{"id":526515,"date":"2021-08-11T07:35:05","date_gmt":"2021-08-11T11:35:05","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\/"},"modified":"2021-08-11T07:35:05","modified_gmt":"2021-08-11T11:35:05","slug":"diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\/","title":{"rendered":"Diffusion Pharmaceuticals Reports Q2 Financial Results  and Provides Business Update"},"content":{"rendered":"<div class=\"mw_release\">\n<ul type=\"disc\">\n<li style=\"margin-top:5pt\">Reports Improved Outcomes in Phase 1b COVID-19 Study and Positive Trend\u00a0in Peripheral Oxygenation in Phase 1b TCOM Study<\/li>\n<li style=\"margin-top:5pt\">Expects to Announce Initial Indication and Regulatory Pathway in Fourth Quarter of 2021 and Initiate Clinical Outcome Study in First Half of 2022<\/li>\n<li style=\"margin-top:5pt\">Anticipates Cash Runway through 2023, Including Completion of TSC Phase 2b Program<\/li>\n<\/ul>\n<p>CHARLOTTESVILLE, Va., Aug.  11, 2021  (GLOBE NEWSWIRE) &#8212; <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=i1kP6S-0-x4H0fbxKPHNZmU-jpx_bnpX3r8_PTR_LgCDRNjd7vr_UrbL4vWEpzQ_C2vtS8jm4f7ohNz8sFyXpUJocPNnUgP6LRk0hDN9hrsirhvXma0zCiKYo6KN7bDU\" rel=\"nofollow noopener\" target=\"_blank\"><strong>Diffusion Pharmaceuticals Inc.<\/strong><\/a><strong> (NASDAQ: DFFN)<\/strong>\u00a0(\u201cDiffusion\u201d or the \u201cCompany\u201d), an innovative biopharmaceutical company developing novel therapies that enhance the body\u2019s ability to deliver oxygen to areas where it is needed most, today announced financial results for the second quarter of 2021 and provided a business update.<\/p>\n<p>\u201cWe met our key milestones for the first half of 2021, completing and announcing topline results from our COVID-19 Trial and the first of our Oxygenation Trials. Our development plan remains on track. With the positive outcomes of the COVID-19 and TCOM studies, as well as our significant capital raise in the first quarter, we believe we have the data and the financial capacity to execute our clinical development strategy for TSC through Phase 2b. For the remainder of 2021, we are focused on the design and execution of the remaining two Oxygenation Trials to further our understanding of TSC\u2019s mechanism of action and potential, as well as the further development of our regulatory and commercial strategy for TSC,\u201d said Robert Cobuzzi, Jr. Ph.D., President and CEO of Diffusion.<\/p>\n<p>\n        <strong>TSC Q2 Development Update<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li style=\"margin-top:5pt;margin-bottom:5pt\">In May 2021, Diffusion reported final results from its Phase 1b trial (the \u201cCOVID-19 Trial\u201d) of trans sodium crocetinate (\u201cTSC\u201d) in hospitalized COVID-19 patients. Although the study was not designed or powered to evaluate efficacy, the study\u2019s external safety monitoring committee observed that patients receiving the 1.5 mg\/kg dose of TSC had improved outcomes in secondary and exploratory endpoints compared to those receiving lower doses. The final results were consistent with topline results previously announced in February 2021, indicating that TSC was safe and well-tolerated when administered on a more frequent dosing regimen than previously tested in a clinical trial setting.<\/li>\n<li style=\"margin-top:5pt\">In June 2021, the Company reported a positive trend in oxygenation from its Phase 1b trial (the \u201cTCOM Trial\u201d) evaluating TSC using transcutaneous oxygen monitoring (\u201cTCOM\u201d). The TCOM Trial was designed to evaluate the effect of TSC versus placebo on peripheral tissue oxygenation in healthy normal volunteers. Topline results based upon analyses of primary endpoint data indicated, as compared to placebo, a positive dose-response trend in TCOM readings after TSC administration that persisted through the measurement period with no evidence of hyperoxygenation. TSC was also safe and well-tolerated at all doses tested.<\/li>\n<\/ul>\n<p>\n        <strong>TSC Development Plans for 2021 and 2022<\/strong>\n      <\/p>\n<p>The positive trend observed in the TCOM Trial is being used to guide dose selection in the additional Oxygenation Trials planned for the latter part of 2021 \u2013 the Altitude Trial, followed by the ILD-DLCO Trial.