{"id":526568,"date":"2021-08-11T08:04:30","date_gmt":"2021-08-11T12:04:30","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021\/"},"modified":"2021-08-11T08:04:30","modified_gmt":"2021-08-11T12:04:30","slug":"summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021\/","title":{"rendered":"Summit Therapeutics Reports Financial Results and Operational Progress for the Second Quarter and Six Months Ended June 30, 2021"},"content":{"rendered":"
\n

Cambridge, Massachusetts, Aug. 11, 2021 (GLOBE NEWSWIRE) — Summit Therapeutics Inc. (NASDAQ: SMMT) (“Summit,” “we,” or the “Company”) today reports its financial results and provides an update on its operational progress for the second quarter and six months ended June 30, 2021.<\/p>\n

\n Note: A glossary of terms is included at the end of this document in order to allow for the ease of understanding of terms or concepts used throughout this release.\u00a0<\/em>
\n \n <\/p>\n

\n Financial Highlights<\/strong>\n <\/p>\n

    \n
  1. Cash and cash equivalents on June 30, 2021, was $103.4 million, as compared to $66.4 million on December 31, 2020.<\/li>\n
  2. In April, the Company commenced a Rights Offering for our existing shareholders to participate in the purchase of additional shares of our common stock, in which the associated subscription rights expired on May 10, 2021.\u00a0 Through this Rights Offering, the Company raised $75 million through the issuance and sale of 14.3 million shares of common stock.\u00a0 Of the $75 million raised through the Rights Offering, $55 million was used to repay an outstanding note payable, which was issued in the previous quarter to initiate our fund raising for the current year.<\/li>\n
  3. The Company\u2019s existing cash and cash equivalents and committed external funding are expected to be sufficient to enable the Company to fund its operating expenses and capital expenditure requirements for at least the next twelve months.<\/li>\n
  4. Net loss for the three months ended June 30, 2021, was $24.4\u00a0million, as compared to a net loss of $15.3\u00a0million for the three months ended June 30, 2020. Net loss for the six months ended June 30, 2021, was $41.9\u00a0million, as compared to a net loss of $21.4\u00a0million for the six months ended June 30, 2020. <\/li>\n<\/ol>\n
      \n
    1. BARDA, in its support of our Ri-CoDIFy clinical trials and regulatory development of ridinilazole, has provided Summit with a financial award, potentially funding of up to $72.5\u00a0million.\u00a0 As of June 30, 2021, an aggregate of $54.7\u00a0million had been received by Summit from BARDA.<\/li>\n<\/ol>\n

      \n Ridinilazole for <\/strong>
      \n
      \n C. difficile<\/em>
      \n <\/strong>
      \n Infection (\u2018CDI\u2019)<\/strong>
      \n
      In conjunction with this release, we have simultaneously issued a press release today providing an update with respect to our Phase III Ri-CoDIFy clinical trials.\u00a0 Please refer to that release for our current operational progress with respect to ridinilazole.<\/p>\n

      \n Discuva Platform<\/strong>
      \n
      \n SMT-738 for Carbapenem-Resistant Enterobacteriaceae Infections<\/em>\n <\/p>\n

      The DDS-04 compound series is a novel class of precision antibiotics generated from our Discuva Platform with a new mechanism of action that acts via the novel bacterial target, LolCDE.\u00a0 SMT-738 is the first molecule of this novel class with the potential to treat multidrug resistant infections caused by a large family of pathogenic Gram-negative bacteria, the Enterobacteriaceae, that include serious human pathogens such as Escherichia coli<\/em> and Klebsiella pneumoniae<\/em>.\u00a0 Combining a novel antibiotic class (SMT-738) with a clinically unexploited target (LolCDE) mitigates the risk of pre-existing resistance, potentially allowing for the effective treatment of Enterobacteriaceae-caused infections that currently have very limited and failing treatment options due to resistance to existing antibiotic classes.<\/p>\n

