\/2a open-label, dose escalation safety and efficacy study of a single injection of human retinal pigment epithelium cells derived from an established pluripotent cell line and transplanted subretinally in patients with advanced dry AMD with geographic atrophy (GA). The study enrolled 24 patients into 4 cohorts. The first 3 cohorts enrolled only legally blind patients with Best Corrected Visual Acuity (BCVA) of 20\/200 or worse. The fourth cohort enrolled 12 better vision patients (BCVA from 20\/65 to 20\/250 with smaller mean areas of GA). Cohort 4 also included patients treated with a new \u201cthaw-and-inject\u201d formulation of OpRegen, which can be shipped directly to sites and used immediately upon thawing, removing the complications and logistics of having to use a dose preparation facility. The primary objective of the study is to evaluate the safety and tolerability of OpRegen as assessed by the incidence and frequency of treatment emergent adverse events. Secondary objectives are to evaluate the preliminary efficacy of OpRegen treatment by assessing the changes in ophthalmological parameters measured by various methods of primary clinical relevance. OpRegen is a registered trademark of Cell Cure Neurosciences Ltd., a majority-owned subsidiary of Lineage Cell Therapeutics, Inc.\n<\/p>\n

About Age-Related Macular Degeneration<\/b><\/p>\n

\nAge-related macular degeneration (AMD) is an eye disease that can blur the sharp, central vision in patients and is the leading cause of vision loss in people over the age of 60. There are two forms of AMD: dry (atrophic) AMD and wet (neovascular) AMD. Dry (atrophic) AMD is the more common of the two forms, accounting for approximately 85-90% of all cases. In atrophic AMD, parts of the macula get thinner with age and accumulations of extracellular material between Bruch’s membrane and the retinal pigmented epithelium (RPE), known as drusen, increase in number and volume, leading to a progressive loss of central vision, typically in both eyes. Global sales of the two leading wet AMD therapies were in excess of $10 billion in 2019. Nearly all cases of wet AMD eventually will develop the underlying atrophic AMD if the newly formed blood vessels are treated correctly. There are currently no U.S. Food and Drug Administration, or European Medicines Agency, approved treatment options available for patients with atrophic AMD.\n<\/p>\n

About Lineage Cell Therapeutics, Inc. <\/b><\/p>\n

\nLineage Cell Therapeutics is a clinical-stage biotechnology company developing novel cell therapies for unmet medical needs. Lineage\u2019s programs are based on its robust proprietary cell-based therapy platform and associated in-house development and manufacturing capabilities. With this platform Lineage develops and manufactures specialized, terminally differentiated human cells from its pluripotent and progenitor cell starting materials. These differentiated cells are developed to either replace or support cells that are dysfunctional or absent due to degenerative disease or traumatic injury or administered as a means of helping the body mount an effective immune response to cancer. Lineage\u2019s clinical programs are in markets with billion dollar opportunities and include three allogeneic (\u201coff-the-shelf\u201d) product candidates: (i) OpRegen\u00ae<\/sup>, a retinal pigment epithelium transplant therapy in Phase 1\/2a development for the treatment of dry age-related macular degeneration, a leading cause of blindness in the developed world; (ii) OPC1, an oligodendrocyte progenitor cell therapy in Phase 1\/2a development for the treatment of subacute spinal cord injuries; and (iii) VAC2, an allogeneic dendritic cell therapy produced from Lineage\u2019s VAC technology platform for immuno-oncology and infectious disease, currently in Phase 1 clinical development for the treatment of non-small cell lung cancer. For more information, please visit www.lineagecell.com<\/a> or follow the Company on Twitter @LineageCell<\/a>.\n<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20210913005252\/en\/<\/a><\/span><\/p>\n

Lineage Cell Therapeutics, Inc. IR
\n<\/b>
Ioana C. Hone
\n
(ir@lineagecell.com<\/a>)
\n
(442) 287-8963\n<\/p>\n

Solebury Trout IR
\n<\/b>
Gitanjali Jain Ogawa
\n
(Gogawa@soleburytrout.com<\/a>)
\n
(646) 378-2949\n<\/p>\n

Russo Partners \u2013 Media Relations
\n<\/b>
Nic Johnson or David Schull
\n
Nic.johnson@russopartnersllc.com
\n<\/a>
David.schull@russopartnersllc.com
\n<\/a>
(212) 845-4242\n<\/p>\n

KEYWORDS:<\/b> California United States North America<\/p>\n

INDUSTRY KEYWORDS:<\/b> Health Genetics Clinical Trials Pharmaceutical Optical Biotechnology<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
Logo<\/b><\/font><\/td>\n<\/tr>\n
\"Logo\"<\/td>\n<\/tr>\n
<\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Opregen\u00ae Data Update Will Be Featured at 54th Annual Retina Society Meeting in Podium Presentation by Christopher D. Riemann, M.D. CARLSBAD, Calif.–(BUSINESS WIRE)–Lineage Cell Therapeutics, Inc. (NYSE American and TASE: LCTX), a clinical-stage biotechnology company developing allogeneic cell therapies for unmet medical needs, reported today that updated interim results from a Phase 1\/2a study of its lead product candidate, OpRegen\u00ae, a retinal pigment epithelium cell transplant therapy currently in development for the treatment of dry age-related macular degeneration (AMD), will be featured in a podium presentation at the 54th Annual Scientific Meeting of the Retina Society, to be held at the Ritz-Carlton Hotel in Chicago, IL (September 29 \u2013 October 2, 2021). The presentation, \u201cPhase 1\/2a Clinical Trial of Transplanted … <\/p>\n

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(NYSE American and TASE: LCTX), a clinical-stage biotechnology company developing allogeneic cell therapies for unmet medical needs, reported today that updated interim results from a Phase 1\/2a study of its lead product candidate, OpRegen\u00ae, a retinal pigment epithelium cell transplant therapy currently in development for the treatment of dry age-related macular degeneration (AMD), will be featured in a podium presentation at the 54th Annual Scientific Meeting of the Retina Society, to be held at the Ritz-Carlton Hotel in Chicago, IL (September 29 \u2013 October 2, 2021). The presentation, \u201cPhase 1\/2a Clinical Trial of Transplanted … Continue reading "Opregen\u00ae Data Update Will Be Featured at 54th Annual Retina Society Meeting in Podium Presentation by Christopher D. 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