<\/p>\n<ul type=\"disc\">\n<li style=\"margin-bottom:7.5pt\">\n          <strong>Altitude Trial (formerly known as the Induced Hypoxia Trial):<\/strong>\u00a0\u00a0 This trial will be a double-blind, randomized, placebo-controlled study which will evaluate the effects of TSC on maximal oxygen consumption, or VO2, and partial pressure of blood oxygen, or PaO2, in normal healthy volunteers subjected to incremental levels of physical exertion while exposed to hypoxic and hypobaric conditions (i.e., simulated altitude). The study is designed to evaluate the effect of TSC versus placebo on maximal oxygen consumption and partial pressure of blood oxygen. Diffusion anticipates initiating and completing the Altitude Trial in the fourth quarter of 2021, with topline results available within one to two months of study completion.<\/li>\n<li style=\"margin-bottom:8pt\">\n          <strong>ILD &#8211; DLCO Trial:<\/strong>\u00a0\u00a0 This trial will be a double-blind, randomized, placebo-controlled study which will evaluate the effects of TSC on the diffusion of carbon monoxide through the lungs (\u201cDLCO\u201d) in patients with previously diagnosed interstitial lung disease (\u201cILD\u201d) who have a baseline DLCO test result that is abnormal. DLCO will act as a surrogate measure of oxygen transfer efficiency, or uptake, from the alveoli of the lungs, through the plasma, and onto hemoglobin within red blood cells. The study will be statistically powered to evaluate the difference in effect of TSC versus placebo on improvement in DLCO as well as in a standard six-minute walk test. Diffusion now anticipates initiating the ILD-DLCO Trial in the late fourth quarter of 2021 and completing the trial in the first quarter of 2022, with topline results available within one to two months of study completion.<\/li>\n<\/ul>\n<p>Diffusion expects to announce in the fourth quarter of 2021 the initial indication in which TSC will be studied to support the planned pathway for regulatory approval and to initiate a controlled, clinical outcome study evaluating TSC in the chosen indication during the first half of 2022, funded with cash-on-hand.<\/p>\n<p>\n        <strong>Operating and Leadership Team Developments<\/strong>\n      <\/p>\n<p>During the second quarter, Diffusion enhanced its operating team with the addition of new employees in the areas of administration, quality assurance, clinical operations, and finance. In addition, in connection with the Diffusion\u2019s annual meeting of stockholders in June 2021, Jane H. Hollingsworth was elected as the new chair of the Company\u2019s board of directors and Diana Lanchoney, M.D. and Eric Francois were newly elected to the board of directors. The Company believes these organizational additions have already had a significant, positive impact on its ability to develop, implement and execute on its corporate strategy and development plans, and position the Company well to build shareholder value through its next stage of growth.<\/p>\n<p>\n        <strong>2Q21 Financial Results<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>Research and development expenses in the second quarter were $2.0 million compared to expenses of $2.2 million in the prior year period. The decrease was attributable to the wind-down of the Company\u2019s clinical trial evaluating TSC in glioblastoma multiforme brain cancer and its COVID-19 Trial completed in February 2021. These decreases were offset by increased headcount and costs related to the TCOM Trial.\n<\/li>\n<li>General and administrative expenses were $1.8 million during the second quarter of 2021 versus $1.5 million in the comparable quarter last year. The increase compared to the prior year period was primarily attributable to increased salaries, wages, stock-based compensation, and professional fees related to increased headcount and costs associated with the separation of former employees that will not recur in future years.\n<\/li>\n<li>As of June 30, 2021, Diffusion had cash and cash equivalents of approximately $43.3 million as compared to $18.5 million as of December 31, 2020.<\/li>\n<\/ul>\n<p>\n        <strong>About Diffusion Pharmaceuticals Inc.