      \n Corporate Highlights<\/strong>\n <\/p>\n

        \n
      1. In May, the Company announced its selection of a new pre-clinical candidate, SMT-738, for development in the fight against multidrug resistant infections, specifically CRE infections. Simultaneously, Summit has received an award from CARB-X to progress this candidate through preclinical development and Phase Ia clinical trials. The award commits initial funding of up to $4.1 million, with the possibility of up to another $3.7 million based on the achievement of future milestones.<\/li>\n
      2. In June, during our Annual Shareholders’ Meeting, we announced our intention to expand our pipeline beyond infectious diseases, and we have begun and will continue to evaluate products and companies with a focus on oncology and the health of the microbiome, in addition to anti-infectives.<\/li>\n
      3. In June, the Company’s NASDAQ-listed shares joined the broad-market Russell 2000\u00ae Index at the conclusion of the 2021 Russell indexes annual reconstitution.<\/li>\n
      4. In July, the Company presented breakthrough research data from our Phase II clinical trials for ridinilazole.\u00a0 Topics included evidence from Phase II trial sample data evidencing ridinilazole’s preservation of the gut microbiome, potential benefits for the control of antimicrobial resistance related to the minimal impact of ridinilazole on the gut resistome, and a novel mechanism of action for ridinilazole.\u00a0 These topics were displayed in the form of three ePosters at the prestigious ECCMID 2021 conference, one of which was an ECCMID-designated Top Rated ePoster.\u00a0 These posters can be found on our corporate website, www.summittxinc.com\/publications.<\/li>\n
      5. Throughout the first half of 2021, we have continued to build supporting layers to our team to fit the expansive vision of our company going forward.\u00a0 In doing so, we have appointed several individuals to positions of senior leadership, continuing to enhance the strong existing core leadership team and positioning the Company well for our strategic goals in the coming years.\u00a0 Leaders who have joined in Q2 and the beginning of Q3 comprise Heads of departments including, but not limited to, Research (Oncology & Inflammation), Biometrics, Marketing, Clinical Pharmacology & DMPK, Clinical Development, Information Technology, and our General Counsel.\u00a0 Each of these leaders brings substantial experience and are respected leaders within their fields.<\/li>\n<\/ol>\n

        \n About C. difficile<\/em> Infection<\/strong>
        \n
        \n Clostridioides difficile<\/em>, or C. difficile,<\/em> infection (CDI) is a bacterial infection of the colon that produces toxins causing inflammation of the colon, severe watery diarrhea, painful abdominal cramping, nausea, fever, and dehydration.\u00a0 CDI can also result in more serious disease complications, including bowel perforation, sepsis, and death.\u00a0 CDI is a contagious infectious disease that represents a serious healthcare issue in hospitals, long-term care facilities, and the wider community.\u00a0 Summit estimates that there are approximately 500,000 cases of CDI each year across the United States with acute care costs exceeding $5.4 billion in the US based on a meta-analysis published in the Journal of Global Health<\/em>, June 2019.<\/p>\n

        \n About Enterobacteriaceae<\/strong>
        \n
        Enterobacteriaceae are a family of bacteria responsible for serious infections across a number of conditions including bloodstream infections, urinary tract infections, and hospital-acquired pneumonias.\u00a0 Multidrug resistant Enterobacteriaceae are resistant to treatment by most or occasionally all existing antibiotics.\u00a0 The most difficult to treat among them are the carbapenem-resistant Enterobacteriaceae (CRE), which are classified as an Urgent Threat by the US Centers for Disease Control and Prevention (CDC).<\/p>\n

        \n About Summit Therapeutics <\/strong>
        \n
        The overriding objective of Summit Therapeutics is to create value for patients, hospital caregivers, and community-based healthcare providers, as well as healthcare payers around the world.\u00a0 We seek to create value by developing drugs with high therapeutic efficacy – curing the cause of the patient’s condition with minimal or zero disease recurrence or antimicrobial resistance, for the longest extent possible – and minimizing the trauma caused to the patient and healthcare ecosystem by minimizing serious side effects, disease recurrence, and inaccessibility to our treatments as a result of financial or other barriers. \u00a0Summit Therapeutics, empowered by its Discuva Platform, the Company\u2019s innovative antibiotic discovery engine, and supported by BARDA and CARB-X funding, intends to be the leader in patient-friendly and paradigm-shifting treatments for infectious diseases and other significant unmet medical needs while being an ally to physicians.\u00a0 Our new mechanism pipeline product candidates are designed with the goal to become the patient-friendly, new-era standard of care, by working in harmony with the human microbiome to treat prospective patients suffering from infectious diseases, initially focusing on Clostridioides difficile<\/em> infection (CDI).\u00a0 Currently, Summit\u2019s lead product candidate, ridinilazole, is a novel, first-in-class drug engaged in a global Phase III trial program versus vancomycin, for use as first-line therapy for the treatment of initial and recurrent Clostridioides difficile<\/em> infection, and to show superiority in sustained clinical response.\u00a0 Commercialization of ridinilazole is subject to regulatory approvals.\u00a0 SMT-738, the second candidate within Summit\u2019s portfolio, is currently in the IND-enabling phase for the treatment of multidrug resistant infections, specifically those caused by carbapenem-resistant Enterobacteriaceae (CRE).<\/p>\n

