{"id":535443,"date":"2021-09-08T08:03:10","date_gmt":"2021-09-08T12:03:10","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/late-breaking-data-at-the-international-headache-society-european-headache-federation-joint-congress-2021-showed-ajovy-fremanezumab-vfrm-injection-reduced-more-monthly-migraine-days-in-a\/"},"modified":"2021-09-08T08:03:10","modified_gmt":"2021-09-08T12:03:10","slug":"late-breaking-data-at-the-international-headache-society-european-headache-federation-joint-congress-2021-showed-ajovy-fremanezumab-vfrm-injection-reduced-more-monthly-migraine-days-in-a","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/late-breaking-data-at-the-international-headache-society-european-headache-federation-joint-congress-2021-showed-ajovy-fremanezumab-vfrm-injection-reduced-more-monthly-migraine-days-in-a\/","title":{"rendered":"Late-Breaking Data at the International Headache Society & European Headache Federation Joint Congress 2021 Showed AJOVY\u00ae (fremanezumab-vfrm) Injection Reduced More Monthly Migraine Days in a Network Meta-Analysis Study with Atogepant and Rimegepant"},"content":{"rendered":"

<\/p>\n

Late-Breaking Data at the International Headache Society & European Headache Federation Joint Congress 2021 Showed AJOVY\u00ae<\/sup> (fremanezumab-vfrm) Injection Reduced More Monthly Migraine Days in a Network Meta-Analysis Study with Atogepant and Rimegepant<\/b><\/p>\n

\nStudy examined efficacy of AJOVY, atogepant and rimegepant in the prevention of episodic migraine\n<\/p>\n

TEL AVIV, Israel & PARSIPPANY, N.J.–(BUSINESS WIRE<\/a>)–
\nTeva Pharmaceuticals USA, Inc., a U.S. affiliate of Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA),today announced results from a network meta-analysis examining the efficacy of AJOVY (fremanezumab-vfrm), atogepant and Nurtec\u00ae<\/sup> ODT (rimegepant) in the preventive treatment of episodic migraine (EM). This data will be presented as a late-breaker ePoster during the International Headache Society (IHS) and European Headache Federation (EHF) Joint Congress taking place virtually on Sept. 8-12, 2021.\n<\/p>\n

\nAJOVY is the first and only long-acting (defined as efficacy measured over a 12-week period following a 675 mg [225 mg x 3] subcutaneous dose) anti-CGRP subcutaneous injection approved for the preventive treatment of migraine in adults with both quarterly and monthly dosing options.1+\u00b1 <\/sup><\/p>\n

\nMigraine is a disabling chronic neurological disease that causes head pain and associated symptoms so severe that people often cannot function during an attack. Migraine reduces quality of life and disrupts the lives of those suffering from migraine and their ability to perform daily activities.2,1<\/sup> It is among the top 10 causes of disability worldwide.2<\/sup><\/p>\n

\n\u201cAs migraine is so prevalent affecting one billion people worldwide3<\/sup>, it\u2019s important for us to explore fremanezumab\u2019s full treatment potential to ensure we\u2019re offering patients an option to help prevent their migraine attacks,\u201d said Matthias Mueller, MD MSc, VP Global Medical Affairs at Teva. \u201cWe\u2019re pleased to see the migraine treatment landscape continue to advance, and these latest data provide clinicians with new insights into the impact of choosing a treatment option for each individual patient, reducing this migraine burden for patients.\u201d\n<\/p>\n

\nThe meta-analysis indirectly assessed changes from baseline in monthly migraine days (MMD) and 50 percent reduction from baseline in MMD for patients receiving AJOVY, atogepant and rimegepant compared to placebo.\n<\/p>\n

\nAdditional retrospective post hoc analyses were conducted to understand migraine and headache frequency and severity for chronic migraine (CM) and EM patients who were treated with AJOVY. The analyses included patients who were initially enrolled in the Phase 3 HALO and FOCUS clinical programs. No determination of statistical significance can be made, and individual results may vary. No new safety signals were identified against the known safety profile of AJOVY.\n<\/p>\n

Late-Breaker ePoster: Network Meta-analysis on Monthly Migraine Day Reductions with Fremanezumab, Rimegepant, and Atogepant in the Prevention of Episodic Migraine
\n
<\/b>This meta-analysis assessed relative efficacy for AJOVY monthly (MLY) and quarterly (QLY) dosing, atogepant daily (QD) and twice-daily (BID) dosing, and rimegepant every-other-day (QOD) dosing in the preventive treatment of EM.\n<\/p>\n