<br \/><\/strong>Diffusion Pharmaceuticals Inc. is an innovative biopharmaceutical company developing novel therapies that enhance the body\u2019s ability to deliver oxygen to areas where it is needed most. Diffusion\u2019s lead product candidate, TSC, is being developed to enhance the diffusion of oxygen to tissues with low oxygen levels, also known as hypoxia, a serious complication of many of medicine\u2019s most intractable and difficult-to-treat conditions. In addition to TSC, Diffusion\u2019s product candidate DFN-529, a novel, allosteric PI3K\/Akt\/mTOR Pathway inhibitor, is in early-stage development. For more information, please visit us at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=VCLrXT6cjDm1tGWHynYyS4YOraasWznkj85nfYsyYRGe9SYdzi6OAAqyjJgMFOTrF5jJY6AEGu4H37eN_nv6XfGd3hGdy_-0CV2CFls5nyw=\" rel=\"nofollow noopener\" target=\"_blank\">www.diffusionpharma.com<\/a>.<\/p>\n<p>\n        <strong>Forward-Looking Statements<br \/><\/strong>This press release includes express and implied forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including regarding the Company\u2019s anticipated cash runway, its near-term strategic priorities, anticipated timelines for the initiation, completion, and announcement of data from the Company\u2019s planned Oxygenation Trials, the impact of organizational changes and the potential therapeutic value of TSC. The Company may, in some cases, use terms such as \u201cbelieves,\u201d \u201cestimates,\u201d \u201canticipates,\u201d \u201cexpects,\u201d \u201cplans,\u201d \u201cintends,\u201d \u201cmay,\u201d \u201ccould,\u201d \u201cmight,\u201d \u201cwill,\u201d \u201cshould,\u201d \u201capproximately,\u201d or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Although the Company believes that it has a reasonable basis for each forward-looking statement contained herein, forward-looking statements by their nature involve risks and uncertainties, known and unknown, many of which are beyond the Company\u2019s control, and as a result the Company\u2019s actual results could differ materially from those expressed or implied in any forward-looking statement. Particular risk and uncertainties include, among other things, those related to: the Company\u2019s ability to design, initiate, enroll, execute, and complete its planned studies evaluating TSC; the optimal doses and dosing regimens of TSC in connection with the potential treatment of any particular disease or indication; general economic, political, business, industry, and market conditions, including the ongoing COVID-19 pandemic; and the other factors discussed under the heading \u201cRisk Factors\u201d in the Company\u2019s filings most recent Annual Report on Form 10-K and other filings with the U.S. Securities and Exchange Commission. Any forward-looking statements in this press release speak only as of the date hereof (or such earlier date as may be identified) and, except as required by applicable law, rule, or regulation, the Company undertakes no obligation to update any such statements after the date hereof.<\/p>\n<p>\n        <strong>Contacts<\/strong><br \/>\n        <br \/>\n        <strong>Investors:\u00a0<\/strong>\u00a0<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=vH_VoAri4aHsFiwoal6GwrU0tccx5KYB6tV8qxAobXpYqh7he4VA3IjaPhpJgB9l6s9WUdvv49fSaFwLPYb_iBFzyq4EerbcCCH3j-egYYc=\" rel=\"nofollow noopener\" target=\"_blank\">Tiberend Strategic Advisors, Inc.<\/a>\u00a0<br \/>Maureen McEnroe, CFA\/ Lisa Sher<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=sVAjqmegTRkyYlkEfk392iYMrvinnyykCieUVrD1pQ8FaCpkUPrVMvSeLDoMZPPLqhwyfH9X4CpftDqGIUuWmYa9IoBKG3l-Bf1NE-vB5NU=\" rel=\"nofollow noopener\" target=\"_blank\">mmcenroe@tiberend.com<\/a>\u00a0\/ <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=DIIKhrKok1Re7MLMHyRgNgXpRqixPPHX9Zela3yVhY4zCB6Z3syJgrz393-BKPdjUhmhEnfhW3G5Hf4JBepeOXO5Ibc_tnvcMF0X8tKIZvM=\" rel=\"nofollow noopener\" target=\"_blank\">lsher@tiberend.com<\/a><\/p>\n<p>\n        <strong>Media:\u00a0<\/strong>\u00a0<br \/>Kate Barrette<br \/>RooneyPartners\u00a0\u00a0<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=-br9IdM8c1JJ656c0u6Tr5SZe3wQrOyXxNu_u_-612rCDh9ZrtKdHCDnTvYq2bxeMiJSZUc-M9P7FY7tiLHyhfjYQwRhHLm3kNXi2xfDw8ktNWDAc3MFEDyvKG8SXiWY\" rel=\"nofollow