        For more information, please visit https:\/\/www.summittxinc.com and follow us on Twitter @summitplc.\u00a0 For more information on the Company\u2019s Discuva Platform, please visit https:\/\/www.summittxinc.com\/our-science\/discuva-platform<\/u><\/a>.\u00a0 <\/p>\n

        \n Contact Summit Investor Relations:<\/strong>\n <\/p>\n

        Dave Gancarz
        Head of Investor Relations & Corporate Strategy
        david.gancarz@summitplc.com<\/p>\n

        General Inquiries:\u00a0
        investors@summitplc.com<\/p>\n

        \n Summit Forward-looking Statements<\/strong>
        \n \n <\/p>\n

        Any statements in this press release about the Company\u2019s future expectations, plans and prospects, including but not limited to, statements about the clinical and preclinical development of the Company\u2019s product candidates, the therapeutic potential of the Company\u2019s product candidates, the potential commercialization of the Company\u2019s product candidates, the timing of initiation, completion and availability of data from clinical trials, the potential submission of applications for marketing approvals, the impact of the COVID-19 pandemic on the Company\u2019s operations and clinical trials and other statements containing the words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would,” and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. \u00a0Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: \u00a0the uncertainties inherent in the initiation of future clinical trials, availability and timing of data from ongoing and future clinical trials and the results of such trials, global public health crises, including the coronavirus COVID-19 outbreak, that may affect timing and status of our clinical trials and operations, whether preliminary results from a clinical trial will be predictive of the final results of that trial or whether results of early clinical trials or preclinical studies will be indicative of the results of later clinical trials, expectations for regulatory approvals, laws and regulations affecting government contracts and funding awards, availability of funding sufficient for the Company\u2019s foreseeable and unforeseeable operating expenses and capital expenditure requirements and other factors discussed in the “Risk Factors” section of filings that the Company makes with the Securities and Exchange Commission. \u00a0Any change to our ongoing trials could cause delays, affect our future expenses, and add uncertainty to our commercialization efforts, as well as to affect the likelihood of the successful completion of clinical development of ridinilazole. \u00a0Accordingly, readers should not place undue reliance on forward-looking statements or information. In addition, any forward-looking statements included in this press release represent the Company\u2019s views only as of the date of this release and should not be relied upon as representing the Company\u2019s views as of any subsequent date. \u00a0The Company specifically disclaims any obligation to update any forward-looking statements included in this press release. <\/p>\n