\nResults observed in this analysis are as follows:\n<\/p>\n

Pairwise Comparisons of the Change from Baseline in MMD at a 12-Week Follow-upa <\/sup>(Mean Difference [95% credible interval])<\/i><\/p>\n\n\n\n\n\n\n\n\n\n\n
\n

AJOVY MLY 225 mg<\/b><\/p>\n<\/td>\n

\n

AJOVY QLY 675 mg<\/b><\/p>\n<\/td>\n

\n

Versus\u2026<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

\n\u22121.30 [\u22122.10, \u22120.51]\n<\/p>\n<\/td>\n

\n

\n\u22121.02 [\u22121.86, \u22120.17]\n<\/p>\n<\/td>\n

\n

Rimegepant<\/b> 75 mg QOD\n<\/p>\n<\/td>\n<\/tr>\n

\n

\n\u22121.00 [\u22121.65, \u22120.34]\n<\/p>\n<\/td>\n

\n

\n\u22120.71 [\u22121.42, \u22120.01]\n<\/p>\n<\/td>\n

\n

Atogepant<\/b> 10 mg QD\n<\/p>\n<\/td>\n<\/tr>\n

\n

\n\u22120.97 [\u22121.60, \u22120.35]\n<\/p>\n<\/td>\n

\n

\n\u22120.69 [\u22121.37, \u22120.00b<\/sup>]\n<\/p>\n<\/td>\n

\n

Atogepant<\/b> 30 mg QD\n<\/p>\n<\/td>\n<\/tr>\n

\n

\n\u22120.92 [\u22121.54, \u22120.30]\n<\/p>\n<\/td>\n

\n

\n\u22120.64 [\u22121.32, 0.05]\n<\/p>\n<\/td>\n

\n

Atogepant<\/b> 60 mg QD\n<\/p>\n<\/td>\n<\/tr>\n

\n

\n\u22120.52 [\u22121.50, 0.45]\n<\/p>\n<\/td>\n

\n

\n\u22120.24 [\u22121.25, 0.78]\n<\/p>\n<\/td>\n

\n

Atogepant<\/b> 30 mg BID\n<\/p>\n<\/td>\n<\/tr>\n

\n

\n\u22120.62 [\u22121.44, 0.21]\n<\/p>\n<\/td>\n

\n

\n\u22120.33 [\u22121.20, 0.53]\n<\/p>\n<\/td>\n

\n

Atogepant<\/b> 60 mg BID\n<\/p>\n<\/td>\n<\/tr>\n

\n\n\u00a0<\/td>\n<\/tr>\n
\n

a<\/sup>1-12 weeks; 9-12 weeks for Rimegepant
\n
<\/i>b<\/sup>Exact value with 3 decimal places: \u22120.004<\/i><\/p>\n<\/td>\n<\/tr>\n<\/table>\n

\nThe following poster presentations are also available as part of the virtual joint congress:\n<\/p>\n

Poster: Time Gained with Long-term Fremanezumab Treatment in Patients with Chronic and Episodic Migraine
\n
<\/b>This post hoc analysis assessed the number of headache-free days (HFD) and migraine-free days (MFD) in patients using fremanezumab from a one-year extension study of the HALO program (HALO LTS). Patients were randomized one-to-one to receive quarterly or monthly dosing of fremanezumab.\n<\/p>\n

Migraine-Free Days
\n
<\/b>It was observed that CM patients gained an average of 80 MFD over the course of one year in the quarterly dosing group (mean expected\/actual migraine days [MD]: 214\/134) and an average of 91 MFD (mean expected\/actual MD: 214\/124) in the monthly dosing group. For EM patients, the analysis observed patients in the quarterly dosing group gained an average of 65 MFD (mean expected\/actual MD: 120\/55) and patients in the monthly dosing group gained an average of 62 MFD (mean expected\/actual MD: 119\/57).\n<\/p>\n

Headache-Free Days
\n
<\/b>It was observed that CM patients gained an average of 78 HFD over the course of one year in the quarterly dosing group (mean expected\/actual headache days [HD]: 211\/134) and an average of 86 HFD (mean expected\/actual: 212\/126) in the monthly dosing group. For EM patients, the analysis also observed patients in the quarterly dosing group gained an average of 58 HFD (mean expected\/actual HD: 112\/53) and an average of 54 HFD (mean expected\/actual HD: 111\/57) in the monthly dosing group.\n<\/p>\n