noopener\" target=\"_blank\">Kbarrette@rooneypartners.com<\/a><\/p>\n<p>      <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODMwNjkyNSM0MzUyNTExIzIwMjg5NDM=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" src=\"https:\/\/ml.globenewswire.com\/media\/MDlkYzhmMWEtNTQ0MC00ODM2LTk1NzktNTRmMjIyZDQ1NjBkLTEwNDA1MTQ=\/tiny\/Diffusion-Pharmaceuticals-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Reports Improved Outcomes in Phase 1b COVID-19 Study and Positive Trend\u00a0in Peripheral Oxygenation in Phase 1b TCOM Study Expects to Announce Initial Indication and Regulatory Pathway in Fourth Quarter of 2021 and Initiate Clinical Outcome Study in First Half of 2022 Anticipates Cash Runway through 2023, Including Completion of TSC Phase 2b Program CHARLOTTESVILLE, Va., Aug. 11, 2021 (GLOBE NEWSWIRE) &#8212; Diffusion Pharmaceuticals Inc. (NASDAQ: DFFN)\u00a0(\u201cDiffusion\u201d or the \u201cCompany\u201d), an innovative biopharmaceutical company developing novel therapies that enhance the body\u2019s ability to deliver oxygen to areas where it is needed most, today announced financial results for the second quarter of 2021 and provided a business update. \u201cWe met our key milestones for the first half of 2021, completing and announcing &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Diffusion Pharmaceuticals Reports Q2 Financial Results  and Provides Business Update&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-526515","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Diffusion Pharmaceuticals Reports Q2 Financial Results and Provides Business Update - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diffusion Pharmaceuticals Reports Q2 Financial Results and Provides Business Update - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Reports Improved Outcomes in Phase 1b COVID-19 Study and Positive Trend\u00a0in Peripheral Oxygenation in Phase 1b TCOM Study Expects to Announce Initial Indication and Regulatory Pathway in Fourth Quarter of 2021 and Initiate Clinical Outcome Study in First Half of 2022 Anticipates Cash Runway through 2023, Including Completion of TSC Phase 2b Program CHARLOTTESVILLE, Va., Aug. 11, 2021 (GLOBE NEWSWIRE) &#8212; Diffusion Pharmaceuticals Inc. (NASDAQ: DFFN)\u00a0(\u201cDiffusion\u201d or the \u201cCompany\u201d), an innovative biopharmaceutical company developing novel therapies that enhance the body\u2019s ability to deliver oxygen to areas where it is needed most, today announced financial results for the second quarter of 2021 and provided a business update. \u201cWe met our key milestones for the first half of 2021, completing and announcing &hellip; Continue reading &quot;Diffusion Pharmaceuticals Reports Q2 Financial Results and Provides Business Update&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-11T11:35:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODMwNjkyNSM0MzUyNTExIzIwMjg5NDM=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Diffusion Pharmaceuticals Reports Q2 Financial Results and Provides Business Update\",\"datePublished\":\"2021-08-11T11:35:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\\\/\"},\"wordCount\":1459,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODMwNjkyNSM0MzUyNTExIzIwMjg5NDM=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\\\/\",\"name\":\"Diffusion Pharmaceuticals Reports Q2 Financial Results and Provides Business Update - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/diffusion-pharmaceuticals-reports-q2-financial-results-and-provides-business-update\/","og_locale":"en_US","og_type":"article","og_title":"Diffusion Pharmaceuticals Reports Q2 Financial Results and Provides Business Update - Market Newsdesk","og_description":"Reports Improved Outcomes in Phase 1b COVID-19 Study and Positive Trend\u00a0in Peripheral Oxygenation in Phase 1b TCOM Study Expects to Announce Initial Indication and Regulatory Pathway in Fourth Quarter of 2021 and Initiate Clinical Outcome Study in First Half of 2022 Anticipates Cash Runway through 2023, Including Completion of TSC Phase 2b Program CHARLOTTESVILLE, Va., Aug. 11, 2021 (GLOBE NEWSWIRE) &#8212; Diffusion Pharmaceuticals Inc. 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