        \n \n <\/p>\n<\/p>\n

        \n \n <\/p>\n<\/p>\n

        \n SUMMIT THERAPEUTICS, INC.<\/strong>
        \n
        \n CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS<\/strong>
        \n
        \n (Unaudited)<\/strong>
        \n
        \n In thousands, except per share data<\/strong>\n <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
        \u00a0<\/td>\n\n Three Months Ended<\/strong>
        \n
        \n June 30,<\/strong>\n <\/td>\n        		\u00a0<\/td>\n\n Six Months Ended<\/strong>
        \n
        \n June 30,<\/strong>\n <\/td>\n<\/tr>\n
        \u00a0<\/td>\n\n 2021<\/strong>\n <\/td>\n\u00a0<\/td>\n\n 2020<\/strong>\n <\/td>\n\u00a0<\/td>\n\n 2021<\/strong>\n <\/td>\n\u00a0<\/td>\n\n 2020<\/strong>\n <\/td>\n<\/tr>\n
        \n Revenue:<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Licensing agreements<\/strong>\n <\/td>\n\n $<\/strong>\n <\/td>\n\n 57\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n 170\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n 249\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n 494\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Total revenue<\/strong>\n <\/td>\n\n 57\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 170\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 249\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 494\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Operating expenses:<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Research and development<\/strong>\n <\/td>\n\n 23,923\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 13,572\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 42,302\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 26,484\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n General and administrative<\/strong>\n <\/td>\n\n 5,984\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 5,774\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 10,169\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 9,346\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Total operating expenses<\/strong>\n <\/td>\n\n 29,907\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 19,346\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 52,471\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 35,830\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Other operating income<\/strong>\n <\/td>\n\n 6,120\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 3,820\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 11,569\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 10,640\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Loss from operations<\/strong>\n <\/td>\n\n (23,730)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (15,356)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (40,653)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (24,696)<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Other income (expense), net<\/strong>\n <\/td>\n\n (686)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (114)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (1,251)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 3,147\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Loss before income tax<\/strong>\n <\/td>\n\n (24,416)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (15,470)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (41,904)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (21,549)<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Income tax benefit<\/strong>\n <\/td>\n\n \u2014\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 191\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n \u2014\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 136\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Net loss<\/strong>\n <\/td>\n\n $<\/strong>\n <\/td>\n\n (24,416)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (15,279)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (41,904)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (21,413)<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Basic and diluted loss per share<\/strong>\n <\/td>\n\n $<\/strong>\n <\/td>\n\n (0.27)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (0.23)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (0.48)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (0.32)<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Other comprehensive income (loss):<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Foreign currency translation adjustment<\/strong>\n <\/td>\n\n 540\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (52)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 1,215\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (4,676)<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Total comprehensive loss<\/strong>\n <\/td>\n\n $<\/strong>\n <\/td>\n\n (23,876)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (15,331)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (40,689)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (26,089)<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n<\/table>\n

        \n \n <\/p>\n

        \n CONDENSED CONSOLIDATED BALANCE SHEET INFORMATION<\/strong>
        \n
        \n (Unaudited)<\/strong>
        \n
        \n In thousands <\/strong>\n <\/p>\n\n\n\n\n\n\n\n
        \u00a0<\/td>\n\u00a0<\/td>\n\n June 30, 2021<\/strong>\n <\/td>\n\u00a0<\/td>\n\n December 31, 2020<\/strong>\n <\/td>\n<\/tr>\n
        \u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Cash and cash equivalents<\/strong>\n <\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n 103,386\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n 66,417\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Total assets<\/strong>\n <\/td>\n\u00a0<\/td>\n\n 145,517\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 102,498\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Total liabilities<\/strong>\n <\/td>\n\u00a0<\/td>\n\n 26,090\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 23,045\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Total stockholders’ equity<\/strong>\n <\/td>\n\u00a0<\/td>\n\n 119,427\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 79,453\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n<\/table>\n

        \n
        \n
        \n <\/strong>\n <\/p>\n

        \n CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOW INFORMATION<\/strong>
        \n
        \n (Unaudited)<\/strong>
        \n
        \n In thousands<\/strong>\n <\/p>\n\n\n\n\n\n\n\n\n\n\n
        \u00a0<\/td>\n\u00a0<\/td>\n\n Six Months Ended<\/strong>
        \n
        \n June 30,<\/strong>\n <\/td>\n<\/tr>\n
        \u00a0<\/td>\n\u00a0<\/td>\n\n 2021<\/strong>\n <\/td>\n\u00a0<\/td>\n\n 2020<\/strong>\n <\/td>\n<\/tr>\n
        \u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Net cash used in operating activities<\/strong>\n <\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (39,843)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (23,492)<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Net cash used in investing activities<\/strong>\n <\/td>\n\u00a0<\/td>\n\n (190)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (327)<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Net cash provided by financing activities<\/strong>\n <\/td>\n\u00a0<\/td>\n\n 75,979\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n 3\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Effect of exchange rates in cash and cash equivalents<\/strong>\n <\/td>\n\u00a0<\/td>\n\n 1,023\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n (3,616)<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n
        \u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
        \n Net increase \/ (decrease) in cash and cash equivalents<\/strong>\n <\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n 36,969\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\n $<\/strong>\n <\/td>\n\n (27,432)<\/strong>\n <\/td>\n\u00a0<\/td>\n<\/tr>\n<\/table>\n

        \n
        \n
        \n <\/strong>\n <\/p>\n

        \n Appendix:\u00a0 Glossary of Critical Terms Contained Herein<\/strong>\n <\/p>\n