\nThe analysis observed, over the course of one year of fremanezumab treatment, CM patients may gain an average of 2.5-3 months of MFDs or HFDs, and EM patients may gain an average of 1.5-2 months, reducing overall migraine burden for these evaluated patients.\n<\/p>\n

Poster: Consecutive Migraine-free Days with Fremanezumab Treatment: Results of the Double-blind, Placebo-controlled FOCUS Study
\n
<\/b>This post hoc analysis of the Phase 3b FOCUS study examined the maximum number of consecutive MFD for patients treated with fremanezumab after inadequate response to 2-4 prior migraine preventive medication classes in the FOCUS trial. For 12 weeks of double-blind treatment in FOCUS, 838 eligible patients were randomized one-to-one-to-one to quarterly fremanezumab, monthly fremanezumab or matched placebo. Change from baseline in monthly average maximum number of consecutive MFD was evaluated.\n<\/p>\n

\nAt baseline, mean numbers of maximum consecutive MFD were comparable across treatment groups (quarterly fremanezumab, 5.1 days [2.84]; monthly fremanezumab, 5.1 days [3.11]; placebo, 4.8 days [3.03]). Increases from BL in consecutive MFD during 12 weeks were significantly higher for fremanezumab (least-squares mean [SE] change from baseline during 12 weeks: quarterly, 8.3 [0.82]; monthly, 9.6 [0.81]) versus placebo (4.0 [0.81]; both P<0.0001).\n<\/p>\n

\nIn migraine patients with inadequate response to 2-4 prior migraine preventive medication classes, patients receiving quarterly or monthly fremanezumab as part of this post hoc analysis had significantly more consecutive MFD versus placebo during 12 weeks of treatment.\n<\/p>\n

Poster: Reductions in Migraine Frequency With Fremanezumab Treatment in Individuals With Chronic and Episodic Migraine
\n
<\/b>This pooled analysis assessed the shift in migraine frequency category for participants treated with fremanezumab from three Phase 3, double-blind, placebo-controlled trials: HALO CM, HALO EM and FOCUS.\n<\/p>\n

\nIn all three studies, patients with CM or EM were randomized one-to-one-to-one to quarterly fremanezumab, monthly fremanezumab or matched placebo. The percentages of patients with a reversion \u22651 category down during 12 weeks of treatment were evaluated by BL frequency category (high-frequency CM [HFCM; \u226519 monthly migraine days (MMD)]; low-frequency CM [LFCM; 15-18 MMD]; high-frequency EM [HFEM; 10-14 MMD]; moderate-frequency [MFEM; 4-9 MMD]).\n<\/p>\n

\nIn this analysis, it was observed that both quarterly and monthly dosing of fremanezumab resulted in favorable migraine frequency category reversions to a greater extent than placebo.\n<\/p>\n

\nAt baseline, 659 patients had LFEM, 515 had HFEM, 511 had LFCM, and 500 had HFCM. Higher proportions of patients with MFEM receiving quarterly dosing (53%) and monthly dosing (52%) of fremanezumab experienced a reversion one category down to LFEM (<4 MMD) versus placebo (29%). Higher proportions of patients receiving quarterly dosing and monthly dosing of fremanezumab versus placebo experienced a reversion \u22651 category down in the BL HFEM subgroup to MFEM or LFEM (quarterly, 77%; monthly, 75%; placebo, 58%), the BL LFCM subgroup to HFEM, MFEM, or LFEM (quarterly, 73%; monthly, 76%; placebo, 57%), or the BL HFCM subgroup to LFCM, HFEM, MFEM, or LFEM (quarterly, 57%; monthly, 59%; placebo, 44%).\n<\/p>\n

Information for Europe about AJOVY\u25bc can be found here<\/a>.<\/b><\/p>\n

\u25bc<\/b>Adverse events should be reported.\n<\/p>\n

\nThis medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse events. Reporting forms and information can be found at https:\/\/www.hpra.ie<\/a>. Adverse events should also be reported to Teva \u2013 please refer to local numbers.\n<\/p>\n

U.S. Important Safety Information about AJOVY (fremanezumab-vfrm) injection<\/b><\/p>\n

Contraindications: <\/b>AJOVY is contraindicated in patients with serious hypersensitivity to fremanezumab-vfrm or to any of the excipients. Reactions have included anaphylaxis and angioedema.\n<\/p>\n