        \n Antibiotic resistance genes <\/strong>\u2013 Genes known to be involved in bacterial resistance; such genes may include for example beta-lactamases which can inactivate various beta-lactam antibiotics.<\/p>\n

        \n Bile acids<\/strong> \u2013 a collection of steroid-based gut metabolites, the balance of the amount of and types of bile acids in the gut microbiome are believed to play an important role in the development of or prevention of an initial and potential recurrent infection of Clostridioides difficile.<\/em>i<\/sup><\/p>\n

        \n Bloodstream infections<\/strong> \u2013 an infectious disease defined by the presence of viable bacterial or fungal microorganisms in the bloodstream that elicit or have elicited an inflammatory response.ii<\/sup><\/p>\n

        \n Carbapenem-Resistant Enterobacteriaceae (CRE) <\/strong>\u2013 Enterobacteriaceae that are resistant to carbapenems, a type of antibiotic used to treat some of the most resistant forms of gram-negative bacteria.\u00a0 This resistance means that there are fewer options available to treat infections caused by these bacteria, as CRE do not respond to commonly used antibiotics.\u00a0 In many cases, including infections such as urinary tract infections caused by CRE germs, more complex treatments are required. Instead of taking oral antibiotics at home, patients with these infections might require hospitalization and intravenous (IV) antibiotics.\u00a0 Occasionally CRE are resistant to all available antibiotics.\u00a0 CRE are a threat to public health.iii<\/sup><\/p>\n

        \n
        \n Clostridioides difficile<\/em>
        \n <\/strong>
        \n (C. difficile<\/em> or C. diff.<\/em>)<\/strong> \u2013 a germ (bacterium) that can cause severe diarrhea and colitis (an inflammation of the colon).\u00a0 C. difficile<\/em> can live naturally in the intestines (gut) of humans and not cause any problem. Sometimes changes in the gut microbiome lead the bacteria to grow and produce toxins from which illness can develop.iv<\/sup><\/p>\n

        \n
        \n C. diff.<\/em>
        \n <\/strong>
        \n Infection (CDI)<\/strong> \u2013 a bacterial infection of the colon that produces toxins causing inflammation of the colon and severe watery diarrhea, very painful and persistent abdominal cramping, nausea, fever, and dehydration. CDI can also result in more serious disease complications, including bowel perforation (a tear in the gastrointestinal tract), sepsis, and death.\u00a0 Most cases of C. diff.<\/em> infection occur while a person is taking antibiotics or not long after a person has finished taking antibiotics.\u00a0 CDI is an insidious and debilitating disease that necessitates patient isolation because of its contagious nature, making it able to be passed from one person to another either in a hospital or long-term care facility setting or in the community.v<\/sup><\/p>\n

        \n DDS-04<\/strong> \u2013 a series of new mechanism antibiotics targeting Enterobacteriaceae.\u00a0 DDS-04 acts via LolCDE, an essential bacterial complex responsible for the transport of lipoproteins from the inner to outer membrane in gram-negative bacteria.\u00a0 Because this complex has not been a previous target of existing antimicrobials, bacterial resistance does not yet exist to this targeted approach, potentially allowing for the treatment of highly-resistant Enterobacteriaceae-caused infections.\u00a0 Some of these infections, particularly in a subset of CRE-caused infections, do not have effective treatments through currently available antibiotics.vi<\/sup><\/p>\n

        \n Discuva Platform<\/strong> \u2013 Summit Therapeutics\u2019 proprietary platform that enables the identification of novel antimicrobials to expand Summit\u2019s pipeline of investigational drugs.\u00a0 The Discuva Platform focuses on identifying new antibiotics against bacteria where increasing resistance has limited treatment via existing antibiotics currently on the market.vii<\/sup><\/p>\n

        \n Enterobacteriaceae<\/strong> \u2013 a large family of different types of bacteria (germs) that commonly cause infections both in healthcare settings, such as hospitals and long-term care facilities, and in communities. Examples of germs in the Enterobacteriaceae family include Escherichia coli<\/em> (commonly known as E. coli<\/em>) and Klebsiella pneumoniae<\/em>.\u00a0 Enterobacteriaceae are frequent carriers of resistance genes to many of the currently available antibiotics used to treat bacterial infections.\u00a0 Because they are bacteria, Enterobacteriaceae can be passed from person to person.viii<\/sup><\/p>\n

        \n
        \n Escherichia coli (E. coli)<\/em>
        \n <\/strong> \u2013 a type of Enterobacteriaceae found in the environment, foods, and intestines of people and animals. E. coli <\/em>are a large and diverse group of bacteria. Although most strains of E. coli<\/em> are harmless, others can make a person sick. Some kinds of E. coli <\/em>can cause diarrhea, while others cause urinary tract infections, bloodstream infections, respiratory illness and pneumonia, and other illnesses.ix<\/sup><\/p>\n

        \n Gastrointestinal tract <\/strong>\u2013 a series of hollow organs joined in a long, twisting tube from the mouth to the anus.\u00a0 These organs also include the esophagus, stomach, small intestine, and large intestine.x<\/sup><\/p>\n

        \n Gut microbiome<\/strong> \u2013 within the human gastrointestinal tract, the gut microbiome is a collection of microbiota, consisting of trillions of microorganisms that inhabit the gut.\u00a0 The gut microbiota is considered an important partner to human cell systems, interacting extensively with other organs in the body to influence a wide range of functions from digestion to immunity.\u00a0 The balance of the different types of cells and microorganisms within the microbiome is considered to be important in the microbiome’s ability to properly play its role within the human body.\u00a0 Disruption in the balance of microorganisms within the gut microbiome (known as dysbiosis) is believed to impact the gut microbiome’s role in keeping a person healthy and free of certain conditions or diseases.xi xii<\/sup><\/p>\n

        \n Gut microbiota<\/strong> \u2013 the trillions of microorganisms, including symbiotic and pathogenic microorganisms, that inhabit the gut.\u00a0 Examples of these microorganisms include bacteria, fungi, viruses, protists, and archaea.<\/p>\n

        \n Gut resistome<\/strong> \u2013 within the human gastrointestinal tract, the diversity and dynamics of the antibiotic resistance genes that are harbored by the gut microbiota.\u00a0 Examples of the gut resistome include genes associated with resistance to carbapenem antibiotics.xiii<\/sup><\/p>\n

        \n Hospital-acquired pneumonia<\/strong>
        \n (HAP)<\/strong> \u2013 pneumonia that occurs 48 hours or more after a patient has been admitted to a hospital and was not present and incubating at the time of admission.\u00a0 Ventilator-associated pneumonia (VAP) is a significant sub-set of HAP, often occurring in intensive care units (ICUs) with a patient on a ventilator.\u00a0 Common pathogens of HAP and VAP include Enterobacteriaceae and Pseudomonas<\/em> species.\u00a0 Due to the presence of the bacteria in a hospital, these bacteria may be resistant to different antibiotics, potentially causing the resulting infection to be more difficult to treat.xiv<\/sup><\/p>\n

        \n
        \n Klebsiella pneumoniae<\/em>
        \n <\/strong> \u2013 a type of Enterobacteriaceae that can cause different types of healthcare-associated infections, including pneumonia, bloodstream infections, wound or surgical site infections, and meningitis. Increasingly, Klebsiella<\/em> bacteria have developed resistance to antibiotics, most recently to the class of antibiotics known as carbapenems. Klebsiella<\/em> bacteria are normally found in the human intestines (where they do not cause disease).\u00a0 In healthcare settings, Klebsiella<\/em> infections commonly occur among sick patients who are receiving treatment for other conditions. \u00a0Patients whose care requires devices like ventilators (breathing machines) or intravenous (vein) catheters, and patients who are receiving long courses of certain antibiotics are most at risk for Klebsiella<\/em> infections. Healthy people typically do not develop Klebsiella<\/em> infections.xv<\/sup><\/p>\n

        \n Sepsis<\/strong> \u2013 the body\u2019s extreme response to an infection and a life-threatening medical emergency.\u00a0 Sepsis occurs when an existing infection triggers a chain reaction throughout a person\u2019s body via the bloodstream.\u00a0 Without timely treatment, sepsis can rapidly lead to tissue damage, multi-organ failure, and death.\u00a0 Almost any type of infection can lead to sepsis. Infections that lead to sepsis most often start in the lung, urinary tract, skin, or gastrointestinal tract.\u00a0 Sepsis is a condition and is not contagious; however, the underlying cause of the infection (e.g., bacteria) can be spread from person to person.\u00a0 Bacterial infections cause most cases of sepsis.xvi<\/sup><\/p>\n