Hypersensitivity Reactions: <\/b>Hypersensitivity reactions, including rash, pruritus, drug hypersensitivity, and urticaria were reported with AJOVY in clinical trials. Most reactions were mild to moderate, but some led to discontinuation or required corticosteroid treatment. Most reactions were reported from within hours to one month after administration. Cases of anaphylaxis and angioedema have been reported in the postmarketing setting. If a hypersensitivity reaction occurs, consider discontinuing AJOVY and institute appropriate therapy.<\/i><\/p>\n

Adverse Reactions: <\/b>The most common adverse reactions in clinical trials (\u22655% and greater than placebo) were injection site reactions.<\/p>\n

\nPlease click here<\/a> for full U.S. Prescribing Information for AJOVY (fremanezumab-vfrm) injection.\n<\/p>\n

About Teva
\n
<\/b>Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) has been developing and producing medicines to improve people\u2019s lives for more than a century. We are a global leader in generic and specialty medicines with a portfolio consisting of over 3,500 products in nearly every therapeutic area. Around 200 million people around the world take a Teva medicine every day, and are served by one of the largest and most complex supply chains in the pharmaceutical industry. Along with our established presence in generics, we have significant innovative research and operations supporting our growing portfolio of specialty and biopharmaceutical products. Learn more at www.tevapharm.com<\/a>.\n<\/p>\n

Cautionary Note Regarding Forward-Looking Statements
\n
<\/b>This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, which are based on management\u2019s current beliefs and expectations and are subject to substantial risks and uncertainties, both known and unknown, that could cause our future results, performance or achievements to differ significantly from that expressed or implied by such forward-looking statements. You can identify these forward-looking statements by the use of words such as \u201cshould,\u201d \u201cexpect,\u201d \u201canticipate,\u201d \u201cestimate,\u201d \u201ctarget,\u201d \u201cmay,\u201d \u201cproject,\u201d \u201cguidance,\u201d \u201cintend,\u201d \u201cplan,\u201d \u201cbelieve\u201d and other words and terms of similar meaning and expression in connection with any discussion of future operating or financial performance. Important factors that could cause or contribute to such differences include risks relating to the commercial success of AJOVY; our ability to successfully compete in the marketplace, including our ability to develop and commercialize biopharmaceutical products, competition for our specialty products, including AUSTEDO\u00ae<\/sup>, AJOVY and COPAXONE\u00ae<\/sup>; our ability to achieve expected results from investments in our product pipeline, our ability to develop and commercialize additional pharmaceutical products, and the effectiveness of our patents and other measures to protect our intellectual property rights; our substantial indebtedness; our business and operations in general, including uncertainty regarding the COVID-19 pandemic and its impact on our business, financial condition, operations, cash flows, and liquidity and on the economy in general, our ability to successfully execute and maintain the activities and efforts related to the measures we have taken or may take in response to the COVID-19 pandemic and associated costs therewith, costs and delays resulting from the extensive pharmaceutical regulation to which we are subject or delays in governmental processing time due to travel and work restrictions caused by the COVID-19 pandemic; compliance, regulatory and litigation matters, including failure to comply with complex legal and regulatory environments; other financial and economic risks; and other factors discussed in our Annual Report on Form 10-K for the year ended December 31, 2020, including in the section captioned \u201cRisk Factors.\u201d Forward-looking statements speak only as of the date on which they are made, and we assume no obligation to update or revise any forward-looking statements or other information contained herein, whether as a result of new information, future events or otherwise. You are cautioned not to put undue reliance on these forward-looking statements.\n<\/p>\n

\n

References<\/b><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

1<\/sup> AJOVY (fremanezumab-vfrm) injection, for subcutaneous use [prescribing information]. Teva Pharmaceuticals USA, Inc.: North Wales, PA; 2020.\n<\/p>\n<\/td>\n<\/tr>\n

\n

+ <\/sup>\u201cLong-acting\u201d defined as efficacy measured over a 12-week period following a 675 mg (225 mg x 3) SC dose.2<\/sup><\/p>\n<\/td>\n<\/tr>\n

\n

\u00b1 <\/sup>225 mg monthly administered as one subcutaneous injection, or 675 mg every three months (quarterly), which is administered as three subcutaneous injections\n<\/p>\n<\/td>\n<\/tr>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

\n

2<\/sup> Buse DC, Rupnow MF, Lipton RB. Assessing and managing all aspects of migraine: migraine attacks, migraine-related functional impairment, common comorbidities, and quality of life. Mayo Clin Proc. 2009;84:422\u2013435. doi: 10.1016\/S0025-6196(11)60561-2.\n<\/p>\n<\/td>\n<\/tr>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