        \n Shotgun metagenomic analysis<\/strong> \u2013 shotgun metagenomic sequencing sequences all genomic DNA present in a sample. This allows a more accurate taxonomic annotation of the microbiota compared to other techniques such as 16S rRNA amplicon sequencing as well as antibiotic resistance gene profiling and metabolic function profiling.<\/p>\n

        \n Urinary tract infections (UTI) <\/strong>\u2013 common infections that happen when bacteria, often from the skin or rectum, enter the urethra, and infect the urinary tract. The infections can affect several parts of the urinary tract, but the most common type is a bladder infection.\u00a0 Kidney infections are another type of UTI and can be more serious than bladder infections.\u00a0 UTIs are usually caused by bacteria and are treated with antibiotics. People who have had multiple UTIs requiring multiple courses of antibiotics are at increased risk of developing antibiotic-resistant infections that can become increasing complex to treat.xvii<\/sup><\/p>\n

        \n Vancomycin<\/strong> \u2013 an antibiotic that is used to treat CDI<\/p>\n

        _____________________________<\/p>\n

        \n i<\/sup> Qian, X, et. al.<\/em> Ridinilazole, a narrow spectrum antibiotic for treatment of Clostridioides difficile <\/em>infection, enhances preservation of microbiota-dependent bile acids.\u00a0 Am J Physiol Gasterintest Liver Physiol<\/em> 319: G227-G237, 2020.<\/p>\n

        \n ii<\/sup> Viscoli C. Bloodstream Infections: The peak of the iceberg. Virulence<\/em>. 7(3):248-251, 2016. <\/p>\n

        \n iii<\/sup> United States Centers for Disease Control and Prevention.\u00a0 https:\/\/www.cdc.gov\/hai\/organisms\/cre\/index.html.\u00a0 Accessed February 2021.<\/p>\n

        \n iv<\/sup> Virginia Department of Health.\u00a0 https:\/\/www.vdh.virginia.gov\/epidemiology\/epidemiology-fact-sheets\/clostridiodes-difficile\/.\u00a0 Accessed February 2021. <\/p>\n

        \n v<\/sup> United States Centers for Disease Control and Prevention.\u00a0 https:\/\/www.cdc.gov\/cdiff\/what-is.html.\u00a0 Accessed February 2021.<\/p>\n

        \n vi<\/sup> Summit Therapeutics, Inc.\u00a0 https:\/\/www.summittxinc.com\/our-programmes\/enterobacteriaceae\/.\u00a0 Accessed February 2021.<\/p>\n

        \n vii<\/sup> Summit Therapeutics, Inc.\u00a0 https:\/\/www.summittxinc.com\/our-science\/discuva-platform\/.\u00a0 Accessed February 2021.<\/p>\n

        \n viii<\/sup> United States Centers for Disease Control and Prevention.\u00a0 https:\/\/www.cdc.gov\/hai\/organisms\/ESBL.html.\u00a0 Accessed February 2021.<\/p>\n

        \n ix<\/sup> United States Centers for Disease Control and Prevention.\u00a0 https:\/\/www.cdc.gov\/ecoli\/index.html.\u00a0 Accessed February 2021.<\/p>\n

        \n x<\/sup> US National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases.\u00a0 https:\/\/www.niddk.nih.gov\/health-information\/digestive-diseases\/digestive-system-how-it-works.\u00a0 Accessed February 2021.<\/p>\n

        \n xi<\/sup> Cani PD.\u00a0 Human gut microbiome: hopes, threats and promises.\u00a0 British Medical Journal (BMJ) Gut <\/em>67:<\/strong>1716-1725, 2018.<\/p>\n

        \n xii<\/sup> Qian, X, et. al.<\/em> Ridinilazole, a narrow spectrum antibiotic for treatment of Clostridioides difficile <\/em>infection, enhances preservation of microbiota-dependent bile acids.\u00a0 Am J Physiol Gasterintest Liver Physiol<\/em> 319: G227-G237, 2020.<\/p>\n

        \n xiii<\/sup> van Schaik, W. The human gut resistome. Philos Trans R Soc Lond B Biol Sci.<\/em> 370(1670):20140087, 2015.<\/p>\n

        \n xiv<\/sup> Shebl E, Gulick PG. Nosocomial Pneumonia. StatPearls.\u00a0 Updated 2020 Jul 21.<\/p>\n