\n

3<\/sup> Lipton RB, Liberman JN, Kolodner KB, et al. Migraine headache disability and health-related quality-of-life: a population-based case-control study from England. Cephalalgia<\/i>. 2003;23:441\u2013450. doi: 10.1046\/j.1468-2982.2003.00546.x.\n<\/p>\n<\/td>\n<\/tr>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

\n

4<\/sup> Steiner TJ, Birbeck GL, Jensen RH, Katsarava Z, Stovner LJ, Martelletti P. Headache disorders are third cause of disability worldwide. J Headache Pain<\/i>. 2015;16:58. doi:10.1186\/s10194-015-0544-2\n<\/p>\n<\/td>\n<\/tr>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

\n

5<\/sup> Migraine Facts. Migraine Research Foundation. https:\/\/migraineresearchfoundation.org\/about-migraine\/migraine-facts\/<\/a>. Accessed August 20, 2021.\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n

\n\u00a0\n<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20210908005207\/en\/<\/a><\/span><\/p>\n

IR Contacts
\n
United States
\n<\/b>
Kevin C. Mannix, (215) 591-8912
\n
Yael Ashman, 972 (3) 914-8262\n<\/p>\n

PR Contacts
\n<\/b>
United States
\n<\/b>
Doris Li, (973) 265-3752
\n
Yonatan Beker, (973) 917-0851\n<\/p>\n

KEYWORDS:<\/b> New York New Jersey United States North America Israel Middle East<\/p>\n

INDUSTRY KEYWORDS:<\/b> Science Biotechnology Research Pharmaceutical Medical Supplies General Health Health Clinical Trials<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
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<\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Late-Breaking Data at the International Headache Society & European Headache Federation Joint Congress 2021 Showed AJOVY\u00ae (fremanezumab-vfrm) Injection Reduced More Monthly Migraine Days in a Network Meta-Analysis Study with Atogepant and Rimegepant Study examined efficacy of AJOVY, atogepant and rimegepant in the prevention of episodic migraine TEL AVIV, Israel & PARSIPPANY, N.J.–(BUSINESS WIRE)– Teva Pharmaceuticals USA, Inc., a U.S. affiliate of Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA),today announced results from a network meta-analysis examining the efficacy of AJOVY (fremanezumab-vfrm), atogepant and Nurtec\u00ae ODT (rimegepant) in the preventive treatment of episodic migraine (EM). This data will be presented as a late-breaker ePoster during the International Headache Society (IHS) and European Headache Federation (EHF) Joint Congress taking place virtually on … <\/p>\n

Continue reading “Late-Breaking Data at the International Headache Society & European Headache Federation Joint Congress 2021 Showed AJOVY\u00ae (fremanezumab-vfrm) Injection Reduced More Monthly Migraine Days in a Network Meta-Analysis Study with Atogepant and Rimegepant”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-535443","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nLate-Breaking Data at the International Headache Society & European Headache Federation Joint Congress 2021 Showed AJOVY\u00ae (fremanezumab-vfrm) Injection Reduced More Monthly Migraine Days in a Network Meta-Analysis Study with Atogepant and Rimegepant - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/late-breaking-data-at-the-international-headache-society-european-headache-federation-joint-congress-2021-showed-ajovy-fremanezumab-vfrm-injection-reduced-more-monthly-migraine-days-in-a\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Late-Breaking Data at the International Headache Society & European Headache Federation Joint Congress 2021 Showed AJOVY\u00ae (fremanezumab-vfrm) Injection Reduced More Monthly Migraine Days in a Network Meta-Analysis Study with Atogepant and Rimegepant - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Late-Breaking Data at the International Headache Society & European Headache Federation Joint Congress 2021 Showed AJOVY\u00ae (fremanezumab-vfrm) Injection Reduced More Monthly Migraine Days in a Network Meta-Analysis Study with Atogepant and Rimegepant Study examined efficacy of AJOVY, atogepant and rimegepant in the prevention of episodic migraine TEL AVIV, Israel & PARSIPPANY, N.J.–(BUSINESS WIRE)– Teva Pharmaceuticals USA, Inc., a U.S. affiliate of Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA),today announced results from a network meta-analysis examining the efficacy of AJOVY (fremanezumab-vfrm), atogepant and Nurtec\u00ae ODT (rimegepant) in the preventive treatment of episodic migraine (EM). 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