        \n xv<\/sup> United States Centers for Disease Control and Prevention.\u00a0 https:\/\/www.cdc.gov\/hai\/organisms\/klebsiella\/klebsiella.html.\u00a0 Accessed February 2021.<\/p>\n

        \n xvi<\/sup> United States Centers for Disease Control and Prevention.\u00a0 https:\/\/www.cdc.gov\/sepsis\/index.html.\u00a0 Accessed February 2021.<\/p>\n

        \n xvii<\/sup> United States Centers for Disease Control and Prevention.\u00a0 https:\/\/www.cdc.gov\/antibiotic-use\/community\/for-patients\/common-illnesses\/uti.html.\u00a0 Accessed February 2021.<\/p>\n


        \n
        \n \n <\/div>\n

        <\/div>\n","protected":false},"excerpt":{"rendered":"

        Cambridge, Massachusetts, Aug. 11, 2021 (GLOBE NEWSWIRE) — Summit Therapeutics Inc. (NASDAQ: SMMT) (“Summit,” “we,” or the “Company”) today reports its financial results and provides an update on its operational progress for the second quarter and six months ended June 30, 2021. Note: A glossary of terms is included at the end of this document in order to allow for the ease of understanding of terms or concepts used throughout this release.\u00a0 Financial Highlights Cash and cash equivalents on June 30, 2021, was $103.4 million, as compared to $66.4 million on December 31, 2020. In April, the Company commenced a Rights Offering for our existing shareholders to participate in the purchase of additional shares of our common stock, in which … <\/p>\n

        Continue reading “Summit Therapeutics Reports Financial Results and Operational Progress for the Second Quarter and Six Months Ended June 30, 2021”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-526568","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nSummit Therapeutics Reports Financial Results and Operational Progress for the Second Quarter and Six Months Ended June 30, 2021 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Summit Therapeutics Reports Financial Results and Operational Progress for the Second Quarter and Six Months Ended June 30, 2021 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Cambridge, Massachusetts, Aug. 11, 2021 (GLOBE NEWSWIRE) — Summit Therapeutics Inc. (NASDAQ: SMMT) (“Summit,” “we,” or the “Company”) today reports its financial results and provides an update on its operational progress for the second quarter and six months ended June 30, 2021. Note: A glossary of terms is included at the end of this document in order to allow for the ease of understanding of terms or concepts used throughout this release.\u00a0 Financial Highlights Cash and cash equivalents on June 30, 2021, was $103.4 million, as compared to $66.4 million on December 31, 2020. 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021\/","og_locale":"en_US","og_type":"article","og_title":"Summit Therapeutics Reports Financial Results and Operational Progress for the Second Quarter and Six Months Ended June 30, 2021 - Market Newsdesk","og_description":"Cambridge, Massachusetts, Aug. 11, 2021 (GLOBE NEWSWIRE) — Summit Therapeutics Inc. (NASDAQ: SMMT) (“Summit,” “we,” or the “Company”) today reports its financial results and provides an update on its operational progress for the second quarter and six months ended June 30, 2021. Note: A glossary of terms is included at the end of this document in order to allow for the ease of understanding of terms or concepts used throughout this release.\u00a0 Financial Highlights Cash and cash equivalents on June 30, 2021, was $103.4 million, as compared to $66.4 million on December 31, 2020. In April, the Company commenced a Rights Offering for our existing shareholders to participate in the purchase of additional shares of our common stock, in which … Continue reading \"Summit Therapeutics Reports Financial Results and Operational Progress for the Second Quarter and Six Months Ended June 30, 2021\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021\/","og_site_name":"Market Newsdesk","article_published_time":"2021-08-11T12:04:30+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODMwNjk0NyM0MzUyNjQyIzIyMDkzODM=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"17 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Summit Therapeutics Reports Financial Results and Operational Progress for the Second Quarter and Six Months Ended June 30, 2021","datePublished":"2021-08-11T12:04:30+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021\/"},"wordCount":3494,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODMwNjk0NyM0MzUyNjQyIzIyMDkzODM=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/summit-therapeutics-reports-financial-results-and-operational-progress-for-the-second-quarter-and-six-months-ended-june-30-2021\/","name":"Summit Therapeutics Reports Financial Results and Operational Progress for the Second Quarter and Six Months Ended June 30, 2021 - 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